Chemical genomics:
Advances in chemistry, biology and genomics coupled with laboratory automation and computational technologies have led to the rapid emergence of the multidisciplinary field of chemical genomics. This edited text, with contributions from experts in the field, discusses the new techniques and applicat...
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Cambridge
Cambridge University Press
2012
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| Schlagworte: | |
| Online-Zugang: | BSB01 FHN01 Volltext |
| Zusammenfassung: | Advances in chemistry, biology and genomics coupled with laboratory automation and computational technologies have led to the rapid emergence of the multidisciplinary field of chemical genomics. This edited text, with contributions from experts in the field, discusses the new techniques and applications that help further the study of chemical genomics. The beginning chapters provide an overview of the basic principles of chemical biology and chemical genomics. This is followed by a technical section that describes the sources of small-molecule chemicals; the basics of high-throughput screening technologies; and various bioassays for biochemical-, cellular- and organism-based screens. The final chapters connect the chemical genomics field with personalized medicine and the druggable genome for future discovery of new therapeutics. This book will be valuable to researchers, professionals and graduate students in many fields, including biology, biomedicine and chemistry |
| Beschreibung: | Title from publisher's bibliographic system (viewed on 05 Oct 2015) |
| Beschreibung: | 1 online resource (xi, 345 pages) |
| ISBN: | 9781139021500 |
| DOI: | 10.1017/CBO9781139021500 |
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| 505 | 8 | |a Harnessing the power of chemistry for biology and medicine / Cheryl L. Meyerkord and Haian Fu -- Exploring biology with small organic molecules / Nicholas Aberle and Craig M. Crews -- Chemical proteomics: a global study of protein-small molecule interactions / Akihisa Matsuyama, Yoko Yashiroda, and Minoru Yoshida -- Diversity-oriented synthesis / Warren R.J.D. Galloway [and others] -- Targeted chemical libraries / Gregory P. Tochtrop and Ryan E. Looper -- Fragment-based ligand discovery / Sandra Bartoli, Antonella Squarcia, and Daniela Fattori -- Basics and principles for building natural product-based libraries for HTS / Ronald J. Quinn -- Essentials for high-throughput screening operations / Stewart P. Rudnicki [and others] -- High content analysis and screening: basics, instrumentation, and applications / Paul A. Johnston -- Phenotypic screens with model organisms / Grant N. Wheeler, Robert A. Field, and Matthew L. Tomlinson -- | |
| 505 | 8 | |a Screening informatics and cheminformatics / Melinda I. Sosa [and others] -- Basics of HTS assay design and optimization / Eduard A. Sergienko -- Molecular sensors for transcriptional and post-transcriptional assays / Douglas S. Auld and Natasha Thorne -- Time-resolved fluorescence resonance energy transfer technologies in HTS / Yuhong Du and Jonathan J. Havel -- Compound profiling with high-content screening methodology / Thomas Mayer and Stephan Schürer -- Use of transgenic zebrafish in a phenotypic screen for angiogenesis inhibitors / Jaeki Min [and others] -- Flow cytometry multiplexed screening methodologies / Virginia M. Salas [and others] -- Label-free biosensor technologies in small molecule modulator discovery / Yuhong Du [and others] -- Basic principles and practices of computer-aided drug design / Chao-Yie Yang, Denzil Bernard, and Shaomeng Wang -- Computational approach for drug target identification / Honglin Li [and others] -- | |
| 505 | 8 | |a Pharmacogenomics to link genetic background with therapeutic efficacy and safety / Mark M. Bouzyk, Weining Tang, and Brian Leyland-Jones -- Drugs, genomic response signatures, and customized cancer therapy / Rafael Rosell, Teresa Moran, and Miguel Taron -- Current drug targets and the druggable genome / Margaret A. Johns, Andreas Russ, and Haian Fu | |
| 520 | |a Advances in chemistry, biology and genomics coupled with laboratory automation and computational technologies have led to the rapid emergence of the multidisciplinary field of chemical genomics. This edited text, with contributions from experts in the field, discusses the new techniques and applications that help further the study of chemical genomics. The beginning chapters provide an overview of the basic principles of chemical biology and chemical genomics. This is followed by a technical section that describes the sources of small-molecule chemicals; the basics of high-throughput screening technologies; and various bioassays for biochemical-, cellular- and organism-based screens. The final chapters connect the chemical genomics field with personalized medicine and the druggable genome for future discovery of new therapeutics. This book will be valuable to researchers, professionals and graduate students in many fields, including biology, biomedicine and chemistry | ||
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Datensatz im Suchindex
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| author2 | Fu, Haian |
| author2_role | edt |
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| author_facet | Fu, Haian |
| building | Verbundindex |
| bvnumber | BV043944436 |
| classification_rvk | VC 6250 |
| collection | ZDB-20-CBO |
| contents | Harnessing the power of chemistry for biology and medicine / Cheryl L. Meyerkord and Haian Fu -- Exploring biology with small organic molecules / Nicholas Aberle and Craig M. Crews -- Chemical proteomics: a global study of protein-small molecule interactions / Akihisa Matsuyama, Yoko Yashiroda, and Minoru Yoshida -- Diversity-oriented synthesis / Warren R.J.D. Galloway [and others] -- Targeted chemical libraries / Gregory P. Tochtrop and Ryan E. Looper -- Fragment-based ligand discovery / Sandra Bartoli, Antonella Squarcia, and Daniela Fattori -- Basics and principles for building natural product-based libraries for HTS / Ronald J. Quinn -- Essentials for high-throughput screening operations / Stewart P. Rudnicki [and others] -- High content analysis and screening: basics, instrumentation, and applications / Paul A. Johnston -- Phenotypic screens with model organisms / Grant N. Wheeler, Robert A. Field, and Matthew L. Tomlinson -- Screening informatics and cheminformatics / Melinda I. Sosa [and others] -- Basics of HTS assay design and optimization / Eduard A. Sergienko -- Molecular sensors for transcriptional and post-transcriptional assays / Douglas S. Auld and Natasha Thorne -- Time-resolved fluorescence resonance energy transfer technologies in HTS / Yuhong Du and Jonathan J. Havel -- Compound profiling with high-content screening methodology / Thomas Mayer and Stephan Schürer -- Use of transgenic zebrafish in a phenotypic screen for angiogenesis inhibitors / Jaeki Min [and others] -- Flow cytometry multiplexed screening methodologies / Virginia M. Salas [and others] -- Label-free biosensor technologies in small molecule modulator discovery / Yuhong Du [and others] -- Basic principles and practices of computer-aided drug design / Chao-Yie Yang, Denzil Bernard, and Shaomeng Wang -- Computational approach for drug target identification / Honglin Li [and others] -- Pharmacogenomics to link genetic background with therapeutic efficacy and safety / Mark M. Bouzyk, Weining Tang, and Brian Leyland-Jones -- Drugs, genomic response signatures, and customized cancer therapy / Rafael Rosell, Teresa Moran, and Miguel Taron -- Current drug targets and the druggable genome / Margaret A. Johns, Andreas Russ, and Haian Fu |
| ctrlnum | (ZDB-20-CBO)CR9781139021500 (OCoLC)992870173 (DE-599)BVBBV043944436 |
| dewey-full | 615/.7 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615/.7 |
| dewey-search | 615/.7 |
| dewey-sort | 3615 17 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Medizin |
| doi_str_mv | 10.1017/CBO9781139021500 |
| format | Electronic eBook |
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| isbn | 9781139021500 |
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| spelling | Chemical genomics edited by Haian Fu Cambridge Cambridge University Press 2012 1 online resource (xi, 345 pages) txt rdacontent c rdamedia cr rdacarrier Title from publisher's bibliographic system (viewed on 05 Oct 2015) Harnessing the power of chemistry for biology and medicine / Cheryl L. Meyerkord and Haian Fu -- Exploring biology with small organic molecules / Nicholas Aberle and Craig M. Crews -- Chemical proteomics: a global study of protein-small molecule interactions / Akihisa Matsuyama, Yoko Yashiroda, and Minoru Yoshida -- Diversity-oriented synthesis / Warren R.J.D. Galloway [and others] -- Targeted chemical libraries / Gregory P. Tochtrop and Ryan E. Looper -- Fragment-based ligand discovery / Sandra Bartoli, Antonella Squarcia, and Daniela Fattori -- Basics and principles for building natural product-based libraries for HTS / Ronald J. Quinn -- Essentials for high-throughput screening operations / Stewart P. Rudnicki [and others] -- High content analysis and screening: basics, instrumentation, and applications / Paul A. Johnston -- Phenotypic screens with model organisms / Grant N. Wheeler, Robert A. Field, and Matthew L. Tomlinson -- Screening informatics and cheminformatics / Melinda I. Sosa [and others] -- Basics of HTS assay design and optimization / Eduard A. Sergienko -- Molecular sensors for transcriptional and post-transcriptional assays / Douglas S. Auld and Natasha Thorne -- Time-resolved fluorescence resonance energy transfer technologies in HTS / Yuhong Du and Jonathan J. Havel -- Compound profiling with high-content screening methodology / Thomas Mayer and Stephan Schürer -- Use of transgenic zebrafish in a phenotypic screen for angiogenesis inhibitors / Jaeki Min [and others] -- Flow cytometry multiplexed screening methodologies / Virginia M. Salas [and others] -- Label-free biosensor technologies in small molecule modulator discovery / Yuhong Du [and others] -- Basic principles and practices of computer-aided drug design / Chao-Yie Yang, Denzil Bernard, and Shaomeng Wang -- Computational approach for drug target identification / Honglin Li [and others] -- Pharmacogenomics to link genetic background with therapeutic efficacy and safety / Mark M. Bouzyk, Weining Tang, and Brian Leyland-Jones -- Drugs, genomic response signatures, and customized cancer therapy / Rafael Rosell, Teresa Moran, and Miguel Taron -- Current drug targets and the druggable genome / Margaret A. Johns, Andreas Russ, and Haian Fu Advances in chemistry, biology and genomics coupled with laboratory automation and computational technologies have led to the rapid emergence of the multidisciplinary field of chemical genomics. This edited text, with contributions from experts in the field, discusses the new techniques and applications that help further the study of chemical genomics. The beginning chapters provide an overview of the basic principles of chemical biology and chemical genomics. This is followed by a technical section that describes the sources of small-molecule chemicals; the basics of high-throughput screening technologies; and various bioassays for biochemical-, cellular- and organism-based screens. The final chapters connect the chemical genomics field with personalized medicine and the druggable genome for future discovery of new therapeutics. This book will be valuable to researchers, professionals and graduate students in many fields, including biology, biomedicine and chemistry Chemogenomics Chemische Genetik (DE-588)7688784-4 gnd rswk-swf 1\p (DE-588)4143413-4 Aufsatzsammlung gnd-content Chemische Genetik (DE-588)7688784-4 s 2\p DE-604 Fu, Haian edt Erscheint auch als Druckausgabe 978-0-521-88948-3 https://doi.org/10.1017/CBO9781139021500 Verlag URL des Erstveröffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Chemical genomics Harnessing the power of chemistry for biology and medicine / Cheryl L. Meyerkord and Haian Fu -- Exploring biology with small organic molecules / Nicholas Aberle and Craig M. Crews -- Chemical proteomics: a global study of protein-small molecule interactions / Akihisa Matsuyama, Yoko Yashiroda, and Minoru Yoshida -- Diversity-oriented synthesis / Warren R.J.D. Galloway [and others] -- Targeted chemical libraries / Gregory P. Tochtrop and Ryan E. Looper -- Fragment-based ligand discovery / Sandra Bartoli, Antonella Squarcia, and Daniela Fattori -- Basics and principles for building natural product-based libraries for HTS / Ronald J. Quinn -- Essentials for high-throughput screening operations / Stewart P. Rudnicki [and others] -- High content analysis and screening: basics, instrumentation, and applications / Paul A. Johnston -- Phenotypic screens with model organisms / Grant N. Wheeler, Robert A. Field, and Matthew L. Tomlinson -- Screening informatics and cheminformatics / Melinda I. Sosa [and others] -- Basics of HTS assay design and optimization / Eduard A. Sergienko -- Molecular sensors for transcriptional and post-transcriptional assays / Douglas S. Auld and Natasha Thorne -- Time-resolved fluorescence resonance energy transfer technologies in HTS / Yuhong Du and Jonathan J. Havel -- Compound profiling with high-content screening methodology / Thomas Mayer and Stephan Schürer -- Use of transgenic zebrafish in a phenotypic screen for angiogenesis inhibitors / Jaeki Min [and others] -- Flow cytometry multiplexed screening methodologies / Virginia M. Salas [and others] -- Label-free biosensor technologies in small molecule modulator discovery / Yuhong Du [and others] -- Basic principles and practices of computer-aided drug design / Chao-Yie Yang, Denzil Bernard, and Shaomeng Wang -- Computational approach for drug target identification / Honglin Li [and others] -- Pharmacogenomics to link genetic background with therapeutic efficacy and safety / Mark M. Bouzyk, Weining Tang, and Brian Leyland-Jones -- Drugs, genomic response signatures, and customized cancer therapy / Rafael Rosell, Teresa Moran, and Miguel Taron -- Current drug targets and the druggable genome / Margaret A. Johns, Andreas Russ, and Haian Fu Chemogenomics Chemische Genetik (DE-588)7688784-4 gnd |
| subject_GND | (DE-588)7688784-4 (DE-588)4143413-4 |
| title | Chemical genomics |
| title_auth | Chemical genomics |
| title_exact_search | Chemical genomics |
| title_full | Chemical genomics edited by Haian Fu |
| title_fullStr | Chemical genomics edited by Haian Fu |
| title_full_unstemmed | Chemical genomics edited by Haian Fu |
| title_short | Chemical genomics |
| title_sort | chemical genomics |
| topic | Chemogenomics Chemische Genetik (DE-588)7688784-4 gnd |
| topic_facet | Chemogenomics Chemische Genetik Aufsatzsammlung |
| url | https://doi.org/10.1017/CBO9781139021500 |
| work_keys_str_mv | AT fuhaian chemicalgenomics |