Blood-brain barrier in drug discovery: optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs
"Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant - and most challenging - areas of drug discovery. Written by world experts to provide...
Gespeichert in:
| Weitere Verfasser: | , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Hoboken, New Jersey
John Wiley & Sons Inc.
[2015]
|
| Schlagworte: | |
| Zusammenfassung: | "Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant - and most challenging - areas of drug discovery. Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects. Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies. Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes. Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK). Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market"--Provided by publisher |
| Beschreibung: | Description based on print version record |
| Beschreibung: | 1 online resource (607 pages) illustrations (some color) |
| ISBN: | 9781118788356 9781118788547 |
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| 520 | |a "Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant - and most challenging - areas of drug discovery. Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects. Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies. Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes. Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK). Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market"--Provided by publisher | ||
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Datensatz im Suchindex
| _version_ | 1804177107589267456 |
|---|---|
| any_adam_object | |
| author2 | Di, Li Kerns, Edward Harvel |
| author2_role | edt edt |
| author2_variant | l d ld e h k eh ehk |
| author_facet | Di, Li Kerns, Edward Harvel |
| building | Verbundindex |
| bvnumber | BV044072354 |
| collection | ZDB-30-PAD |
| ctrlnum | (ZDB-30-PAD)EBC1895601 (ZDB-89-EBL)EBL1895601 (ZDB-38-EBR)ebr11005763 (OCoLC)899941813 (DE-599)BVBBV044072354 |
| dewey-full | 615.7/8 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.7/8 |
| dewey-search | 615.7/8 |
| dewey-sort | 3615.7 18 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Electronic eBook |
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| id | DE-604.BV044072354 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T07:42:49Z |
| institution | BVB |
| isbn | 9781118788356 9781118788547 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-029479199 |
| oclc_num | 899941813 |
| open_access_boolean | |
| physical | 1 online resource (607 pages) illustrations (some color) |
| psigel | ZDB-30-PAD |
| publishDate | 2015 |
| publishDateSearch | 2015 |
| publishDateSort | 2015 |
| publisher | John Wiley & Sons Inc. |
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| spelling | Blood-brain barrier in drug discovery optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs edited by Li Di, Edward H. Kerns Hoboken, New Jersey John Wiley & Sons Inc. [2015] © 2015 1 online resource (607 pages) illustrations (some color) txt rdacontent c rdamedia cr rdacarrier Description based on print version record "Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant - and most challenging - areas of drug discovery. Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects. Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies. Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes. Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK). Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market"--Provided by publisher Brain Effect of drugs on Blood-brain barrier Neuropharmakologie (DE-588)4041896-0 gnd rswk-swf Blut-Hirn-Schranke (DE-588)4007279-4 gnd rswk-swf Arzneimittelforschung (DE-588)4003120-2 gnd rswk-swf Wirkstofffreisetzung (DE-588)4190018-2 gnd rswk-swf Blut-Hirn-Schranke (DE-588)4007279-4 s Neuropharmakologie (DE-588)4041896-0 s Arzneimittelforschung (DE-588)4003120-2 s Wirkstofffreisetzung (DE-588)4190018-2 s 1\p DE-604 Di, Li edt Kerns, Edward Harvel edt Erscheint auch als Druck-Ausgabe Blood-brain barrier in drug discovery : optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Blood-brain barrier in drug discovery optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs Brain Effect of drugs on Blood-brain barrier Neuropharmakologie (DE-588)4041896-0 gnd Blut-Hirn-Schranke (DE-588)4007279-4 gnd Arzneimittelforschung (DE-588)4003120-2 gnd Wirkstofffreisetzung (DE-588)4190018-2 gnd |
| subject_GND | (DE-588)4041896-0 (DE-588)4007279-4 (DE-588)4003120-2 (DE-588)4190018-2 |
| title | Blood-brain barrier in drug discovery optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs |
| title_auth | Blood-brain barrier in drug discovery optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs |
| title_exact_search | Blood-brain barrier in drug discovery optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs |
| title_full | Blood-brain barrier in drug discovery optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs edited by Li Di, Edward H. Kerns |
| title_fullStr | Blood-brain barrier in drug discovery optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs edited by Li Di, Edward H. Kerns |
| title_full_unstemmed | Blood-brain barrier in drug discovery optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs edited by Li Di, Edward H. Kerns |
| title_short | Blood-brain barrier in drug discovery |
| title_sort | blood brain barrier in drug discovery optimizing brain exposure of cns drugs and minimizing brain side effects for peripheral drugs |
| title_sub | optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs |
| topic | Brain Effect of drugs on Blood-brain barrier Neuropharmakologie (DE-588)4041896-0 gnd Blut-Hirn-Schranke (DE-588)4007279-4 gnd Arzneimittelforschung (DE-588)4003120-2 gnd Wirkstofffreisetzung (DE-588)4190018-2 gnd |
| topic_facet | Brain Effect of drugs on Blood-brain barrier Neuropharmakologie Blut-Hirn-Schranke Arzneimittelforschung Wirkstofffreisetzung |
| work_keys_str_mv | AT dili bloodbrainbarrierindrugdiscoveryoptimizingbrainexposureofcnsdrugsandminimizingbrainsideeffectsforperipheraldrugs AT kernsedwardharvel bloodbrainbarrierindrugdiscoveryoptimizingbrainexposureofcnsdrugsandminimizingbrainsideeffectsforperipheraldrugs |