The Zebrafish: disease models and chemical screens:
Gespeichert in:
| Weitere Verfasser: | , , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Cambridge
Elsevier, Academic Press
2017
|
| Ausgabe: | Fourth edition |
| Schriftenreihe: | Methods in cell biology
Volume 138 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Bis zur 3. Auflage andere Bandeinteilung |
| Beschreibung: | xxiv, 721 Seiten Illustrationen |
| ISBN: | 9780128034736 |
Internformat
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Datensatz im Suchindex
| _version_ | 1804177355541839872 |
|---|---|
| adam_text | Contents
Contributors....................................................xvii
Preface.........................................................xxiii
PART I ADIPOSE TISSUE
CHAPTER 1 In Vivo Imaging and Quantification of Regional
Adiposity in Zebrafish.....................................3
J.E.N. Minchin, i.F. Rawls
Introduction...............................................4
1. Rationale.................................................5
2. Materials............................................... 7
3. Methods.............................................. 11
4. Summary..................................................23
Acknowledgments......................................... 24
References........................................... ..24
PART II INNATE AND ADAPTIVE IMMUNE SYSTEMS
CHAPTER 2 Innate Immune Cells and Bacterial Infection in
Zebrafish.................................................31
J, W. Astin, P. Keerthisinghe, L Du, L.E. Sanderson,
K. E. Crosier, P.S. Crosier, CJ. Hall
Introduction............................................32
1. Quantifying the Innate Immune Cell Response to Bacterial
Infection.................................................35
2. Bioassays for Assessing Neutrophil Bactericidal Function.42
3. Bioassays for Assessing Macrophage Bactericidal Function.46
4. Drug Discovery Platform to Identify New
Immunomodulatory Drugs.................................. 50
Acknowledgments...........................................55
References................................................55
Contents
CHAPTER 3 Best Practices for Germ-Free Derivation and
Gnotobiotic Zebrafish Husbandry...........................61
E. Melancon, S. Gomez De La Torre Canny, S. Sichel,
M. Kelly, T.i. Wiles, i.F. Rawls, J.S. Eisen, K. Guillemin
Introduction..............................................62
1. Experimental Procedures..................................66
2. Prospectus...............................................89
3. Solutions................................................93
Acknowledgments...........................................95
References................................................95
CHAPTER 4 Infectious Disease Models in Zebrafish...................101
C. Sullivan, M.A. Matty, D. Jurczyszak, K.A. Gabor,
P.J. Millard, D.M. Tobin, C.H. Kim
Introduction.............................................103
1. Methods for Systemic Bacterial and Viral Infections.....104
2. Methods for Localized Bacterial and Viral Infections....123
Conclusion...............................................128
References...............................................129
CHAPTER 5 Live Imaging the Earliest Host Innate Immune
Response to Preneoplastic Cells Using
a Zebrafish Inducible KalTA4-ERT2/UAS
System...................................................137
D. W. Laux, L. Kelly, I. Ribeiro Bravo, T. Ramezani,
Y. Feng
Introduction.............................................138
1. Generation of Preneoplastic Cell Clones Using the
KalTA4-ERT2/UAS System in Zebrafish Larvae...............141
2. Live Imaging Preneoplastic Cell: Neutrophil Interaction
Using Confocal Microscopy.............................. 143
3. Image Analysis and 4D Reconstruction....................145
Conclusion...............................................147
Acknowledgments..........................................147
References...............................................147
Contents
ix
CHAPTER 6 Studying the Adaptive Immune System in
Zebrafish by Transplantation of Hematopoietic
Precursor Cells.......................................151
N. Iwanami, I. Hess, M. Schorpp, T. Boehm
Introduction..........................................152
1. Methodology for the Transplantation of Hematopoietic Cells... 155
2. Discussion............................................157
3. Future Directions.....................................159
Acknowledgments.......................................159
References............................................160
PART III BLOOD AND LYMPH
CHAPTER 7 Hematopoietic Stem Cell Development: Using the
Zebrafish to Identify Extrinsic and Intrinsic
Mechanisms Regulating Hematopoiesis.....................165
J.M. Frame, S.-E. Urn, T.E. North
Introduction to Hematopoietic Development...............166
1. Use of Zebrafish to investigate Hematopoietic Stem Cell
Development.............................................171
2. Zebrafish Tools and Protocols..........................179
References..............................................184
CHAPTER 8 Studying Disorders of Vertebrate Iron and Heme
Metabolism Using Zebrafish..............................193
Lisa N. van der Vorm, Barry H. Paw
1. Overview of Vertebrate Cellular Iron and Heme
Metabolism..............................................194
2. Advantageous Properties of Zebrafish to Study Genetics.196
3. Tools to Study Iron and Heme Metabolism Using
Zebrafish............................................. 197
Conclusions and Future Directions.......................212
Acknowledgments.........................................212
References..............................................212
X
Contents
CHAPTER 9 The Lymphatic Vasculature Revisited—New
Developments in the Zebrafish.......................221
Y. Padberg, S. Schulte-Merker, A. van Impel
1. Development of the Lymphatic System in the
Zebrafish Trunk.....................................222
2. Molecular Mechanisms Regulating Lymphatic Cell Fate
Specification.......................................224
3. Vegfc Signaling and Sprouting From the Posterior
Cardinal Vein.......................................227
4. Parachordal Lymphangioblast Migration at the Level
of the Horizontal Myoseptum.........................229
5. Development of Lymphatic Structures in the Head and
the Gut.............................................231
Concluding Remarks..................................233
References.......................................... 233
PART IV VISCERAL ORGANS
CHAPTER 10 Modeling Intestinal Disorders Using Zebrafish...............241
X. Zhao, M. Pack
1. Intestinal Development, Morphology, and Physiology......242
2. Intestinal Microbiota and Host—Microbe Interactions.....245
3. Intestinal Inflammatory Conditions......................247
4. Enteric Nervous System and Motility Disorders...........254
5. Intestinal Tumorigenesis and Cancer.....................258
Concluding Remarks.......................................259
Acknowledgments..........................................260
References...............................................260
CHAPTER 11 Analysis of Pancreatic Disease in Zebrafish..............271
S.C. Eames Nalle, K.F. Franse, M.D. Kinkel
Introduction.............................................272
1. Method 1. Fasting Adult Zebrafish.......................273
2. Method 2. Weighing Live, Swimming Zebrafish Without
Anesthetic...............................................275
3. Method 3. Glucose Delivery to Adult Zebrafish Using
Intraperitoneal Injection................................276
4. Method 4. Dissection of the Pancreas, En Bloc, for
Histology................................................285
Contents
X!
5. Method 5. Sterile Dissection and Culture of the Principal
Islet...........................................288
Acknowledgments.................................294
References......................................294
PART V MUSCULOSKELETAL SYSTEM
CHAPTER 12 Using the Zebrafish to Understand Tendon
Development and Repair..................................299
J.W. Chen, J.L. Galloway
Introduction............................................300
1. Tendon Structure........................................301
2. Tendon Formation and Differentiation...................301
3. Tissue Interactions Within the Developing Musculoskeletal
System..................................................304
4. Methods to Study the Embryonic Tendon Program in
Zebrafish...............................................306
Conclusion..............................................314
Acknowledgments....................................... 314
References..............................................315
CHAPTER 13 Small Teleost Fish Provide New Insights Into
Human Skeletal Diseases............................... 321
P.E. Witten, M.P. Harris, A. Huysseune, C. Winkler
Introduction............................................322
1. A Fresh View on the Teleost Skeleton and Its Special
Characters..............................................323
2. Analyzing Skeletal Phenotypes of Small Fish............327
3. Mutant and Transgenic Fish Open New Directions
in Skeletal Research....................................332
4. Genetic Phenocopies of Human Skeletal Diseases.........334
5. Lifelong Tooth Replacement.............................335
Concluding Remarks......................................336
Acknowledgments.........................................337
References..............................................337
xii Contents
CHAPTER 14 Muscular Dystrophy Modeling in Zebrafish....................347
M. Li, K.J. Hromowyk, S.L. Amacher, P.D. Currie
Introduction............................................348
1. Muscular Dystrophies and the Dystrophin-Associated
Glycoprotein Complex....................................350
2. Skeletal Muscle Properties in Zebrafish................354
3. Models of Muscular Dystrophy in Zebrafish..............361
4. Small Molecule Screens..................................366
Conclusions..............................................368
References...............................................369
PART VI CENTRAL AND SENSORY NERVOUS SYSTEMS
CHAPTER 15 Analysis of Myelinated Axon Formation in
Zebrafish................................................383
M. D’Rozario, K.R. Monk, S.C. Petersen
Introduction.............................................384
1. Visualization of Myelinating Glia in Zebrafish...........386
2. Genetic Analysis of Myelin Development in Zebrafish.....392
3. Pharmacological Manipulation of Myelinated Axons in
Zebrafish................................................398
4. Plasticity, Maintenance, and Regeneration of Myelinated
Axons in Zebrafish.......................................401
Conclusions..............................................404
Acknowledgments........................................ 404
References...............................................404
CHAPTER 16 Zebrafish Models of Human Eye and Inner Ear
Diseases............................................. 415
B. Blanco-Sanchez, A. Clément, J.B. Phillips,
M. Westerfield
Introduction.............................................416
1. Zebrafish Models of Eye Disease..........................419
2. Zebrafish Models of Ear Disease.........................423
3. Zebrafish Models of Syndromes Affecting Eye and/or Ear .... 432
Conclusion...............................................445
References...............................................446
Contents xiii
PART VII CANCER
CHAPTER 17 A Zebrafish Xenograft Model for Studying
Human Cancer Stem Cells in Distant Metastasis
and Therapy Response.....................................471
L. Chen, A. Groenewoud, C. Tulotta, E. Zoni,
M. Kruithof-de Julio, G. van der Horst, G. van der Pluijm,
B. Ewa Snaar-Jagalska
Introduction.............................................472
1. Establishment of Human Cancer Stem Cells Xenograft
Model....................................................474
2. Analysis of Interaction Between Cancer
Stem/Progenitor-Likc Cells and Microenvironment..........480
3. Genetic and Chemical Targeting of Tumor-Stroma
Interactions in Cancer Stem/Progenitor-Like
Cells—Xenograft..........................................486
Conclusion...............................................489
Acknowledgments..........................................490
References...............................................490
CHAPTER 18 Zebrafish as a Model for Von Hippel Lindau
and Hypoxia-inducible Factor Signaling............497
H.R. Kim, 0. Greenaid, A. Vettori, E. Markham,
K. Santhakumar, F. Argenton, F. van Eeden
Introduction............................................498
1. Hypoxic Signaling......................................499
2. Hypoxic Signaling: Overview of the Zebrafish
Orthologucs.............................................500
3. The Zebrafish HIF Genes................................500
4. HIF Protein Expression.................................501
5. The HIF Hydroxylases...................................504
6. The VHL Genes..........................................504
7. HIF Binding Sites in the Genome........................505
8. Hypoxic/HIF Target Gene Comparison.....................506
9. Hypoxic Signaling Reporters in Zebrafish...............507
10. Links Between HIF and the Circadian Clock..............507
11. Zebrafish VHL Mutants as Models of Hif Hyperactivation... 508
Contents
12. Hematopoietic and Angiogenic Phenotypes in VHL
Mutants...............................................509
13. VHL/HIF Effects on Metabolism.......................510
14. Kidney Defects in VHL Mutants and Cancer.............511
15. Links Between VHL HIF and P53........................512
Appendix A. Supplementary data........................514
References............................................514
CHAPTER 19 Discovering Novel Oncogenic Pathways and
New Therapies Using Zebrafish Models of
Sarcoma........................................... 525
M.N. Hayes, D.M. Langenau
Introduction..........................................526
1. Rhabdomyosarcoma......................................529
2. Malignant Peripheral Nerve Sheath Tumors..............537
3. Ewing’s Sarcoma.......................................543
4. Chordoma..............................................546
5. Hemangiosarcoma.......................................549
6. Liposarcoma...........................................551
7. Future Perspectives and Opportunities.................554
References........................................... 554
CHAPTER 20 Zebrafish Models of Leukemia..............................563
S. He, C.-B. Jing, A.T. Look
1. T-Cell Acute Lymphoblastic Leukemia...................564
2. B-Cell Acute Lymphoblastic Leukemia...................572
3. Myeloid Malignancies..................................574
Conclusions...........................................581
References............................................581
CHAPTER 21 Investigating Microglia-Brain Tumor Cell
Interactions In Vivo in the Larval
Zebrafish Brain.......................................593
K.R. Astell, D. Sieger
Introduction..........................................594
1. Methods..............................................598
2. Summary..............................................620
Acknowledgments.......................................620
References............................................621
Contents
PART VIII TRANSPLANTATION
CHAPTER 22 Transplantation in Zebrafish.........................629
J.M. Gansner, M. Dang, M. Ammerman, L.l. Zon
Introduction........................................630
1. Rationale..........................................631
2. Methods............................................634
3. Discussion.........................................641
Acknowledgments.....................................643
References..........................................643
PART IX CHEMICAL SCREENING
CHAPTER 23 Chemical Screening in Zebrafish for Novel
Biological and Therapeutic Discovery....................651
D.S. Wiley, S.E. Redfield, L.l. Zon
Introduction............................................652
1. Rationale............................................ 656
2. Materials and Methods..................................656
3. Discussion/caveats.....................................669
Summary.................................................671
Acknowledgments.........................................672
References..............................................672
Index................................................................681
Volumes in Series......................................................709
|
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| owner | DE-355 DE-BY-UBR DE-11 DE-20 |
| owner_facet | DE-355 DE-BY-UBR DE-11 DE-20 |
| physical | xxiv, 721 Seiten Illustrationen |
| publishDate | 2017 |
| publishDateSearch | 2017 |
| publishDateSort | 2017 |
| publisher | Elsevier, Academic Press |
| record_format | marc |
| series | Methods in cell biology |
| series2 | Methods in cell biology |
| spelling | The Zebrafish: disease models and chemical screens edited by H. William Detrich, III, Monte Westerfield, Leonard I. Zon Fourth edition Cambridge Elsevier, Academic Press 2017 xxiv, 721 Seiten Illustrationen txt rdacontent n rdamedia nc rdacarrier Methods in cell biology Volume 138 Bis zur 3. Auflage andere Bandeinteilung Genomik (DE-588)4776397-8 gnd rswk-swf Zebrabärbling (DE-588)4079468-4 gnd rswk-swf Tiermodell (DE-588)4140660-6 gnd rswk-swf Transkriptomanalyse (DE-588)4775956-2 gnd rswk-swf Methode (DE-588)4038971-6 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Zebrabärbling (DE-588)4079468-4 s Tiermodell (DE-588)4140660-6 s Methode (DE-588)4038971-6 s DE-604 Genomik (DE-588)4776397-8 s Transkriptomanalyse (DE-588)4775956-2 s 1\p DE-604 Detrich, H. William (DE-588)1013514475 edt Westerfield, Monte edt Zon, Leonard I. edt Methods in cell biology Volume 138 (DE-604)BV002534878 138 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029618898&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | The Zebrafish: disease models and chemical screens Methods in cell biology Genomik (DE-588)4776397-8 gnd Zebrabärbling (DE-588)4079468-4 gnd Tiermodell (DE-588)4140660-6 gnd Transkriptomanalyse (DE-588)4775956-2 gnd Methode (DE-588)4038971-6 gnd |
| subject_GND | (DE-588)4776397-8 (DE-588)4079468-4 (DE-588)4140660-6 (DE-588)4775956-2 (DE-588)4038971-6 (DE-588)4143413-4 |
| title | The Zebrafish: disease models and chemical screens |
| title_auth | The Zebrafish: disease models and chemical screens |
| title_exact_search | The Zebrafish: disease models and chemical screens |
| title_full | The Zebrafish: disease models and chemical screens edited by H. William Detrich, III, Monte Westerfield, Leonard I. Zon |
| title_fullStr | The Zebrafish: disease models and chemical screens edited by H. William Detrich, III, Monte Westerfield, Leonard I. Zon |
| title_full_unstemmed | The Zebrafish: disease models and chemical screens edited by H. William Detrich, III, Monte Westerfield, Leonard I. Zon |
| title_short | The Zebrafish: disease models and chemical screens |
| title_sort | the zebrafish disease models and chemical screens |
| topic | Genomik (DE-588)4776397-8 gnd Zebrabärbling (DE-588)4079468-4 gnd Tiermodell (DE-588)4140660-6 gnd Transkriptomanalyse (DE-588)4775956-2 gnd Methode (DE-588)4038971-6 gnd |
| topic_facet | Genomik Zebrabärbling Tiermodell Transkriptomanalyse Methode Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029618898&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002534878 |
| work_keys_str_mv | AT detrichhwilliam thezebrafishdiseasemodelsandchemicalscreens AT westerfieldmonte thezebrafishdiseasemodelsandchemicalscreens AT zonleonardi thezebrafishdiseasemodelsandchemicalscreens |