Tumor immunology:
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Amsterdam ; Boston ; Heidelberg ; London ; New York ; Oxford ; Paris ; San Diego ; San Francisco ; Singapore ; Sydney ; Tokyo
Elsevier
2016
|
| Ausgabe: | First edition |
| Schriftenreihe: | Advances in immunology
volume 130 |
| Schlagworte: | |
| Online-Zugang: | UER01 Volltext Inhaltsverzeichnis |
| Beschreibung: | 1 Online-Ressource (xiii, 318 Seiten) Illustrationen |
| ISBN: | 9780128096550 |
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Datensatz im Suchindex
| _version_ | 1804176689233657856 |
|---|---|
| adam_text | Titel: Tumor immunology
Autor: Schreiber, Robert D
Jahr: 2016
CONTENTS
Contributors ix
Preface xi
1. Mouse Models of Tumor Immunotherapy 1
Shin Foong Ngiow, Sherene Loi, David Thomas, and Mark J. Smyth
1. Introduction 2
2. Transplantable Tumor Models 3
3. Genetically Engineered Tumor Models 6
4. Carcinogen-Induced Tumor Models 9
5. Humanized Mouse Tumor Models 11
6. Perspectives 14
7. Materials and Methods 16
Acknowledgments 17
References 17
2. The Role of Neoantigens in Naturally Occurring and
Therapeutically Induced Immune Responses to Cancer 25
Jeffrey P. Ward, Matthew M. Gubin, and Robert D. Schreiber
1. Introduction 26
2. Cancer Immunoediting as an Encompassing Model of Immune
System-Tumor Interactions 30
3. Antigenic Targets of Cancer Immunoediting 39
4. Setting the Groundwork: Genomic Approaches to Cancer
Antigen Identification 42
5. Developing Cancer Immunotherapies Based on Genomic
Identification of Tumor-Specific Neoantigens 44
6. Neoantigens as Therapeutic Targets in Human Cancer 51
7. Concluding Remarks 61
Acknowledgments 62
References 62
3. Tumor and Host Factors Controlling Antitumor Immunity
and Efficacy of Cancer Immunotherapy 75
Stefani Spranger, Ayelet Sivan, Leticia Corrales, and Thomas F. Gajewski
1. Rationale for Studying Regulation of the T Cell-Inflamed Tumor
Microenvironment Phenotype 76
2. Molecular and Cellular Drivers of the T Cell-Inflamed Tumor
Microenvironment 77
v
vi
Contents
3. Tumor-Intrinsic Oncogene Pathways Mediating the Non-T Cell-Inflamed
Tumor Microenvironment
4. Environmental Factors Influencing the Tumor Microenvironment:
79
The Host Microbiota
5. Germline Genetic Differences as an Additional Source of Interpatient
84
Heterogeneity
6. Conclusions and Implications
References
89
89
90
4. Immune Contexture, Immunoscore, and Malignant
Cell Molecular Subgroups for Prognostic and Theranostic
Classifications of Cancers 95
Etienne Becht, Nicolas A. Giraldo, Claire Germain, Aur£lien de Reynies,
Pierre Laurent-Puig, Jessica Zucman-Rossi, Marie-Caroline Dieu-Nosjean,
Catherine Sautes-Fridman, and Wolf H. Fridman
1. Introduction 97
2. The Immune Microenvironment of Different Cancer Subtypes 108
3. Classification of Tumors in the Era of Omic Techniques 140
4. The Tumor Microenvironment and the Molecularly Defined Subgroups
of Human Cancers 144
5. Conclusions: From the Immune Contexture of Tumor Subgroups to
Precision Medicine 154
Acknowledgments 155
References 155
5. Advances in Therapeutic Cancer Vaccines 191
Karrie K. Wong, WeiWei Aileen Li, David J. Mooney, and Glenn Dranoff
1. Introduction 192
2. Cancer Antigens 193
3. Approaches to Cancer Vaccines: What We Have Learned 195
4. In Situ Vaccination 214
5. Engineering Approaches 222
6. Concluding Remarks 228
References 229
6. Combinatorial Cancer Immunotherapies 251
Matthew D. Hellmann, Claire F. Friedman, and Jedd D. Wolchok
1. Introduction 252
2. Combinations of Coinhibitory Checkpoints 253
Contents vii
3. Combinations with Costimulatory Checkpoints 259
4. Combinations with Other Molecules in the Tumor Microenvironment 261
5. Other Anticancer Treatment Modalities in Combination with T Cell
Checkpoint Blockade 263
6. Conclusions 266
References 267
7. Adoptive T-Cell Therapy for Cancer 279
James C. Yang and Steven A. Rosenberg
1. Identifying Tumor-Associated Antigens Recognized by T-Cells 280
2. Cell Therapy with Genetically Engineered T-Cells 282
3. Cell Therapy with TIL 284
4. Cell Therapy Targeting Mutated Neoantigens 286
5. The Future of ACT 290
References 291
Index 295
Contents of Recent Volumes 303
|
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| isbn | 9780128096550 |
| language | English |
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| spelling | Tumor immunology edited by Robert D. Schreiber, Washington University School of Medicine, St. Louis, Missouri, USA First edition Amsterdam ; Boston ; Heidelberg ; London ; New York ; Oxford ; Paris ; San Diego ; San Francisco ; Singapore ; Sydney ; Tokyo Elsevier 2016 1 Online-Ressource (xiii, 318 Seiten) Illustrationen txt rdacontent c rdamedia cr rdacarrier Advances in immunology volume 130 Geschichte gnd rswk-swf Tumors / Immunological aspects Philosophie (DE-588)4045791-6 gnd rswk-swf Naturwissenschaften (DE-588)4041421-8 gnd rswk-swf Methodologie (DE-588)4139716-2 gnd rswk-swf Wissenschaftstheorie (DE-588)4117665-0 gnd rswk-swf Naturwissenschaften (DE-588)4041421-8 s Methodologie (DE-588)4139716-2 s Geschichte z DE-604 Philosophie (DE-588)4045791-6 s Wissenschaftstheorie (DE-588)4117665-0 s Schreiber, Robert 1946- (DE-588)1097301591 edt Erscheint auch als Druck-Ausgabe, Hardcover 978-0-12-805156-6 Advances in immunology volume 130 (DE-604)BV021797661 130 http://www.sciencedirect.com/science/bookseries/00652776/130 Verlag URL des Erstveröffentlichers Volltext HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029239488&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Tumor immunology Advances in immunology Tumors / Immunological aspects Philosophie (DE-588)4045791-6 gnd Naturwissenschaften (DE-588)4041421-8 gnd Methodologie (DE-588)4139716-2 gnd Wissenschaftstheorie (DE-588)4117665-0 gnd |
| subject_GND | (DE-588)4045791-6 (DE-588)4041421-8 (DE-588)4139716-2 (DE-588)4117665-0 |
| title | Tumor immunology |
| title_auth | Tumor immunology |
| title_exact_search | Tumor immunology |
| title_full | Tumor immunology edited by Robert D. Schreiber, Washington University School of Medicine, St. Louis, Missouri, USA |
| title_fullStr | Tumor immunology edited by Robert D. Schreiber, Washington University School of Medicine, St. Louis, Missouri, USA |
| title_full_unstemmed | Tumor immunology edited by Robert D. Schreiber, Washington University School of Medicine, St. Louis, Missouri, USA |
| title_short | Tumor immunology |
| title_sort | tumor immunology |
| topic | Tumors / Immunological aspects Philosophie (DE-588)4045791-6 gnd Naturwissenschaften (DE-588)4041421-8 gnd Methodologie (DE-588)4139716-2 gnd Wissenschaftstheorie (DE-588)4117665-0 gnd |
| topic_facet | Tumors / Immunological aspects Philosophie Naturwissenschaften Methodologie Wissenschaftstheorie |
| url | http://www.sciencedirect.com/science/bookseries/00652776/130 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029239488&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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