Verfügbarkeit: Molecular virology of human pathogenic viruses

Molecular virology of human pathogenic viruses:

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1. Verfasser:	Ryu, Wang-Shick 1956- (VerfasserIn)
Format:	Buch
Sprache:	English
Veröffentlicht:	Amsterdam Elsevier [2017]
Schlagworte:	Medical virology Virus diseases Molekulare Virologie
Online-Zugang:	Inhaltsverzeichnis Inhaltsverzeichnis
Beschreibung:	xv, 423 Seiten Illustrationen, Diagramme, Karten 28 cm
ISBN:	9780128008386

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adam_text	Titel: Molecular virology of human pathogenic viruses Autor: Ryu, Wang-Shic Jahr: 2017 Contents Preface Acknowledgments Part I Principles 1. Discovery and Classification 1.1. Discovery of Virus 1.1.1. Virus in Ancient History 1.1.2. Discovery of Virus in Plants and Animals 1.1.3. Discovery of the Human Viruses 1.1.4. Discovery of Genetic Materials 1.2. Definition of Virus 1.3. Advances in Virology 1.4. Classification of Viruses 1.4.1. Genome-Based Classification 1.4.2. Taxonomy of Virus 1.4.3. Mutation and Evolution 1.5. Viruses in Other Organisms 1.6. Subviral Agents 1.7. Perspectives 1.8. Summary Study Questions Suggested Reading Journal Club Book Club Internet Resources 2. Virus Structure 2.1. Terminologies 2.2. Envelope and Capsid 2.3. Capsid Structure 2.4. Roles of Virus Structure 2.5. Tools Used for Virus Structure Research 2.5.1. Electron Microscopy 2.5.2. Cryo-Electron Microscopy 2.5.3. X-ray Crystallography 2.6. Perspectives 29 2.7. Summary 29 Study Questions 29 Suggested Reading 29 Journal Club 29 3. Virus Life Cycle 3.1. Steps in Virus Life Cycle 31 3.2. Viral Entry 31 3.2.1. Attachment 31 3.2.2. Penetration 35 3.2.3. Intracellular Trafficking 37 3.2.4. Uncoating 38 3.3. Viral Gene Expression and Genome Replication 38 3.4. Exit 39 3.4.1. Capsid Assembly 39 3.4.2. Release 39 3.4.3. Maturation 42 3.5. Types of Virus Infection 42 3.6. Perspectives 43 3.7. Summary 44 Study Questions 44 Suggested Reading 44 Journal Club 45 4. Diagnosis and Methods 4.1. Virus Diagnosis 47 4.1.1. Protein Detection 47 4.1.2. Nucleic Acids Detection 50 4.1.3. Hemagglutination 52 4.2. Cultivation of Viruses 53 4.2.1. Tissue Culture 53 4.2.2. Embryonated Eggs 55 4.2.3. Experimental Animals 55 4.2.4. Animal Models 56 4.3. Quantification of Viruses 56 4.3.1. Plaque Assay 56 4.3.2. End-Point Dilution Assay 57 4.4. Purification of Viruses 57 4.4.1. Plaque Isolation 58 4.4.2. Centrifugation 58 xiii xv 3 3 3 5 6 7 8 10 10 10 12 13 17 18 19 19 19 19 20 20 21 21 22 26 26 26 27 28 vii viii Contents 4.5. Genetic Manipulation of Viruses 4.6. Laboratory Safety 4.7. Perspectives 4.8. Summary Study Questions Book Club Internet Resources 5. Host Immune Response 5.1. 5.2. 5.3. 5.4. 5.5. 5.6. Defense System of Human 5.1.1. Innate Immunity Versus Adaptive Immunity Innate Immunity 5.2.1. Cells Constituting Innate Immunity 5.2.2. Toll-Like Receptors 5.2.3. RIG-I 5.2.4. Antiviral Function of Interferon Adaptive Immunity 5.3.1. Components of Adaptive Immunity 5.3.2. Humoral Immunity 5.3.3. Cellular Immunity Immune Evasion 5.4.1. Immune Suppression 5.4.2. Infection of Immune Cells 5.4.3. Immune Escape 5.4.4. Latent Infection Perspectives Summary Study Questions Suggested Reading journal Club Part II DNA Viruses 6. Polyomaviruses: SV40 6.1. Discovery of Polyomaviruses 6.2. The Genome Structure of SV40 6.3. The Life Cycle of SV40 6.3.1. Early Phase 6.3.2. Late Phase 6.4. Effects on Host 6.5. Perspectives 6.6. Summary Study Questions Suggested Reading Journal Club 7. Papillomaviruses 7.1. Discovery of Papillomaviruses 7.1.1. Classification and Epidemiology 7.1.2. Transmission 59 60 61 61 62 62 62 63 63 65 81 81 81 82 82 82 82 85 87 88 89 89 91 94 94 94 95 95 97 98 98 7.2. 7.3. 7.4. 7.5. 7.6. The Genome Structure of HPV The Life Cycle of HPV 7.3.1. Early Phase 7.3.2. Late Phase Effects on Host Perspectives Summary Study Questions Suggested Reading journal Club 8. Adenoviruses 9. Herpesviruses 98 100 101 102 104 107 108 109 109 109 65 8.1. Discovery and Classification 111 8.2. The Virion and Genome Structure 111 65 8.3. The Life Cycle of Adenovirus 112 67 8.3.1. Early Phase 115 69 8.3.2. Late Phase 115 72 8.4. Effects on Host 118 73 8.5. Tumorigenesis 120 77 8.6. Perspectives 121 78 8.7. Summary 122 79 Study Questions 123 80 Suggested Reading 124 81 Journal Club 124 9.1. Classification 125 9.2. The Virion and Genome Structure of HSV-1 126 9.3. The Life Cycle of HSV-1 128 9.3.1. Viral Gene Expression 129 9.3.2. Late Phase 131 9.4. Latent Infection 133 9.5. Effects on Host 136 9.6. Clinical Significance of HSV-1 Infection 137 9.7. Other Alpha-Herpesviruses 137 9.8. Perspectives 138 9.9. Summary 139 Study Questions 139 Suggested Reading 139 Journal Club 139 Other DNA Viruses 10.1. Parvovirus 141 10.2. Poxvirus 144 10.3. Perspectives 146 10.4. Summary 147 Study Questions 147 Suggested Reading 148 Journal Club 148 Contents ix Part ill RNA Viruses Part 111-1 Positive-Strand RNA Viruses 11. Picornavirus 11.1. Classification of Picornaviruses 11.2. The Virion and Genome Structure of Poliovirus 11.3. The Life Cycle of Poliovirus 11.4. Effects on Host 11.5. Perspectives 11.6. Summary Study Questions Suggested Reading Journal Club 12. Flaviviruses 12.1. Classification of Flaviviruses 165 12.2. Hepatitis C Virus 165 12.3. The Virion and Genome Structure of HCV 167 12.4. The Life Cycle of HCV 168 12.5. Effects on Host 173 12.6. Perspectives 173 12.7. Summary 174 Study Questions 174 Suggested Reading 175 Journal Club 175 13. Other Positive-Strand RNA Viruses 13.1. Calicivivirus 177 13.1.1. Norovirus 177 13.2. Togavirus 179 13.3. Coronavirus 180 13.4. Perspectives 183 13.5. Summary 183 Study Questions 183 Suggested Reading 183 journal Club 184 Part III-2 Negative-Strand RNA Viruses 14. Rhabdovirus 14.1. Classification 187 14.2. The Virion and Genome Structure ofVSV 187 14.3. The Life Cycle ofVSV 189 14.4. Effects on Host 14.5. Perspectives 14.6. Summary Study Questions Suggested Reading Journal Club 15. Influenza Viruses 153 15.1. 153 157 15.2. 162 15.3. 163 15.4. 163 15.5. 163 15.6. 163 15.7. 164 15.8. 15.9. Influenza Virus and Flu 15.1.1. Vaccines and Therapy Classification The Virion and Genome Structure The Life Cycle Effects on Host Genetic Reassortment Variants: Antigenic Drift Versus Antigenic Shift Perspectives Summary Study Questions Suggested Reading Journal Club 16. Other Negative-Strand RNA Viruses 16.1. Paramyxovirus 16.1.1. Sendai Virus 16.2. Filovirus 16.2.1. Ebola Virus 16.3. Bunyavirus 16.3.1. Hantavirus 16.4. Arenavirus 16.4.1. Lassa Virus 16.5. Reovirus 16.6. Perspectives 16.7. Summary Study Questions Suggested Reading Journal Club Part IV RT Viruses 17. Retroviruses 17.1. Discovery and Classification 17.2. Simple Retrovirus: MLV 17.3. The Life Cycle of Retrovirus 17.4. Lentivirus: HIV 17.4.1. Discovery and Classification 17.4.2. Virion and Genome Structure 17.4.3. The Life Cycle of HIV 17.4.4. Accessory Proteins 193 193 194 194 194 194 195 195 196 197 198 204 206 206 208 210 211 211 211 213 214 215 215 217 218 219 221 222 222 223 224 224 224 227 227 230 237 237 238 239 240 x Contents 17.5. Host Restriction Factors 17.6. Perspectives 17.7. Summary Study Questions Suggested Reading Journal Club Book Club 18. Hepadnaviruses 243 245 245 246 246 246 246 21. New Emerging Viruses Epidemiology Newly Emerging Viruses 21.1. 21.2. 21.2.1. Ebola Virus 21.2.2. West Nile Virus 21.2.3. Sin Nombre Virus 21.2.4. Nipah Virus 21.2.5. SARS-Coronavirus (SARS) 21.2.6. MERS-Coronavirus 18.1. Discovery 247 21.2.7. Why Do New Viruses 18.2. The Virion and Genome Structure 247 Emerge? 18.3. The Life Cycle of HBV 249 21.3. Reemerging Viruses 18.4. X Protein 254 21.4. New Epidemic of Existing Viruses 18.5. Effects on Host 258 21.5. Perspectives 18.6. Liver Cancer 258 21.6. Summary 18.7. Perspectives 259 Study Questions 18.8. Summary 260 Suggested Reading Study Questions 260 Journal Club Suggested Reading 260 Journal Club 260 289 290 291 291 293 294 294 296 297 297 299 301 301 302 302 302 Part V Other Viruses 19. Virus Vectors 19.1. Gene Expression Vectors 19.1.1. CMV Expression Plasmid 19.1.2. EBV Expression Plasmid 19.2. Recombinant Virus Vectors 19.2.1. Principles 19.2.2. Retrovirus Vectors 19.2.3. Lentivirus Vectors 19.3. Gene Therapy Vectors 19.3.1. Retrovirus Vectors 19.3.2. Adenovirus Vectors 19.3.3. AAV Vectors 19.3.4. Nonviral Vectors 19.4. Perspectives 19.5. Summary Study Questions Suggested Reading Journal Club 20. Subviral Agents and Prions 20.1. Subviral Agents 20.2. Satellite Viruses 20.3. Viroids 20.4. Prions and Mad Cow Disease 20.5. Perspectives 20.6. Summary Study Questions Suggested Reading Journal Club 263 263 265 265 265 266 269 270 271 271 272 274 274 275 275 275 Part VI Viruses and Disease 22. HIV and AIDS 22.1. Epidemiology 22.2. Clinical Consequences 22.3. HIV Biology and Pathogenesis 22.4. Diagnosis 22.5. Therapy 22.6. Prevention 22.7. Perspectives 22.8. Summary Study Questions Suggested Reading Journal Club Internet Resources 23. Hepatitis Viruses 305 306 308 311 311 314 316 316 316 316 317 317 275 23.1. Hepatitis A Virus 320 23.2. Hepatitis B Virus 323 23.2.1. Clinical Course 324 23.3. Hepatitis C Virus 328 277 23.3.1. Clinical Course 329 277 23.4. Hepatitis D Virus 331 278 23.5. Hepatitis E Virus 332 281 23.6. Perspectives 333 287 23.7. Summary 333 288 Study Questions 333 288 Suggested Reading 333 288 Journal Club 334 288 Internet Resources 334 Contents xi 24. Tumor Viruses 26. Antiviral Therapy 24.3. 24.4. 24.5. 24.1. Discovery of Tumor Viruses 24.2. DNA Tumor Viruses 24.2.1. Polyomavirus 24.2.2. Papillomavirus 24.2.3. Adenovirus 24.2.4. Attributes of DNA Tumor Viruses RNA Tumor Viruses 24.3.1. RSV Versus ALV 24.3.2. The Origin of RSV Perspectives Summary Study Questions Suggested Reading Journal Club 25. Vaccines 25.1. Poxvirus Vaccine 25.2. Poliovirus Vaccines 25.3. Basic Elements of Vaccines 25.4. Types of Vaccines 25.5. Adjuvants 25.6. Passive Immunization 25.7. Perspectives 25.8. Summary Study Questions Suggested Reading Journal Club Book Club Internet Resource 336 338 338 340 341 342 346 346 347 349 349 349 349 349 351 351 352 355 361 363 364 365 366 366 366 366 366 26.1. 26.2. 26.3. 26.4. 26.5. 26.6. 26.7. 26.8. 26.9. Antiviral Drugs 367 Molecular Targets of Antiviral Drugs 367 Antiviral Drugs for HIV 371 26.3.1. Entry Inhibitor of HIV 371 26.3.2. HIV RT Inhibitors 371 26.3.3. HIV PR Inhibitors 374 26.3.4. HIV IN Inhibitors 374 26.3.5. Combination Therapy 374 Antiviral Drugs for HCV 376 26.4.1. NS3 Protease 376 26.4.2. NS5B RdRp 377 26.4.3. NS5A 377 Antiviral Drugs for Influenza Virus 377 26.5.1. Entry 378 26.5.2. RdRp 378 26.5.3. NS1 378 26.5.4. Exit 379 New Concept of Antivirals 379 Antibody Therapy 380 Perspectives 380 Summary 381 Study Questions 381 Suggested Reading 381 Journal Club 381 Answers to Study Questions Glossary List of Credits List of Figures List of Tables Index 383 391 397 403 411 413
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spelling	Ryu, Wang-Shick 1956- Verfasser (DE-588)1121032737 aut Molecular virology of human pathogenic viruses Wang-Shick Ryu, Department of Biochemistry, Yonsei University, Seoul, Korea Amsterdam Elsevier [2017] © 2017 xv, 423 Seiten Illustrationen, Diagramme, Karten 28 cm txt rdacontent n rdamedia nc rdacarrier Medical virology Virus diseases Molekulare Virologie (DE-588)4170393-5 gnd rswk-swf Molekulare Virologie (DE-588)4170393-5 s DE-604 http://digitool.hbz-nrw.de:1801/webclient/DeliveryManager?pid=6798189&custom_att_2=simple_viewer Molecular virology of human pathogenic viruses Inhaltsverzeichnis HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029282162&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
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title	Molecular virology of human pathogenic viruses
title_auth	Molecular virology of human pathogenic viruses
title_exact_search	Molecular virology of human pathogenic viruses
title_full	Molecular virology of human pathogenic viruses Wang-Shick Ryu, Department of Biochemistry, Yonsei University, Seoul, Korea
title_fullStr	Molecular virology of human pathogenic viruses Wang-Shick Ryu, Department of Biochemistry, Yonsei University, Seoul, Korea
title_full_unstemmed	Molecular virology of human pathogenic viruses Wang-Shick Ryu, Department of Biochemistry, Yonsei University, Seoul, Korea
title_short	Molecular virology of human pathogenic viruses
title_sort	molecular virology of human pathogenic viruses
topic	Medical virology Virus diseases Molekulare Virologie (DE-588)4170393-5 gnd
topic_facet	Medical virology Virus diseases Molekulare Virologie
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