In vitro phenotypical and transcriptomic characterization of canine macrophages:
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Gießen
DVG Service GmbH
2016
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| Ausgabe: | 1. Auflage |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | v, 174 Seiten Diagramme, Illustrationen |
| ISBN: | 9783863453121 |
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Datensatz im Suchindex
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|---|---|
| adam_text | University of Veterinary Medicine Hannover
Department of Pathology and
Center for Systems Neuroscience
In vitro phenotypical and transcriptomic characterization of canine
macrophages
THESIS
Submitted in partial fulfilment of the requirements for the degree
DOCTOR OF PHILOSOPHY
(PhD)
awarded by the University of Veterinary Medicine Hannover
by
Franziska Heinrich
(Berlin)
Hannover, Germany 2015
Table of contents
1 CHAPTER 1: AIMS OF THE STUDY 1
2 CHAPTER 2: GENERAL INTRODUCTION 3
2 1 Microglia/macrophages-effector cells of the innate immune system 3
2 2 Polarization properties of microglia/macrophages 11
221 The paradigm of microglia/macrophage polarization 11
222 Functional properties of M1-/M2-microglia/macrophages 13
2221 The classically activated M1 -microglia/macrophage 13
2222 The alternatively activated M2-microglia/macrophage 14
2223 The functional role of M1-/M2-microglia/macrophages during infectious,
allergic, neoplastic, and metabolic disorders 15
223 Morphologic properties of M1-/M2-microglia/macrophages 17
224 Phenotypic properties of M1-/M2-microglia/macrophages 18
2 3 Role of microglia/macrophage polarization in demyelinating central
nervous system (CNS) diseases 26
231 Microglia/macrophages in multiple sclerosis 26
232 Microglia/macrophages in experimental rodent demyelinating diseases 28
2 4 Role of microglia/macrophage polarization in the pathogenesis of
spinal cord injury (SCI) 31
241 Microglia/macrophages in human and experimental rodent SCI 31
242 Canine spinal cord injury as a translational model for spontaneous human
SCI r 39
3 CHAPTER 3: DH82 CELLS - A PERSISTENT CANINE MACROPHAGE
CELL LINE 45
4 CHAPTER 4: POLARIZATION PROPERTIES OF CANINE Ml -/M2-
MACROPHAGES IN VITRO
49
Table of contents
5 CHAPTER 5: GENERAL DISCUSSION 123
51 Passage-dependent morphological and phenotypical changes of a
canine histiocytic sarcoma cell line (DH82 cells) 124
511 Morphologic and phenotypic changes in DH82 cells during in vitro
cultivation 125
512 Comparison of cell surface marker expression in DH82 cells with the
literature and ex vivo isolated monocytes 126
5 2 Polarization properties of canine Ml-/M2-macrophages in vitro 129
521 Morphological characterization of polarized canine macrophages 129
522 Phenotypical characterization of polarized canine macrophages 131
523 Differentially expressed genes between MO-, Ml-, and M2-polarized canine
macrophages 133
5231 Pairwise comparison and hierarchical cluster analysis 133
5232 Pairwise comparison of the top hits (fold change / 50) 136
524 Literature-based gene signatures and marker genes 138
525 Biomarker Selection 140
6 CHAPTER 6: SUMMARY 143
1 7 CHAPTER 7: ZUSAMMENFASSUNG 147
1 8 CHAPTER 8: REFERENCES 151
9 CHAPTER 9: APPENDIX 171
9 10 CHAPTER 10: ACKNOWLEDGMENTS 173
5
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| spelling | Heinrich, Franziska 1993- Verfasser (DE-588)140348638 aut In vitro phenotypical and transcriptomic characterization of canine macrophages vorgelegt von Franziska Heinrich 1. Auflage Gießen DVG Service GmbH 2016 v, 174 Seiten Diagramme, Illustrationen txt rdacontent n rdamedia nc rdacarrier Dissertation Tierärztliche Hochschule Hannover 2016 dogs cabt phenotypes cabt transcriptomics cabt macrophages cabt invitro cabt morphology cabt Hund (DE-588)4026181-5 gnd rswk-swf Zelllinie (DE-588)4231928-6 gnd rswk-swf Makrophage (DE-588)4193041-1 gnd rswk-swf Phänotyp (DE-588)4248244-6 gnd rswk-swf Dissertation (DE-588)4012494-0 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Phänotyp (DE-588)4248244-6 s Makrophage (DE-588)4193041-1 s Zelllinie (DE-588)4231928-6 s Hund (DE-588)4026181-5 s Dissertation (DE-588)4012494-0 s DE-604 Erscheint auch als Online-Ausgabe Heinrich, Franziska In vitro phenotypical and transcriptomic characterization of canine macrophages HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029453283&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Heinrich, Franziska 1993- In vitro phenotypical and transcriptomic characterization of canine macrophages dogs cabt phenotypes cabt transcriptomics cabt macrophages cabt invitro cabt morphology cabt Hund (DE-588)4026181-5 gnd Zelllinie (DE-588)4231928-6 gnd Makrophage (DE-588)4193041-1 gnd Phänotyp (DE-588)4248244-6 gnd Dissertation (DE-588)4012494-0 gnd |
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| title | In vitro phenotypical and transcriptomic characterization of canine macrophages |
| title_auth | In vitro phenotypical and transcriptomic characterization of canine macrophages |
| title_exact_search | In vitro phenotypical and transcriptomic characterization of canine macrophages |
| title_full | In vitro phenotypical and transcriptomic characterization of canine macrophages vorgelegt von Franziska Heinrich |
| title_fullStr | In vitro phenotypical and transcriptomic characterization of canine macrophages vorgelegt von Franziska Heinrich |
| title_full_unstemmed | In vitro phenotypical and transcriptomic characterization of canine macrophages vorgelegt von Franziska Heinrich |
| title_short | In vitro phenotypical and transcriptomic characterization of canine macrophages |
| title_sort | in vitro phenotypical and transcriptomic characterization of canine macrophages |
| topic | dogs cabt phenotypes cabt transcriptomics cabt macrophages cabt invitro cabt morphology cabt Hund (DE-588)4026181-5 gnd Zelllinie (DE-588)4231928-6 gnd Makrophage (DE-588)4193041-1 gnd Phänotyp (DE-588)4248244-6 gnd Dissertation (DE-588)4012494-0 gnd |
| topic_facet | dogs phenotypes transcriptomics macrophages invitro morphology Hund Zelllinie Makrophage Phänotyp Dissertation Hochschulschrift |
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