Genomic clinical trials and predictive medicine:
Genomics is majorly impacting therapeutics development in medicine. This book contains up-to-date information on the use of genomics in the design and analysis of therapeutic clinical trials with a focus on novel approaches that provide a reliable basis for identifying which patients are most likely...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Cambridge
Cambridge University Press
2013
|
| Schriftenreihe: | Practical guides to biostatistics and epidemiology
|
| Schlagworte: | |
| Online-Zugang: | BSB01 FHN01 Volltext |
| Zusammenfassung: | Genomics is majorly impacting therapeutics development in medicine. This book contains up-to-date information on the use of genomics in the design and analysis of therapeutic clinical trials with a focus on novel approaches that provide a reliable basis for identifying which patients are most likely to benefit from each treatment. It is oriented to both clinical investigators and statisticians. For clinical investigators, it includes background information on clinical trial design and statistical analysis. For statisticians and others who want to go deeper, it covers state-of-the-art adaptive designs and the development and validation of probabilistic classifiers. The author describes the development and validation of prognostic and predictive biomarkers and their integration into clinical trials that establish their clinical utility for informing treatment decisions for future patients |
| Beschreibung: | Title from publisher's bibliographic system (viewed on 05 Oct 2015) |
| Beschreibung: | 1 online resource (xiii, 144 pages) |
| ISBN: | 9781139026451 |
| DOI: | 10.1017/CBO9781139026451 |
Internformat
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| 490 | 0 | |a Practical guides to biostatistics and epidemiology | |
| 500 | |a Title from publisher's bibliographic system (viewed on 05 Oct 2015) | ||
| 505 | 8 | |a Clinical trial basics -- Actionable prognostic biomarkers -- Phase II designs -- Enrichment designs -- Including both test positive and test negative patients -- Adaptive threshold design -- Multiple predictive biomarkers predictive analysis of clinical trials -- Prospective : retrospective design | |
| 520 | |a Genomics is majorly impacting therapeutics development in medicine. This book contains up-to-date information on the use of genomics in the design and analysis of therapeutic clinical trials with a focus on novel approaches that provide a reliable basis for identifying which patients are most likely to benefit from each treatment. It is oriented to both clinical investigators and statisticians. For clinical investigators, it includes background information on clinical trial design and statistical analysis. For statisticians and others who want to go deeper, it covers state-of-the-art adaptive designs and the development and validation of probabilistic classifiers. The author describes the development and validation of prognostic and predictive biomarkers and their integration into clinical trials that establish their clinical utility for informing treatment decisions for future patients | ||
| 650 | 4 | |a Clinical trials / Statistical methods | |
| 650 | 4 | |a Genomics / Statistical methods | |
| 650 | 4 | |a Tumor markers / Statistical methods | |
| 650 | 4 | |a Therapeutics, Experimental / Statistical methods | |
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Datensatz im Suchindex
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| author | Simon, Richard M. 1943- |
| author_GND | (DE-588)128738170 |
| author_facet | Simon, Richard M. 1943- |
| author_role | aut |
| author_sort | Simon, Richard M. 1943- |
| author_variant | r m s rm rms |
| building | Verbundindex |
| bvnumber | BV043941000 |
| classification_rvk | WG 7000 |
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| contents | Clinical trial basics -- Actionable prognostic biomarkers -- Phase II designs -- Enrichment designs -- Including both test positive and test negative patients -- Adaptive threshold design -- Multiple predictive biomarkers predictive analysis of clinical trials -- Prospective : retrospective design |
| ctrlnum | (ZDB-20-CBO)CR9781139026451 (OCoLC)830954962 (DE-599)BVBBV043941000 |
| dewey-full | 610.72/4 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 610 - Medicine and health |
| dewey-raw | 610.72/4 |
| dewey-search | 610.72/4 |
| dewey-sort | 3610.72 14 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Medizin |
| doi_str_mv | 10.1017/CBO9781139026451 |
| format | Electronic eBook |
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| id | DE-604.BV043941000 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T07:39:14Z |
| institution | BVB |
| isbn | 9781139026451 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-029349969 |
| oclc_num | 830954962 |
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| owner_facet | DE-12 DE-92 |
| physical | 1 online resource (xiii, 144 pages) |
| psigel | ZDB-20-CBO ZDB-20-CBO BSB_PDA_CBO ZDB-20-CBO FHN_PDA_CBO |
| publishDate | 2013 |
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| publisher | Cambridge University Press |
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| series2 | Practical guides to biostatistics and epidemiology |
| spelling | Simon, Richard M. 1943- Verfasser (DE-588)128738170 aut Genomic clinical trials and predictive medicine Richard M. Simon Genomic Clinical Trials & Predictive Medicine Cambridge Cambridge University Press 2013 1 online resource (xiii, 144 pages) txt rdacontent c rdamedia cr rdacarrier Practical guides to biostatistics and epidemiology Title from publisher's bibliographic system (viewed on 05 Oct 2015) Clinical trial basics -- Actionable prognostic biomarkers -- Phase II designs -- Enrichment designs -- Including both test positive and test negative patients -- Adaptive threshold design -- Multiple predictive biomarkers predictive analysis of clinical trials -- Prospective : retrospective design Genomics is majorly impacting therapeutics development in medicine. This book contains up-to-date information on the use of genomics in the design and analysis of therapeutic clinical trials with a focus on novel approaches that provide a reliable basis for identifying which patients are most likely to benefit from each treatment. It is oriented to both clinical investigators and statisticians. For clinical investigators, it includes background information on clinical trial design and statistical analysis. For statisticians and others who want to go deeper, it covers state-of-the-art adaptive designs and the development and validation of probabilistic classifiers. The author describes the development and validation of prognostic and predictive biomarkers and their integration into clinical trials that establish their clinical utility for informing treatment decisions for future patients Clinical trials / Statistical methods Genomics / Statistical methods Tumor markers / Statistical methods Therapeutics, Experimental / Statistical methods Genomik (DE-588)4776397-8 gnd rswk-swf Klinisches Experiment (DE-588)4164223-5 gnd rswk-swf Klinisches Experiment (DE-588)4164223-5 s Genomik (DE-588)4776397-8 s 1\p DE-604 Erscheint auch als Druckausgabe 978-1-107-00880-9 Erscheint auch als Druckausgabe 978-1-107-40135-8 https://doi.org/10.1017/CBO9781139026451 Verlag URL des Erstveröffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Simon, Richard M. 1943- Genomic clinical trials and predictive medicine Clinical trial basics -- Actionable prognostic biomarkers -- Phase II designs -- Enrichment designs -- Including both test positive and test negative patients -- Adaptive threshold design -- Multiple predictive biomarkers predictive analysis of clinical trials -- Prospective : retrospective design Clinical trials / Statistical methods Genomics / Statistical methods Tumor markers / Statistical methods Therapeutics, Experimental / Statistical methods Genomik (DE-588)4776397-8 gnd Klinisches Experiment (DE-588)4164223-5 gnd |
| subject_GND | (DE-588)4776397-8 (DE-588)4164223-5 |
| title | Genomic clinical trials and predictive medicine |
| title_alt | Genomic Clinical Trials & Predictive Medicine |
| title_auth | Genomic clinical trials and predictive medicine |
| title_exact_search | Genomic clinical trials and predictive medicine |
| title_full | Genomic clinical trials and predictive medicine Richard M. Simon |
| title_fullStr | Genomic clinical trials and predictive medicine Richard M. Simon |
| title_full_unstemmed | Genomic clinical trials and predictive medicine Richard M. Simon |
| title_short | Genomic clinical trials and predictive medicine |
| title_sort | genomic clinical trials and predictive medicine |
| topic | Clinical trials / Statistical methods Genomics / Statistical methods Tumor markers / Statistical methods Therapeutics, Experimental / Statistical methods Genomik (DE-588)4776397-8 gnd Klinisches Experiment (DE-588)4164223-5 gnd |
| topic_facet | Clinical trials / Statistical methods Genomics / Statistical methods Tumor markers / Statistical methods Therapeutics, Experimental / Statistical methods Genomik Klinisches Experiment |
| url | https://doi.org/10.1017/CBO9781139026451 |
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