G protein-coupled receptors: structure, signaling, and physiology
Provides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs). Recent advances include the first mammalian non-rhodopsin GPCR structures and reconstitution of purified GPCRs into membrane discs for defined studies, novel signaling features...
Gespeichert in:
| Weitere Verfasser: | , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Cambridge
Cambridge University Press
2011
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| Schlagworte: | |
| Online-Zugang: | BSB01 FHN01 URL des Erstveröffentlichers |
| Zusammenfassung: | Provides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs). Recent advances include the first mammalian non-rhodopsin GPCR structures and reconstitution of purified GPCRs into membrane discs for defined studies, novel signaling features including oligomerization, and advances in understanding the complex ligand pharmacology and physiology of GPCRs, in new assay technologies and drug targeting. The authors take time to detail the importance of the pathophysiological function and drug targeting of GPCRs, specifically β-adrenoceptors in cardiovascular and respiratory diseases, metabotropic glutamate receptors in CNS disorders, S1P receptors in the immune system, and Wnt/Frizzled receptors in osteoporosis. This book will be invaluable to researchers and graduate students in academia and industry who are interested in the GPCR field |
| Beschreibung: | Title from publisher's bibliographic system (viewed on 05 Oct 2015) |
| Beschreibung: | 1 online resource (xvi, 430 pages) |
| ISBN: | 9780511760334 |
| DOI: | 10.1017/CBO9780511760334 |
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| 505 | 8 | |a Part I. Advances in GPCR Protein Research: 1. The evolution of the repertoire and structure of G protein-coupled receptors / Torsten Schöneberg, Kristin Schröck, Claudia Stäubert and Andreas Russ -- 2. Functional studies of isolated GPCR-G protein complexes in the membrane bilayer of lipoprotein particles / Adam J. Kuszak, Xiao Jie Yao, Sören G.F. Rasmussen, Brian K. Kobilka and Roger K. Sunahara -- Part II. Oligomerization of GPCRs: 3. GPCR-G protein fusions : use in functional dimerization analysis / Graeme Milligan -- 4. Time-resolved FRET approaches to study GPCR complexes / Jean Phillipe Pin, Damien Maurel, Laetitia Comps-Agrar, Carine Monnier, Marie-Laure Rives, Etienne Doumazane, Philippe Rondard, Thierry Durroux, Laurent Prézeau and Erin Trinquet -- 5. Signaling of dopamine receptor homo- and hetero-oligomers / Ahmed Hasbi, Brian F. O'Dowd and Susan R. George -- | |
| 505 | 8 | |a 6. Functional consequences of chemokine receptor dimerization / Mario Mellado, Carlos Martínez-A., and José Miguel Rodgríguez-Frade -- Part III. GPCR Signaling Features: 7. G protein functions identified using genetic mouse models / Stefan Offermanns -- 8. Kinetics of GPCR, G protein and effector activation / Peter Hein -- 9. RGS-RhoGEFs and other RGS multidomain proteins as effector molecules in GPCR-dependent and GPCR-independent cell signaling / José Vázquez-Prado and J. Silvio Gutkind -- 10. Adenylyl cyclase isoform-specific signaling of GPCRs / Karin F.K. Ejendal, Julie A. Przybyla, and Val J. Watts -- 11. G protein-independent and [beta] arrestin-dependent GPCR signaling / Zhongzhen Nie and Yehia Daaka -- 12. Assays to read GPCR modulation and signaling / Ralf Heilker and Michael Wolff -- Part IV. Ligand Pharmacology of GPCRs: 13. Quantifying allosteric ligand-receptor interactions / Ivan Toma Vranesic and Daniel Hoyer -- | |
| 505 | 8 | |a 14. 7TM receptor functional selectivity / Terry Kenakin -- Part V. Physiological Functions and Drug Targeting of GPCRs: 15. [Beta]-Adrenoreceptors in cardiovascular and respiratory diseases / Michele Ciccarelli, J. Kurt Chuprun and Walter J. Koch -- 16. Role of metabotropic glutamate receptors in CNS disorders / Richard M. O'Connor and John F. Cryan -- 17. S1P receptor agonists, a novel generation of immunosuppressants / Rósa Lopez Almagro, Gema Tarrasón, and Nuria Godessart -- 18. Wnt/Frizzled receptor signaling in osteoporosis / Georges Rawadi | |
| 520 | |a Provides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs). Recent advances include the first mammalian non-rhodopsin GPCR structures and reconstitution of purified GPCRs into membrane discs for defined studies, novel signaling features including oligomerization, and advances in understanding the complex ligand pharmacology and physiology of GPCRs, in new assay technologies and drug targeting. The authors take time to detail the importance of the pathophysiological function and drug targeting of GPCRs, specifically β-adrenoceptors in cardiovascular and respiratory diseases, metabotropic glutamate receptors in CNS disorders, S1P receptors in the immune system, and Wnt/Frizzled receptors in osteoporosis. This book will be invaluable to researchers and graduate students in academia and industry who are interested in the GPCR field | ||
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| 650 | 4 | |a Drug delivery systems | |
| 650 | 4 | |a Cell receptors | |
| 650 | 4 | |a Cellular signal transduction | |
| 700 | 1 | |a Siehler, Sandra |4 edt | |
| 700 | 1 | |a Milligan, Graeme |4 edt | |
| 776 | 0 | 8 | |i Erscheint auch als |n Druckausgabe |z 978-0-521-11208-6 |
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Datensatz im Suchindex
| _version_ | 1804176889660571648 |
|---|---|
| any_adam_object | |
| author2 | Siehler, Sandra Milligan, Graeme |
| author2_role | edt edt |
| author2_variant | s s ss g m gm |
| author_facet | Siehler, Sandra Milligan, Graeme |
| building | Verbundindex |
| bvnumber | BV043944599 |
| collection | ZDB-20-CBO |
| contents | Part I. Advances in GPCR Protein Research: 1. The evolution of the repertoire and structure of G protein-coupled receptors / Torsten Schöneberg, Kristin Schröck, Claudia Stäubert and Andreas Russ -- 2. Functional studies of isolated GPCR-G protein complexes in the membrane bilayer of lipoprotein particles / Adam J. Kuszak, Xiao Jie Yao, Sören G.F. Rasmussen, Brian K. Kobilka and Roger K. Sunahara -- Part II. Oligomerization of GPCRs: 3. GPCR-G protein fusions : use in functional dimerization analysis / Graeme Milligan -- 4. Time-resolved FRET approaches to study GPCR complexes / Jean Phillipe Pin, Damien Maurel, Laetitia Comps-Agrar, Carine Monnier, Marie-Laure Rives, Etienne Doumazane, Philippe Rondard, Thierry Durroux, Laurent Prézeau and Erin Trinquet -- 5. Signaling of dopamine receptor homo- and hetero-oligomers / Ahmed Hasbi, Brian F. O'Dowd and Susan R. George -- 6. Functional consequences of chemokine receptor dimerization / Mario Mellado, Carlos Martínez-A., and José Miguel Rodgríguez-Frade -- Part III. GPCR Signaling Features: 7. G protein functions identified using genetic mouse models / Stefan Offermanns -- 8. Kinetics of GPCR, G protein and effector activation / Peter Hein -- 9. RGS-RhoGEFs and other RGS multidomain proteins as effector molecules in GPCR-dependent and GPCR-independent cell signaling / José Vázquez-Prado and J. Silvio Gutkind -- 10. Adenylyl cyclase isoform-specific signaling of GPCRs / Karin F.K. Ejendal, Julie A. Przybyla, and Val J. Watts -- 11. G protein-independent and [beta] arrestin-dependent GPCR signaling / Zhongzhen Nie and Yehia Daaka -- 12. Assays to read GPCR modulation and signaling / Ralf Heilker and Michael Wolff -- Part IV. Ligand Pharmacology of GPCRs: 13. Quantifying allosteric ligand-receptor interactions / Ivan Toma Vranesic and Daniel Hoyer -- 14. 7TM receptor functional selectivity / Terry Kenakin -- Part V. Physiological Functions and Drug Targeting of GPCRs: 15. [Beta]-Adrenoreceptors in cardiovascular and respiratory diseases / Michele Ciccarelli, J. Kurt Chuprun and Walter J. Koch -- 16. Role of metabotropic glutamate receptors in CNS disorders / Richard M. O'Connor and John F. Cryan -- 17. S1P receptor agonists, a novel generation of immunosuppressants / Rósa Lopez Almagro, Gema Tarrasón, and Nuria Godessart -- 18. Wnt/Frizzled receptor signaling in osteoporosis / Georges Rawadi |
| ctrlnum | (ZDB-20-CBO)CR9780511760334 (OCoLC)852517875 (DE-599)BVBBV043944599 |
| dewey-full | 572/.696 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 572 - Biochemistry |
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| dewey-search | 572/.696 |
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| dewey-tens | 570 - Biology |
| discipline | Biologie |
| doi_str_mv | 10.1017/CBO9780511760334 |
| format | Electronic eBook |
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| id | DE-604.BV043944599 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T07:39:21Z |
| institution | BVB |
| isbn | 9780511760334 |
| language | English |
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| physical | 1 online resource (xvi, 430 pages) |
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| spelling | G protein-coupled receptors structure, signaling, and physiology edited by Sandra Siehler, Graeme Milligan Cambridge Cambridge University Press 2011 1 online resource (xvi, 430 pages) txt rdacontent c rdamedia cr rdacarrier Title from publisher's bibliographic system (viewed on 05 Oct 2015) Part I. Advances in GPCR Protein Research: 1. The evolution of the repertoire and structure of G protein-coupled receptors / Torsten Schöneberg, Kristin Schröck, Claudia Stäubert and Andreas Russ -- 2. Functional studies of isolated GPCR-G protein complexes in the membrane bilayer of lipoprotein particles / Adam J. Kuszak, Xiao Jie Yao, Sören G.F. Rasmussen, Brian K. Kobilka and Roger K. Sunahara -- Part II. Oligomerization of GPCRs: 3. GPCR-G protein fusions : use in functional dimerization analysis / Graeme Milligan -- 4. Time-resolved FRET approaches to study GPCR complexes / Jean Phillipe Pin, Damien Maurel, Laetitia Comps-Agrar, Carine Monnier, Marie-Laure Rives, Etienne Doumazane, Philippe Rondard, Thierry Durroux, Laurent Prézeau and Erin Trinquet -- 5. Signaling of dopamine receptor homo- and hetero-oligomers / Ahmed Hasbi, Brian F. O'Dowd and Susan R. George -- 6. Functional consequences of chemokine receptor dimerization / Mario Mellado, Carlos Martínez-A., and José Miguel Rodgríguez-Frade -- Part III. GPCR Signaling Features: 7. G protein functions identified using genetic mouse models / Stefan Offermanns -- 8. Kinetics of GPCR, G protein and effector activation / Peter Hein -- 9. RGS-RhoGEFs and other RGS multidomain proteins as effector molecules in GPCR-dependent and GPCR-independent cell signaling / José Vázquez-Prado and J. Silvio Gutkind -- 10. Adenylyl cyclase isoform-specific signaling of GPCRs / Karin F.K. Ejendal, Julie A. Przybyla, and Val J. Watts -- 11. G protein-independent and [beta] arrestin-dependent GPCR signaling / Zhongzhen Nie and Yehia Daaka -- 12. Assays to read GPCR modulation and signaling / Ralf Heilker and Michael Wolff -- Part IV. Ligand Pharmacology of GPCRs: 13. Quantifying allosteric ligand-receptor interactions / Ivan Toma Vranesic and Daniel Hoyer -- 14. 7TM receptor functional selectivity / Terry Kenakin -- Part V. Physiological Functions and Drug Targeting of GPCRs: 15. [Beta]-Adrenoreceptors in cardiovascular and respiratory diseases / Michele Ciccarelli, J. Kurt Chuprun and Walter J. Koch -- 16. Role of metabotropic glutamate receptors in CNS disorders / Richard M. O'Connor and John F. Cryan -- 17. S1P receptor agonists, a novel generation of immunosuppressants / Rósa Lopez Almagro, Gema Tarrasón, and Nuria Godessart -- 18. Wnt/Frizzled receptor signaling in osteoporosis / Georges Rawadi Provides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs). Recent advances include the first mammalian non-rhodopsin GPCR structures and reconstitution of purified GPCRs into membrane discs for defined studies, novel signaling features including oligomerization, and advances in understanding the complex ligand pharmacology and physiology of GPCRs, in new assay technologies and drug targeting. The authors take time to detail the importance of the pathophysiological function and drug targeting of GPCRs, specifically β-adrenoceptors in cardiovascular and respiratory diseases, metabotropic glutamate receptors in CNS disorders, S1P receptors in the immune system, and Wnt/Frizzled receptors in osteoporosis. This book will be invaluable to researchers and graduate students in academia and industry who are interested in the GPCR field G proteins Drug delivery systems Cell receptors Cellular signal transduction Siehler, Sandra edt Milligan, Graeme edt Erscheint auch als Druckausgabe 978-0-521-11208-6 https://doi.org/10.1017/CBO9780511760334 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | G protein-coupled receptors structure, signaling, and physiology Part I. Advances in GPCR Protein Research: 1. The evolution of the repertoire and structure of G protein-coupled receptors / Torsten Schöneberg, Kristin Schröck, Claudia Stäubert and Andreas Russ -- 2. Functional studies of isolated GPCR-G protein complexes in the membrane bilayer of lipoprotein particles / Adam J. Kuszak, Xiao Jie Yao, Sören G.F. Rasmussen, Brian K. Kobilka and Roger K. Sunahara -- Part II. Oligomerization of GPCRs: 3. GPCR-G protein fusions : use in functional dimerization analysis / Graeme Milligan -- 4. Time-resolved FRET approaches to study GPCR complexes / Jean Phillipe Pin, Damien Maurel, Laetitia Comps-Agrar, Carine Monnier, Marie-Laure Rives, Etienne Doumazane, Philippe Rondard, Thierry Durroux, Laurent Prézeau and Erin Trinquet -- 5. Signaling of dopamine receptor homo- and hetero-oligomers / Ahmed Hasbi, Brian F. O'Dowd and Susan R. George -- 6. Functional consequences of chemokine receptor dimerization / Mario Mellado, Carlos Martínez-A., and José Miguel Rodgríguez-Frade -- Part III. GPCR Signaling Features: 7. G protein functions identified using genetic mouse models / Stefan Offermanns -- 8. Kinetics of GPCR, G protein and effector activation / Peter Hein -- 9. RGS-RhoGEFs and other RGS multidomain proteins as effector molecules in GPCR-dependent and GPCR-independent cell signaling / José Vázquez-Prado and J. Silvio Gutkind -- 10. Adenylyl cyclase isoform-specific signaling of GPCRs / Karin F.K. Ejendal, Julie A. Przybyla, and Val J. Watts -- 11. G protein-independent and [beta] arrestin-dependent GPCR signaling / Zhongzhen Nie and Yehia Daaka -- 12. Assays to read GPCR modulation and signaling / Ralf Heilker and Michael Wolff -- Part IV. Ligand Pharmacology of GPCRs: 13. Quantifying allosteric ligand-receptor interactions / Ivan Toma Vranesic and Daniel Hoyer -- 14. 7TM receptor functional selectivity / Terry Kenakin -- Part V. Physiological Functions and Drug Targeting of GPCRs: 15. [Beta]-Adrenoreceptors in cardiovascular and respiratory diseases / Michele Ciccarelli, J. Kurt Chuprun and Walter J. Koch -- 16. Role of metabotropic glutamate receptors in CNS disorders / Richard M. O'Connor and John F. Cryan -- 17. S1P receptor agonists, a novel generation of immunosuppressants / Rósa Lopez Almagro, Gema Tarrasón, and Nuria Godessart -- 18. Wnt/Frizzled receptor signaling in osteoporosis / Georges Rawadi G proteins Drug delivery systems Cell receptors Cellular signal transduction |
| title | G protein-coupled receptors structure, signaling, and physiology |
| title_auth | G protein-coupled receptors structure, signaling, and physiology |
| title_exact_search | G protein-coupled receptors structure, signaling, and physiology |
| title_full | G protein-coupled receptors structure, signaling, and physiology edited by Sandra Siehler, Graeme Milligan |
| title_fullStr | G protein-coupled receptors structure, signaling, and physiology edited by Sandra Siehler, Graeme Milligan |
| title_full_unstemmed | G protein-coupled receptors structure, signaling, and physiology edited by Sandra Siehler, Graeme Milligan |
| title_short | G protein-coupled receptors |
| title_sort | g protein coupled receptors structure signaling and physiology |
| title_sub | structure, signaling, and physiology |
| topic | G proteins Drug delivery systems Cell receptors Cellular signal transduction |
| topic_facet | G proteins Drug delivery systems Cell receptors Cellular signal transduction |
| url | https://doi.org/10.1017/CBO9780511760334 |
| work_keys_str_mv | AT siehlersandra gproteincoupledreceptorsstructuresignalingandphysiology AT milligangraeme gproteincoupledreceptorsstructuresignalingandphysiology |