Na channels from Phyla to function:
Gespeichert in:
| Weitere Verfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Amsterdam
Elsevier, AP
2016
|
| Ausgabe: | First edition |
| Schriftenreihe: | Current topics in membranes
78 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | xxx, 648 Seiten Illustrationen |
| ISBN: | 9780128053867 |
Internformat
MARC
| LEADER | 00000nam a2200000 cb4500 | ||
|---|---|---|---|
| 001 | BV043811657 | ||
| 003 | DE-604 | ||
| 005 | 20161010 | ||
| 007 | t | ||
| 008 | 161005s2016 a||| |||| 00||| eng d | ||
| 020 | |a 9780128053867 |9 978-0-12-805386-7 | ||
| 035 | |a (OCoLC)964319947 | ||
| 035 | |a (DE-599)BVBBV043811657 | ||
| 040 | |a DE-604 |b ger |e rda | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-355 | ||
| 084 | |a WE 5000 |0 (DE-625)148296: |2 rvk | ||
| 084 | |a WE 5460 |0 (DE-625)148311: |2 rvk | ||
| 245 | 1 | 0 | |a Na channels from Phyla to function |c edited by Robert J. French , Sergei Yu. Noskov |
| 250 | |a First edition | ||
| 264 | 1 | |a Amsterdam |b Elsevier, AP |c 2016 | |
| 300 | |a xxx, 648 Seiten |b Illustrationen | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Current topics in membranes |v 78 | |
| 650 | 0 | 7 | |a Natriumkanal |0 (DE-588)4244067-1 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 689 | 0 | 0 | |a Natriumkanal |0 (DE-588)4244067-1 |D s |
| 689 | 0 | |C b |5 DE-604 | |
| 700 | 1 | |a French, Robert J. |4 edt | |
| 700 | 1 | |a Noskov, Sergei Yu. |4 edt | |
| 830 | 0 | |a Current topics in membranes |v 78 |w (DE-604)BV036839511 |9 78 | |
| 856 | 4 | 2 | |m Digitalisierung UB Regensburg - ADAM Catalogue Enrichment |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029222901&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-029222901 | ||
Datensatz im Suchindex
| _version_ | 1804176660717633536 |
|---|---|
| adam_text | CONTENTS
Contributors xv
Preface xix
Acknowledgments xxv
Previous Volumes in Senes xxvn
Section 1 Historical Overview
1. On the Natural and Unnatural History of the Voltage-Gated
Na+ Channel 3
E.G. Moczydlowski
1. introduction to NaV as Surrogate Vital Spirit 4
2. NaV as Physics Lesson: Eiectrobiology Experiments Led to
Electromagnetism 9
3. NaV as Discovery Channel: Finding Our Inner Action Potential 13
4. NaV as Biomolecule: The Other Secret of Life 20
5. NaV as Biotransistor: Elementary On-Off Switch of Neuronal Intelligence 22
6. NaV as a Pharmacologically Tunable On-Off Switch of Pain and
Consciousness 25
7. NaV as Tragedy: A Locus of Nervous System Maladies 26
8. NaV as the Favorite Target of Nature s Venoms 28
9. NaV Exobiology: Why Na + ? 30
10. NaV Endgame 32
References 32
Section 2 Evolutionary Adaptations of Channels and Toxins
2. Biophysical Adaptations of Prokaryotic Voltage-Gated Sodium
Channels 39
T.N. Vien, P,G. DeCaen
1. introduction 40
2. Adaptations in Cation Selectivity in Nav Channels 44
3. Adaptations in Voltage-Dependent Processes in the Prokaryotic Nav Fam y 49
4. Divergence in the Eukaryotic and Prokaryotic Nav Pharmacophores 55
References 59
vii
Contents
viîi
3. Venom Peptides From Cone Snails: Pharmacological Probes
for Voltage-Gated Sodium Channels 65
B.R. Green, B.M. Olivers
1. Introduction 66
2. Overview of Physiological Roles of Voltage-Gated Sodium
Channel-Targeted Conus Venom Peptides 68
3. Conotoxin Interactions With Nav1 73
4. Navp Effects on Conotoxin Activity 79
5. Conclusions and Future Prospects 81
Acknowledgments 83
References 83
4. Convergent Evolution of Tetrodotoxin-Resistant Sodium
Channels in Predators and Prey 87
G. Toledo, C. Hanifin, S. Geffeney, E.D. Brodie, III
1. Introduction 88
2. Tetrodotoxin as an Agent of Selection 90
3. Molecular Patterns of Convergence in Tetrodotoxin-Resistant Nav Channels 93
4. Convergence Across Other Nav Paralogs 97
5. Convergence of Nay in Invertebrates 99
6. Implications of Molecular Convergence in Nav 99
7. Conclusion 108
Acknowledgments 3 09
References 109
Section 3 Computational Studies and Modeling
5. Computational Structural Pharmacology and Toxicology
of Voltage-Gated Sodium Channels 117
B.S. Zhorov, D.B. Tikhonov
1. Introduction 118
2. Structure of Sodium Channels 119
3. Homology Modeling 123
4. Progress in Modeling Sodium Channel With Ligands 125
5. Conclusions 138
Acknowledgments 139
References 139
Contents
IX
6. Understanding Sodium Channel Function and Modulation
Using Atomistic Simulations of Bacterial Channel Structures 145
C Boiteux, T.W. Allen
1. Introduction 146
2. Sodium Channel Architecture 151
3. Principles of Sodium Conduction and Selectivity 156
4. Structural Basis for Activation and Inactivation 161
5. Drug Binding and Modulation 168
6. Discussion and Conclusions 173
Acknowledgments 175
References 175
7. Voltage-Gated Sodium Channels: Mechanistic Insights
From Atomistic Molecular Dynamics Simulations 183
V. Oakes, S. Furini, C. Domene
1. Introduction 184
2. Voltage-Gated Sodium Channels 185
3. Structural Basis of HT Versus Na T Conduction 187
4. Overview of Computational Studies 192
5. Conclusions 207
Acknowledgments 208
References 208
8. Simulation Studies of Ion Permeation and Selectivity
in Voltage-Gated Sodium Channels 215
C. ing, R. Pomes
1. Introduction 216
2. Voltage-Gated Sodium Cna^neis 217
3. Mechanism of Ion Permeation and Selectivity in KT Channels 222
4. Molecular Sim Carols of Sod um Channels 224
5. Ion Binding and Permea: o~ m Nav Cha^ne s 229
6. ionic Selectivity of Nav Channels 239
7. Critica! Discussion 244
8. Perspectives 252
Acknowledgments 254
References
254
X
Contents
9. Voltage-Gated Sodium Channels: Evolutionary History
and Distinctive Sequence Features 261
M.A. Kasimova, D. Granata, V. Carnevate
1. Introduction 262
2. Evolutionary History of Nav 269
3. Distinctive Sequence Features of Pseudotetrameric Channels 272
4. Summary and Conclusion: What Can We Learn From Sequences
About Nav Gating7 276
References 280
10. Cardiac Na Channels: Structure to Function 287
K.R. DeMarco, C.E. Clancy
1. Na+ Channels: l^a the Fast Voltage-Gated Na+ Channel 288
2. Activation of the Cardiac Na+ Channel Navi.5 292
3. Inactivation 294
4. Fast Inactivation 294
5. Slow Inactivation 298
6. Recovery From Inactivation 299
7. Regulation of Cardiac Navi .5 301
8. Summary 303
Acknowledgments 303
References 304
Section 4 Functional Studies - Modulation by Other
Molecules and Roles of Inactivation and Prolonged Currents
11. Developmental and Regulatory Functions of Na+ Channel
Non-pore-forming p Subunits 315
JJ. Winters, L.L. Isom
1. Introduction to the p Subunits 316
2. p Subunit Evolution, Genes, and Structure 317
3. p Subunit Expression, Localization, and Posttranslationa! Modification 324
4. p Subunits Modulate a Subunit Localization and Function 329
5. p Subunits Are CAMs That Have Roles in Brain Development 334
6. p Subunit Gene Mutations Are Linked to Epilepsy and Cardiac Arrhythmia 337
7. Concluding Remarks 339
References 340
Contents
xi
12. Lipid Regulation of Sodium Channels 353
N. D Avanzo
1. Introduction 354
2. Regulation of Nay Channels by the Physiochemical Properties of the Bilayer 357
3. Fatty Acids 360
4. Glycerophospholipids 370
5. Sterols 376
6. Sphingolipids 379
7. Cannabinoids 385
8. Conclusions 389
References 390
13. Mechanism of inactivation in Voltage-Gated Na+ Channels 409
V.S. Gawali, H. Todt
1. Molecular Architecture of Voltage-Gated Na Channels 410
2. The Kinetic States of Voltage-Gated Na^ Channels 411
3. Fast Inactivation 412
4. Long-Term Inactivation 418
5. Slow inactivation 418
6. Summary and Outlook 436
References 437
14. Current—Voltage Relationship for Late Na+ Current in Adult
Rat Ventricular Myocytes 451
R.B. Clark, W.R. Giles
1. Introduction 452
2. Methods 455
3. Results 457
4. Discussion 466
Acknowledgments 474
References 474
15. Physiology and Pathophysiology of Sodium Channel
Inactivation 479
M-R. Ghovanloo, K. Airman R. Ghadiry-TavL A. Yu, P.C. Ruben
1. Physiology and Structural Basis of Inactivation 480
2. Navi .1 483
3. Nayl .2 485
4. Nav1.3 487
5. Nay1. .4 488
xii Contents
6. Nay1.5 491
7. Nay! .6 494
8. Nav1.7 495
9. Nav1.8 497
10. Nayl.9 498
11. Drug Interactions 499
12. Concluding Remarks 500
References 501
Section 5 Sodium Channels Under Stress and in Disease
16. Cardiac Sodium Channel Mutations: Why so Many
Phenotypes? 513
M. Liu, K.-C Yang, S.C. Dudley, Jr.
1. Introduction 514
2. The Cardiac Nayl .5 517
3. Phenotypic Variability of Cardiac Nav1.5 Mutations 518
4. Sources of Phenotypic Variability 527
5. Summary 545
6. Disclosures 546
Acknowledgments 547
References 547
17. Nav Channels in Damaged Membranes 561
C.E. Morris, B. Joos
1. The Problem: Acquired Sodium Channelopathies—A Feature of Sick
Excitable Cells 562
2. Modeling: Underlying Simplicity for Diverse Excitability Pathologies 565
3. Therapeutic Agents: A Need to Recognize Bleb-Damaged Membrane 567
4. Irreversible Bleb-Type Damage in Membrane Patches 570
5. Navi.4 in Damaged Oocyte Membranes—Trauma-Induced Switch
From Slow to Fast Mode 572
6. Nav! .6 in Damaged Oocyte Membranes 573
7. MS Modulation of Squid Axon Voltage-Gated Channels 575
8. Coupled Left-Shift: Kinetic Linkage of Activation to Inactivation 575
9. Does the Domain-4 V-Sensor, the Site of Coupling Mutants, Play
a Role in Nav-CLS? 577
10. Using the Hodgkin—Huxley Formulation to Simulate the Coupling
of g(V) and Availabillty(V) in MS Nav-CLS 578
11. Computations to Illustrate the Parhoexcitability Spectrum of Nav-CLS 578
Contents
xiii
12. An Aside on Excitability Thresholds and Ion Homeostasis 579
13. An Excitable Cell s injury Worsens—Modeled 582
14. Tactile Allodynia (Hypersensitivity to Stimuli) and Left-Shifted
Nav Currents 584
15. Threshold Tracking, Peripheral Neuropathies, Cancer Chemotherapy 585
16. When a Nav Channel Left-Shifts Due to Membrane Damage Does
This Affect Both Fast and Slow Modes? 588
17. Bieb-Damaged T-Tubular Membranes 588
18. Propagation Infidelities and Block Due to Nav-CLS 589
19. Mildly Injured Excitable Membrane? Do Not Disturb 590
20. Nav-CLS Modeling of Acute Mild Traumatic Brain Injury 590
21. Conclusion 591
References 591
18. Unusual Voltage-Gated Sodium Currents as Targets for Pain 599
C. Barbosa, T.R. Cummins
1. Overview 600
2. Sodium Channels in Peripheral Sensory Neurons 602
3. Inactivation and Resurgent Current Contribution to Excitability of
Sensory Neurons 608
4. Classic Sodium Currents Role in Pain 612
5. Atypical Sodium Currents and Pain 615
6. Therapeutic Strategies 622
References 625
Index
639
|
| any_adam_object | 1 |
| author2 | French, Robert J. Noskov, Sergei Yu |
| author2_role | edt edt |
| author2_variant | r j f rj rjf s y n sy syn |
| author_facet | French, Robert J. Noskov, Sergei Yu |
| building | Verbundindex |
| bvnumber | BV043811657 |
| classification_rvk | WE 5000 WE 5460 |
| ctrlnum | (OCoLC)964319947 (DE-599)BVBBV043811657 |
| discipline | Biologie |
| edition | First edition |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01509nam a2200385 cb4500</leader><controlfield tag="001">BV043811657</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20161010 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">161005s2016 a||| |||| 00||| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9780128053867</subfield><subfield code="9">978-0-12-805386-7</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)964319947</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV043811657</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">WE 5000</subfield><subfield code="0">(DE-625)148296:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">WE 5460</subfield><subfield code="0">(DE-625)148311:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Na channels from Phyla to function</subfield><subfield code="c">edited by Robert J. French , Sergei Yu. Noskov</subfield></datafield><datafield tag="250" ind1=" " ind2=" "><subfield code="a">First edition</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Amsterdam</subfield><subfield code="b">Elsevier, AP</subfield><subfield code="c">2016</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">xxx, 648 Seiten</subfield><subfield code="b">Illustrationen</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="1" ind2=" "><subfield code="a">Current topics in membranes</subfield><subfield code="v">78</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Natriumkanal</subfield><subfield code="0">(DE-588)4244067-1</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4143413-4</subfield><subfield code="a">Aufsatzsammlung</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Natriumkanal</subfield><subfield code="0">(DE-588)4244067-1</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="C">b</subfield><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">French, Robert J.</subfield><subfield code="4">edt</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Noskov, Sergei Yu.</subfield><subfield code="4">edt</subfield></datafield><datafield tag="830" ind1=" " ind2="0"><subfield code="a">Current topics in membranes</subfield><subfield code="v">78</subfield><subfield code="w">(DE-604)BV036839511</subfield><subfield code="9">78</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">Digitalisierung UB Regensburg - ADAM Catalogue Enrichment</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029222901&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-029222901</subfield></datafield></record></collection> |
| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV043811657 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T07:35:43Z |
| institution | BVB |
| isbn | 9780128053867 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-029222901 |
| oclc_num | 964319947 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | xxx, 648 Seiten Illustrationen |
| publishDate | 2016 |
| publishDateSearch | 2016 |
| publishDateSort | 2016 |
| publisher | Elsevier, AP |
| record_format | marc |
| series | Current topics in membranes |
| series2 | Current topics in membranes |
| spelling | Na channels from Phyla to function edited by Robert J. French , Sergei Yu. Noskov First edition Amsterdam Elsevier, AP 2016 xxx, 648 Seiten Illustrationen txt rdacontent n rdamedia nc rdacarrier Current topics in membranes 78 Natriumkanal (DE-588)4244067-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Natriumkanal (DE-588)4244067-1 s b DE-604 French, Robert J. edt Noskov, Sergei Yu. edt Current topics in membranes 78 (DE-604)BV036839511 78 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029222901&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Na channels from Phyla to function Current topics in membranes Natriumkanal (DE-588)4244067-1 gnd |
| subject_GND | (DE-588)4244067-1 (DE-588)4143413-4 |
| title | Na channels from Phyla to function |
| title_auth | Na channels from Phyla to function |
| title_exact_search | Na channels from Phyla to function |
| title_full | Na channels from Phyla to function edited by Robert J. French , Sergei Yu. Noskov |
| title_fullStr | Na channels from Phyla to function edited by Robert J. French , Sergei Yu. Noskov |
| title_full_unstemmed | Na channels from Phyla to function edited by Robert J. French , Sergei Yu. Noskov |
| title_short | Na channels from Phyla to function |
| title_sort | na channels from phyla to function |
| topic | Natriumkanal (DE-588)4244067-1 gnd |
| topic_facet | Natriumkanal Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029222901&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV036839511 |
| work_keys_str_mv | AT frenchrobertj nachannelsfromphylatofunction AT noskovsergeiyu nachannelsfromphylatofunction |