Nanotechnology and the brain:
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Amsterdam
Elsevier AP
2016
|
| Ausgabe: | First edition |
| Schriftenreihe: | International review of neurobiology
volume 130 |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | xiv, 320 Seiten Illustrationen |
| ISBN: | 9780128046364 |
Internformat
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Datensatz im Suchindex
| _version_ | 1804176692290256896 |
|---|---|
| adam_text | Titel: Nanotechnology and the brain
Autor: Al-Jamal, Khuloud T
Jahr: 2016
CONTENTS
Contributors ix
Preface xi
1. Recent Trends in Nanotechnology Toward CNS Diseases:
Lipid-Based Nanoparticles and Exosomes for Targeted
Therapeutic Delivery 1
A.M. Cardoso, J.R. Guedes, A.L. Cardoso, C. Morais, P. Cunha,
A.T. Viegas, R. Costa, A. Jurado, and M.C. Pedroso de Lima
1. Introduction 2
2. Lipid-Based Nanoparticles for Nucleic Acid and Drug
Delivery to the CNS 7
3. Exosomes as Delivery Systems for CNS Diseases 27
4. Conclusions 31
Acknowledgments 32
References 32
2. From the Blood to the Central Nervous System:
A Nanoparticle s Journey Through the Blood-Brain
Barrier by Transcytosis 41
G. Fullstone, S. Nyberg, X. Tian, and G. Battaglia
1. Transcytosis: An Entry Portal into the Central Nervous System 42
2. Distribution of Nanoparticles in the Blood 44
3. Binding of a Blood-Borne Nanoparticle 46
4. Wrapping 52
5. Trafficking: Transcytosis at the Brain Endothelium 53
6. Release and Receptor Recycling 61
7. Nanoparticle Transcytosis: The Story So Far 62
8. Summary 65
References 65
3. Application of Nanomedicine to the CNS Diseases 73
D. Carradori, A. Gaudin, D. Brambilla, and K. Andrieux
1. Introduction 74
2. NPs for Brain Cancer 75
3. NPs for Alzheimer s Disease Therapy 84
vi
Contents
4. Nanotechnology for the Treatment of Stroke
5. General Conclusion
References
94
102
103
4. Carbohydrate Nanopartides for Brain Delivery
115
A. Lalatsa and E. Barbu
References
1. Drug Delivery to the Brain
1.1 The BBB
1.2 Invasive Strategies for Drug Delivery to the Brain
1.3 Noninvasive Strategies for Drug Delivery to the Brain
1.4 Carbohydrate Nanopartides for Brain Delivery
1.5 Concluding Remarks
116
116
117
121
124
145
146
5. Gold Nanopartides for Imaging and Drug Transport to the CNS 155
D. Male, R. Gromnicova, and C. McQuaid
6. Metal Nanopartides as Targeted Carriers Circumventing the
Blood-Brain Barrier 199
A.C. Sintov, C. Velasco-Aguirre, E. Gallardo-Toledo, E. Araya, and MJ. Kogan
1. Introduction 200
2. The BBB and Mechanisms of Nanopartides by Which
They Cross This Barrier 201
3. Imaging and Treatment of Neurological Diseases Associated
with Metal Nanopartides 204
4. Trafficking of Metal Nanopartides to the CNS and
Neurotoxicological Considerations 212
5. The Intranasal Administration: Nose-to-Brain Route for
Metal Nanoparticle Delivery 214
6. Conclusion and Future Perspective 220
Acknowledgments 221
References 221
1. Introduction
2. The Chemistry and Properties of Gold Nanopartides
3. Biological Properties of Gold Nanopartides
4. Detecting Gold Nanopartides in Cells and Tissues
5. Cellular Routes for Nanoparticle Transport into the CNS
6. Conclusions
References
156
157
165
171
178
186
189
Contents
vii
7. Current Perspective of Carbon Nanotubes Application
in Neurology 229
H. Kafa, J.T.-W. Wang, and K.T. AI-Jamal
1. Overview of Carbon Nanotubes 230
2. Functionalization Strategies of CNTs 233
3. The Scaffolding Effect of CNTs on Neuronal Cells as Growth
Substrates In Vitro 235
4. CNTs as Heating Devices for Hyperthermal Therapy Applications in
Glioblastoma In Vitro 238
5. The Intrinsic Therapeutic Action of CNTs in Brain Tissues as
Active Agents 241
6. CNTs as Local Delivery Tools of Therapeutics to the Brain
via Direct Intracranial Administration In Vivo 243
7. CNTs as Delivery Tools of Therapeutics to the Brain
Using Systemic Administration In Vivo 245
8. Mechanistic Studies Investigating the BBB Crossing of f-CNTs 246
9. Toxicity Studies of CNTs in Brain Tissues 255
10. Biodegradation of CNTs 256
References 257
Index 265
Contents of Recent Volumes 273
|
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| illustrated | Illustrated |
| indexdate | 2024-07-10T07:36:13Z |
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| isbn | 9780128046364 |
| language | English |
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| series | International review of neurobiology |
| series2 | International review of neurobiology |
| spelling | Nanotechnology and the brain edited by Khuloud T. Al-Jamal First edition Amsterdam Elsevier AP 2016 xiv, 320 Seiten Illustrationen txt rdacontent n rdamedia nc rdacarrier International review of neurobiology volume 130 Al-Jamal, Khuloud T. (DE-588)1116299216 edt International review of neurobiology volume 130 (DE-604)BV002534817 130 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029241193&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Nanotechnology and the brain International review of neurobiology |
| title | Nanotechnology and the brain |
| title_auth | Nanotechnology and the brain |
| title_exact_search | Nanotechnology and the brain |
| title_full | Nanotechnology and the brain edited by Khuloud T. Al-Jamal |
| title_fullStr | Nanotechnology and the brain edited by Khuloud T. Al-Jamal |
| title_full_unstemmed | Nanotechnology and the brain edited by Khuloud T. Al-Jamal |
| title_short | Nanotechnology and the brain |
| title_sort | nanotechnology and the brain |
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