Therapeutisches Drug Monitoring neuer oraler Antikoagulantien:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | German English |
| Veröffentlicht: |
Köln
2016
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 86 Seiten Illustrationen, Diagramme 21 cm |
Internformat
MARC
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| 502 | |b Dissertation |c Universität zu Köln |d 2016 | ||
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Datensatz im Suchindex
| _version_ | 1804177015139467264 |
|---|---|
| adam_text | INHALTSVERZEICHNIS
ABKUERZUNGSVERZEICHNIS....................................................................................................
1
1
EINLEITUNG..............................................................................................................
3
1.1 DIE
GERINNUNGSKASKADE.........................................................................................
3
1.2
VITAMIN-K-ANTAGONISTEN........................................................................................
4
1.3 NEUE ORALE ANTIKOAGULANTIEN (NOAKS)
.................................................................
6
1.3.1 PHARMAKOKINETISCHE EIGENSCHAFTEN
.................................................................
6
1.3.2
INDIKATIONSGEBIETE............................................................................................
8
1.3.3 AUFHEBUNG DER ANTIKOAGULATORISCHEN WIRKUNG / ANTIDOTS
............................
11
1.3.4 BESTIMMUNG DER ANTIKOAGULATORISCHEN AKTIVITAET MITTELS
GERINNUNGSTESTS.... 12
1.4
LC-MS/MS.............................................................................................................
14
1.4.1
FLUESSIGKEITSCHROMATOGRAPHIE..............................................
15
1.4.2
MASSENSPEKTROMETRIE......................................................................................16
1.4.3
MATRIXEFFEKTE...................................................................................................
19
1.4.4 INTERNE STANDARDISIERUNG UND METHODENVALIDIERUNG
....................................
22
1.5 THERAPEUTISCHES DRUG MONITORING
(TDM)..........................................................23
1.5.1 TDM IN SPEZIELLEN MATRICES AM BEISPIEL DER
LAKTATION.................................25
1.6 ZIEL DER
ARBEIT......................................................................................................
28
2 THERAPEUTISCHES DRUG MONITORING DER
NOAKS..............................................29
3 DER DIREKTE FAKTOR-XA-INHIBITOR RIVAROXABAN GEHT IN DIE MUTTERMILCH
UEBER
.......
.
.............................................................................................................
41
4
DISKUSSION..........................................................................................................
55
4.1 THERAPEUTISCHES DRUG MONITORING DER
NOAKS................................................... 55
4.2 METHODEN ZUR BESTIMMUNG DER ANTIKOAGULATORISCHEN AKTIVITAET DER NOAKS
IM RAHMEN DES
TDM............................................................................................57
4.3 MATRIXEFFEKTE IN DER
LC-MS/MS...........................................................................60
4.4 MULTI-ANALYTISCHE LC-MS/MS-METHODEN ZUR SIMULTANEN BESTIMMUNG DER
NOAKS...................................................................................................................
61
4.5 LC-MS/MS IN SPEZIELLEN MATRICES AM BEISPIEL DER
LAKTATION.............................65
4.6 PERSPEKTIVEN DER NOAKS IM KLINISCHEN ALLTAG
...................................................
67
5
ZUSAMMENFASSUNG.............................................................................................
70
6
LITERATURVERZEICHNIS..........................................................................................71
7 VORABVEROEFFENTLICHUNG VON
ERGEBNISSEN........................................................85
8
LEBENSLAUF...........................................................................................................86
|
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| ctrlnum | (OCoLC)971023193 (DE-599)DNB1124398023 |
| discipline | Medizin |
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| indexdate | 2024-07-10T07:41:21Z |
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| language | German English |
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| spelling | Blaich, Cornelia 1987- Verfasser (DE-588)1122121210 aut Therapeutisches Drug Monitoring neuer oraler Antikoagulantien vorgelegt von Cornelia Blaich Köln 2016 86 Seiten Illustrationen, Diagramme 21 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Universität zu Köln 2016 (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029427380&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Blaich, Cornelia 1987- Therapeutisches Drug Monitoring neuer oraler Antikoagulantien |
| subject_GND | (DE-588)4113937-9 |
| title | Therapeutisches Drug Monitoring neuer oraler Antikoagulantien |
| title_auth | Therapeutisches Drug Monitoring neuer oraler Antikoagulantien |
| title_exact_search | Therapeutisches Drug Monitoring neuer oraler Antikoagulantien |
| title_full | Therapeutisches Drug Monitoring neuer oraler Antikoagulantien vorgelegt von Cornelia Blaich |
| title_fullStr | Therapeutisches Drug Monitoring neuer oraler Antikoagulantien vorgelegt von Cornelia Blaich |
| title_full_unstemmed | Therapeutisches Drug Monitoring neuer oraler Antikoagulantien vorgelegt von Cornelia Blaich |
| title_short | Therapeutisches Drug Monitoring neuer oraler Antikoagulantien |
| title_sort | therapeutisches drug monitoring neuer oraler antikoagulantien |
| topic_facet | Hochschulschrift |
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