Translational animal models in drug discovery and development:
Gespeichert in:
Bibliographische Detailangaben
Format: Elektronisch E-Book
Sprache:English
Veröffentlicht: [Place of publication not identified] Bentham Science Publishers 2012
Schlagworte:
Online-Zugang:FAW01
FAW02
Beschreibung:Includes bibliographical references and index
Cover; Title; EUL; Contents; Foreword; Preface; List of Contributors; Chapter 01; Chapter 02; Chapter 03; Chapter 04; Chapter 05; Chapter 06; Chapter 07; Chapter 08; Chapter 09; Chapter 10; Index
Animal models of diseases play a pivotal role in drug discovery and development, not only for proof of the concept studies of efficacy, PK/PD relationship but also for drug safety assessment. Since considerable differences in variables exist between animal models and human models (such as genetics, physiology, anatomy, gene expression, heterogeneity of disease conditions, etc.), not all the preclinical models are able to represent the pathophysiological conditions in human diseases. Therefore, partly due to the lack of congruency between animal and human disease models, several proposed therap
Beschreibung:viii, 275 pages
ISBN:9781608054695
1608054691
9781608055913

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