Organic chemistry of drug degradation:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Cambridge, U.K.
RSC Publishing
©2012
|
| Schriftenreihe: | RSC drug discovery series
no. 29 |
| Schlagworte: | |
| Online-Zugang: | FAW01 FAW02 |
| Beschreibung: | Includes bibliographical references and index "The vast majority of drugs are organic molecular entities. A clear understanding of the organic chemistry of drug degradation is essential to maintaining the stability, efficacy, and safety of a drug product throughout its shelf-life. During analytical method development, stability testing, and pharmaceutical manufacturing troubleshooting activities, one of the frequently occurring and usually challenging events would be the identification of drug degradants and understanding of drug degradation mechanisms and pathways. This book is written by a veteran of the pharmaceutical industry who has first-hand experience in drug design and development, drug degradation mechanism studies, analytical development, and manufacturing process troubleshooting and improvement. The author discusses various degradation pathways with an emphasis on the mechanisms of the underlying organic chemistry, which should aid greatly in the efforts of degradant identification, formulation development, analytical development, and manufacturing process improvement. Organic reactions that are significant in drug degradation will first be reviewed and then illustrated by examples of drug degradation reported in the literature. The author brings the book to a close with a final chapter dedicated to the strategy for rapid elucidation of drug degradants with regard to the current regulatory requirements and guidelines. One chapter that should be given special attention is Chapter 3, Oxidative Degradation. Oxidative degradation is one of the most common degradation pathways but perhaps the most complex one. This chapter employs more than sixty drug degradation case studies with in-depth discussion in regard to their unique degradation pathways. With the increasing regulatory requirements on the quality and safety of pharmaceutical products, in particular with regard to drug impurities and degradants, the book will be an invaluable resource for pharmaceutical and analytical scientists who engage in formulation development, analytical development, stability studies, degradant identification, and support of manufacturing process improvement. In addition, it will also be helpful to scientists engaged in drug discovery and development as well as in drug metabolism studies."-- |
| Beschreibung: | xvii, 287 pages |
| ISBN: | 9781849735360 1849735360 9781849734219 1849734216 |
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| 082 | 0 | |a 615.19 |2 23 | |
| 100 | 1 | |a Li, Min |d 1962- |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Organic chemistry of drug degradation |c Min Li |
| 264 | 1 | |a Cambridge, U.K. |b RSC Publishing |c ©2012 | |
| 300 | |a xvii, 287 pages | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b c |2 rdamedia | ||
| 338 | |b cr |2 rdacarrier | ||
| 490 | 0 | |a RSC drug discovery series |v no. 29 | |
| 500 | |a Includes bibliographical references and index | ||
| 500 | |a "The vast majority of drugs are organic molecular entities. A clear understanding of the organic chemistry of drug degradation is essential to maintaining the stability, efficacy, and safety of a drug product throughout its shelf-life. During analytical method development, stability testing, and pharmaceutical manufacturing troubleshooting activities, one of the frequently occurring and usually challenging events would be the identification of drug degradants and understanding of drug degradation mechanisms and pathways. This book is written by a veteran of the pharmaceutical industry who has first-hand experience in drug design and development, drug degradation mechanism studies, analytical development, and manufacturing process troubleshooting and improvement. | ||
| 500 | |a The author discusses various degradation pathways with an emphasis on the mechanisms of the underlying organic chemistry, which should aid greatly in the efforts of degradant identification, formulation development, analytical development, and manufacturing process improvement. Organic reactions that are significant in drug degradation will first be reviewed and then illustrated by examples of drug degradation reported in the literature. The author brings the book to a close with a final chapter dedicated to the strategy for rapid elucidation of drug degradants with regard to the current regulatory requirements and guidelines. One chapter that should be given special attention is Chapter 3, Oxidative Degradation. Oxidative degradation is one of the most common degradation pathways but perhaps the most complex one. This chapter employs more than sixty drug degradation case studies with in-depth discussion in regard to their unique degradation pathways. | ||
| 500 | |a With the increasing regulatory requirements on the quality and safety of pharmaceutical products, in particular with regard to drug impurities and degradants, the book will be an invaluable resource for pharmaceutical and analytical scientists who engage in formulation development, analytical development, stability studies, degradant identification, and support of manufacturing process improvement. In addition, it will also be helpful to scientists engaged in drug discovery and development as well as in drug metabolism studies."-- | ||
| 650 | 7 | |a MEDICAL / Drug Guides |2 bisacsh | |
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| 650 | 7 | |a MEDICAL / Pharmacology |2 bisacsh | |
| 650 | 7 | |a MEDICAL / Pharmacy |2 bisacsh | |
| 650 | 7 | |a Chemistry, Organic |2 fast | |
| 650 | 7 | |a Drug stability |2 fast | |
| 650 | 4 | |a Medizin | |
| 650 | 4 | |a Drug stability | |
| 650 | 4 | |a Chemistry, Organic | |
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Datensatz im Suchindex
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| any_adam_object | |
| author | Li, Min 1962- |
| author_facet | Li, Min 1962- |
| author_role | aut |
| author_sort | Li, Min 1962- |
| author_variant | m l ml |
| building | Verbundindex |
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| ctrlnum | (ZDB-4-EBA)ocn823237651 (OCoLC)823237651 (DE-599)BVBBV043774536 |
| dewey-full | 615.19 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.19 |
| dewey-search | 615.19 |
| dewey-sort | 3615.19 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Electronic eBook |
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| id | DE-604.BV043774536 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T07:34:45Z |
| institution | BVB |
| isbn | 9781849735360 1849735360 9781849734219 1849734216 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-029185596 |
| oclc_num | 823237651 |
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| owner_facet | DE-1046 DE-1047 |
| physical | xvii, 287 pages |
| psigel | ZDB-4-EBA ZDB-4-EBA FAW_PDA_EBA |
| publishDate | 2012 |
| publishDateSearch | 2012 |
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| publisher | RSC Publishing |
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| series2 | RSC drug discovery series |
| spelling | Li, Min 1962- Verfasser aut Organic chemistry of drug degradation Min Li Cambridge, U.K. RSC Publishing ©2012 xvii, 287 pages txt rdacontent c rdamedia cr rdacarrier RSC drug discovery series no. 29 Includes bibliographical references and index "The vast majority of drugs are organic molecular entities. A clear understanding of the organic chemistry of drug degradation is essential to maintaining the stability, efficacy, and safety of a drug product throughout its shelf-life. During analytical method development, stability testing, and pharmaceutical manufacturing troubleshooting activities, one of the frequently occurring and usually challenging events would be the identification of drug degradants and understanding of drug degradation mechanisms and pathways. This book is written by a veteran of the pharmaceutical industry who has first-hand experience in drug design and development, drug degradation mechanism studies, analytical development, and manufacturing process troubleshooting and improvement. The author discusses various degradation pathways with an emphasis on the mechanisms of the underlying organic chemistry, which should aid greatly in the efforts of degradant identification, formulation development, analytical development, and manufacturing process improvement. Organic reactions that are significant in drug degradation will first be reviewed and then illustrated by examples of drug degradation reported in the literature. The author brings the book to a close with a final chapter dedicated to the strategy for rapid elucidation of drug degradants with regard to the current regulatory requirements and guidelines. One chapter that should be given special attention is Chapter 3, Oxidative Degradation. Oxidative degradation is one of the most common degradation pathways but perhaps the most complex one. This chapter employs more than sixty drug degradation case studies with in-depth discussion in regard to their unique degradation pathways. With the increasing regulatory requirements on the quality and safety of pharmaceutical products, in particular with regard to drug impurities and degradants, the book will be an invaluable resource for pharmaceutical and analytical scientists who engage in formulation development, analytical development, stability studies, degradant identification, and support of manufacturing process improvement. In addition, it will also be helpful to scientists engaged in drug discovery and development as well as in drug metabolism studies."-- MEDICAL / Drug Guides bisacsh MEDICAL / Nursing / Pharmacology bisacsh MEDICAL / Pharmacology bisacsh MEDICAL / Pharmacy bisacsh Chemistry, Organic fast Drug stability fast Medizin Drug stability Chemistry, Organic |
| spellingShingle | Li, Min 1962- Organic chemistry of drug degradation MEDICAL / Drug Guides bisacsh MEDICAL / Nursing / Pharmacology bisacsh MEDICAL / Pharmacology bisacsh MEDICAL / Pharmacy bisacsh Chemistry, Organic fast Drug stability fast Medizin Drug stability Chemistry, Organic |
| title | Organic chemistry of drug degradation |
| title_auth | Organic chemistry of drug degradation |
| title_exact_search | Organic chemistry of drug degradation |
| title_full | Organic chemistry of drug degradation Min Li |
| title_fullStr | Organic chemistry of drug degradation Min Li |
| title_full_unstemmed | Organic chemistry of drug degradation Min Li |
| title_short | Organic chemistry of drug degradation |
| title_sort | organic chemistry of drug degradation |
| topic | MEDICAL / Drug Guides bisacsh MEDICAL / Nursing / Pharmacology bisacsh MEDICAL / Pharmacology bisacsh MEDICAL / Pharmacy bisacsh Chemistry, Organic fast Drug stability fast Medizin Drug stability Chemistry, Organic |
| topic_facet | MEDICAL / Drug Guides MEDICAL / Nursing / Pharmacology MEDICAL / Pharmacology MEDICAL / Pharmacy Chemistry, Organic Drug stability Medizin |
| work_keys_str_mv | AT limin organicchemistryofdrugdegradation |