Animal and plant stem cells: concepts, propagation and engineering
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| Main Author: | |
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| Format: | Electronic eBook |
| Language: | English |
| Published: |
Cham
Springer
2017
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| Subjects: | |
| Online Access: | BTU01 FAB01 FAW01 FHA01 FHI01 FHN01 FHR01 FKE01 FLA01 FRO01 FWS01 FWS02 TUM01 UBY01 Volltext Inhaltsverzeichnis |
| Physical Description: | 1 Online-Ressource (xvii, 234 Seiten) Illustrationen |
| ISBN: | 9783319477633 |
| DOI: | 10.1007/978-3-319-47763-3 |
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Record in the Search Index
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| adam_text | Contents
1 Introduction 1
References 3
Part I Bioengineering and Animal Stem Cells
2 Current Status and Perspectives in Stem Cell Research:
The Concept of Normal Stem (NSC) and Cancer
Stem Cell (CSC) 7
2 1 Introduction 7
2 2 Sternness, Migration, Circulation, and Seeding 8
2 3 Mobilization 8
2 4 Similarities and Differences Between Embryonic
and Adult Stem Cells 9
2 5 Similarities and Differences Between Normal and Cancer
Stem Cell 9
2 6 Resume Based upon Similarities and Differences Between
NSCs and CSCs 10
2 7 What and Which Molecular Markers of CSCs We Know
Today? 11
2 8 Isolation of CSCs Using Magnetic Beads 11
2 9 Theories of Origin of CSCs 11
2 10 Current Tests for Determination of the Presence of CSCs 12
2 11 Sorting and Isolation of CTC Using the Method
of Magnetic Levitation 12
2 12 The Emergence/Origin and Development of CSC:
Mechanisms 13
2 13 Aberrant Methylation 13
2 14 What Do We Need to Do with the Sum of Information? 14
2 15 How Was the Concept of CSC Therapy Designed? 14
References 14
IX
X
Contents
3 Essential Characteristics of Stem Cells: Self-renewal,
and Plasticity 17
3 1 The Nature of Stem Cells 17
3 2 Self-renewal and Its Significance for Stem Cells 18
3 3 Plasticity/Pluripotency of Animal Stem Cells
and Its Mechanisms 19
3 4 Other Features of Significance 19
References 20
4 Stem Cell Sources and Types of Animal Stem Cells 23
4 1 Introduction 23
4 2 Embryonic SCs (ES or ESC) 23
4 3 Fetal Stem Cells (FSC) 24
4 4 Bone Marrow and Other Adult Stem Cells Sources 24
References 26
5 Sternness and Stem Cell Markers 27
5 1 Introduction 27
5 2 Human Embryonic Stem Cell Markers and Pluripotency 28
5 3 Fetal Stem Cell Markers 29
5 4 Cord Blood Stem Cell Markers 30
5 5 Placental Stem Cell Markers 30
5 6 Adult Stem Cell Markers 30
References 31
6 Stem Cell Signaling Molecules and Pathways 33
6 1 Introduction 33
6 2 ESC-Wnt Signaling 35
621 Significant Discoveries in Wnt 35
6 3 Notch Signaling 37
6 4 The Human Hedgehog Signaling 37
6 5 TGF-Beta Signaling 37
6 6 Signaling Mechanisms in Adult Human Cells
(HSC and MSC) 37
6 7 Pathways in Adult HSC 39
6 8 Pathways in Adult Mesenchymal Stem Cells 39
6 9 Pathways in CSC 40
6 10 The JAK (Janus Kinase)/STAT3 (Signal Transducer
and Activator of Transcription) Signal Mechanism 41
References 42
Contents
xi
7 Expansion of Stem Cells: Propagation of Animal
Stem Cells Ex Vivo (In Culture) 45
7 1 What Is Expansion and What Do We Expect
from Expansion? 45
7 2 Basic Concept—Ex Vivo Expansion of Hematopoietic
Cells Today 46
721 Molecules 46
722 Distinct Stimuli 47
723 Media for Expansion 47
724 Hypoxia 47
References 48
8 Stem Cell Pool: What Are the Best Patterns
for Cellular Therapy? 51
8 1 Introduction 52
8 2 Organogenesis from Adult Stem Cells and Problems
with Different Tissues 54
8 3 Therapeutic Implications for TCSCs as a New Concept 55
8 4 The Concept of VSEL 56
8 5 The Concept of Mesenchymal Stem Cell (MSC)
with Dental Pulp Cells (DPSCs) as an Example 60
8 6 Mobilization as a New Noninvasive Therapeutic
Concept 62
8 7 New Concepts in Adult Stem Cell Research
with Development of New Strategies: Personal Experience
in the Light of Significance of Growing Information 63
871 Background and Significance 63
8 8 Directions and Relevant Studies: We and Others 64
8 9 Optimization of Primitive Stem Cell Patterns
for Regeneration and Repair 65
References 66
9 Induced Pluripotent Stem Cells (iPSCs) and Nuclear
Reprogramming 71
9 1 Breakthrough: Induced Pluripotent Stem Cells (iPSC) 72
911 Reprogramming as a Therapeutic Event 72
9 2 Induced Pluripotent Stem Cells (iPSCs)
and Nanotechnology: State of the Art 74
9 3 Nanoparticles for Genetic Reprogramming of Somatic
Cells to iPSCs 75
931 Poly(Beta-Amino Ester) Nanoparticle-Based
Non-viral Protocol 76
932 Calcium Phosphate Nanoparticle Based Non-viral
Protocol 77
Contents
933 Polyketal Nanoparticle-Mediated Non-viral,
Non-genetic Approach for Delivery
of Mature MicroRNAs 77
934 Non-viral Magnetic Nanoparticle Based
Transfection 78
935 The Impact of iPSC upon the Research
and Practical Application 79
References 80
10 Cancer Stem Cell Concept 93
References 96
11 Metabolic Reprogramming in Cancer and Metabolic
Theory of CSC 99
11 1 Metabolism of CSC: New Explanations
and the Old Fundament 99
11 2 Terminology of Energy Metabolism 100
11 3 Coupling of the Respiration with OXPHOX 102
11 4 Mechanisms of ATP Synthesis 102
11 5 Metabolic Abnormalities in Cancer Cells
and Mitochondria 102
11 6 The Hallmarks of Cancer Cell Energy Metabolism:
The Warburg Effect and the Crabtree Effect 105
11 7 Resume: Energy Metabolism in Cancer Cell
Compromised? 107
11 8 The Overview on CSC Metabolic Activity 107
11 9 New Cancer Therapy Concept 109
References 109
12 Concept of Targeted Cancer Stem Cell Therapy
and New Versions 113
12 1 The Idea of Targeted Therapy: Before, Now,
and in the Future 113
12 2 Can We Use NSCs in the Therapy of Cancer? 114
12 3 Mitochondria as the Target 114
12 4 Other Targeting Possibilities 114
12 5 New Modalities of Targeted Therapy and Idea
of Remote Control 115
12 6 Principles of Targeted Therapy Based on Nanoparticles 115
12 7 What is the Best Way to Kill CSC: New Methods? 115
12 8 Different Combinations of Targeted Therapy 115
12 9 The Use of Electromagnetic Fields for Growth
Inhibition of CSC 116
12 10 Cancer and Electromagnetism 116
12 11 Different Principles: Drug Delivery Based upon
Nanoparticles of Ferrous Oxide 117
Contents
xiii
12 12 3D-Printed Tumor Model 117
12 13 Computerized 3D Model for Analysis of Aggregation
of Tumorigenic Cells Is Revealing Specialized Behavior
and Unique Cell Types Which Accelerate the Aggregation
Process 118
12 14 Possible Mechanisms of Tumor Cellular Heterogeneity:
Mediated Coalescence? 118
12 15 Summary 118
12 16 Conclusions 119
12 17 A Look Ahead; What Does the Future Say? 120
References 121
13 HLA Typization Choice of Donors: Match or Match Me Not 125
13 1 Distinction Between HLA and MSH Genes Molecules
and Functions 125
13 1 1 HLA (H-Histocompatibility Locus Antigen) 125
13 1 2 MHC (Major Histocompatibility Complex) 125
13 1 3 HLA Genes 126
13 1 4 MHC Genes 126
13 1 5 Polygeny and Polymorhysm of MHC 126
13 1 6 The Mechanism of Gene Rearrangement Is
Contributing to and Allowing for Antigen
Diversity 128
13 1 7 Transplantation Needs Matching to Support
Engraftment 128
References 129
14 Engraftment: Homing and Use of Genetic Markers 131
14 1 What is Engraftment/Homing? 131
14 2 Genetic Markers 131
References 132
15 Nanotechnology in Stem Cell Research 133
15 1 Nanotechnology/Nanoparticles 133
References 134
16 Stem Cell Therapy: Optimization, Regeneration,
Reprogramming, Expansion, Tissue Engineering 137
16 1 Optimization of the Pattern for Stem Cell Treatment 137
16 2 Regeneration in Animals and Humans 137
16 3 Nuclear Reprogramming as One of the Methodological
Modalities to Get iPSC 138
16 4 Significance of Expansion 138
16 5 Stem Cell as a Part of TE Triangle 138
References 139
XIV
Contents
17 What Are Positive Results of Stem Cell Therapies? 141
17 1 An Overview of Some Disease States in Which Stem
Cells Could Help 141
17 2 Heart Attack 142
17 2 1 Optimization of the Stem Cell Source
for Intracoronary Grafting 142
17 3 Physically Induced Injury of Neural Tissues 143
17 4 Degenerative Injuries 144
17 5 Persistent Disease States 146
17 6 Concerns with Stem Cells 147
17 7 The Recovery of the Five Senses with Stem Cells:
Are the Concepts Realistic? 148
17 8 Conclusions 151
References 152
18 Topic Novelties in Animal Stem Cell Research 163
18 1 Biomagnetism, Electromagnetism, and Biophotonics 163
References 164
19 Resume 165
19 1 The Directions in Animal Stem Cell Research
Development Require Further Work 165
19 2 Quo Vadis? 167
References 167
Part II Plant Stem Cells and Bioengineering
20 Stem Cells in Plants Meristems 171
References 174
21 Shoot and Root Apical Meristems 175
21 1 Shoot Apical Meristems 175
21 1 1 Functional Zones and Layers of Shoot Apical
Meristem 176
21 2 Root Meristems 177
References 178
22 Lateral Meristems 179
References 180
23 External Control of the Plant Stem Cells 181
References 182
24 Signaling and Genetic Regulation of the Plant Stem Cells 183
24 1 Signaling and Regulation in Shoot Apical Meristem 183
24 1 1 Regulation by WUS Transcription Factor 184
24 1 2 Regulation by KNOX Genes 186
Contents
xv
24 1 3 Signaling Molecules: Auxin 186
24 1 4 Signaling Molecules: Cytokinines 190
24 2 Signaling and Regulation in the Root Apical Meristem 191
24 2 1 Control of the Root Stem Cells via Auxin
and PLT Genes 192
24 2 2 Control of the Root Stem Cells by Transcription
Factors 193
24 3 Regulation in Vascular Meristems 194
24 4 Regulation in Grass Meristems 196
24 4 1 Phyllotaxy and Plastochron Regulation 197
24 4 2 The Floral Transition 198
24 4 3 Inflorescence Meristem Identity 198
24 5 Similarities of Plant Stem Cells at the Molecular Level 199
References 200
25 Meristems and Primary and Secondary Growth in a Plant 207
References 208
26 Propagation of Plant Stem Cells in Culture 209
References 210
27 Cultured Plant Stem Cells as a Source of Plant Natural
Products 211
27 1 Plant Stem Cell Extracts as a Source for Regenerative
Therapy of Human Cells 213
References 215
28 Mitochondria, a Vital Organelle in Stem Cell Maintenance 217
28 1 Mitochondria: Energy Metabolism in Animal Normal
and Cancer Stem Cells 217
28 2 Mitochondria in Plant Stem Cells 219
28 2 1 Specific Architecture of Mitochondria in Shoot
Apical and Leaf Primordial Meristems 219
28 2 2 Role of Dysfunctional Mitochondria in Meristem
Regulation 221
28 3 Molecular Difference in Mitochondria Between Plants
and Animals 221
References 223
29 Molecular Similarities Between Plant and Animal Stem Cells 225
29 1 Sternness Factors 226
29 2 Stem Cells in Plants and the Method of Clonal Analysis 228
29 3 Homologs of Breast Cancer Genes in Plants 230
29 4 Chromatin States in Animal and Plant Stem Cells 231
29 5 Just Coincidence? 232
|
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| id | DE-604.BV044206595 |
| illustrated | Not Illustrated |
| indexdate | 2025-02-20T06:54:07Z |
| institution | BVB |
| isbn | 9783319477633 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-029612989 |
| oclc_num | 975003109 |
| open_access_boolean | |
| owner | DE-859 DE-860 DE-91 DE-BY-TUM DE-1046 DE-1043 DE-Aug4 DE-898 DE-BY-UBR DE-861 DE-573 DE-863 DE-BY-FWS DE-706 DE-634 DE-862 DE-BY-FWS DE-92 |
| owner_facet | DE-859 DE-860 DE-91 DE-BY-TUM DE-1046 DE-1043 DE-Aug4 DE-898 DE-BY-UBR DE-861 DE-573 DE-863 DE-BY-FWS DE-706 DE-634 DE-862 DE-BY-FWS DE-92 |
| physical | 1 Online-Ressource (xvii, 234 Seiten) Illustrationen |
| psigel | ZDB-2-ENG ZDB-2-ENG_2017 |
| publishDate | 2017 |
| publishDateSearch | 2017 |
| publishDateSort | 2017 |
| publisher | Springer |
| record_format | marc |
| spellingShingle | Pavlović, Mirjana Animal and plant stem cells concepts, propagation and engineering Engineering Bioinformatics Plant biochemistry Biomedical engineering Biomedical Engineering Computational Biology/Bioinformatics Plant Biochemistry Ingenieurwissenschaften |
| title | Animal and plant stem cells concepts, propagation and engineering |
| title_auth | Animal and plant stem cells concepts, propagation and engineering |
| title_exact_search | Animal and plant stem cells concepts, propagation and engineering |
| title_full | Animal and plant stem cells concepts, propagation and engineering Mirjana Pavlović, Ksenija Radotić |
| title_fullStr | Animal and plant stem cells concepts, propagation and engineering Mirjana Pavlović, Ksenija Radotić |
| title_full_unstemmed | Animal and plant stem cells concepts, propagation and engineering Mirjana Pavlović, Ksenija Radotić |
| title_short | Animal and plant stem cells |
| title_sort | animal and plant stem cells concepts propagation and engineering |
| title_sub | concepts, propagation and engineering |
| topic | Engineering Bioinformatics Plant biochemistry Biomedical engineering Biomedical Engineering Computational Biology/Bioinformatics Plant Biochemistry Ingenieurwissenschaften |
| topic_facet | Engineering Bioinformatics Plant biochemistry Biomedical engineering Biomedical Engineering Computational Biology/Bioinformatics Plant Biochemistry Ingenieurwissenschaften |
| url | https://doi.org/10.1007/978-3-319-47763-3 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029612989&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT pavlovicmirjana animalandplantstemcellsconceptspropagationandengineering AT radoticksenija animalandplantstemcellsconceptspropagationandengineering |