Applied biocatalysis: from fundamental science to industrial applications
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| Format: | Buch |
| Sprache: | English |
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Weinheim
Wiley-VCH Verlag GmbH & Co. KGaA
[2016]
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| Online-Zugang: | Weitere Informationen Inhaltsverzeichnis |
| Beschreibung: | XXVI, 435 Seiten Illustrationen, Diagramme |
| ISBN: | 3527336699 9783527336692 9783527677122 |
Internformat
MARC
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| 245 | 1 | 0 | |a Applied biocatalysis |b from fundamental science to industrial applications |c edited by Lutz Hilterhaus, Andreas Liese, Ulrich Kettling, and Garabed Antranikian |
| 264 | 1 | |a Weinheim |b Wiley-VCH Verlag GmbH & Co. KGaA |c [2016] | |
| 264 | 4 | |c © 2016 | |
| 300 | |a XXVI, 435 Seiten |b Illustrationen, Diagramme | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 0 | 7 | |a Biokatalyse |0 (DE-588)4393622-2 |2 gnd |9 rswk-swf |
| 653 | |a Biocatalysis | ||
| 653 | |a Biokatalyse | ||
| 653 | |a Biotechnologie i. d. Chemie | ||
| 653 | |a Biotechnology | ||
| 653 | |a Chemie | ||
| 653 | |a Chemistry | ||
| 653 | |a Nachhaltige u. Grüne Chemie | ||
| 653 | |a Sustainable Chemistry & Green Chemistry | ||
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 689 | 0 | 0 | |a Biokatalyse |0 (DE-588)4393622-2 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Hilterhaus, Lutz |d 1978- |0 (DE-588)136187684 |4 edt | |
| 700 | 1 | |a Liese, Andreas |d 1966- |0 (DE-588)12031830X |4 edt | |
| 700 | 1 | |a Kettling, Ulrich |0 (DE-588)1114309443 |4 edt | |
| 700 | 1 | |a Antranikian, Garabed |d 1951- |0 (DE-588)109822382 |4 edt | |
| 710 | 2 | |a Wiley-VCH |0 (DE-588)16179388-5 |4 pbl | |
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| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe, MOBI |z 978-3-527-67711-5 |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe, PDF |z 978-3-527-67713-9 |
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Datensatz im Suchindex
| _version_ | 1804176389512888320 |
|---|---|
| adam_text | 1
1.1
1.2
1.3
1.4
1.5
1.6
1.7
2
2.1
2.2
2
.
2.1
2
.
2.2
2
.
2
.
2.1
2
.
2
.
2.2
2.2.2.S
2.3
CONTENTS
LIST OF CONTRIBUTORS
XVII
PREFACE
XXV
PART A MOLECULAR BIOLOGY, ENZYME SCREENING AND BIOINFORMATICS 1
ENGINEERING LIPASES WITH AN EXPANDED GENETIC CODE
3
ALESSANDRO DE SIMONE, MICHAEL GEORG HOESL, AND NEDILJKO BUDISA
INTRODUCTION 3
ENZYME ACTIVITY OF LIPASES FROM DIFFERENT SOURCES AND ENGINEERING
APPROACHES 4
NONCANONICAL AMINO ACIDS IN LIPASE DESIGN AND ENGINEERING 5
CASE STUDY: MANIPULATING PROLINE, PHENYLALANINE, AND METHIONINE
RESIDUES IN LIPASE 7
UNNATURAL* LIPASES ARE ABLE TO CATALYZE REACTIONS UNDER DIFFERENT
HOSTILE ENVIRONMENTS 8
LIPASE ENGINEERING VIA BIOORTHOGONAL CHEMISTRIES: ACTIVITY AND
IMMOBILIZATION 9
CONCLUSIONS AND PERSPECTIVES 10
REFERENCES 11
SCREENING OF ENZYMES: NOVEL SCREENING TECHNOLOGIES TO EXPLOIT
NONCULTIVATED MICROBES FOR BIOTECHNOLOGY
13
JENNIFER CHOW AND WOLFGANG R. STREIT
INTRODUCTION 13
SEQUENCE- VERSUS FUNCTION-BASED METAGENOMIC APPROACH TO FIND
NOVEL BIOCATALYSTS 14
FUNCTIONAL METAGENOMICS - FROM SINGLE CLONES TO HIGH-THROUGHPUT
SCREENING 16
SCREENING FOR DIFFERENT CLASSES OF ENZYMES 16
EC 1: OXIDOREDUCTASES 17
EC 2: TRANSFERASES 18
EC3: HYDROLASES 19
ALTERNATIVE HOSTS, METATRANSCRIPTOMICS, AND METAPROTEOMICS 25
VIII I
CONTENTS
2.4 FUTURE PERSPECTIVES 26
REFERENCES 27
3 ROBUST BIOCATALYSTS - ROUTES TO NEW DIVERSITY
31
ANNA KRUEGER, SKANDER ELLEUCHE, KERSTIN SAHM, AND GARABED ANTRANIKIAN
3.1 INTRODUCTION 31
3.2 METAGENOMICS TO RETRIEVE NEW GENES FROM EXTREMOPHILIC
MICROORGANISMS 32
3.3 MICROBIAL EXPRESSION HOSTS FOR THE PRODUCTION OF
EXTREMOZYMES 36
3.4 MOLECULAR BIOLOGY APPROACHES FOR ENZYME IMPROVEMENT 39
3.4.1 GENE FUSIONS IN MOLECULAR BIOLOGY 40
3.4.2 SYNERGISM OF FUSION ENZYMES FOR LIGNOCELLULOSE BIOMASS
DEGRADATION 44
3.5 CONCLUSIONS AND FUTURE PERSPECTIVES 45
REFERENCES 46
4 APPLICATION OF HIGH-THROUGHPUT SCREENING IN BIOCATALYSIS
53
XIN JU, LIE ZHANG, KUI CHAN, XIAOLIANG LIANG, JUNHUA TAO, AND JIAN-HE XU
4.1 INTRODUCTION 53
4.2 DISCUSSIONS 54
4.2.1 SCREENING OF KETOREDUCTASES (KREDS) 54
4.2.2 SCREENING OF NITRILASES 56
4.2.3 SCREENING OF OXYGENASES 58
4.2.4 SCREENING OF ALCOHOL OXIDASES 59
4.2.5 SCREENING OF EPOXIDE HYDROLASES 60
4.2.6 SCREENING OF LIPASES AND ESTERASES 60
4.2.7 SCREENING TRANSAMINASES 63
4.2.8 SCREENING OF ALDOLASES 64
4.2.9 SCREENING OF HYDROXYNITRILE LYASES (OXYNITRILASES) 64
4.2.10 SCREENING OF GLYCOSIDE HYDROLASES 66
4.2.11 SCREENING GLYCOSYLTRANSFERASES 66
4.3 SUMMARY
68
REFERENCES 68
5 SUPPORTING BIOCATALYSIS RESEARCH WITH STRUCTURAL BIOINFORMATICS
71
NADINE SCHNEIDER, ANDREA VOLKAMER, EVA NITTINGER, AND MATTHIAS RAREY
5.1 INTRODUCTION 71
5.2 COMPUTATIONAL TOOLS TO ASSIST BIOCATALYSIS RESEARCH 71
5.2.1 COMPUTATIONAL TOOLS FOR PROTEIN ENGINEERING 72
5.2.2 COMPUTATIONAL TOOLS FOR FUNCTION PREDICTION AND ANALYSIS OF
ENZYMES 73
5.3 FROM ACTIVE SITE ANALYSIS TO PROTEIN STABILITY CONSIDERATIONS 75
5.3.1 COMPUTER-AIDED ACTIVE SITE ANALYSIS OF PROTEIN STRUCTURES 76
5.3.1.1 DOGSITE: BINDING SITE DETECTION AND DERIVATION OF REPRESENTATIVE
BINDING SITE DESCRIPTORS 77
5.3.1.2
5.3.2
5.3.3
5.3.3.1
5.3.3.2
5.3.3.3
5.4
5.4.1
5.4.2
5.4.3
5.4.4
5.4.5
5.4.6
5.4.7
5.5
6
6.1
6.2
6.3
6.4
6.5
6.6
6.7
6.8
DOGSITESCORER: DESCRIPTOR-BASED PROTEIN CLASSIFICATION 78
MOLECULAR DOCKING TO ASSIST FUNCTIONAL CHARACTERIZATION OF NEW
ENZYMES
80
ENERGETIC ESTIMATION OF PROTEIN-LIGAND AND PROTEIN-PROTEIN
INTERACTIONS 81
THE CONCEPT BEHIND THE HYDE SCORING FUNCTION 82
HYDE - ESTIMATION OF HYDROGEN BONDING AND DEHYDRATION
ENERGY
83
ESTIMATION OF PROTEIN-PROTEIN INTERACTIONS USING HYDE 84
APPLYING DOGSITESCORER AND HYDE TO BIOCATALYTICAL QUESTIONS 85
ENZYMATIC FUNCTION PREDICTION USING THE DOGSITESCORER 86
DOCKING-BASED FUNCTIONAL PROTEIN CLASSIFICATION 87
PREDICTING POTENTIAL MUTATION SITES USING DOGSITE AND MOLECULAR
MODELING 88
PREDICTING THE POTENTIAL OF A TARGET TO BE MODULATED BY
LOW-MOLECULAR-WEIGHT COMPOUNDS 90
PREDICTION OF COMPETITIVE SUBSTRATE INHIBITION 91
CLASSIFICATION OF BIOLOGICAL AND ARTIFICIAL PROTEIN COMPLEXES 93
AVAILABLE WEB SERVICES TO SUPPORT BIOCATALYSIS RESEARCH 94
CONCLUSION AND FUTURE DIRECTIONS 95
ACKNOWLEDGMENTS 96
REFERENCES 97
ENGINEERING PROTEASES FOR INDUSTRIAL APPLICATIONS
101
LJUBICA VOJCIC, FELIX JAKOB, RONNY MARTINEZ, HENDRIK HELLMUTH, TIMOTHY
O CONNELL, HELGE MUEHL, MICHAEL G. LORENZ, AND ULRICH SCHWANEBERG
PROTEASES IN INDUSTRY 101
SERINE PROTEASES AND SUBTILISINS 102
PROTEASES AS ADDITIVES IN LAUNDRY DETERGENTS 104
ENGINEERING
B. LENTUS ALKALINE PROTEASE TOWARD INCREASED INHIBITION
BY BENZYLMALONIC ACID 105
ENGINEERING SUBTILISIN PROTEASE TOWARD INCREASED OXIDATIVE
RESISTANCE 108
INCREASING PROTEASE TOLERANCE AGAINST CHAOTROPIC AGENTS 111
DIRECTED EVOLUTION OF SUBTILISIN E TOWARD HIGH ACTIVITY IN THE
PRESENCE OF GUANIDINIUM CHLORIDE AND SODIUM DODECYLSULFATE
112
SUMMARY 116
ACKNOWLEDGMENT 116
REFERENCES 117
PART B BIOCATALYTIC SYNTHESIS 121
BIOCATALYTIC SYNTHESIS OF NATURAL PRODUCTS BY
O-METHYLTRANSFERASES
123
LUDGER WESSJOHANN, ANNE-KATRIN BAUER, MARTIN DIPPE, JAKOB LEY, AND
TORSTEN GEISSLER
7.1
7.2
7.3
7.4
7.5
7.6
IN
8
8.1
8.2
8
.
2.1
8
.
2.2
8.2.3
8.2.4
8.3
8.3.1
8.3.2
8.4
8.5
8.6
8.7
8.7.1
8.7.2
8.7.3
8.8
9
9.1
9.1.1
9.1.2
9.1.2.1
9.1.2.2
9.2
INTRODUCTION 123
CLASSIFICATION AND MECHANISTIC ASPECTS OF
O-METHYL TRANSFERASES
124
COFACTOR DEPENDENCE AND REGENERATION 126
NATURAL OMT PRODUCTS IN INDUSTRIAL APPLICATIONS 129
OMTS IN BIOCATALYTIC SYNTHESIS 132
CHALLENGES AND PERSPECTIVES 139
CONCLUSIONS 141
ABBREVIATIONS 141
ACKNOWLEDGMENTS 142
REFERENCES 142
BIOCATALYTIC PHOSPHORYLATION OF METABOLITES
147
DOMINIK GAUSS, BERNHARD SCHOENENBERGER, GETACHEWS. MOLLA, BIRHANU M.
KINFU, JENNIFER CHOW, ANDREAS LIESE, WOLFGANG R. STREIT, AND
ROLAND WOHLGEMUTH
INTRODUCTION 147
SYNTHETIC ASPECTS OF BIOCATALYTIC PHOSPHORYLATIONS 149
BIOCATALYTIC O-PHOSPHORYLATIONS 149
BIOCATALYTIC N-PHOSPHORYLATIONS 151
BIOCATALYTIC C-PHOSPHORYLATIONS 151
BIOCATALYTIC S-PHOSPHORYLATIONS 152
DEVELOPMENT OF ANALYTICAL METHODS 152
SEPARATION METHODOLOGIES 152
SPECTROSCOPIC METHODS 153
STABILITY OF PHOSPHORYLATED METABOLITES 154
PHOSPHATE DONORS 156
EMERGING BIOCATALYTIC PHOSPHORYLATION REACTIONS 157
REACTION ENGINEERING FOR BIOCATALYTIC PHOSPHORYLATION
PROCESSES 160
REACTION SYSTEM OPTIMIZATION 160
REACTION KINETICS OF BIOCATALYTIC PHOSPHORYLATION 164
PROCESS OPTIMIZATION 165
SUMMARY AND OUTLOOK 167
REFERENCES 168
FLAVONOID BIOTECHNOLOGY - NEW WAYS TO HIGH-ADDED-VALUE
COMPOUNDS
179
IOANN IS V. PAVLIDIS, MECHTHILD GALL, TORSTEN GEISSLER, EGON GROSS, AND
UWE T
BORNSCHEUER
FLAVONOIDS 179
FLAVONOIDS CHEMISTRY 179
BIOACTIVITY OF FLAVONOIDS 179
ROLE OF FLAVONOIDS IN PLANTS 179
NUTRITIONAL AND HEALTH BENEFITS FOR HUMAN 181
METABOLIC PATHWAYS OF FLAVONOIDS 182
9.2.1 BIOSYNTHESIS OF FLAVONOIDS IN PLANTS 182
9.2.2 DEGRADATION PATHWAYS 183
9.3 BIOTECHNOLOGICAL PROCESSES FOR THE PRODUCTION OF HIGH-ADDED-VALUE
FLAVONOIDS 186
9.3.1 HOST SYSTEMS FOR THE PRODUCTION OF FLAVONOIDS 187
9.3.2 RECONSTITUTION OF BIOSYNTHETIC PATHWAYS FOR THE PRODUCTION OF
NATURAL OCCURRING FLAVONOIDS 187
9.3.3 PRODUCTION OF HIGH-ADDED-VALUE FLAVONOIDS OR NOVEL (NONNATURALLY
OCCURRING) FLAVONOIDS 189
9.4 FUTURE PROSPECTS 191
ACKNOWLEDGMENTS 192
REFERENCES 192
10 TRANSAMINASES - A BIOSYNTHETIC ROUTE FOR CHIRAL AMINES
199
HENRIKE BRUNDIEK AND MATTHIAS HOEHNE
10.1 INTRODUCTION 199
10.2 BIOCATALYSTS AS ATTRACTIVE ALTERNATIVES TO ACCESS ENANTIOPURE
CHIRAL
AMINES 199
10.3 TRANSAMINASES AS A BIOSYNTHETIC ROUTE FOR CHIRAL AMINES 201
10.4 AMINE TRANSAMINASES (ATAS) FOR THE PRODUCTION OF CHIRAL
AMINES 203
10.4.1 TRANSAMINASE MECHANISM 203
10.4.2 (R)- AND (S)-SELECTIVE ATAS 204
10.5 KINETIC RESOLUTION AND ASYMMETRIC REDUCTIVE AMINATION USING
ATAS 207
10.5.1 KINETIC RESOLUTION OF AMINES EMPLOYING ATAS 207
10.5.2 ASYMMETRIC SYNTHESIS OF AMINES USING ATAS 208
10.5.3 RECENT ADVANCES IN INDUSTRIALLY RELEVANT ASYMMETRIC REDUCTIVE
AMINATION REACTIONS 211
10.5.4 ATA SCREENING KIT 212
10.6 OUTLOOK 213
ACKNOWLEDGMENT 214
REFERENCES 214
11
BIOCATALYTIC PROCESSES FOR THE SYNTHESIS OF CHIRAL ALCOHOLS
219
GAO-WEIZHENG, YAN NI, ANDJIAN-HEXU
11.1 INTRODUCTION 219
11.2 STATIN SIDE CHAIN 220
11.2.1 REDUCTASE AND DEHALOGENASE 220
11.2.2 NITRILASE 223
11.2.3 ALDOLASE 223
11.2.4 LIPASE 224
11.3 O-CHLOROMANDELIC ACID AND ITS DERIVATIVES 226
11.3.1 HYDROXYNITRILE LYASE 226
11.3.2 NITRILASE 227
11.3.3 KETOREDUCTASE 228
11.4 ETHYL 2-HYDROXY-4-PHENYLBUTYRATE 229
11.4.1 LIPASE 229
11.4.2 REDUCTASE 229
11.5 ETHYL 4-CHLORO-3-HYDROXYBUTANOATE 230
11.5.1 KETOREDUCTASE 231
11.5.2 HALOHYDRIN DEHALOGENASE 232
11.6 3-QUINUCLIDINOL 232
11.6.1 PROTEASE 232
11.6.2 KETOREDUCTASE 233
11.7 3-HYDROXY-3-PHENYLPROPANENITRILE 235
11.7.1 LIPASE 235
11.7.2 NITRILASE 236
11.7.3 KETOREDUCTASE
236
11.8 MENTHOL 237
11.9 HALOGEN-SUBSTITUTED 1-PHENYLETHANOL 240
11.9.1 L-(4 -FLUOROPHENYL)ETHANOL 240
11.9.2 2,2,2-TRIFLUORO-1 -PHENYLETHANOL 240
11.9.3 1 - [3 ,5; -BIS-(TRIFLUOROMETHYL)PHENYL] ETHANOL 241
11.9.4 2-CHLORO-1 - PHENYLETHANOL 242
11.9.5 L-(4 -CHLOROPHENYL)ETHANOL 243
11.10 SUMMARY AND OUTLOOK 243
REFERENCES 244
PART C REACTION AND PROCESS ENGINEERING
251
12 INORGANIC ADSORBENTS IN ENZYMATIC PROCESSES
253
ULRICH SOHLING, KIRSTIN SUCK, PATRICK JONCZYK, FRIEDERIKE SANDER, SASCHA
BEUTEL,
THOMAS SCHEPER, AXEL THIEFES, UTE SCHULDT, CLAUDIA ALDENHOVEN, GABRIELLA
EGRI, LARS DAEHNE, ANNAMARIA FIETHEN, HUBERT KUHN, OLIVER WENZEL, HEIKE
TEMME, BERND NIEMEYER, PAUL BUBENHEIM, AND ANDREAS LIESE
12.1 INTRODUCTION 253
12.1.1 INORGANIC ADSORBENTS 254
12.1.1.1 KEROLITE CLAYS 254
12.1.1.2 SYNTHETIC ZEOLITES 254
12.1.1.3 ALUMINUM OXIDE/OXIDE HYDRATE AND AMORPHOUS
ALUMINOSILICATE 257
12.1.1.4 PRECIPITATED SILICA 258
12.2 POROUS INORGANIC ADSORBENTS FOR ENZYME PURIFICATION PROCESSES
(ALUMINA, ALUMINOSILICATES, PRECIPITATED SILICA) 259
12.2.1 INTRODUCTION 259
12.2.2 STATIC ADSORPTION EXPERIMENTS 260
12.2.3 DYNAMIC ADSORPTION SYSTEMS 261
12.2.4 LIPASE AND ESTERASE PURIFICATION FROM CULTURE SUPERNATANTS 262
12.2.5 CONCLUSION 265
12.3 IMMOBILIZATION OF PHOSPHOLIPASE A1 AND A2 FOR THE DEGUMMING OF
EDIBLE OILS 265
12.4 IMMOBILIZATION OF ALCOHOL DEHYDROGENASE A* AND CANDIDA ANTARCTICA
LIPASE B ON PRECIPITATED SILICA BY LAYER-BY-LAYER-TECHNOLOGY 270
12.5 MOLECULAR MODELING CALCULATIONS OF THE ADH-A IMMOBILIZATION
ONTO POLY ELECTROLYTE SURFACES 273
12.5.1 THE POLYETHYLENIMINE LAYER ON THE SUBSTRATE SURFACE 273
12.5.2 MODELING OF THE PHYSISORPTION OF THE ADH-A 274
12.5.3 PREDICTION OF THE ORIENTATIONS OF THE ADH IN THE COVALENTLY
COUPLED
FORM 277
12.5.4 CONCLUSIONS 277
12.6 APPLICATION OF CLAYS AND ZEOLITES FOR ADSORPTION OF EDUCTS AND
PRODUCTS OF REACTIONS WITH ALCOHOL DEHYDROGENASE IN AQUEOUS
REACTION MEDIA 278
12.7 PRODUCT SEPARATION FROM COMPLEX MIXTURES OF BIOCATALYTIC
TRANSFORMATIONS 283
12.7.1 SEPARATION OF DIOLS FROM KETONE-ALCOHOL MIXTURES 283
12.8 CONTINUOUS PRODUCTION AND DISCONTINUOUS SELECTIVE ADSORPTION OF
SHORT-CHAIN ALCOHOLS IN A FIXED-BED REACTOR WITH ALUMINA
OXIDES 287
12.9 SUMMARY AND OUTLOOK 290
ACKNOWLEDGMENT 291
REFERENCES 291
13 INDUSTRIAL APPLICATION OF MEMBRANE CHROMATOGRAPHY FOR THE
PURIFICATION OF ENZYMES
297
SASCHA BEUTEL, LOUIS VILLAIN, AND THOMAS SCHEPER
13.1 INTRODUCTION 297
13.2 MEMBRANE ADSORBER 298
13.2.1 USED MEMBRANE PLATFORM 298
13.2.2 USED FUNCTIONAL GROUPS 299
13.2.3 MEMBRANE ADSORBER MODULE DESIGN FOR BIND&ELUTE
APPLICATION 299
13.3 CASE STUDIES AND USED MODEL ENZYMES 301
13.4 EXPERIMENTAL 302
13.4.1 CHEMICALS 302
13.4.2 MEMBRANE ADSORBER MODULES 302
13.5 CASE STUDY 1: PURIFICATION OF PENICILLIN G AMIDASE 302
13.6 CASE STUDY 2: PURIFICATION OF CELLULASE CEL5A 307
13.7 CASE STUDY 3: PURIFICATION OF LIPASE AGTL 310
13.8 CONCLUSION AND OUTLOOK 313
ACKNOWLEDGMENT 313
REFERENCES 314
14.1
14.1.1
14.1.2
14.1.2.1
14.1.2.2
14.1.2.3
14.2
14.3
14.4
14.4.1
14.4.2
14.5
15
15.1
15.2
15.2.1
15.2.2
15.3
15.3.1
15.3.2
15.3.3
15.4
15.4.1
15.4.2
15.5
16
16.1
FERMENTATION OF LACTIC ACID BACTERIA: STATE OF THE ART AND NEW
PERSPECTIVES
317
RALFPOERTNER, REBECCA FASCHIAN, AND DETLEF GOELLING
INTRODUCTION 317
TAXONOMY AND METABOLISM 317
APPLICATIONS OF LAB 319
LAB IN DAIRY INDUSTRY 319
LAB USED FOR THE PRODUCTION OF LACTIC ACID 320
LAB USED FOR THE PRODUCTION OF 3-HPA 321
FACTORS EFFECTING GROWTH AND PRODUCTIVITY OF LACTIC ACID
BACTERIA 322
FERMENTATION TECHNIQUES FOR GROWTH AND PRODUCTION 323
CASE STUDY: FIXED-BED REACTOR WITH IMMOBILIZED CELLS 328
FIXED-BED REACTOR SYSTEM - PRINCIPLE 328
EXAMPLES FOR FIXED-BED CULTIVATION 330
CONCLUSIONS 335
ACKNOWLEDGMENT 336
REFERENCES 337
THE BUBBLE COLUMN REACTOR: A NOVEL REACTOR TYPE FOR COSMETIC
ESTERS
343
SOEREN BAUM, JAKOB J. MUELLER, LUTZ HILTERHAUS, MARRIT ECKSTEIN, OLIVER
THUM,
AND ANDREAS LIESE
INTRODUCTION 343
BUBBLE COLUMN REACTOR IN COMPARISON TO OTHER REACTOR
TYPES 346
BUBBLE COLUMN REACTOR 346
OTHER REACTOR TYPES FOR THE SYNTHESIS OF COSMETIC ESTERS 348
CASE STUDY: ENZYMATIC PRODUCTION OF COSMETIC ESTERS 349
SYNTHESIS OF HIGH-VISCOUS POLYGLYCEROL-3 LAURATE 349
SYNTHESIS OF LOW-VISCOUS MYRISTYL MYRISTATE 351
SYNTHESIS OF HIGH-VISCOUS -METHYL GLYCOSIDE LAURATE 355
IN SITU ONLINE MEASUREMENTS IN A BUBBLE COLUMN REACTOR BY MEANS
OF FOURIER TRANSFORMED MID-INFRARED SPECTROSCOPY 357
ONLINE MONITORING OF FATTY ACID CONVERSION AND WATER
CONCENTRATION 358
ONLINE MONITORING OF MONO-, DI-, AND TRIGLYCERIDES
COMPOSITION 362
SUMMARY AND OUTLOOK 364
REFERENCES 365
PHARMACEUTICAL INTERMEDIATES BY BIOCATALYSIS: FROM FUNDAMENTAL
SCIENCE TO INDUSTRIAL APPLICATIONS
367
RAMESH N. PATEL
INTRODUCTION 367
16.2 BOCEPREVIR: OXIDATION OF 6,6-DIMETHYL-3-AZABICYCLO[3.1.0]HEXANE BY
MONOAMINE OXIDASE 367
16.3 PREGABALIN: ENZYMATIC PREPARATION OF (S)-3-CYANO-5-METHYLHEXANOIC
ACID ETHYL ESTER 369
16.4 GLUCAGON-LIKE PEPTIDE-1 (GLP-1): ENZYMATIC SYNTHESIS OF
(S)-AMINO-3-[3-{6-(2-METHYLPHENYL)} PYRIDYL]-PROPIONIC ACID 371
16.5 RHINOVIRUS PROTEASE INHIBITOR: ENZYMATIC PREPARATION OF
(R) -3-(4-FLUOROPHENYL)-2-HYDROXY PROPIONIC ACID 373
16.6 SAXAGLIPTIN: ENZYMATIC SYNTHESIS OF
(S) -IV-BOC-3-HYDROXYADAMANTYLGLYCINE 374
16.7 SITAGLIPTIN: ENZYMATIC SYNTHESIS OF CHIRAL AMINE 375
16.8 MONTELUKAST: ENZYMATIC REDUCTION FOR THE SYNTHESIS OF LEUKOTRIENE
D (LTD) 4 ANTAGONISTS 377
16.9 CLOPIDOGREL: ENZYMATIC PREPARATION OF (S)-2-CHLOROMANDELIC ACID
ESTERS 378
16.10 CALCITONIN GENE-RELATED PEPTIDE RECEPTORS ANTAGONIST: ENZYMATIC
PREPARATION OF (R)-2-AMINO-3-(7-METHYL-L H-INDAZOL-5-YL)PROPANOIC
ACID 379
16.11 CHEMOKINE RECEPTOR MODULATORS: ENZYMATIC DESYMMETRIZATION OF
DIMETHYL ESTER 381
16.12 REGIOSELECTIVE ENZYMATIC ACYLATION OF RIBAVIRIN 383
16.13 ATORVASTATIN: ENZYMATIC PREPARATION OF
(R) -4-CYANO-3-HYDROXYBUTYRATE 384
16.14 ATAZANAVIR, TELAPREVIR, BOCEPREVIR: ENZYMATIC SYNTHESIS OF
(S) -TERTIARY-LEUCINE 385
16.15 RELENZA (ZANAMIVIR): ENZYMATIC SYNTHESIS OF AAACETYLNEURAMINIC
ACID 387
16.16 ATORVASTATIN, ROSUVASTATIN: ALDOLASE-CATALYZED SYNTHESIS OF CHIRAL
LACTOL INTERMEDIATES 389
16.17 ANTICANCER DRUGS: EPOTHILONE B AND MICROBIAL HYDROXYLATION OF
EPOTHIOLONE B 390
16.18 CORTICOTROPIN-RELEASING FACTOR-1 (CRF-1) RECEPTOR ANTAGONIST:
ENZYMATIC SYNTHESIS OF
(5)-1 -CYCLOPROPYL-2-METHOXYETHANAMINE 392
16.19 CONCLUSION 393
ACKNOWLEDGMENT 394
REFERENCES 395
17 BIOCATALYSIS TOWARD NEW BIOBASED BUILDING BLOCKS FOR POLYMERIC
MATERIALS
405
KATRIEN BERNAERTS, LUUK MESTROM, AND STEFAAN DE WILDEMAN
17.1 INTRODUCTION 405
17.2 QUESTIONS AND ANSWERS THAT LEAD US TOWARD SUSTAINABILITY IN PLASTIC
MATERIALS 406
17.2.1 HOW DOMINANT ARE THE FOSSIL *EVERGREEN* BUILDING BLOCKS USED
TODAY IN THE BIOECONOMY OF THE FUTURE? 406
17.2.2 HOW MATCHING (TO THEIR APPLICATIONS) ARE THE PLASTICS WE USE
TODAY? 408
17.2.3 HOW DO WE MEASURE ECOLOGICAL IMPACT OF BIOBASED MATERIALS
DERIVED FROM CHEMICALS? 408
17.2.4 HOW GLOBAL CAN A BIOECONOMY BE? 409
17.2.5 HOW COMMODITY LEVEL CAN A NOVEL PLASTIC BE INTRODUCED IN THE
MARKET? 410
17.2.6 HOW ARE BIOBASED PRODUCTS PERCEIVED? 410
17.2.7 *BIOBASED BUILDING BLOCKS HAVE A LARGE POTENTIAL.* WHICH BIOBASED
BUILDING BLOCKS HAVE A LARGE POTENTIAL? 411
17.2.8 NEW RESOURCES - NEW LAWS 412
17.3 CRITERIA AND QUALIFIERS FOR NEW BIOBASED BUILDING BLOCKS FOR
PLASTICS
APPLICATIONS 413
17.4 CRITERIA AND QUALIFIERS FOR LAUNCHING NEW BIOBASED BUILDING BLOCKS
FOR PLASTICS APPLICATIONS IN NEW VALUE CHAINS 414
17.5 POSITION OF BIOBASED BUILDING BLOCKS INNOVATION IN THE PLASTICS
PYRAMID 414
17.6 BIOCATALYSIS CONVERSIONS AND CHALLENGES TOWARD NEWBBBB 415
17.6.1 EC 1: OXIDOREDUCTASES 416
17.6.1.1 REPORTED AND/OR ESTABLISHED BIOCATALYZED REDOX REACTIONS TOWARD
NEWBBBB 417
17.6.1.2 CHALLENGING BUT POTENTIALLY DESIRED BIOCATALYTIC REDOX
REACTIONS
TOWARD NEWBBBB 418
17.6.2 EC 2: TRANSFERASES 420
17.6.3 EC 3: HYDROLASES 420
17.6.4 EC 4: LYASES 421
17.6.4.1 HYDRATASES: BROADER SUBSTRATE SPECTRUM ON UNACTIVATED DOUBLE
BONDS 422
17.6.4.2 CYCLASES 422
17.7 BIOCATALYTIC CASCADE REACTIONS TO FUNCTIONAL BUILDING BLOCKS FOR
MATERIALS 423
17.7.1 EXAMPLE 1: COMPLETE BIOCATALYTIC CONVERSION FROM AMINO ACID
WASTE 423
17.7.2 EXAMPLE 2: ENZYMATIC RESOLUTION AS A TOOL TO UPGRADE THE MATERIAL
PROPERTIES 423
17.7.2.1 EXAMPLE 3: EXPLOITING REGIOSELECTIVE CONTROL FOR NEW BBBBS 423
17.8 CONCLUSION 424
REFERENCES 426
INDEX 429
|
| any_adam_object | 1 |
| author2 | Hilterhaus, Lutz 1978- Liese, Andreas 1966- Kettling, Ulrich Antranikian, Garabed 1951- |
| author2_role | edt edt edt edt |
| author2_variant | l h lh a l al u k uk g a ga |
| author_GND | (DE-588)136187684 (DE-588)12031830X (DE-588)1114309443 (DE-588)109822382 |
| author_facet | Hilterhaus, Lutz 1978- Liese, Andreas 1966- Kettling, Ulrich Antranikian, Garabed 1951- |
| building | Verbundindex |
| bvnumber | BV043645524 |
| classification_rvk | VE 7040 VK 5580 VK 8700 VN 7280 WF 9720 |
| ctrlnum | (OCoLC)959562852 (DE-599)DNB1084600056 |
| dewey-full | 540 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 540 - Chemistry and allied sciences |
| dewey-raw | 540 |
| dewey-search | 540 |
| dewey-sort | 3540 |
| dewey-tens | 540 - Chemistry and allied sciences |
| discipline | Chemie / Pharmazie Biologie |
| format | Book |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV043645524 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T07:31:24Z |
| institution | BVB |
| institution_GND | (DE-588)16179388-5 |
| isbn | 3527336699 9783527336692 9783527677122 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-029059241 |
| oclc_num | 959562852 |
| open_access_boolean | |
| owner | DE-703 DE-83 DE-11 DE-19 DE-BY-UBM |
| owner_facet | DE-703 DE-83 DE-11 DE-19 DE-BY-UBM |
| physical | XXVI, 435 Seiten Illustrationen, Diagramme |
| publishDate | 2016 |
| publishDateSearch | 2016 |
| publishDateSort | 2016 |
| publisher | Wiley-VCH Verlag GmbH & Co. KGaA |
| record_format | marc |
| spelling | Applied biocatalysis from fundamental science to industrial applications edited by Lutz Hilterhaus, Andreas Liese, Ulrich Kettling, and Garabed Antranikian Weinheim Wiley-VCH Verlag GmbH & Co. KGaA [2016] © 2016 XXVI, 435 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Biokatalyse (DE-588)4393622-2 gnd rswk-swf Biocatalysis Biokatalyse Biotechnologie i. d. Chemie Biotechnology Chemie Chemistry Nachhaltige u. Grüne Chemie Sustainable Chemistry & Green Chemistry (DE-588)4143413-4 Aufsatzsammlung gnd-content Biokatalyse (DE-588)4393622-2 s DE-604 Hilterhaus, Lutz 1978- (DE-588)136187684 edt Liese, Andreas 1966- (DE-588)12031830X edt Kettling, Ulrich (DE-588)1114309443 edt Antranikian, Garabed 1951- (DE-588)109822382 edt Wiley-VCH (DE-588)16179388-5 pbl Erscheint auch als Online-Ausgabe, EPUB 978-3-527-67714-6 Erscheint auch als Online-Ausgabe, MOBI 978-3-527-67711-5 Erscheint auch als Online-Ausgabe, PDF 978-3-527-67713-9 http://www.wiley-vch.de/publish/dt/books/ISBN978-3-527-33669-2/ Weitere Informationen DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029059241&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Applied biocatalysis from fundamental science to industrial applications Biokatalyse (DE-588)4393622-2 gnd |
| subject_GND | (DE-588)4393622-2 (DE-588)4143413-4 |
| title | Applied biocatalysis from fundamental science to industrial applications |
| title_auth | Applied biocatalysis from fundamental science to industrial applications |
| title_exact_search | Applied biocatalysis from fundamental science to industrial applications |
| title_full | Applied biocatalysis from fundamental science to industrial applications edited by Lutz Hilterhaus, Andreas Liese, Ulrich Kettling, and Garabed Antranikian |
| title_fullStr | Applied biocatalysis from fundamental science to industrial applications edited by Lutz Hilterhaus, Andreas Liese, Ulrich Kettling, and Garabed Antranikian |
| title_full_unstemmed | Applied biocatalysis from fundamental science to industrial applications edited by Lutz Hilterhaus, Andreas Liese, Ulrich Kettling, and Garabed Antranikian |
| title_short | Applied biocatalysis |
| title_sort | applied biocatalysis from fundamental science to industrial applications |
| title_sub | from fundamental science to industrial applications |
| topic | Biokatalyse (DE-588)4393622-2 gnd |
| topic_facet | Biokatalyse Aufsatzsammlung |
| url | http://www.wiley-vch.de/publish/dt/books/ISBN978-3-527-33669-2/ http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029059241&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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