Construction law in the United Arab Emirates and the Gulf:
"The book is an authoritative guide to construction law in the United Arab Emirates and the Gulf. The principal theme is the contrast between construction law in an Islamic civil law jurisdiction and construction law in a common law jurisdiction. There is a tendency for these differences to be...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Hoboken
Wiley
2016
|
| Schlagworte: | |
| Online-Zugang: | FRO01 UBG01 Volltext Inhaltsverzeichnis |
| Zusammenfassung: | "The book is an authoritative guide to construction law in the United Arab Emirates and the Gulf. The principal theme is the contrast between construction law in an Islamic civil law jurisdiction and construction law in a common law jurisdiction. There is a tendency for these differences to be glossed over due to a lack of any detailed comparative analysis. The book provides the first authoritative text on the application of the laws of the UAE, and to a lesser extent of the wider Gulf region, to the most commonly occurring issues of controversy arising from construction projects. There are extensive extracts from the region's applicable laws, all translated from the original Arabic, and hundreds of judgments of the most senior courts used to back up the analysis provided. The text is presented in two parts: A narrative covering the main areas of practical concern to those dealing with construction contract and disputes; and A commentary on the standard FIDIC conditions that are widely employed on construction contracts in the Gulf region, applying principles from the narrative wherever relevant. The sources of information contained in the book are not readily available to those without access to a database of relevant laws and judgments"-- |
| Beschreibung: | Includes index |
| Beschreibung: | 1 online resource |
| ISBN: | 1119085934 1119085942 1119085950 1119085969 9781119085935 9781119085942 9781119085959 9781119085966 |
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| 245 | 1 | 0 | |a Construction law in the United Arab Emirates and the Gulf |c Michael Grose |
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| 500 | |a Includes index | ||
| 520 | |a "The book is an authoritative guide to construction law in the United Arab Emirates and the Gulf. The principal theme is the contrast between construction law in an Islamic civil law jurisdiction and construction law in a common law jurisdiction. There is a tendency for these differences to be glossed over due to a lack of any detailed comparative analysis. The book provides the first authoritative text on the application of the laws of the UAE, and to a lesser extent of the wider Gulf region, to the most commonly occurring issues of controversy arising from construction projects. There are extensive extracts from the region's applicable laws, all translated from the original Arabic, and hundreds of judgments of the most senior courts used to back up the analysis provided. The text is presented in two parts: A narrative covering the main areas of practical concern to those dealing with construction contract and disputes; and A commentary on the standard FIDIC conditions that are widely employed on construction contracts in the Gulf region, applying principles from the narrative wherever relevant. The sources of information contained in the book are not readily available to those without access to a database of relevant laws and judgments"-- | ||
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| 650 | 4 | |a Construction industry / Law and legislation / United Arab Emirates | |
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Datensatz im Suchindex
| _version_ | 1804176685565739008 |
|---|---|
| adam_text | DOCTORAL THESIS FOR A DOCTORAL DEGREE
AT THE GRADUATE SCHOOL OF LIFE SCIENCES
JULIUS-MAXIMILIANS-UNIVERSITAET WUERZBURG
SECTION BIOMEDICINE
THE ROLE OF ENTERIC GLIAL CELLS
UNDER INFLAMMATORY CONDITIONS OF THE INTESTINE
DIE ROLLE VON ENTERISCHEN GLIAZELLEN
UNTER ENTZUENDLICHEN BEDINGUNGEN IM DARM
SUBMITTED BY
CORINNA ROSENBAUM
BORN IN BONN
WUERZBURG 2016
CONTENTS
ABSTRACT I
ZUSAMMENFASSUNG III
LIST OF ABBREVIATIONS AND UNITS V
LIST OF FIGURES IX
LIST OF TABLES XI
1 INTRODUCTION 1
1.1 ANATOMY AND FUNCTION OF THE GASTROINTESTINAL T R A C T
................................................ 1
1.2 THE
ENTERIC NERVOUS SYSTEM CIR C U ITR Y
.......................................................................
2
1.3 ENTERIC GLIAL CELLS AS REGULATORS OF GL
HOMEOSTASIS................................................... 5
1.4 THE
INTESTINAL IMMUNE SYSTEM
...................................................................................
8
1.5
INTERACTIONS OF THE
ENS
WITH THE INTESTINAL IMMUNE S Y S T E M
................................. 9
1.6 INFLAMMATORY BOWEL DISEASES (IB D )
..........................................................................
11
1.7 SEPSIS AS ACUTE HYPERINFLAMMATORY CONDITION OF THE B O W E
L.................................... 14
1.8 AIM OF THE TH E S IS
........................................................................................................
15
2 MATERIALS 17
2.1 BIOLOGICAL
MATERIALS.....................................................................................................
17
2.2 EQUIPMENT AND
CONSUMABLES......................................................................................
17
2.3 CHEMICALS AND CELL CULTURE REAGENTS
..........................................................................
21
2.4
COMPOSITION OF MEDIA AND SOLUTIONS
.........................................................................
23
2.5 COMMERCIALLY OBTAINED K I T S
......................................................................................
26
2.6 OLIGONUCLEOTIDES AND RESOURCES FOR TRANSCRIPTOMIC
ANALYSES.................................... 27
2.6.1 PCR PRIMERS FOR QPCR ANALYSIS AND GEN O TY P IN G
........................................
27
2.6.2 NCOUNTER ELEMENTS DESIGN
.............................................................................
28
2.6.3 GSE DATASETS EMPLOYED IN THE COMPARATIVE TRANSCRIPTOMIC ANALYSIS
.... 29
2.7
ANTIBODIES....................................................................................................................
31
2.8
SOFTWARE.......................................................................................................................
31
3 METHODS 33
3.1 ESTABLISHMENT OF DISEASE MODELS IN V I V O
.................................................................
33
3.1.1 RAT ANIMAL MODEL OF HYPERINFLAMMATION
.....................................................
33
3.1.2 MURINE ANIMAL MODEL OF ACUTE IB D
................................................................ 34
3.2 MURINE INTESTINAL TISSUE PREPARATION
.......................................................................
35
3.2.1 EARLY POSTNATAL SMALL INTESTINAL LMMP PRE P A RA TIO N
..................................
35
3.2.2 ADULT COLON TISSUE PREPARATION
................................................................. 36
3.3 IN VITRO CELL CULTURE OF GFAP-EGFP E G C S
..............................................................
37
3.3.1 LPS-STIM
ULATION............................................................................................
37
3.4 ESTABLISHMENT OF 3D CO-CULTURE MODELS OF ENTERIC NEURAL CELLS AND
IECS IN VITRO . 37
3.4.1 GENERATION OF THE DECELLULARIZED SMALL INTESTINAL SUBMUCOSAL (SIS)
BIOLOGI-
CAL M A TRIX
........................................................................................................
37
3.4.2 SEEDING OF CELLS ONTO THE BIOLOGICAL SIS-SCAFFOLD
...........................................
38
3.5 STAINING PROCEDURES
..................................................................................................
39
3.5.1 PREPARATION OF CRYOSECTIONS
..........................................................................
39
3.5.2 PARAFFIN EMBEDDING AND PREPARATION OF PARAFFIN SE C TIO N S
...........................
39
3.5.3 HEMATOXYLIN AND EOSIN (H&E) S T A I N
............................................................ 40
3.5.4 CRESYL VIOLET STAIN FOR LASER CAPTURE
MICRODISSECTION.................................... 41
3.5.5
IMMUNOHISTOCHEMISTRY...................................................................................
42
3.5.6 WHOLE-MOUNT STAINING FOR LIGHT SHEET FLUORESCENCE MICROSCOPY
(LSFM) . . 43
3.6 LASER CAPTURE MICRODISSECTION
...................................................................................
44
3.7 TRANSCRIPTOMIC AN ALY
SES............................................................................................
45
3.7.1 RNA ISOLATION
...............................................................................................
45
3.7.2 CDNA
SYNTHESIS...............................................................................................
46
3.7.3 QUANTITATIVE REAL-TIME PCR AN ALY SIS
...........................................................
46
3.7.4 G
ENOTYPING.....................................................................................................
48
3.7.5 TRANSCRIPTOMIC PROFILING BY MICROARRAY
........................................................
49
3.7.6 COMPARATIVE TRANSCRIPTOME A N A LY SIS
...........................................................
50
3.7.7 TRANSCRIPTOMIC PROFILING BY NCOUNTER
TECHNOLOGY....................................... 50
3.8 PROTEOMIC ANALYSIS WITH BEADARRAY
TECHNOLOGY...................................................... 51
3.9 DATA
ANALYSES..............................................................................................................
52
3.9.1 ANALYSIS OF IMMUNOHISTOCHEMICAL AND HISTOLOGICAL STAINING
........................
52
3.9.1.1 HISTOLOGICAL S C O RIN G
.......................................................................
52
3.9.2 STATISTICAL
ANALYSES.........................................................................................
53
4 RESULTS 55
4.1 ACUTE HYPERINFLAMMATORY MODEL IN V I V O
.................................................................
55
4.1.1 ENS-ALTERATIONS ALONG THE ROSTRO-CAUDAL
AXIS................................................ 57
4.1.2 ANALYSIS OF EGCS ALONG THE LUMINAL-SEROSAL
AXIS.......................................... 60
4.2 IN VITRO CULTURE OF MYENTERIC GFAP-GLIA AS
GLIOSPHERES.......................................... 63
4.3 INFLAMMATORY STIMULATION OF GLIOSPHERES IN
VITRO...................................................... 64
4.3.1 TRANSCRIPTOMIC META-ANALYSIS OF
GLIOSPHERES................................................ 71
4.3.2 SIGNALING MOLECULES SECRETED BY
GLIOSPHERES................................................ 74
4.4 ACUTE INFLAMMATORY BOWEL DISEASE MODEL IN VIVO
................................................... 74
4.4.1 DISEASE ACTIVITY INDEX (DAI) SCORING OF THE IBD M
ODEL.............................. 76
4.4.2 TRANSCRIPTOMIC ANALYSIS OF ISOLATED GFAP-EGCS FROM THE IBD MODEL .
. 79
4.4.3 COLOCALIZATION STUDY OF GFAP-EGCS AND IMMUNE CELLS IN V I V O
...............
81
4.5 PRIMARY 3D INTESTINAL NEURO-EPITHELIAL MODELS IN VITRO: PRELIMINARY
D A T A
............
84
5 DISCUSSION 87
5.1 ENS ALTERATIONS IN THE ACUTE HYPERINFLAMMATORY MODEL IN V I V O
........................... 87
5.1.1 GLIAL-SPECIFIC ALTERATIONS IN THE HYPERINFLAMMATORY M O D E L
........................
90
5.1.1.1 REGION-SPECIFICITY OF LPS-RESPONSIVE E G C S
................................. 92
5.2 CHARACTERIZATION OF GFAP-GLIOSPHERE CULTURES IN V I T R O
.......................................... 92
5.3 ALTERATIONS IN ENTERIC GLIOSPHERES UPON INFLAMMATORY STIM ULATION
........................
94
5.3.1 TRANSCRIPTOMIC ANALYIS OF LPS-STIMULATED
GLIOSPHERES................................. 94
5.3.1.1 VALIDATION OF ILLUMINA EXPRESSION BEADCHIP TECHNOLOGY BY NANOS-
TRING*S NCOUNTER
TECHNOLOGY............................................................
96
5.3.2 PROTEOMIC ANALYSES OF LPS-STIMULATED
GLIOSPHERES....................................... 98
5.3.3 TRANSCRIPTOMIC META-PROFILING OF
GFAP-EGCS............................................. 100
5.4 GFAP-GLIA IN AN ACUTE INFLAMMATORY BOWEL DISEASE MODEL IN VIVO
........................
102
5.5 FUTURE MODELS FOR THE STUDY OF EGCS IN INTESTINAL
PHYSIOLOGY.............................. 105
5.6 CLINICAL RELEVANCE OF THE STU D Y
...................................................................................
106
5.7 OUTLOOK ON FUTURE STRATEGIES TO ELUCIDATE THE CONTRIBUTIONS OF EGCS
TO INTESTINAL
PHYSIOLOGY....................................................................................................................
108
6 BIBLIOGRAPHY 109
APPENDIX AI
CURRICULUM V IT A E
.................................................................................................................
AL
LIST OF
PUBLICATIONS..............................................................................................................
A3
AFFIDAVIT................................................................................................................................
A5
EIDESSTATTLICHE E RK LAE RU N G
..................................................................................................
A5
DANKSAGUNG..........................................................................................................................
A7
|
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| spelling | Grose, Michael (Lawyer) aut Construction law in the United Arab Emirates and the Gulf Michael Grose Hoboken Wiley 2016 1 online resource txt rdacontent c rdamedia cr rdacarrier Includes index "The book is an authoritative guide to construction law in the United Arab Emirates and the Gulf. The principal theme is the contrast between construction law in an Islamic civil law jurisdiction and construction law in a common law jurisdiction. There is a tendency for these differences to be glossed over due to a lack of any detailed comparative analysis. The book provides the first authoritative text on the application of the laws of the UAE, and to a lesser extent of the wider Gulf region, to the most commonly occurring issues of controversy arising from construction projects. There are extensive extracts from the region's applicable laws, all translated from the original Arabic, and hundreds of judgments of the most senior courts used to back up the analysis provided. The text is presented in two parts: A narrative covering the main areas of practical concern to those dealing with construction contract and disputes; and A commentary on the standard FIDIC conditions that are widely employed on construction contracts in the Gulf region, applying principles from the narrative wherever relevant. The sources of information contained in the book are not readily available to those without access to a database of relevant laws and judgments"-- LAW / Construction bisacsh Recht Construction industry / Law and legislation / United Arab Emirates Construction contracts / United Arab Emirates Construction industry / Law and legislation / Persian Gulf Coast (Persian Gulf States) Construction contracts / Persian Gulf Coast (Persian Gulf States) Erscheint auch als Druckausgabe 978-1-119-08593-5 https://onlinelibrary.wiley.com/doi/book/10.1002/9781119085966 Verlag URL des Erstveröffentlichers Volltext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029237192&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Grose, Michael (Lawyer) Construction law in the United Arab Emirates and the Gulf LAW / Construction bisacsh Recht Construction industry / Law and legislation / United Arab Emirates Construction contracts / United Arab Emirates Construction industry / Law and legislation / Persian Gulf Coast (Persian Gulf States) Construction contracts / Persian Gulf Coast (Persian Gulf States) |
| title | Construction law in the United Arab Emirates and the Gulf |
| title_auth | Construction law in the United Arab Emirates and the Gulf |
| title_exact_search | Construction law in the United Arab Emirates and the Gulf |
| title_full | Construction law in the United Arab Emirates and the Gulf Michael Grose |
| title_fullStr | Construction law in the United Arab Emirates and the Gulf Michael Grose |
| title_full_unstemmed | Construction law in the United Arab Emirates and the Gulf Michael Grose |
| title_short | Construction law in the United Arab Emirates and the Gulf |
| title_sort | construction law in the united arab emirates and the gulf |
| topic | LAW / Construction bisacsh Recht Construction industry / Law and legislation / United Arab Emirates Construction contracts / United Arab Emirates Construction industry / Law and legislation / Persian Gulf Coast (Persian Gulf States) Construction contracts / Persian Gulf Coast (Persian Gulf States) |
| topic_facet | LAW / Construction Recht Construction industry / Law and legislation / United Arab Emirates Construction contracts / United Arab Emirates Construction industry / Law and legislation / Persian Gulf Coast (Persian Gulf States) Construction contracts / Persian Gulf Coast (Persian Gulf States) |
| url | https://onlinelibrary.wiley.com/doi/book/10.1002/9781119085966 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029237192&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT grosemichael constructionlawintheunitedarabemiratesandthegulf |