Verfügbarkeit: Intraoperative radiotherapy for breast cancer

Intraoperative radiotherapy for breast cancer:

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Bibliographische Detailangaben
Hauptverfasser:	Wenz, Frederik 1966- (VerfasserIn, HerausgeberIn), Kraus-Tiefenbacher, Uta 1969- (VerfasserIn, HerausgeberIn), Baum, Michael 1937- (VerfasserIn)
Format:	Buch
Sprache:	English
Veröffentlicht:	Bremen ; London ; Boston Uni-Med Verlag AG [2016]
Ausgabe:	2nd edition
Schriftenreihe:	UNI-MED science
Schlagworte:	Brustkrebs Intraoperative Strahlentherapie Aufsatzsammlung
Online-Zugang:	Inhaltsverzeichnis
Beschreibung:	78 Seiten Illustrationen, Diagramme
ISBN:	9783837415223

Internformat

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Datensatz im Suchindex

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adam_text	CONTENTS M INTRODUCTION 12 1.1. REFERENCES.......................................................................................................................................................... 12 THE TUMOR BED IN BREAST CANCER - DEFINITION AND RELEVANCE 14 2.1. DEFINITION AND RELEVANCE.................................................................................................................................14 2.1.1. REFERENCES............................................................................................................................................................ 15 2.2. RATIONALE FOR P B I................................................................................................................................................16 2.2.1. REFERENCES............................................................................................................................................................ 17 2.3. HISTORIC AND ONGOING PBI TRIALS...................................................................................................................... 18 2.3.1. REFERENCES............................................................................................................................................................ 19 RADIOBIOLOGICAL ASPECTS OF IORT IN BREAST CANCER 22 3.1. DOSE RESPONSE FOR TUM OR CELLS AND NORMAL TISSUE................................................................................... 22 3.2. BASIC RADIOBIOLOGICAL FA C TO RS ..........................................................................................................................23 3.2.1. THE L-Q M O D E L.....................................................................................................................................................23 3.2.2. EXTRAPOLATION TO HIGH SINGLE DOSES.................................................................................................................24 3.2.3. BIOLOGICAL EFFECTS OF HIGH SINGLE DOSES........................................................................................................... 25 3.2.4. REPAIR DURING PROTRACTED IRRADIATION............................................................................................................. 26 3.2.5. RBE OF 50 KV X-RAYS FROM INTRABEAM......................................................................................................... 27 3.3. MODELLING BIOLOGICAL EFFECTS OF 50 KV X-RAYS FROM INTRABEAM..........................................................29 3.3.1. TARGET VOLUME AND RISK OF RECURRENCE........................................................................................................... 29 3.3.2. LATE NORMAL-TISSUE REACTION..............................................................................................................................31 3.3.3. IORT AS INTRAOPERATIVE BOOST............................................................................................................................ 31 3.4. C ONCLUSIONS....................................................................................................................................................... 31 3.5. REFERENCES........................................................................................................................................................... 32 U INDICATIONS FOR IORT IN BREAST CANCER 36 4.1. IORT AS A B O O S T................................................................................................................................................. 37 4.2. IORT AS SINGLE TREATM ENT (I.E. PARTIAL BREAST IRRADIATION ) ...................................................................... 37 4.3. REFERENCES.................................................................................................................. 38 M IORT WITH 50 KV X-RAYS 40 5.1. PHYSICAL AND TECHNICAL ASPECTS...................................................................................................................... 40 5.1.1. INTRABEAM SYSTEM ..........................................................................................................................................40 5.1.2. QUALITY ASSURANCE.............................................................................................................................................. 41 5.1.3. W ORKFLOW ............................................................................................................................................................. 41 5.1.4. RADIATION PROTECTION.........................................................................................................................................42 5.2. SURGICAL ASPECTS........................................................................................................................................* 44 5.3. RADIOTHERAPEUTIC ASPECTS OF LOW-KV IO R T................................................................................................47 5.3.1. REFERENCES............................................................................................................................................................ 48 5.4. LORT AS A BOOST - CLINICAL RESULTS...................................................................................................................49 5.4.1. ACUTE TOXICITY....................................................................................................................................................... 49 5.4.2. LATE TOXICITY..........................................................................................................................................................51 5.4.3. POSTOPERATIVE SEROMA FORMATION.................................................................................................................... 51 5.4.4. INFLUENCE OF THE INTERVAL BETWEEN IORT AND WBRT ON LATE TOXICITY ........................................................... 52 5.4.5. THE FIRST FIVE YEARS OF EXPERIENCE WITH A NOVEL APPROACH: TOXICITY...........................................................53 5.4.6. THE FIRST FIVE YEARS OF EXPERIENCE WITH A NOVEL APPROACH: SURVIVAL AND LOCAL C O N TRO L..........................54 5.4.7. QUALITY OF LIFE......................................................................................................................................................55 5.4.8. CONCLUSION........................................................................................................................................................... 56 5.4.9. REFERENCES........................................................................................................................................................... 56 5.5. INTRAOPERATIVE RADIOTHERAPY FOR BREAST CANCER - THE TARGIT TRIA L.....................................................57 5.5.1. PRELIMINARY RESULTS OF THE TARGIT TRIA L........................................................................................................... 60 5.5.2. REFERENCES........................................................................................................................................................... 62 5.6. UPDATED RESULTS OF THE TARGIT A T R IA L........................................................................................................62 5.6.1. REFERENCES........................................................................................................................................................... 63 5.7. TARGIT-E (IDERLY) TRIAL.......................................................................................................................................63 5.7.1. STUDY DESIGN....................................................................................................................................................... 64 5.7.2. REFERENCES........................................................................................................................................................... 65 5.8. THE HISTORY OF THE DEVELOPM ENT OF THE INTRABEAM SYSTEM..............................................................65 5.8.1. REFERENCES........................................................................................................................................................... 68 IORT WITH LINEAR ACCELERATORS 70 6.1. IOERT M E TH O D S .................................................................................................................................................70 6.1.1. TARGET VOLUME AND DESIGN OF AN IOERT BOOST.............................................................................................. 71 6.2. TREATM ENT CONCEPTS: INTRAOPERATIVE BOOST (BIO-BOOST) VERSUS FULL-DOSE IO E R T.............................72 6.3. CLINICAL EVIDENCE...............................................................................................................................................72 6.3.1. BOOST CONCEPT......................................................................................................................................................72 6.3.2. SOLE IOERT CONCEPT............................................................................................................................................ 73 6.3.3. TOXICITY / LATE REACTIONS / COSMESIS.................................................................................................................74 6.4. IOERT DURING NIPPLE-SPARING MASTECTOMY................................................................................................74 6.5. ONGOING TRIA LS ...................................................................................................................................................74 6.6. SUM M ARY.............................................................................................................................................................75 6.7. REFERENCES.......................................................................................................................................................... 75 INDEX 78
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author	Wenz, Frederik 1966- Kraus-Tiefenbacher, Uta 1969- Baum, Michael 1937-
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spelling	Intraoperative radiotherapy for breast cancer Frederik Wenz, Uta Kraus-Tiefenbacher ; in collaboration with Michael Baum [und 8 weiteren] 2nd edition Bremen ; London ; Boston Uni-Med Verlag AG [2016] 78 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier UNI-MED science Brustkrebs (DE-588)4008528-4 gnd rswk-swf Intraoperative Strahlentherapie (DE-588)7754023-2 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Brustkrebs (DE-588)4008528-4 s Intraoperative Strahlentherapie (DE-588)7754023-2 s DE-604 Wenz, Frederik 1966- (DE-588)113310390 edt aut Kraus-Tiefenbacher, Uta 1969- (DE-588)1013173406 edt aut Baum, Michael 1937- (DE-588)1020660422 aut DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029601463&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Wenz, Frederik 1966- Kraus-Tiefenbacher, Uta 1969- Baum, Michael 1937- Intraoperative radiotherapy for breast cancer Brustkrebs (DE-588)4008528-4 gnd Intraoperative Strahlentherapie (DE-588)7754023-2 gnd
subject_GND	(DE-588)4008528-4 (DE-588)7754023-2 (DE-588)4143413-4
title	Intraoperative radiotherapy for breast cancer
title_auth	Intraoperative radiotherapy for breast cancer
title_exact_search	Intraoperative radiotherapy for breast cancer
title_full	Intraoperative radiotherapy for breast cancer Frederik Wenz, Uta Kraus-Tiefenbacher ; in collaboration with Michael Baum [und 8 weiteren]
title_fullStr	Intraoperative radiotherapy for breast cancer Frederik Wenz, Uta Kraus-Tiefenbacher ; in collaboration with Michael Baum [und 8 weiteren]
title_full_unstemmed	Intraoperative radiotherapy for breast cancer Frederik Wenz, Uta Kraus-Tiefenbacher ; in collaboration with Michael Baum [und 8 weiteren]
title_short	Intraoperative radiotherapy for breast cancer
title_sort	intraoperative radiotherapy for breast cancer
topic	Brustkrebs (DE-588)4008528-4 gnd Intraoperative Strahlentherapie (DE-588)7754023-2 gnd
topic_facet	Brustkrebs Intraoperative Strahlentherapie Aufsatzsammlung
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