Strategic leadership for turbulent times:
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
New York
Palgrave Macmillan
[2016]
|
| Schlagworte: | |
| Online-Zugang: | BTU01 FAB01 FAW01 FHA01 FHI01 FHM01 FHN01 FHR01 FKE01 FNU01 FRO01 FWS01 FWS02 HTW01 HWR01 TUBA1 UBG01 UBR01 UBT01 UBY01 UEI01 UER01 UPA01 Volltext Inhaltsverzeichnis |
| Beschreibung: | 1 Online-Ressource (XV, 164 Seiten) 8 Illustrationen |
| ISBN: | 9781137403803 |
| DOI: | 10.1057/978-1-137-40380-3 |
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Datensatz im Suchindex
| DE-BY-FWS_katkey | 625763 |
|---|---|
| _version_ | 1806180150086205440 |
| adam_text | B
IOCHEMICAL
AND
MOLECULAR
CHARACTERIZATION
OF
AN
ORIGINAL
MASTER
SEX
DETERMINING
GENE
IN SALMONIDS
DOCTORAL THESIS FOR A DOCTORAL DEGREE AT THE FACULTY OF BIOLOGY
JULIUS-MAXIMILIANS-UNIVERSITAET WUERZBURG AND AGROCAMPUS QUEST
BIOLOGY
SUBMITTED BY
SYLVAIN BERTHO
WUERZBURG, 2016
TABLE OF CONTENTS
AFFIDAVIT---------------------------------------------------------------------------------------------------------------------------------------------------4
ABSTRACT
-----------------------------------
6
RESUME------------------------------------------------------------------------------------------------------------------------------------------------------
8
ZUSAMMENFASSUNG--------------------------------------------------------------------------------------------------------------------------------
10
INTRODUCTION-----------------------------------------------------------------------------------------------------------------------------------------
20
1. SEX
DETERMINATION-------------------------------------------------------------------------------------------------------------------------22
1.1 G
E N E R A L
O V E R V IE W
O F
T H E
S E X
D E T E R M IN A T IO N
--------------------------------------------------------------------------------22
1.2
G
ENETIC
SEX
DETERMINATION
----------------------------------------------------- 22
1.3 S
E X
D E T E R M IN IN G
G E N E S
: F
R O M
FIS H
T O
M A M M A L S
*
----------------------------------------------------------------------24
1.3.1 DMRTL RELATED SEX DETERMINING GENES
------------------
*
--------
---------------------------
------
26
1.3.2 SOX RELATED SEX DETERMINING GENES
------
--------------------------------------------------------------
28
1.3.3 TGF-SS RELATED SEX DETERMINING GENES
-----------------------------------------------------------------
30
1.3.4 SEX DETERMINING GENE NOT RELATED TO SEX
PATHWAY-----------------------------------------------34
1.4 T
U R N
-
O V E R
O F
T H E
S E X
D ET E R M IN A T IO N
S Y S T E M
A N D
E V O L U T IO N
------------------------------------------------------38
2. SEX
DIFFERENTIATION-----------------------------------------------------------------------------------------------------------------------
42
2.1
M
AIN
PLAYERS
DURING
SEX
DIFFERENTIATION
--------------------------------------------------------------------------------------42
2.1.1 MALE ACTORS----------------------------- 42
2.1.1.1 SOX9 - SRY BOX 9
------------------------------------------------------------- 42
2.1.1.2 N R 5A
1--------------------------------------------------------------------------
44
2.1.1.3AMH (ANTI MULLERIAN HORMONE OR MIS, MULLERIAN INHIBITING
SUBSTANCE)
---------------
46
2.1.1.4 DMRTL -D OUBLE SEXLMALE-ABNORMAL-3 RELATED TRANSCRIPTION FACTOR*
---------------
48
2.1.2 FEMALE
ACTORS------------------------------------------------------------------------
50
2.1.2.1 R-SPONDIN11 WNT4 I SS-CATENIN PATHWAY! FOLLISTATIN
-------------------------------------------
50
2.1.2.2 FOLLISTATIN
(FST)------------------------------------------------------------------------------------------------50
2.1.2.3 FOX
GENES------------------------------------------------------------------------------------------------------52
2.1.2.3.1 FO XL2-------------------------------------------------- 52
2.1.2.3.2 FO XL3
--------------------------------------------
64
2.1.2.4
CYP19A1---------------------------------------------------------------------------------------------------------
66
2.2
S
EX
DIFFERENTIATION
PLASTICITY
---------------------------------------------------- - - 6 8
3- SALMON!D FA M ILY
------------------
:-------------------------------------------------------------------------------------------------------70
3.1 R
A IN B O W
T R O U T
A S
M O D E L
S P E C IE
TO
S T U D Y
S E X
D E T E R M IN A T IO N
-
D IF F E R E N T IA T IO N
------------------------70
3.2
S
EX
DIFFERENTIATION
IN
TROUT
---------------------------------
72
3.2.1 FORMATION OF THE GONAD - EARLY MOLECULAR DIFFERENTIATION
--------------
-
------------ ---------
72
3.2.2 FORMATION OF THE GONAD - HISTOLOGICAL
DIFFERENTIATION-------------------------------------------74
MATERIALS AND
METHODS-----------------------------------------------------------------------------------------------------------------------
80
RESULTS---------------------------------------------------------------------------
104
S
D
Y LOCALIZES PREDOMINANTLY IN THE CYTOPLASM
-----------------------
107
S
D
Y DOES NOT SHOW ANY POST-TRANSLATIONAL
MODIFICATIONS-----------------------------------------------------------
112
BLOINFORMATIC TOOLS SUGGEST THAT S
D
Y IS A MONOMER AND CONSTITUTED OF AN INTERACTION
PLATFORM
-----------------------------
114
SDY INTERACTS WITH FORKHEAD BOX
PROTEINS------------------------------------------------------------------------------------
116
S
D
Y
T R A N S L O C A T E S
IN
TH E
N U C LE U S
IN
P R E S E N C E
OF
F
O X L
2 ---------------------------------------------------------------- 120
-16
S
D
Y
P H Y S IC A L L Y
IN T E R A C T S
W IT H
F
O X L
2
----------------------------------------------------------------------------------------------
126 -
P
H Y S IO L O G IC A L
IM P A C T
O F
TH E
IN T E R A C T IO N
----------------------------------------------------------------------------------------130
-
S
D
Y I183N SHOWS REDUCED INTERACTION WITH
TFOXL2B--------------------------------------------------------------
-----
144 -
U
N S T A B L E
S
D
Y I183N
T R IG G E R S
ITS
D E G R A D A T IO N
-----------------------
--
----------------------------------------------------1 4 6 .
DISCUSSION AND
PERSPECTIVES-----------------------------------------------------------------------------------------------------
-
------
150 -
2. CHARACTERIZATION OF
SDY------------------------------------------------------------------------------------------------------------
--
.
1.1 C
E L L U L A R
L O C A L IZ A T IO N
O F
S
D
Y
-------------------
-
---------
----------------------------------------------------------
----------
1 5 2 .
2 . 2
----------------------------------------------------------------------------
IS S
D
Y
C A N
BE
P O S T
-
T R A N S L A T IO N A L L Y
M O D IF IE D
?
--------
--
---------------------------------------------------------------------------------------------------------------------------
1 5 2 -
2 . 3
----
B
A S E D
O N
ITS
3D
S TR U C T U R E
R E C O N S T R U C T IO N
,
C O U LD
S
D
Y,
BE
IN V O L V E D
IN
T G F -
B
S IG N A L IN G
?
-------------------- 1 5 4 -
3. SDY
INTERACTOME-------------------------------------------------------------------------------------------------------------------------
--
4. HOW COULD SDY TRIGGER TESTICULAR
DIFFERENTIATION?------------------------------------------------------------164
-
5. DOES SDY I183N DEFINES A THRESHOLD TO INDUCE TESTICULAR
DIFFERENTIATION?
-------------
---------170 -
CONCLUSION------------------------------------------------------------------------------------------------------------------------------------------
--
_
BIBLIOGRAPHY----------------------------------------------------------------------------------------------------------------------------------------180
-
APPENDIX------------------------------------------------------------------------------------------------------------------------------------------------204
-
II - REVIEW SUBMITTED TO SEXUAL DEVELOPMENT
------
---------------------------------------------------------
206 -
-
16
-
|
| any_adam_object | 1 |
| author | Kriger, Mark P. Zhovtobryukh, Yuriy |
| author_GND | (DE-588)170603997 |
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| author_role | aut aut |
| author_sort | Kriger, Mark P. |
| author_variant | m p k mp mpk y z yz |
| building | Verbundindex |
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| dewey-full | 658.4092 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
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| dewey-sort | 3658.4092 |
| dewey-tens | 650 - Management and auxiliary services |
| discipline | Wirtschaftswissenschaften |
| doi_str_mv | 10.1057/978-1-137-40380-3 |
| format | Electronic eBook |
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| id | DE-604.BV043746905 |
| illustrated | Not Illustrated |
| indexdate | 2024-08-01T12:20:19Z |
| institution | BVB |
| isbn | 9781137403803 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-029158543 |
| oclc_num | 958047700 |
| open_access_boolean | |
| owner | DE-634 DE-1043 DE-1046 DE-Aug4 DE-573 DE-M347 DE-92 DE-898 DE-BY-UBR DE-859 DE-1049 DE-861 DE-863 DE-BY-FWS DE-862 DE-BY-FWS DE-523 DE-2070s DE-83 DE-473 DE-BY-UBG DE-355 DE-BY-UBR DE-703 DE-706 DE-824 DE-29 DE-739 |
| owner_facet | DE-634 DE-1043 DE-1046 DE-Aug4 DE-573 DE-M347 DE-92 DE-898 DE-BY-UBR DE-859 DE-1049 DE-861 DE-863 DE-BY-FWS DE-862 DE-BY-FWS DE-523 DE-2070s DE-83 DE-473 DE-BY-UBG DE-355 DE-BY-UBR DE-703 DE-706 DE-824 DE-29 DE-739 |
| physical | 1 Online-Ressource (XV, 164 Seiten) 8 Illustrationen |
| psigel | ZDB-2-BUM ZDB-2-BUM_2016 |
| publishDate | 2016 |
| publishDateSearch | 2016 |
| publishDateSort | 2016 |
| publisher | Palgrave Macmillan |
| record_format | marc |
| spellingShingle | Kriger, Mark P. Zhovtobryukh, Yuriy Strategic leadership for turbulent times Business Leadership Organization Planning Personnel management Economic sociology Business and Management Business Strategy/Leadership Human Resource Management Organizational Studies, Economic Sociology Führung Wirtschaft Strategisches Management (DE-588)4124261-0 gnd |
| subject_GND | (DE-588)4124261-0 |
| title | Strategic leadership for turbulent times |
| title_auth | Strategic leadership for turbulent times |
| title_exact_search | Strategic leadership for turbulent times |
| title_full | Strategic leadership for turbulent times Mark Kriger, Yuriy Zhovtobryukh |
| title_fullStr | Strategic leadership for turbulent times Mark Kriger, Yuriy Zhovtobryukh |
| title_full_unstemmed | Strategic leadership for turbulent times Mark Kriger, Yuriy Zhovtobryukh |
| title_short | Strategic leadership for turbulent times |
| title_sort | strategic leadership for turbulent times |
| topic | Business Leadership Organization Planning Personnel management Economic sociology Business and Management Business Strategy/Leadership Human Resource Management Organizational Studies, Economic Sociology Führung Wirtschaft Strategisches Management (DE-588)4124261-0 gnd |
| topic_facet | Business Leadership Organization Planning Personnel management Economic sociology Business and Management Business Strategy/Leadership Human Resource Management Organizational Studies, Economic Sociology Führung Wirtschaft Strategisches Management |
| url | https://doi.org/10.1057/978-1-137-40380-3 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029158543&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT krigermarkp strategicleadershipforturbulenttimes AT zhovtobryukhyuriy strategicleadershipforturbulenttimes |