Industrial biotechnology: products and processes
Gespeichert in:
| Weitere Verfasser: | , |
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| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Weinheim
Wiley-VCH
[2017]
|
| Ausgabe: | 1. Auflage |
| Schriftenreihe: | Advanced biotechnology
4 |
| Schlagworte: | |
| Online-Zugang: | http://www.wiley-vch.de/publish/dt/books/ISBN978-3-527-34181-8/ Inhaltsverzeichnis |
| Beschreibung: | XXXIV, 605 Seiten Illustrationen, Diagramme |
| ISBN: | 9783527341818 3527341811 |
Internformat
MARC
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| 245 | 1 | 0 | |a Industrial biotechnology |b products and processes |c edited by Christoph Wittmann, James C. Liao |
| 250 | |a 1. Auflage | ||
| 264 | 1 | |a Weinheim |b Wiley-VCH |c [2017] | |
| 264 | 4 | |c © 2017 | |
| 300 | |a XXXIV, 605 Seiten |b Illustrationen, Diagramme | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Advanced biotechnology |v 4 | |
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| 650 | 0 | 7 | |a Biotechnologie |0 (DE-588)4069491-4 |2 gnd |9 rswk-swf |
| 653 | |a Biotechnologie | ||
| 653 | |a Biotechnologie i. d. Biowissenschaften | ||
| 653 | |a Biotechnologie i. d. Chemie | ||
| 653 | |a Biotechnology | ||
| 653 | |a Biowissenschaften | ||
| 653 | |a Chemie | ||
| 653 | |a Chemistry | ||
| 653 | |a Industrial Chemistry | ||
| 653 | |a Industrielle Biotechnologie | ||
| 653 | |a Life Sciences | ||
| 653 | |a Technische u. Industrielle Chemie | ||
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| 700 | 1 | |a Wittmann, Christoph |d 1967- |0 (DE-588)115547673 |4 edt | |
| 700 | 1 | |a Liao, James C. |d 1958- |0 (DE-588)1128341034 |4 edt | |
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Datensatz im Suchindex
| _version_ | 1804177034964893696 |
|---|---|
| adam_text | CONTENTS
LIST OF CONTRIBUTORS XXI
ABOUT THE SERIES EDITORS XXXI
PREFACE XXXIII
PART I ENABLING AND IMPROVING LARGE-SCALE BIO-PRODUCTION 1
1 INDUSTRIAL-SCALE FERMENTATION 3
HANS-PETER MEYER, WOLFGANG MINAS, AND DIEGO SCHMIDHALTER
1.1 INTRODUCTION 3
1.2 INDUSTRIAL-SCALE FERMENTATION TODAY 5
1.2.1 ORGANISMS USED IN LARGE-SCALE FERMENTATION 5
1.2.2 CONTEMPORARY LARGE-SCALE FERMENTATION 7
1.2.3 ECONOMIC ASPECTS OF INDUSTRIAL FERMENTATION FROM A MARKET
PERSPECTIVE 14
1.2.4 THE DRIVERS AND THE FUTURE OF INDUSTRIAL FERMENTATION 15
1.3 ENGINEERING AND DESIGN ASPECTS 18
1.3.1 PROCESS DEVELOPMENT - SCALE-UP STARTS AT LABORATORY SCALE 18
1.3.2 PLANT DESIGN ASPECTS 19
1.3.2.1 GENERAL ASPECTS OF PLANT DESIGN 19
1.3.2.2 DESIGN CONSTRAINTS AND GUIDELINES 21
1.3.2.3 SEED LINES 24
1.3.2.4 VESSEL GEOMETRY 25
1.3.2.5 MIXING AND MASS TRANSFER 27
1.3.2.6 TEMPERATURE CONTROL AND HEAT TRANSFER 31
1.3.2.7 OXYGENATION 32
1.4 INDUSTRIAL DESIGN EXAMPLES 36
1.4.1 CEPHALOSPORIN C PRODUCTION 36
1.4.2 MONOCLONAL ANTIBODY PRODUCTION AT THE 10 M3 SCALE 39
1.4.3 NONSTERILE FERMENTATIONS 42
1.5 COST ANALYSIS FOR THE MANUFACTURE OF BIOTECHNOLOGICAL PRODUCTS 42
1.5.1 INVESTMENT 42
1.5.2 OPERATIONAL COST, COST OF MANUFACTURING 43
1.5.3 RETURN ON INVESTED CAPITAL 47
1.6
1
.
6.1
1
.
6.2
2
2.1
2.2
2.3
2.4
2.4.1
2.4.1.1
2.4.1.2
2.4.2
2.4.2.1
2.4.2.2
2.4.2.3
2.4.2.4
2.5
2.5.1
2.5.1.1
2.5.2
2.5.3
2.6
2.7
3
3.1
3.1.1
3.1.2
3.2
3.2.1
3.2.2
3.2.3
3.2.4
INFLUENCE OF PROCESS- AND FACILITY-RELATED ASPECTS ON COST
STRUCTURE
47
PROCESS-RELATED ASPECTS
48
SITE-RELATED ASPECTS
48
ACKNOWLEDGMENTS
51
REFERENCES
52
SCALE-DOWN: SIMULATING LARGE-SCALE CULTURES IN THE LABORATORY 55
ALVARO R. LARA, LAURA A. PALOMARES, AND OCTAVIO T RAMIREZ
INTRODUCTION 55
HETEROGENEITIES AT LARGE SCALE AND THE NEED FOR SCALING DOWN
56
BIOREACTOR SCALE-DOWN
58
TOOLS TO STUDY CELL RESPONSES TO ENVIRONMENTAL HETEROGENEITIES
62
SCALE-DOWN SIMULATORS
62
ONE-COMPARTMENT SCALE-DOWN SYSTEMS
63
MULTICOMPARTMENT SCALE-DOWN SYSTEMS
64
ANALYTICAL TECHNIQUES 66
METABOLIC STUDIES 66
DIFFERENTIAL GENE EXPRESSION AND PROTEIN ACCUMULATION 67
PHYSICAL MEASUREMENTS 67
MATHEMATICAL MODELING
68
PHYSIOLOGICAL EFFECTS OF ENVIRONMENTAL HETEROGENEITIES
68
NEGATIVE EFFECTS
68
NEGATIVE EFFECTS ON ANIMAL CELLS
70
POSITIVE EFFECTS
71
FURTHER OBSERVATIONS 72
IMPROVEMENTS BASED ON SCALE-DOWN STUDIES: BIOREACTOR DESIGN AND
CELL ENGINEERING 72
PERSPECTIVES
73
ACKNOWLEDGMENT
74
REFERENCES
74
BIOREACTOR MODELING
81
ROB MUDDE, HENK NOORMAN, AND MATTHIAS REUSS
LARGE-SCALE INDUSTRIAL FERMENTATIONS: CHALLENGES FOR BIOREACTOR
MODELING
81
GLOBAL STATUS
81
PERSPECTIVES
82
BIOREACTORS
83
STIRRED-TANK BIOREACTORS
83
BUBBLE COLUMNS AND AIR-LIFT REACTORS
86
OTHER REACTORS
86
BIOREACTOR MODELING
87
3.3 COMPARTMENT AND HYBRID MULTIZONAL/COMPUTATIONAL FLUID
DYNAMICS APPROACHES FOR THE DESCRIPTION OF LARGE-SCALE BIOREACTOR
PHENOMENA 89
3.3.1 COMPARTMENT MODELS 89
3.3.2 HYBRID MULTIZONAL/CFD MODELS 91
3.4 COMPUTATIONAL FLUID DYNAMICS MODELING: UNSTRUCTURED CONTINUUM
APPROACH (EULER-EULER) 92
3.4.1 INTRODUCTION 92
3.4.2 SINGLE PHASE 93
3.4.2.1 TURBULENCE MODELING 95
3.4.3 TWO-PHASE FLOW 100
3.4.3.1 APPROACHES 100
3.4.3.2 EULER-EULER MODEL 100
3.4.3.3 INTERACTION FORCES 102
3.4.3.4 TURBULENCE MODELING 103
3.4.4 CFD OF GASSED STIRRED TANKS 104
3.4.4.1 BUBBLE SIZE 105
3.4.4.2 GLUCOSE UPTAKE 110
3.4.4.3 OXYGEN UPTAKE - DISTRIBUTION OF DISSOLVED OXYGEN 111
3.4.5 SUMMARY OF CFD 112
3.5 COMPUTATIONAL FLUID DYNAMICS MODELING: STRUCTURED SEGREGATED
APPROACH (EULER-LAGRANGE) 114
3.5.1 INTRODUCTION 114
3.5.2 EULER-LAGARANGE MODELING 115
3.5.3 METABOLIC STRUCTURING 117
3.5.4 MODEL SIMULATIONS AND DETAILED INSIGHT INTO CELL RESPONSES TO
DYNAMIC CONDITIONS IN LARGE BIO REACTORS 118
3.6 CONCLUSION 122
3.7 OUTLOOK 122
REFERENCES 124
4 CELL CULTURE TECHNOLOGY 129
RALFPOERTNER, UWEJONDT, AND AN-PING ZENG
4.1 INTRODUCTION 129
4.2 OVERVIEW OF APPLICATIONS FOR CELL CULTURE PRODUCTS AND TISSUE
ENGINEERING 129
4.3 FUNDAMENTALS 131
4.3.1 CELL SOURCES 131
4.3.2 CELL PHYSIOLOGY AND KINETICS FOR PROCESS ENGINEERING 132
4.3.3 POPULATION DYNAMICS, CELL-CYCLE DEPENDENCE, AND IMPLICATIONS ON
PROCESS CONTROL 134
4.3.3.1 SEPARATION METHODS AND ANALYTICS 135
4.3.3.2 POPULATION-RESOLVED MODELING AND DATA TREATMENT 136
4.3.3.3 POPULATION-RESOLVED ONLINE MONITORING AND PROCESS CONTROL 138
4.3.4 MEDIUM DESIGN 139
4.4 BIOREACTORS FOR CELL CULTURE 140
4.4.1 REQUIREMENTS 140
4.4.2 BIOREACTORS FOR SUSPENDED CELLS 142
4.4.3 SINGLE-USE BIOREACTORS 144
4.4.4 FIXED-BED AND FLUIDIZED-BED REACTORS 144
4.4.5 HOLLOW-FIBER AND MEMBRANE REACTORS 145
4.4.6 PROCESS STRATEGIES AND CONTROL 145
4.5 DOWNSTREAM 146
4.6 REGULATORY AND SAFETY ISSUES 150
4.7 CONCLUSIONS AND OUTLOOK 152
REFERENCES 152
PART II GETTING OUT MORE: STRATEGIES FOR ENHANCED
BIOPROCESSING 159
5 PRODUCTION OF FUELS AND CHEMICALS FROM BIOMASS BY INTEGRATED
BIOPROCESSES 161
TOMOHISA HASUNUMA AND AKIHIKO KONDO
5.1 INTRODUCTION 161
5.2 UTILIZATION OF STARCHY BIOMASS 163
5.2.1 PRETREATMENT AND ENZYMATIC HYDROLYSIS OF STARCH 163
5.2.2 CONSOLIDATED BIOPROCESSING FOR STARCH UTILIZATION 164
5.3 UTILIZATION OF LIGNOCELLULOSIC BIOMASS 166
5.3.1 PRETREATMENT AND ENZYMATIC HYDROLYSIS OF LIGNOCELLULOSE 166
5.3.2 CONSOLIDATED BIOPROCESSING FOR LIGNOCELLULOSE UTILIZATION 167
5.3.2.1 INTRODUCTION 167
5.3.2.2 PRODUCTION OF CHEMICALS WITH NATIVE CELLULASE-PRODUCING
MICROBES 16S
5.3.2.3 PRODUCTION OF CHEMICALS WITH RECOMBINANT CELLULOSE-UTILIZING
MICROBES 169
5.4 CONCLUSIONS AND PERSPECTIVES 177
ACKNOWLEDGMENT 177
REFERENCES 178
6 SOLID-STATE FERMENTATION 187
REETA RANI SINGHANIA, ANIL KUMAR PATEL
LEYA
THOMAS, AND ASHOK PANDEY
6.1 INTRODUCTION 1S7
6.2 FUNDAMENTALS ASPECTS OF SSF 188
6.2.1 SELECTION OF MICROORGANISMS 188
6.2.2 SPECIFIC GROWTH RATE 189
6.2.2.1 BIOMASS MEASUREMENT 192
6.3 FACTORS AFFECTING SOLID-STATE FERMENTATION 193
6.3.1 MOISTURE 193
6.3.2 WATER ACTIVITY 193
6.3.3 TEMPERATURE 194
6.3.4 PH 194
6.3.5 INOCULUM TYPE 194
6.3.6 SUBSTRATES 194
6.3.6.1 PARTICLE SIZE 195
6.3.7 AERATION AND AGITATION 196
6.4 SCALE-UP 196
6.4.1 LARGE-SCALE INOCULUM DEVELOPMENT 196
6.4.2 MEDIUM STERILIZATION 196
6.4.3 AERATION AND AGITATION 197
6.4.4 HEAT REMOVAL AND MOISTURE BALANCE 197
6.4.5 PH CONTROL 198
6.5 PRODUCT RECOVERY 198
6.6 BIOREACTOR DESIGNING 198
6.6.1 SHALLOW-TRAY FERMENTER 199
6.6.2 COLUMN/FIXED-BED FERMENTERS 199
6.6.3 ROTATING-DRUM BIOREACTORS 199
6.7 KINETICS AND MODELING 200
6.8 APPLICATIONS 201
6.9 CHALLENGES IN SSF 202
6.10 SUMMARY 203
REFERENCES 203
7 CELL IMMOBILIZATION: FUNDAMENTALS, TECHNOLOGIES, AND
APPLICATIONS 205
XU MENG GE, LIANGCHENG YANG
,
AND JIANFENG XU
7.1 INTRODUCTION 205
7.2 FUNDAMENTALS OF CELL IMMOBILIZATION 206
7.3 IMMOBILIZATION WITH SUPPORT MATERIALS 207
7.3.1 SURFACE ATTACHMENT 208
7.3.1.1 ADSORPTION 208
7.3.1.2 COVALENT BINDING 209
7.3.1.3 BIOFILM FORMATION 209
7.3.2 ENTRAPMENT 210
7.3.2.1 ENTRAPMENT IN GEL MATRIXES 210
7.3.2.2 ENTRAPMENT IN POROUS PARTICLES 210
7.3.3 ENCAPSULATION 211
7.3.4 MEMBRANE RETENTION 212
7.4 SELF-IMMOBILIZATION 212
7.4.1 MICROORGANISMS 213
7.4.1.1 PROKARYOTIC CELLS 213
7.4.1.2 EUKARYOTIC CELLS 214
7.4.2 PLANT CELLS 218
7.5 IMMOBILIZED CELLS AND THEIR APPLICATIONS 218
7.5.1 MICROORGANISMS 219
7.5.2 PLANT CELLS 221
7.5.3 MAMMALIAN AND INSECT CELLS 221
7.6 BIOREACTORS FOR CELL IMMOBILIZATION 225
7.6.1 STIRRED-TANK BIOREACTOR 226
7.6.2 PACKED-BED BIOREACTOR 227
7.6.3 FLUIDIZED-BED BIOREACTOR 227
7.6.4 AIR-LIFT BIOREACTOR 228
7.6.5 MEMBRANE BIOREACTOR 228
7.7 CHALLENGES AND RECOMMENDATIONS FOR FUTURE RESEARCH 229
7.8 CONCLUSIONS 230
REFERENCES 231
PART III MOLECULES FOR HUMAN USE: HIGH-VALUE DRUGS, FLAVORS, AND
NUTRACEUTICALS 237
8 ANTICANCER DRUGS 239
LE ZHAO, ZENGYI SHAO, AND JACQUELINE V SHANKS
8.1 NATURAL PRODUCTS AS ANTICANCER DRUGS 239
8.2 ANTICANCER DRUG PRODUCTION 239
8.2.1 PRODUCTION SYSTEMS 239
8.2.2 APPROACHES FOR IMPROVING PRODUCTION 241
8.2.3 GENE DISCOVERY 242
8.3 IMPORTANT ANTICANCER NATURAL PRODUCTS 243
8.3.1 VINCA ALKALOIDS 243
8.3.2 TAXANE DITERPENOIDS 250
8.3.3 PODOPHYLLOTOXIN LIGNANS 256
8.3.4 CAMPTOTHECIN QUINOLINE ALKALOIDS 258
8.4 PROSPECTS 261
8.4.1 IDENTIFICATION OF INTERMEDIATES IN THE BIOSYNTHETIC PATHWAYS OF
ANTICANCER DRUGS 261
8.4.2 DISCOVERY OF UNKNOWN GENES IN BIOSYNTHETIC PATHWAYS 262
8.4.3 PRODUCTION OF ANTICANCER DRUGS IN MICROBIAL HOSTS 262
REFERENCES 263
9 BIOTECHNOLOGICAL PRODUCTION OF FLAVORS 271
MARIA ELISABETTA BRENNA AND FABIO PARMEGGIANI
9.1 HISTORY 271
9.2 SURVEY ON TODAYS INDUSTRY 272
9.3 REGULATIONS 273
9.4 FLAVOR PRODUCTION
274
9.5 BIOTECHNOLOGICAL PRODUCTION OF FLAVORS 275
9.5.1 TRADITIONAL FERMENTATIONS 275
9.5.2
DE NOVO
SYNTHESIS 276
9.5.3 BIOCONVERSIONS 277
9.6 VANILLIN 277
9.6.1 FROM EUGENOL 278
9.6.2 FROM ISOEUGENOL 278
9.6.3 FROM FERULIC ACID 280
9.6.4 FROM LIGNIN 281
9.7 2-PHENYLETHANOL 281
9.8 BENZALDEHYDE 283
9.9 LACTONES 285
9.10 RASPBERRY KETONE 289
9.11 GREEN NOTES 291
9.12 NOOTKATONE 293
9.13 FUTURE PERSPECTIVES 296
REFERENCES 297
10 NUTRACEUTICALS (VITAMIN C, CAROTENOIDS, RESVERATROL) 309
SANJAY GUIERIA, JINGWEN ZHOU, AND MATTHEOS A.G. KOFFAS
10.1 INTRODUCTION 309
10.2 VITAMIN C 310
10.2.1 PRODUCTION OF
L
-AA BY CHEMICAL SYNTHESIS 311
10.2.2 PRODUCTION OF
L
-AA BY A TWO-STEP FERMENTATION PROCESS 311
10.2.3 CLASSICAL TWO-STEP FERMENTATION PROCESS 312
10.2.4 NEW TWO-STEP FERMENTATION PROCESS 313
10.2.5 PRODUCTION OF
L
-AA BY A ONE-STEP FERMENTATION PROCESS 314
10.2.6 CLASSICAL TWO-STEP FERMENTATION PROCESS-BASED ATTEMPTS 314
10.2.7 NEW TWO-STEP FERMENTATION PROCESS-BASED ATTEMPTS 316
10.2.8 RECONSTRUCTION OF
L
-AA BIOSYNTHESIS PATHWAY FROM HIGHER
ORGANISMS IN MICROORGANISMS 316
10.3 CAROTENOIDS 317
10.3.1 BIOSYNTHESIS OF CAROTENOIDS 319
10.3.2 METABOLIC ENGINEERING OF CAROTENOID BIOSYNTHESIS IN MICROBES 321
10.4 RESVERATROL 323
10.4.1 BIOSYNTHESIS OF RESVERATROL AND ITS DERIVATIVES 324
10.4.2 METABOLIC ENGINEERING OF RESVERATROL AND ITS DERIVATIVES 327
10.5 FUTURE PERSPECTIVES 329
REFERENCES 330
PART IV INDUSTRIAL AMINO ACIDS 337
11 GLUTAMIC ACID FERMENTATION: DISCOVERY OF GLUTAMIC ACID-PRODUCING
MICROORGANISMS, ANALYSIS OF THE PRODUCTION MECHANISM, METABOLIC
ENGINEERING, AND INDUSTRIAL PRODUCTION PROCESS 339
TAKASHI HIRASAWA AND HIROSHI SHIMIZU
11.1 INTRODUCTION 339
11.2 DISCOVERY OF THE GLUTAMIC ACID-PRODUCING BACTERIUM
C.GLUTAMICUM 340
11.2.1 GLUTAMIC ACID PRODUCTION PRIOR TO THE DISCOVERY OF GLUTAMIC
ACID-PRODUCING MICROORGANISMS 340
11
.
2.2
11.2.3
11.3
11.3.1
11.3.2
11.3.2.1
11.3.2.2
11.3.2.3
11.3.2.4
11.3.3
11.4
11.4.1
11.4.2
11.4.2.1
11.4.2.2
11.4.3
11.5
11.6
11.7
12
12.1
12
.
1.1
12
.
1.2
12.2
12
.
2.1
12
.
2.2
12
.
2
.
2.1
12
.
2
.
2.2
12.2.2.3
12.2.2.4
12.2.2.5
DISCOVERY OF C. GLUTAMICUM, A GLUTAMIC ACID-PRODUCING
BACTERIUM 340
CHARACTERISTICS OF C.
GLUTAMICUM 342
ANALYSIS OF THE MECHANISM OF GLUTAMIC ACID PRODUCTION BY
C. GLUTAMICUM 342
RELATIONSHIP BETWEEN CELL-SURFACE STRUCTURE AND GLUTAMIC ACID
PRODUCTION IN C.
GLUTAMICUM 343
METABOLIC REGULATION DURING GLUTAMIC ACID OVERPRODUCTION IN
C. GLUTAMICUM 345
BIOSYNTHESIS OF GLUTAMIC ACID IN C.
GLUTAMICUM 345
RELATIONSHIP BETWEEN ENZYME ACTIVITY OF THE 2-OXOGLUTARATE
DEHYDROGENASE COMPLEX AND GLUTAMIC ACID PRODUCTION 346
ODHI DECREASES THE ENZYMATIC ACTIVITY OF THE 2-OXOGLUTARATE
DEHYDROGENASE COMPLEX 347
ANAPLEROTIC REACTIONS IN GLUTAMIC ACID OVERPRODUCTION 348
INVOLVEMENT OF A MECHANOSENSITIVE CHANNEL, NCGLL221, IN GLUTAMIC
ACID SECRETION IN C.
GLUTAMICUM 349
METABOLIC ENGINEERING OF C.
GLUTAMICUM FOR GLUTAMIC ACID
PRODUCTION 350
METABOLIC ENGINEERING 350
METABOLIC FLUX ANALYSIS IN GLUTAMIC ACID PRODUCTION 350
ANALYSIS OF THE IMPACT OF ACTIVITIES OF ENZYMES RELATED TO GLUTAMIC
ACID PRODUCTION ON THE FLUX OF GLUTAMIC ACID PRODUCTION 351
USE OF 13C-MFA TO INVESTIGATE THE IMPORTANCE OF ANAPLEROTIC
REACTIONS TO GLUTAMIC ACID PRODUCTION 351
METABOLIC ENGINEERING FOR IMPROVEMENT OF GLUTAMIC ACID
PRODUCTION 351
GLUTAMIC ACID FERMENTATION BY OTHER MICROORGANISMS 352
INDUSTRIAL PROCESS OF GLUTAMIC ACID PRODUCTION 353
FUTURE PERSPECTIVES 354
REFERENCES 355
I-LYSINE 361
VOLKER F. WENDISCH
USES OF
L-
LYSINE 361
FEED USE OF AMINO ACIDS 361
ECONOMIC IMPORTANCE AND MEANS OF PRODUCTION OF L-LYSINE 362
BIOSYNTHESIS AND PRODUCTION OF L-LYSINE 363
L-LYSINE BIOSYNTHESIS 363
STRAIN DEVELOPMENT FOR THE PRODUCTION OF L-LYSINE 363
L-LYSINE TRANSPORT 365
DE-BOTTLENECKING L-LYSINE BIOSYNTHESIS 366
NADPH SUPPLY FOR L-LYSINE PRODUCTION 366
REDUCTION OF BYPRODUCTS OF L-LYSINE PRODUCTION 367
PRECURSOR SUPPLY FOR L-LYSINE PRODUCTION 367
12.2.3
12.2.4
12.2.4.1
12.2.4.2
12.2.4.3
12.2.4.4
12.2.4.5
12.2.4.6
12.3
12.3.1
12.3.2
12.4
12.4.1
12.4.2
12.5
13
13.1
13.2
13.3
13.3.1
13.3.2
13.3.3
13.4
13.4.1
13.4.2
13.4.3
13.4.4
13.5
14
14.1
INDUSTRIAL PROCESSES OF L-LYSINE PRODUCTION 368
FLEXIBLE FEEDSTOCK CONCEPT OF C GLUTAMICUM: ENGINEERING CARBON
SOURCE UTILIZATION 369
MOLASSES, GLUCOSE, FRUCTOSE, SUCROSE, AND STARCH 370
LIGNOCELLULOSICS, CELLULOSE, XYLOSE, ARABINOSE, ACETATE,
GALACTOSE 371
SILAGE JUICE AND LACTIC ACID 373
AMINO SUGARS 373
DICARBOXYLIC ACIDS 374
GLYCEROL 374
THE CHASSIS CONCEPT: BIOTIN PROTOTROPHY AND GENOME
REDUCTION 374
ENGINEERING BIOTIN PROTOTROPHIC C GLUTAMICUM 375
GENOME-STREAMLINED C GLUTAMICUM STRAINS 375
L-LYSINE BIOSENSORS FOR STRAIN SELECTION AND ON-DEMAND FLUX
CONTROL 377
TRANSCRIPTIONAL REGULATORS AS DIAGNOSTIC METABOLITE SENSORS FOR
SCREENING
377
RIBOSWITCHES AS METABOLITE SENSORS FOR ON-DEMAND METABOLIC FLUX
CONTROL 379
PERSPECTIVE 380
REFERENCES 380
PART V BIO-BASED MONOMERS AND POLYMERS 391
DIAMINES FOR BIO-BASED MATERIALS 393
JUDITH BECKER AND CHRISTOPH WITTMANN
INTRODUCTION 393
DIAMINE METABOLISM IN BACTERIA 395
PUTRESCINE - 1,4-DIAMINOBUTANE 395
METABOLISM OF PUTRESCINE 396
BIOSYNTHESIS AND PATHWAY REGULATION 396
METABOLIC ENGINEERING FOR PUTRESCINE PRODUCTION 398
CADAVERINE - 1,5-DIAMINOPENTANE 399
METABOLISM OF DIAMINOPENTANE 399
BIOSYNTHESIS AND PATHWAY REGULATION 400
METABOLIC ENGINEERING FOR CADAVERINE PRODUCTION 400
BIO-BASED POLYAMIDE PA5.10 - A SUCCESS STORY 403
CONCLUSIONS AND PERSPECTIVES 403
REFERENCES 404
MICROBIAL PRODUCTION OF 3-HYDROXYPROPIONIC ACID 411
YOKIMIKO DAVID, YOUNG HOON OH, MARY GRACE BAYLON, KEI-ANNE BARITUGO,
JEONG CHAN JOO, CHEOL GI CHAE, YOU JIN KIM, AND SI JAE PARK
INTRODUCTION 411
14.2 3-HP OBTAINED FROM NATIVE PRODUCERS 413
14.2.1 3-HP AS AN INTERMEDIATE OF C 0 2 FIXATION 413
14.2.2 DEGRADATION PATHWAYS 415
14.2.2.1 ACRYLIC ACID 415
14.2.2.2 PYRIMIDINES (URACIL AND THYMINE) 415
14.2.3 3-HP AS A NEMATICIDE 417
14.3 SYNTHESIS OF 3-HP FROM GLUCOSE 417
14.4 SYNTHESIS OF 3-HP FROM GLYCEROL 421
14.4.1 COA-INDEPENDENT DHA OPERON 422
14.4.2 COA-DEPENDENT
PDU OPERON 425
14.4.3 REDIRECTING THE FLUX TOWARD 3-HP PRODUCTION 426
14.4.4 K. PNEUMONIAE AS A HOST FOR GLYCEROL-DERIVED 3-HP
PRODUCTION 426
14.4.5 3-HP PRODUCTION FROM GLYCEROL IN RECOMBINANT
E. COLI 431
14.5 BRIDGING THE GAP BETWEEN GLUCOSE AND GLYCEROL IN 3-HP
PRODUCTION 437
14.6 OTHER STRAINS FOR 3-HP PRODUCTION FROM GLYCEROL 438
14.7 LIMITATIONS OF 3-HP SYNTHESIS 440
14.8 CONCLUSIONS AND FUTURE PROSPECTS 442
ACKNOWLEDGMENTS 443
REFERENCES 444
15 ITACONIC ACID - AN EMERGING BUILDING BLOCK 453
MATTHIAS
G.
STEIGER, NICK WIERCKX, LARS M. BLANK, DIETHARD MATTANOVICH, AND
MICHAEL SAUER
15.1 BACKGROUND, HISTORY, AND ECONOMY 453
15.2 BIOSYNTHESIS OF ITACONIC ACID 455
15.2.1 ASPERGILLUS TERREUS 455
15.2.2 GENES AND ENZYMES INVOLVED IN THE BIOSYNTHESIS OF ITACONIC ACID
IN
A. TERREUS 455
15.2.3 GENES AND ENZYMES INVOLVED IN THE BIOSYNTHESIS OF ITACONIC ACID
IN
USTILAGO MAYDIS 459
15.3 PRODUCTION CONDITIONS FOR ITACONIC ACID 459
15.4 PHYSIOLOGICAL EFFECTS AND METABOLISM OF ITACONIC ACID 461
15.5 METABOLIC ENGINEERING FOR ITACONIC ACID PRODUCTION 462
15.6 OUTLOOK 467
ACKNOWLEDGMENTS 468
REFERENCES 469
PART VI TOP-VALUE PLATFORM CHEMICALS 473
16 MICROBIAL PRODUCTION OF ISOPRENE: OPPORTUNITIES AND CHALLENGES 475
HUIBIN ZOU, HUI LIU, ELHUSSINY ABOUTNAGA, HUIZHOU LIU, TAO CHENG, AND
MO XIAN
16.1 INTRODUCTION 475
16.2 THE MILESTONES OF ISOPRENE PRODUCTION 476
16.3 MICROBIAL PRODUCTION OF ISOPRENE: OUT OF THE LABORATORY 477
16.3.1 ADVANTAGES OF BIOISOPRENE AGAINST PETROLEUM-DERIVED
ISOPRENE 477
16.3.2 METABOLIC PATHWAYS AND KEY ENZYME OF BIOISOPRENE 477
16.3.3 METABOLIC ENGINEERING OF MVA AND MEP PATHWAYS FOR MICROBIAL
PRODUCTION OF ISOPRENE 480
16.3.4 SUBSTRATE FOR THE MICROBIAL PRODUCTION OF ISOPRENE 481
16.3.5 EVALUATION OF ISOPRENE BIOSYNTHETIC PROCESS FROM DIFFERENT
SUBSTRATES 482
16.3.6 CHASSIS STRAINS FOR THE MICROBIAL PRODUCTION OF ISOPRENE 485
16.3.7 RECOVERY TECHNIQUES FOR THE GAS-PHASE BIOISOPRENE 486
16.3.8 SCALE-UP FERMENTATION AND PROCESS CONTROL OF
BIOISOPRENE 487
16.4 MAIN CHALLENGES FOR BIOISOPRENE PRODUCTION 489
16.5 FUTURE PROSPECTS 491
16.5.1 RATIONAL DESIGN OF CENTRAL METABOLIC PATHWAY TO INCREASE THE
YIELD
AND PRODUCTIVITY OF ISOPRENE 491
16.5.2 IMPROVING THE YIELD VIA METABOLIC PATHWAYS (MVA/MEP)
ENGINEERING 492
16.5.3 IMPROVING THE INTERMEDIATE PRECURSORS VIA ENZYME
ENGINEERING 494
16.5.4 NOVEL SUBSTRATES FOR BIOISOPRENE 494
16.5.5 INTEGRATION OF BIO AND CHEMO SUBSTRATES AND PROCESS FOR ISOPRENE
PRODUCTION 495
16.5.6 NOVEL HOSTS FOR ISOPRENE PRODUCTION 495
16.5.7 EXPLORING ANAEROBIC ROUTES 496
16.5.8 BIOSYNTHESIS OF VALUE-ADDED ISOPRENE DERIVATIVES 497
ACKNOWLEDGMENTS 498
REFERENCES 498
17 SUCCINIC ACID 505
JUNG HO AHN, YU-SIN JANG, AND SANG YUP LEE
17.1 INTRODUCTION 505
17.2 DEVELOPMENT OF SUCCINIC ACID PRODUCERS AND FERMENTATION
STRATEGIES 506
17.2.1 ACTINOBACILLUSSUCCINOGEN.ES 507
17.2.2 ANAEROBIOSPIRILLUM SUCCINICIPRODUCENS 510
17.2.3 CORYNEBACTERIUM GLUTAMICUM 512
17.2.4 ESCHERICHIA COLI 515
17.2.5 MANNHEIMIA SUCCINICIPRODUCENS 526
17.2.6 SACCHAROMYCES CEREVISIAE 530
17.3 SUCCINIC ACID RECOVERY AND PURIFICATION 533
17.3.1 PRECIPITATION 533
17.3.2 ELECTRODIALYSIS 534
17.3.3 REACTIVE EXTRACTION 535
17.3.4 ADSORPTION 536
17.4 SUMMARY 536
ACKNOWLEDGMENTS 537
REFERENCES 537
PART VII BIORENEWABLE FUELS
545
18 ETHANOL: A MODEL BIORENEWABLE FUEL 547
TAO JIN, JIENI LIAN, AND LAURA R. JARBOE
18.1 INTRODUCTION 547
18.2 METABOLIC ENGINEERING: DESIGN, BUILD, TEST, LEARN 549
18.2.1 DESIGN: METABOLIC PATHWAY ENGINEERING 550
18.2.1.1 INTRODUCTION OF A FOREIGN PATHWAY TO ENABLE NON-NATIVE
SUBSTRATE
UTILIZATION 550
18.2.1.2 INTRODUCTION OF A FOREIGN PATHWAY TO ENABLE HOMOETHANOL
PRODUCTION 552
18.2.1.3 SELECTION OF METABOLIC PATHWAYS FOR MODIFICATION 554
18.2.1.4 METABOLIC ENGINEERING TO ENABLE MIXED-SUBSTRATE
UTILIZATION 554
18.2.1.5 SELECTION OF PATHWAY COMPONENTS FOR TUNING 555
18.2.2 DESIGN: MEMBRANE ENGINEERING FOR IMPROVED TOLERANCE 555
18.2.3 BUILD: TARGETED GENETIC MANIPULATION TECHNIQUES 556
18.2.3.1 ONE-STEP CHROMOSOMAL EDITING OF. COLI 556
18.2.3.2 SHUTTLE VECTORS FOR 5. CEREVISIAE ENGINEERING 556
18.2.3.3 CRISPR/CAS 9 557
18.2.4 BUILD: EVOLUTIONARY STRAIN IMPROVEMENT 557
18.2.4.1 GENOME-WIDE EVOLUTION FOR IMPROVED TOLERANCE AND
PRODUCTION 557
18.2.4.2 ENZYME EVOLUTION TO ENABLE NONRECOMBINANT HOMOETHANOL
PRODUCTION 558
18.2.5 TEST: SCREENING OF EXPRESSION LIBRARIES 559
18.2.5.1 EXPRESSION LIBRARIES CONTAINING SEQUENCE VARIANTS OF A
PRESELECTED
GENE 559
18.2.5.2 EXPRESSION LIBRARIES THAT ALTER GENE ABUNDANCE 560
18.2.5.3 EXPRESSION LIBRARIES THAT VARY GENOMIC INTEGRATION SITE 560
18.2.6 LEARN: IDENTIFYING STRATEGIES AND TARGETS FOR THE NEXT DESIGN
STAGE 561
18.2.6.1 REVERSE ENGINEERING OF IMPROVED STRAINS 561
18.2.6.2 LEARN: IDENTIFICATION OF METABOLIC BURDENS DURING
PRODUCTION 562
18.3 BIOMASS DECONSTRUCTION 563
18.4 CLOSING REMARKS 564
ACKNOWLEDGMENTS 564
REFERENCES 564
19 MICROBIAL PRODUCTION OF BUTANOLS 573
SIO SI WONG, LUO MI, AND JAMES
C.
LIAO
19.1 INTRODUCTION 573
19.2 A HISTORICAL PERSPECTIVE OF -BUTANOL PRODUCTION 574
19.3 ABE FERMENTATION 575
19.3.1 THE BIOCHEMISTRY OF ABE FERMENTATION 575
19.3.2 DEVELOPING GENETICS TOOLS IN CLOSTRIDIUM ACETOBUTYLICUM 577
19.3.3 METABOLIC ENGINEERING OF CLOSTRIDIUM ACETOBUTYLICUM FOR BUTANOL
FERMENTATION 578
19.4 -BUTANOL PRODUCTION IN NON-NATIVE PRODUCERS 580
19.4.1 RATIONALE FOR USING NON-NATIVE PRODUCERS 580
19.4.2 PATHWAYS FOR -BUTANOL BIOSYNTHESIS 580
19.4.3 IMPROVED -BUTANOL PRODUCTION WITH DRIVING FORCES 582
19.5 ISOBUTANOL PRODUCTION 583
19.5.1 THE BIOCHEMISTRY OF ISOBUTANOL PRODUCTION 583
19.5.2 ISOBUTANOL PRODUCTION FROM SUGAR 584
19.5.3 ISOBUTANOL PRODUCTION FROM CELLULOSE 586
19.5.4 ISOBUTANOL PRODUCTION FROM C 0 2 586
19.5.5 ISOBUTANOL PRODUCTION FROM WASTE PROTEIN 587
19.5.6 ISOBUTANOL TOLERANCE OF E. COLI 588
19.5.7 OTHER PRODUCTS FROM THE KETO-ACID PATHWAY 588
19.6 SUMMARY AND OUTLOOK 589
ACKNOWLEDGMENTS 589
REFERENCES 589
INDEX 597
|
| any_adam_object | 1 |
| author2 | Wittmann, Christoph 1967- Liao, James C. 1958- |
| author2_role | edt edt |
| author2_variant | c w cw j c l jc jcl |
| author_GND | (DE-588)115547673 (DE-588)1128341034 |
| author_facet | Wittmann, Christoph 1967- Liao, James C. 1958- |
| building | Verbundindex |
| bvnumber | BV044031496 |
| classification_rvk | WF 9700 |
| ctrlnum | (OCoLC)976414517 (DE-599)DNB1101835583 |
| dewey-full | 540 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 540 - Chemistry and allied sciences |
| dewey-raw | 540 |
| dewey-search | 540 |
| dewey-sort | 3540 |
| dewey-tens | 540 - Chemistry and allied sciences |
| discipline | Chemie / Pharmazie Biologie |
| edition | 1. Auflage |
| format | Book |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV044031496 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T07:41:40Z |
| institution | BVB |
| institution_GND | (DE-588)16179388-5 |
| isbn | 9783527341818 3527341811 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-029438756 |
| oclc_num | 976414517 |
| open_access_boolean | |
| owner | DE-703 DE-12 DE-83 |
| owner_facet | DE-703 DE-12 DE-83 |
| physical | XXXIV, 605 Seiten Illustrationen, Diagramme |
| publishDate | 2017 |
| publishDateSearch | 2017 |
| publishDateSort | 2017 |
| publisher | Wiley-VCH |
| record_format | marc |
| series | Advanced biotechnology |
| series2 | Advanced biotechnology |
| spelling | Industrial biotechnology products and processes edited by Christoph Wittmann, James C. Liao 1. Auflage Weinheim Wiley-VCH [2017] © 2017 XXXIV, 605 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Advanced biotechnology 4 Bioverfahrenstechnik (DE-588)4307166-1 gnd rswk-swf Biotechnologie (DE-588)4069491-4 gnd rswk-swf Biotechnologie Biotechnologie i. d. Biowissenschaften Biotechnologie i. d. Chemie Biotechnology Biowissenschaften Chemie Chemistry Industrial Chemistry Industrielle Biotechnologie Life Sciences Technische u. Industrielle Chemie (DE-588)4143413-4 Aufsatzsammlung gnd-content Biotechnologie (DE-588)4069491-4 s DE-604 Bioverfahrenstechnik (DE-588)4307166-1 s 1\p DE-604 Wittmann, Christoph 1967- (DE-588)115547673 edt Liao, James C. 1958- (DE-588)1128341034 edt Wiley-VCH (DE-588)16179388-5 pbl Erscheint auch als Online-Ausgabe, ePDF 978-3-527-80782-6 Erscheint auch als Online-Ausgabe, ePub 978-3-527-80784-0 Erscheint auch als Online-Ausgabe, Mobi 978-3-527-80785-7 Erscheint auch als Online-Ausgabe, oBook 978-3-527-80783-3 Advanced biotechnology 4 (DE-604)BV043302234 4 http://www.wiley-vch.de/publish/dt/books/ISBN978-3-527-34181-8/ Verlag DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029438756&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Industrial biotechnology products and processes Advanced biotechnology Bioverfahrenstechnik (DE-588)4307166-1 gnd Biotechnologie (DE-588)4069491-4 gnd |
| subject_GND | (DE-588)4307166-1 (DE-588)4069491-4 (DE-588)4143413-4 |
| title | Industrial biotechnology products and processes |
| title_auth | Industrial biotechnology products and processes |
| title_exact_search | Industrial biotechnology products and processes |
| title_full | Industrial biotechnology products and processes edited by Christoph Wittmann, James C. Liao |
| title_fullStr | Industrial biotechnology products and processes edited by Christoph Wittmann, James C. Liao |
| title_full_unstemmed | Industrial biotechnology products and processes edited by Christoph Wittmann, James C. Liao |
| title_short | Industrial biotechnology |
| title_sort | industrial biotechnology products and processes |
| title_sub | products and processes |
| topic | Bioverfahrenstechnik (DE-588)4307166-1 gnd Biotechnologie (DE-588)4069491-4 gnd |
| topic_facet | Bioverfahrenstechnik Biotechnologie Aufsatzsammlung |
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| volume_link | (DE-604)BV043302234 |
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