Improving the utility and translation of animal models for nervous system disorders: workshop summary
Gespeichert in:
1. Verfasser: | |
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Format: | Elektronisch E-Book |
Sprache: | English |
Veröffentlicht: |
Washington, D.C.
The National Academies Press
[2013]
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Schlagworte: | |
Online-Zugang: | FAW01 FAW02 |
Beschreibung: | Title from PDF title page Description based on online resource (viewed Dec. 11, 2013) |
Beschreibung: | 1 online resource (1 PDF file (xi, 97 pages)) illustrations |
ISBN: | 9780309266338 0309266335 9780309266345 0309266343 |
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245 | 1 | 0 | |a Improving the utility and translation of animal models for nervous system disorders |b workshop summary |c Diana E. Pankevich, Theresa M. Wizemann, and Bruce M. Altevogt, rapporteurs ; Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy, Institute of Medicine of the National Academies |
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505 | 8 | |a Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in humans? On March 28 and 29, 2012, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened the workshop "Improving Translation of Animal Models for Nervous System Disorders" to discuss potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus of the workshop was to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected | |
505 | 8 | |a Introduction and overview -- Evaluation of current animal models -- Translation from animal models to the clinic: case examples from neuroscience research -- Perspectives on standardization -- Perspectives on corresponding animal and clinical endpoints -- Addressing the translational disconnect -- Summary of workshop topics | |
650 | 4 | |a Nervous System Diseases / drug therapy / Congresses | |
650 | 4 | |a Clinical Trials as Topic / Congresses | |
650 | 4 | |a Drug Evaluation, Preclinical / Congresses | |
650 | 4 | |a Models, Animal / Congresses | |
650 | 4 | |a Research Design / Congresses | |
650 | 4 | |a Translational Medical Research / Congresses | |
650 | 7 | |a Animal models in research |2 fast | |
650 | 7 | |a Nervous system / Diseases / Animal models |2 fast | |
650 | 7 | |a HEALTH & FITNESS / Diseases / General |2 bisacsh | |
650 | 7 | |a MEDICAL / Clinical Medicine |2 bisacsh | |
650 | 7 | |a MEDICAL / Diseases |2 bisacsh | |
650 | 7 | |a MEDICAL / Evidence-Based Medicine |2 bisacsh | |
650 | 7 | |a MEDICAL / Internal Medicine |2 bisacsh | |
650 | 4 | |a Evidenz-basierte Medizin | |
650 | 4 | |a Innere Medizin | |
650 | 4 | |a Medizin | |
650 | 4 | |a Nervous system |x Diseases |x Animal models |a Animal models in research | |
655 | 7 | |0 (DE-588)1071861417 |a Konferenzschrift |2 gnd-content | |
700 | 1 | |a Wizemann, Theresa M. |e Sonstige |4 oth | |
700 | 1 | |a Altevogt, Bruce M. |e Sonstige |4 oth | |
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710 | 2 | |a Workshop "Improving Translation of Animal Models for Nervous System Disorders" <2012, Institute of Medicine (U.S.)> |e Sonstige |4 oth | |
776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |a Improving the utility and translation of animal models for nervous system disorders |
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Datensatz im Suchindex
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any_adam_object | |
author | Pankevich, Diana E. 1975- |
author_facet | Pankevich, Diana E. 1975- |
author_role | aut |
author_sort | Pankevich, Diana E. 1975- |
author_variant | d e p de dep |
building | Verbundindex |
bvnumber | BV043779308 |
collection | ZDB-4-EBA |
contents | Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in humans? On March 28 and 29, 2012, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened the workshop "Improving Translation of Animal Models for Nervous System Disorders" to discuss potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus of the workshop was to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected Introduction and overview -- Evaluation of current animal models -- Translation from animal models to the clinic: case examples from neuroscience research -- Perspectives on standardization -- Perspectives on corresponding animal and clinical endpoints -- Addressing the translational disconnect -- Summary of workshop topics |
ctrlnum | (ZDB-4-EBA)ocn827359047 (OCoLC)827359047 (DE-599)BVBBV043779308 |
dewey-full | 616.02/7 |
dewey-hundreds | 600 - Technology (Applied sciences) |
dewey-ones | 616 - Diseases |
dewey-raw | 616.02/7 |
dewey-search | 616.02/7 |
dewey-sort | 3616.02 17 |
dewey-tens | 610 - Medicine and health |
discipline | Medizin |
format | Electronic eBook |
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spelling | Pankevich, Diana E. 1975- Verfasser aut Improving the utility and translation of animal models for nervous system disorders workshop summary Diana E. Pankevich, Theresa M. Wizemann, and Bruce M. Altevogt, rapporteurs ; Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy, Institute of Medicine of the National Academies Washington, D.C. The National Academies Press [2013] 1 online resource (1 PDF file (xi, 97 pages)) illustrations txt rdacontent c rdamedia cr rdacarrier Title from PDF title page Description based on online resource (viewed Dec. 11, 2013) Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in humans? On March 28 and 29, 2012, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened the workshop "Improving Translation of Animal Models for Nervous System Disorders" to discuss potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus of the workshop was to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected Introduction and overview -- Evaluation of current animal models -- Translation from animal models to the clinic: case examples from neuroscience research -- Perspectives on standardization -- Perspectives on corresponding animal and clinical endpoints -- Addressing the translational disconnect -- Summary of workshop topics Nervous System Diseases / drug therapy / Congresses Clinical Trials as Topic / Congresses Drug Evaluation, Preclinical / Congresses Models, Animal / Congresses Research Design / Congresses Translational Medical Research / Congresses Animal models in research fast Nervous system / Diseases / Animal models fast HEALTH & FITNESS / Diseases / General bisacsh MEDICAL / Clinical Medicine bisacsh MEDICAL / Diseases bisacsh MEDICAL / Evidence-Based Medicine bisacsh MEDICAL / Internal Medicine bisacsh Evidenz-basierte Medizin Innere Medizin Medizin Nervous system Diseases Animal models Animal models in research (DE-588)1071861417 Konferenzschrift gnd-content Wizemann, Theresa M. Sonstige oth Altevogt, Bruce M. Sonstige oth Institute of Medicine (U.S.)XXbForum on Neuroscience and Nervous System DisordersXXesponsoring body Sonstige oth Workshop "Improving Translation of Animal Models for Nervous System Disorders" <2012, Institute of Medicine (U.S.)> Sonstige oth Erscheint auch als Druck-Ausgabe Improving the utility and translation of animal models for nervous system disorders |
spellingShingle | Pankevich, Diana E. 1975- Improving the utility and translation of animal models for nervous system disorders workshop summary Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in humans? On March 28 and 29, 2012, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened the workshop "Improving Translation of Animal Models for Nervous System Disorders" to discuss potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus of the workshop was to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected Introduction and overview -- Evaluation of current animal models -- Translation from animal models to the clinic: case examples from neuroscience research -- Perspectives on standardization -- Perspectives on corresponding animal and clinical endpoints -- Addressing the translational disconnect -- Summary of workshop topics Nervous System Diseases / drug therapy / Congresses Clinical Trials as Topic / Congresses Drug Evaluation, Preclinical / Congresses Models, Animal / Congresses Research Design / Congresses Translational Medical Research / Congresses Animal models in research fast Nervous system / Diseases / Animal models fast HEALTH & FITNESS / Diseases / General bisacsh MEDICAL / Clinical Medicine bisacsh MEDICAL / Diseases bisacsh MEDICAL / Evidence-Based Medicine bisacsh MEDICAL / Internal Medicine bisacsh Evidenz-basierte Medizin Innere Medizin Medizin Nervous system Diseases Animal models Animal models in research |
subject_GND | (DE-588)1071861417 |
title | Improving the utility and translation of animal models for nervous system disorders workshop summary |
title_auth | Improving the utility and translation of animal models for nervous system disorders workshop summary |
title_exact_search | Improving the utility and translation of animal models for nervous system disorders workshop summary |
title_full | Improving the utility and translation of animal models for nervous system disorders workshop summary Diana E. Pankevich, Theresa M. Wizemann, and Bruce M. Altevogt, rapporteurs ; Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy, Institute of Medicine of the National Academies |
title_fullStr | Improving the utility and translation of animal models for nervous system disorders workshop summary Diana E. Pankevich, Theresa M. Wizemann, and Bruce M. Altevogt, rapporteurs ; Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy, Institute of Medicine of the National Academies |
title_full_unstemmed | Improving the utility and translation of animal models for nervous system disorders workshop summary Diana E. Pankevich, Theresa M. Wizemann, and Bruce M. Altevogt, rapporteurs ; Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy, Institute of Medicine of the National Academies |
title_short | Improving the utility and translation of animal models for nervous system disorders |
title_sort | improving the utility and translation of animal models for nervous system disorders workshop summary |
title_sub | workshop summary |
topic | Nervous System Diseases / drug therapy / Congresses Clinical Trials as Topic / Congresses Drug Evaluation, Preclinical / Congresses Models, Animal / Congresses Research Design / Congresses Translational Medical Research / Congresses Animal models in research fast Nervous system / Diseases / Animal models fast HEALTH & FITNESS / Diseases / General bisacsh MEDICAL / Clinical Medicine bisacsh MEDICAL / Diseases bisacsh MEDICAL / Evidence-Based Medicine bisacsh MEDICAL / Internal Medicine bisacsh Evidenz-basierte Medizin Innere Medizin Medizin Nervous system Diseases Animal models Animal models in research |
topic_facet | Nervous System Diseases / drug therapy / Congresses Clinical Trials as Topic / Congresses Drug Evaluation, Preclinical / Congresses Models, Animal / Congresses Research Design / Congresses Translational Medical Research / Congresses Animal models in research Nervous system / Diseases / Animal models HEALTH & FITNESS / Diseases / General MEDICAL / Clinical Medicine MEDICAL / Diseases MEDICAL / Evidence-Based Medicine MEDICAL / Internal Medicine Evidenz-basierte Medizin Innere Medizin Medizin Nervous system Diseases Animal models Animal models in research Konferenzschrift |
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