Therapeutisches Drug Monitoring neuer oraler Antikoagulantien:
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | German English |
| Published: |
Köln
2016
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | 86 Seiten Illustrationen, Diagramme 21 cm |
Staff View
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV044019836 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | t | ||
| 008 | 170130s2016 gw a||| m||| 00||| ger d | ||
| 016 | 7 | |a 1124398023 |2 DE-101 | |
| 035 | |a (OCoLC)971023193 | ||
| 035 | |a (DE-599)DNB1124398023 | ||
| 040 | |a DE-604 |b ger |e rda | ||
| 041 | 0 | |a ger |a eng | |
| 044 | |a gw |c XA-DE | ||
| 049 | |a DE-355 | ||
| 084 | |a 610 |2 sdnb | ||
| 100 | 1 | |a Blaich, Cornelia |d 1987- |e Verfasser |0 (DE-588)1122121210 |4 aut | |
| 245 | 1 | 0 | |a Therapeutisches Drug Monitoring neuer oraler Antikoagulantien |c vorgelegt von Cornelia Blaich |
| 264 | 1 | |a Köln |c 2016 | |
| 300 | |a 86 Seiten |b Illustrationen, Diagramme |c 21 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 502 | |b Dissertation |c Universität zu Köln |d 2016 | ||
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029427380&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-029427380 | ||
Record in the Search Index
| _version_ | 1804177015139467264 |
|---|---|
| adam_text | INHALTSVERZEICHNIS
ABKUERZUNGSVERZEICHNIS....................................................................................................
1
1
EINLEITUNG..............................................................................................................
3
1.1 DIE
GERINNUNGSKASKADE.........................................................................................
3
1.2
VITAMIN-K-ANTAGONISTEN........................................................................................
4
1.3 NEUE ORALE ANTIKOAGULANTIEN (NOAKS)
.................................................................
6
1.3.1 PHARMAKOKINETISCHE EIGENSCHAFTEN
.................................................................
6
1.3.2
INDIKATIONSGEBIETE............................................................................................
8
1.3.3 AUFHEBUNG DER ANTIKOAGULATORISCHEN WIRKUNG / ANTIDOTS
............................
11
1.3.4 BESTIMMUNG DER ANTIKOAGULATORISCHEN AKTIVITAET MITTELS
GERINNUNGSTESTS.... 12
1.4
LC-MS/MS.............................................................................................................
14
1.4.1
FLUESSIGKEITSCHROMATOGRAPHIE..............................................
15
1.4.2
MASSENSPEKTROMETRIE......................................................................................16
1.4.3
MATRIXEFFEKTE...................................................................................................
19
1.4.4 INTERNE STANDARDISIERUNG UND METHODENVALIDIERUNG
....................................
22
1.5 THERAPEUTISCHES DRUG MONITORING
(TDM)..........................................................23
1.5.1 TDM IN SPEZIELLEN MATRICES AM BEISPIEL DER
LAKTATION.................................25
1.6 ZIEL DER
ARBEIT......................................................................................................
28
2 THERAPEUTISCHES DRUG MONITORING DER
NOAKS..............................................29
3 DER DIREKTE FAKTOR-XA-INHIBITOR RIVAROXABAN GEHT IN DIE MUTTERMILCH
UEBER
.......
.
.............................................................................................................
41
4
DISKUSSION..........................................................................................................
55
4.1 THERAPEUTISCHES DRUG MONITORING DER
NOAKS................................................... 55
4.2 METHODEN ZUR BESTIMMUNG DER ANTIKOAGULATORISCHEN AKTIVITAET DER NOAKS
IM RAHMEN DES
TDM............................................................................................57
4.3 MATRIXEFFEKTE IN DER
LC-MS/MS...........................................................................60
4.4 MULTI-ANALYTISCHE LC-MS/MS-METHODEN ZUR SIMULTANEN BESTIMMUNG DER
NOAKS...................................................................................................................
61
4.5 LC-MS/MS IN SPEZIELLEN MATRICES AM BEISPIEL DER
LAKTATION.............................65
4.6 PERSPEKTIVEN DER NOAKS IM KLINISCHEN ALLTAG
...................................................
67
5
ZUSAMMENFASSUNG.............................................................................................
70
6
LITERATURVERZEICHNIS..........................................................................................71
7 VORABVEROEFFENTLICHUNG VON
ERGEBNISSEN........................................................85
8
LEBENSLAUF...........................................................................................................86
|
| any_adam_object | 1 |
| author | Blaich, Cornelia 1987- |
| author_GND | (DE-588)1122121210 |
| author_facet | Blaich, Cornelia 1987- |
| author_role | aut |
| author_sort | Blaich, Cornelia 1987- |
| author_variant | c b cb |
| building | Verbundindex |
| bvnumber | BV044019836 |
| ctrlnum | (OCoLC)971023193 (DE-599)DNB1124398023 |
| discipline | Medizin |
| format | Thesis Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01189nam a2200313 c 4500</leader><controlfield tag="001">BV044019836</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">170130s2016 gw a||| m||| 00||| ger d</controlfield><datafield tag="016" ind1="7" ind2=" "><subfield code="a">1124398023</subfield><subfield code="2">DE-101</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)971023193</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DNB1124398023</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">ger</subfield><subfield code="a">eng</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">gw</subfield><subfield code="c">XA-DE</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">610</subfield><subfield code="2">sdnb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Blaich, Cornelia</subfield><subfield code="d">1987-</subfield><subfield code="e">Verfasser</subfield><subfield code="0">(DE-588)1122121210</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Therapeutisches Drug Monitoring neuer oraler Antikoagulantien</subfield><subfield code="c">vorgelegt von Cornelia Blaich</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Köln</subfield><subfield code="c">2016</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">86 Seiten</subfield><subfield code="b">Illustrationen, Diagramme</subfield><subfield code="c">21 cm</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="502" ind1=" " ind2=" "><subfield code="b">Dissertation</subfield><subfield code="c">Universität zu Köln</subfield><subfield code="d">2016</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4113937-9</subfield><subfield code="a">Hochschulschrift</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">DNB Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029427380&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-029427380</subfield></datafield></record></collection> |
| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV044019836 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T07:41:21Z |
| institution | BVB |
| language | German English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-029427380 |
| oclc_num | 971023193 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | 86 Seiten Illustrationen, Diagramme 21 cm |
| publishDate | 2016 |
| publishDateSearch | 2016 |
| publishDateSort | 2016 |
| record_format | marc |
| spelling | Blaich, Cornelia 1987- Verfasser (DE-588)1122121210 aut Therapeutisches Drug Monitoring neuer oraler Antikoagulantien vorgelegt von Cornelia Blaich Köln 2016 86 Seiten Illustrationen, Diagramme 21 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Universität zu Köln 2016 (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029427380&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Blaich, Cornelia 1987- Therapeutisches Drug Monitoring neuer oraler Antikoagulantien |
| subject_GND | (DE-588)4113937-9 |
| title | Therapeutisches Drug Monitoring neuer oraler Antikoagulantien |
| title_auth | Therapeutisches Drug Monitoring neuer oraler Antikoagulantien |
| title_exact_search | Therapeutisches Drug Monitoring neuer oraler Antikoagulantien |
| title_full | Therapeutisches Drug Monitoring neuer oraler Antikoagulantien vorgelegt von Cornelia Blaich |
| title_fullStr | Therapeutisches Drug Monitoring neuer oraler Antikoagulantien vorgelegt von Cornelia Blaich |
| title_full_unstemmed | Therapeutisches Drug Monitoring neuer oraler Antikoagulantien vorgelegt von Cornelia Blaich |
| title_short | Therapeutisches Drug Monitoring neuer oraler Antikoagulantien |
| title_sort | therapeutisches drug monitoring neuer oraler antikoagulantien |
| topic_facet | Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029427380&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT blaichcornelia therapeutischesdrugmonitoringneueroralerantikoagulantien |