The HPLC expert: possibilities and limitations of modern high performance liquid chromatography
Gespeichert in:
| Weitere Verfasser: | |
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| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Weinheim
Wiley-VCH
[2016]
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVII, 357 Seiten Diagramme, Illustrationen |
| ISBN: | 9783527336814 9783527677610 |
Internformat
MARC
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| 020 | |a 9783527336814 |c Print |9 978-3-527-33681-4 | ||
| 020 | |a 9783527677610 |c oBook |9 978-3-527-67761-0 | ||
| 035 | |a (OCoLC)934811533 | ||
| 035 | |a (DE-599)DNB108081180X | ||
| 040 | |a DE-604 |b ger |e rda | ||
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| 044 | |a gw |c XA-DE-BW | ||
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| 084 | |a VG 7500 |0 (DE-625)147206:253 |2 rvk | ||
| 100 | 1 | |a Kromidas, Stavros |d 1954- |0 (DE-588)122124685 |4 edt | |
| 245 | 1 | 0 | |a The HPLC expert |b possibilities and limitations of modern high performance liquid chromatography |c edited by Stavros Kromidas |
| 264 | 1 | |a Weinheim |b Wiley-VCH |c [2016] | |
| 264 | 4 | |c © 2016 | |
| 300 | |a XVII, 357 Seiten |b Diagramme, Illustrationen | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 0 | 7 | |a HPLC |0 (DE-588)4072641-1 |2 gnd |9 rswk-swf |
| 653 | |a Chemie | ||
| 653 | |a Chemische Analyse | ||
| 653 | |a Chemistry | ||
| 653 | |a Chromatographie | ||
| 653 | |a Chromatographie / Trennverfahren | ||
| 653 | |a Chromatography / Separation Techniques | ||
| 653 | |a Environmental Analysis | ||
| 653 | |a Flüssigkeitschromatographie | ||
| 653 | |a Pharmaceutical & Medicinal Chemistry | ||
| 653 | |a Pharmazeutische u. Medizinische Chemie | ||
| 653 | |a Trennverfahren | ||
| 653 | |a Umweltanalytik | ||
| 689 | 0 | 0 | |a HPLC |0 (DE-588)4072641-1 |D s |
| 689 | 0 | |5 DE-604 | |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe, EPUB |z 978-3-527-67763-4 |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe, MOBI |z 978-3-527-67764-1 |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe, PDF |z 978-3-527-67762-7 |
| 787 | 0 | 8 | |i In Beziehung stehendes Werk |a Kromidas, Stavros |t The HPLC expert II |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029009051&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-029009051 | ||
Datensatz im Suchindex
| _version_ | 1804176334292779008 |
|---|---|
| adam_text | CONTENTS
LIST OF CONTRIBUTORS X III
THE STRUCTURE O F*THEHPLC*EXPERT* X V
PREFACE X V II
] LC/MSCOUPLING 1
1.1 STATE O FTH E A RT IN LC /M S
1
OLIVERSCHMITZ
1.1.1 INTRO D U CTIO N
1
1.1.2 IONIZATION M ETHODS AT ATM OSPHERIC PRESSURE
3
* *
* * O VERVIEW ABOUT A PI METHODS
4
1.1.2.2 ESI
*
1.1.2.3 A PC I
6
1.1.2.4 APPI 7
1.1.2.5 A PLI 7
1.1.2.6 D ETERM INATION O F ION SUPPRESSION
8
1.1.2.7 BEST IONIZATION FO R EACH QUESTION 9
1.1.3 MASS ANALYZER
9
1.1.4 FUTURE DEVELOPMENTS
11
1.1.5
**
SHOULD YOU LOOK FO R
*
^ BUYING A
1.2 TECHNICAL ASPECTS AND PITFALLS O FL C /M S HYPHENATION
12
MARKUS M. MARTIN
1.2.1 INSTRUM ENTAL CONSIDERATIONS
13
1.2.1.1 DOES YOUR MASS SPECTROMETER FIT YOUR PURPOSE?
13
1.2.1.2 (U)HPLC AND MASS SPECTROM ETRY
17
1.2.2 W HEN LC M ETHODS AND MS CONDITIONS M EET EACH O THER
35
1.2.2.1 FLOW RATE AND PRINCIPLE O F ION FORMATION
35
1.2.2.2 M OBILE PHASE C OM POSITION
37
1.2.3 Q UALITY O F YOUR MASS SPECTRA AND LC /M S CHROMATOGRAMS
39
1.2.3.1 N O SIGNAL AT A LL
40
I.2.3.2
INAPPROPRIATE ION SOURCE SETTINGS AND THEIR IM PACT ON THE
CHROMATOGRAM
41
1.2.3.3 ION SUPPRESSION
43
1.2.3.4 U NKNOW N MASS SIGNALS IN THE MASS SPECTRUM
44
1.2.3.5
194
1.2.5
1.3
13.1
1.3.2
1.3.3
2
2.1
2.1.1
2
.
1.2
2.1.3
914
2.2
2
.
2.1
2.2.2
2
.
2
.
2.1
1222
2.2.2.3
2.2.3
2.3
23.1
23.1.1
2.31.2
2.32
2.3.2.1
2.3.2.2
23.3
23.4
2.34.1
2.3.4.2
2.3.5
23.6
INSTRUM ENTAL REASONS FO R THE M ISINTERPRETATION O F MASS SPECTRA
49
CONCLUSION
51
ABBREVIATIONS
52
LC COUPLED TO M S - A U E R REPORT
53
ALBON MULLER AND ANDREOS HOFMANN
C ONDITIONS O F THE ION CHROMATOGRAPHY
56
GRADIENT GENERATOR
56
TRANSITIONS
56
REFERENCES
58
OPTIM IZATION STRATEGIES IN RP-HPLC
61
FRONKSTEINER
*
STEFAN LAMOTTE, ARIDSTAVROS KROMIDAS
IN TRO D U CTIO N
61
SPEED O F ANALYSIS
61
PEAK RESOLUTION
62
L IM IT O F DETECTION AND L IM IT O F QUANTIFICATION
62
COSTS O F ANALYSIS
63
LC FUNDAMENTALS
64
PEAK RESOLUTION
64
O PTIM IZATION O F EFFICIENCY ( ^ E KINETIC APPROACH)
69
THE TERM DESCRIBING THE EDDY DISPERSION (A-TERM)
71
TERM DESCRIBING THE LONGITUDINAL D IFFUSION O F ANALYTE
MOLECULES (B*TERM) 72
THE TERM DESCRIBING THE HINDRANCE O F ANALYTE MASS TRANSFER
(C*TERM)
72
INFLUENCE O F THE C OLUM N DIMENSION
73
M ETHODOLOGY O F OPTIM IZATION 76
H OW TO O PTIM IZE SELECTIVITY
76
THE ROLE O F SELECTIVITY IN PRACTICAL M ETHOD O PTIM IZATION 77
H OW TO C ONTROL SELECTIVITY IN HPLC?
78
ROLE O F TEMPERATURE IN HPLC
85
RETENTION AND SELECTIVITY C ONTROL VIA TEMPERATURE: POSSIBILITIES AND
LIM ITATIONS
86
SEPARATION ACCELERATION THROUGH TEMPERATURE INCREASE
90
VALUE O F MOBILE PHASE COM POSITION VERSUS TEMPERATURE IN THE
STRIVE FOR O PTIM IZATION IN HPLC
98
ACCELERATING SEPARATIONS THROUGH EFFICIENCY IM PROVEM ENT O F
STATIONARY PHASES
104
SYSTEMATIC SPEED-UP BY O PTIM IZATION O F PARTICLE DIAMETER AND
COLUM N LENGTH
104
M ONOLITHS AND SOLID CORE VERSUS FULLY POROUS PHASE MATERIALS
113
O P TIM IZIN G RESOLUTION BY PARTICLE SIZE AND/OR C OLUM N LENGTH
116
HIGH-RESOLUTION 1D-LC AND 2D-LC TO FULLY EXPLOIT THE
POTENTIAL
120
3.1.1
3.1.2
3.1.3
3.1.4
3.1.4.1
3.1.4.2
3.1.5
3.1.6
3.1.6.1
3.1.6.2
3.1.7
3.2
3.2.1
3.2.1.1
3.2.1.2
3.2.1.3
3.2.1.4
3.2.1.5
3.2.1.6
3.2.1.7
3.2.1.8
3.2.2
3.2.2.1
2.3.6.1
2.3.6.2
2.3.7
2.3.7.1
2.37.2
2.3.8
2.3.8.1
2.3.8.2
2.4
THE 2D -LC APPROACH TO INCREASE PEAK CAPACITIES BEYOND ^ E S E
LIM ITS
121
BOOSTING PEAK CAPACITY IN 1D-LC FURTHER AND H OW THIS TRANSLATES
INTO ANALYTICAL VALUE
127
O PTIM IZATION O F LIM ITS O F DETECTION AND Q UANTIFICATION
131
ABSOLUTE D ETECTION L IM IT (RELATED TO ANALYTE MASS ON
COLUM N)
132
CONCENTRATION D ETECTION L IM IT
134
PRACTICAL GUIDE FO R O PTIM IZATION
135
GENERAL O PTIM IZATION W ORKFLOW AND IM PO RTA N T CONSIDERATIONS AND
PRECAUTIONS
135
O VERVIEW ON VALUABLE RULES AND FORMULA
136
O UTLOOK
*
7
REFERENCES
148
THE GRADIENT IN RP-CHROMATOGRAPHY
151
ASPECTS O F GRADIENT O PTIM IZATION
151
STAVROSKROMIDAS, FRANKSTEINER. AND STEFAN LAMOTTE
INTRO D U CTIO N
151
SPECIAL FEATURES O F THE GRADIENT
151
SOME CHROMATOGRAPHIC D EFINITIONS AND FORMULAS
153
DETECTION L IM IT, PEAK CAPACITY, RESOLUTION: POSSIBILITIES FO R
GRADIENT
O PTIM IZATION
156
DETECTION L IM IT
156
PEAK CAPACITY AND RESOLUTION
158
GRADIENT * M YTHS
162
EXAMPLES FO R THE O PTIM IZATION O F GRADIENT RUNS: SUFFICIENT
RESOLUTION IN AN ADEQUATE TIM E
1*4
A BOUT IRREGULAR COMPONENTS
164
PRELIM INARY REMARKS, GENERAL CONDITIONS
164
G RA D E N T APHORISMS
173
PREDICTION O F GRADIENTS
177
HANS-JOACHIM KUSS
LINEAR M ODEL: PREDICTION FRO M TWO CHROMATOGRAMS
177
W HAT DOES THE RETENTION FACTOR
K
TELL US?
178
^^HAT DO THE TWO RETENTION FACTORS
*
AND MEAN?
181
H OW DOES THE INTEGRATION- AND C ONTROL SYSTEM SEE THE
GRADIENT?
182
H OW DOES THE HPLC*C OLUM N SEE THE GRADIENT?
182
H OW DO THE SUBSTANCES TO BE ANALYZED SEE THE GRADIENT?
183
INTERPRETATION O F THE LN(*S) TO
0/0*
GRAPH
183
INSTRUM ENTAL GRADIENT DELAY (DWELL TIME)
185
EXTENSION O F THE GRADIENT DOWNWARDS BY CONSTANT SLOPE
*89
C URVILINEAR M ODEL: M ORE THAN TWO IN P U T IH ROM ATOGRAM S
189
LN (/:)*STRAIGHT LINES ARE OFTEN NOT STRAIGHT AT A LL
189
3
3
3.2.2.2 1
*
(/
*
) TO
0/0*
FIT ACCORDING TO NEUE
190
3.2.2.3 PREDICTIONS W ITH EXCEL
193
3.2.2.4 THE INTERACTION IS TEMPERATURE DEPENDANT
194
3.2.2.5 O PTIM IZATION PAAMETERS
195
3.2.2.6 COMMERCIAL O PTIM IZATION PROGRAMS
195
3.2.2.7
H OW ACCURATE M UST THE PREDICTION
OIKG
AND
KE
BE?
197
3.2.3 H OW TO A CT SYSTEMATICALLY?
198
3.2.4 LIST O F ABBREVIATIONS
199
REFERENCES
200
4 COMPARISON AND SELECTION OF MODERN HPLC COLUMNS
203
STEFAN LAMOTTE, STAVROS KROMIDASF AND FRANK STEINER
4.1 SUPPORTS
203
4.1.1 W H Y SILICA GEL? 2*4
4.2 STATIONARY PHASES FOR THE HPLC: H ISTORICAL DEVELOPMENT
20S
4.3 PH STABILITY AND RESTRICTIONS IN THE USE O F SILICA
208
4.4 THE KEY PROPERTIES O F REVERSED PHASES
209
4.4.1 THE H YDROPHOBICITY O F REVERSED PHASES
209
4.4.2 HYDROPHOBIC SELECTIVITY
210
4.4.3 SILANOPHILIC A C TIV ITY
210
4.4.4 SHAPE SELECTIVITY (M OLECULAR SHAPE RECOGNITION)
211
4.4.4.1 W HY IS * I S SO?
211
4.4.5 THE POLAR SELECTIVITY
211
4.4.6 THE M ETAL CONTENT
212
4.5 CHARACTERIZATION AND CLASSIFICATION O F REVERSED PHASES
212
4.5.1 THE SIGNIFICANCE O F RETENTION AND SELECTIVITY FACTORS IN COLUM N
TESTS
216
4.5.1.1 PRELIM INARY REMARK
216
4.5.1.2 C RITERIA FO R THE COMPARISON O F COLUMNS
216
4.5.2 C OLUM N COMPARISON, COMPARISON C RITE RIA S IM ILARITY O F
SELECTIVITIES
220
4.5.3 TWO SIMPLE TESTS FOR THE CHARACTERIZATION O F RP PHASES
223
4.5.3.1 774
4.5.3.2 TEST 2
224
4.6 PROCEDURE FOR PRACTICAL M ETHOD DEVELOPMENT
224
4.6.1 INTERACTION BETWEEN M OBILE AND STATIONARY PHASE
224
4.6.1.1 W H Y LS T H IS ? 225
4.6.2 W HICH COLUMNS SHOULD BE USED, AND H OW DO I USE ^ E M ?
226
4.6.3 W HAT TO DO, W HEN THE ANALYTES ARE VERY POLAR AND ARE NOT
RETAINED ON THE ABOVE-MENTIONED COLUMNS?
229
4.6.3.1 A Q COLUMNS, POLAR RP COLUMNS, AND ION-PAIR
CHROMATOGRAPHY
229
4.6.3.2 M IXED-M ODE COLUMNS
231
4.6.3.3 ION-EXCHANGE COLUMNS/LIGAND-EXCHANGE CHROMATOGRAPHY
232
4.6.3.4 H IL IC (H YDROPHILIC INTERACTION LIQUID CHROMATOGRAPHY)
232
CONTENTS
IIX
4.6.3.5 POROUS CARBON
233
4.7 C OLUM N SCREENING
234
4.8 C OLUM N DATABASES
239
REFERENCES
240
5 INTRODUCTION TO BIOCHROMATOGRAPHY
243
SURGEN MAIER-ROSENKRANZ
5.1 IN TRO D U CTIO N
243
5.2 O VERVIEW O FTH E STATIONARY PHASES
245
5.2.1 BASE MATERIALS
246
5.2.2 CHARACTERIZATION O F STATIONARY PHASES
246
5.2.21
PARTICLE FORM
247
5.2.2.2 PARTICLE SIZE
247
5.2.2.3 PORE SIZE AND SURFACE
249
5.2.2.4 LOADING DENSITY
250
5.2.2.5 P URITY 257
5.2.2.O FUNCTIONAL GROUP
252
5.3 REVERSED-PHASE CHROMATOGRAPHY O F PEPTIDES AND PROTEINS
252
5.3.1 RETENTION BEHAVIOR O F PEPTIDES AND PROTEINS
252
5.3.2 GRADIENT DESIGN
252
5.3.3 ORGANIC M O D IFIE R
254
5.3.4 ION PAIR REAGENT
255
5.3.5 INFLUENCE O F THE PH VALUE
255
5.3.6 PORE SIZE
256
5.3.7 BONDING C HEM ISTRY
257
5.4 IEC CHROMATOGRAPHY O F PEPTIDES AND PROTEINS
257
5.4.1 IEC PARAMETERS
259
*
.4.1.1 IONIC STRENGTH O F THE SAMPLE
259
5.4.1.2 BUFFER CONCENTRATION O F THE ELUENT
259
5.4.1.3 PH V ALUE
259
5.4.1.4 ORGANIC M O D IFIE R
259
5.4.1.5 TEMPERATURE
259
5.4.1.6 FLOW RATE
260
5.4.1.7 PORE SIZE
260
5.4.1.8 LOADING AND INJECTION VOLUME
260
5.5 SIZE-EXCLUSION CHROMATOGRAPHY O F PEPTIDES AND PROTEINS
261
5.5.1 SEC PARAMETERS
263
5.5.1.1 PARTICLE SIZE
263
5.5.1.2 PORE SIZE D ISTRIB U TIO N
263
5.5.1.3 PORE VOLUME
264
5.5.1.4 FLOW RATE
264
5.5.1.5 TEMPERATURE
264
5.5.1.6 VISCOSITY
264
5 .5 1 7 LOADING AND INJECTION VOLUME
264
5.6 FURTHER TYPES O F CHROMATOGRAPHY * B RIEF DESCRIPTIONS
264
5.6.1
5.6.2
5.63
5.7
*
6.1
6.2
6.3
6.4
6.5
6.6
6.7
6.8
6.9
6.9.1
6.9.2
6.9.3
6.9.4
6.9.5
6.9.6
6.9.7
6.10
6
.
10.1
6
.
10.2
6.10.3
6.11
6.11.1
6.11.2
6.11.3
6.11.4
6.12
6.12.1
6.13
H YDROPHOBIC INTERACTION CHROMATOGRAPHY
264
H YDROPHILIC INTERACTION CHROMATOGRAPHY
264
A FFIN ITY C HROMATOGRAPHY (AC)
265
SUMMARY
266
COMPARISON OF MODERN CHROMATOGRAPHIC DATA SYSTEMS
267
ARNO SIMON
IN TRO D U CTIO N
267
THE FORERUNNERS FOR CDS
267
CDS TODAY
268
ADVANTAGES AND DISADVANTAGES O F FILE-BASED CDS
268
ADVANTAGES AND DISADVANTAGES O F DATABASE-SUPPORTED
CDS
269
CDS IN A N ETW ORK ENVIRONM ENT
270
INSTRUM ENT C ONTROL
271
D OCUM ENTATION AND COMPLIANCE
272
B RIEF OVERVIEW O F CURRENT SYSTEMS
273
ATLAS
273
CHEMSTATION
273
A GILENT OPENLAB CDS
274
CHROMELEON
274
EMPOWER
274
EZCHROM
274
TABULAR COMPARISON O F EMPOWER AND CHROMELEON
275
THE CDS O F TOM ORROW
277
MS INTEGRATION 277
LARGE INSTALLATION
278
EASY AND INTUITIVE USABILITY
279
SPECIAL EXTENSIONS
279
SUPPORT O F PEAK INTEGRATION
279
C OLUM N A DM INISTRATION
280
INSTRUM ENT USAGE
280
CONNECTION O F BALANCES
281
OPEN INTERFACES
282
INSTRUM ENT INTEGRATION
282
I CDS IN 20 YEARS
283
ACKNOWLEDGM ENT
283
POSSIBILITIES OF INTEGRATION TODAY
285
MIKEHIUEBRAND
PEAK OVERLAY - EFFECT ON THE CHROMATOGRAM
285
SEPARATION TECHNIQUES FO R HIGHER-LEVEL PEAKS
286
LOT M ETHOD
286
E RROR BY THE VERTICAL SKIM OVERLAPPING PEAKS (AREA RULES TO V.R.
MEYER)
287
1
2
.
1
.
2
.
2
.
.
2
.
7
7
7
7
8.4.1
49
8.5
9
9.1
*
9
9.2.1
*
9 9
9.2.3
9.2.4
9.2.5
9.2.6
9.3
9.4
9.4.1
9.4.2
9.4.3
9 4.4
*
.9.4
TANGENTIAL AND VALLEY*TO *VALLEY SEPARATION M ETHOD
288
GAUSSIAN AND EXPONENTIAL SEPARATION M ETHOD
288
A PPLICATION O F SEPARATION M ETHODS
288
C HROM ATOGRAM M SIM ULATION
289
DECONVOLUTION
290
EVALUATION O F SEPARATION M ETHODS
292
PRACTICAL A PPLICATION O F DECONVOLUTION
294
REFERENCES
299
SMART DOCUMENTATION STRATEGIES
301
STEFAN SCHMITZ
INTRO D U CTIO N
301
OBJECTIVES O F DOCUM ENTATION
303
DOCUM ENTATION FROM THE ORGANIZATIONAL POINT O F VIEW
304
D OCUM ENTATION FROM THE PROCESS POINT O F VIEW
305
D OCUM ENTATION FROM THE COM M UNICATION POINT O F VIEW
307
D OCUM ENTATION FROM THE INFORM ATION POINT O F VIEW
309
D OCUM ENTATION FROM THE KNOWLEDGE STORAGE POINT O F VIEW
310
REGULATORY REQUIREMENTS FO R LABORATORY D OCUM ENTATION
314
THE LIFE CYCLE M ODEL FOR REGULATED DOCUMENTS IN PRACTICE
315
DEALING W ITH H YBRID SYSTEMS C OM PRISING PAPER AND ELECTRONIC
RECORDS
317
ADVANTAGES AND DISADVANTAGES O F PAPER VERSUS ELECTRONIC
DOCUMENTS
317
IM PLEM ENTATION STRATEGY
319
PREVIEW
*9*
REFERENCES
321
TIPS FOR A SUCCESSFUL FDA INSPECTION
323
STEFAN SCHMITZ AND IRIS RETZKO
INTRO D U CTIO N
323
PREPARATION W ITH THE INSPECTION M ODEL
324
MATERIALS, REAGENTS, AND R EFEE^
325
FACILITIES AND EQUIPM ENT *
LABORATORY CONTROLS
328
PERSONNEL
Y G
Q UALITY MANAGEMENT
330
DOCUMENTS AND RECORDS
332
TYPICAL COURSE O F AN FDA INSPECTION
333
D URING THE INSPECTION
33* )
BEHAVIOR IN INSPECTIONS
336
LAB W ALKTHROUGH
338
THE INSPECTION IN THE A U D IT ROOM (FRONT OFFICE)
338
DEALING W ITH OBVIOUSLY SERIOUS OBSERVATIONS
339
D OCUM ENTATION O F OBSERVATIONS ON FORM FDA 483
340
3
4
1
2
3
4
5
6
2
2
3
4
5
6
7
1
2
2
2
2
2
2
2
3
4
7
*
7.
7
*
7
7
8
*
*
8
8
8
8
8
8
8
*
*
*
*
9.5 POST-PROCESSING O F THE INSPECTION
341
FURTHER READINGS
341
IN HPLC-LINKLIST
343
TORSTEN BEYER
10.1 CHEMICAL DATA
343
10.2 APPLICATIONS/M ETHODS
344
10.2.1 A UTHORITIES AND INSTITUTIONS
344
10.2.2 MANUFACTURERS O F ANALYTICAL INSTRUM ENTS AND COLUMNS
344
10.2.3 JOURNALS AND WEB PORTALS
345
10.3 TROUBLESHOOTING
345
10.4 BACKGROUND INFORM ATION AND ^ E O R Y
346
10.5 LITERATURE
347
10.5.1 PUBLISHING COMPANIES FO R JOURNALS, BOOKS
*
AND DATABASES
347
10.5.2 SCIENTIFIC JOURNALS (FULL ACCESS W ITH COSTS)
347
10.5.3 OPENACCESS JOURNALS
349
10.5.4 FREE COMMERCIAL JOURNALS AND WEB PAGES W ITH FOCUS ON
CHROMATOGRAPHY
349
10.5.5 LITERATURE SEARCH ENGINES
350
10.6 DATABASES W ITH COSTS
350
10.6.1 STN DATABASES
350
10.6.2 DATA ON CHEMICAL M EDIA
350
10.6.3 LITERATURE
350
10.7 APPS
350
10.8 SOCIAL MEDIA
351
10.9 T W ITTE R PAGES (EXAMPLES)
351
10.10 FACEBOOK PAGES (EXAMPLES)
351
INDEX
353
|
| any_adam_object | 1 |
| author2 | Kromidas, Stavros 1954- |
| author2_role | edt |
| author2_variant | s k sk |
| author_GND | (DE-588)122124685 |
| author_facet | Kromidas, Stavros 1954- |
| building | Verbundindex |
| bvnumber | BV043594749 |
| classification_rvk | VG 7500 |
| ctrlnum | (OCoLC)934811533 (DE-599)DNB108081180X |
| dewey-full | 540 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 540 - Chemistry and allied sciences |
| dewey-raw | 540 |
| dewey-search | 540 |
| dewey-sort | 3540 |
| dewey-tens | 540 - Chemistry and allied sciences |
| discipline | Chemie / Pharmazie |
| format | Book |
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| id | DE-604.BV043594749 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T07:30:32Z |
| institution | BVB |
| isbn | 9783527336814 9783527677610 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-029009051 |
| oclc_num | 934811533 |
| open_access_boolean | |
| owner | DE-11 |
| owner_facet | DE-11 |
| physical | XVII, 357 Seiten Diagramme, Illustrationen |
| publishDate | 2016 |
| publishDateSearch | 2016 |
| publishDateSort | 2016 |
| publisher | Wiley-VCH |
| record_format | marc |
| spelling | Kromidas, Stavros 1954- (DE-588)122124685 edt The HPLC expert possibilities and limitations of modern high performance liquid chromatography edited by Stavros Kromidas Weinheim Wiley-VCH [2016] © 2016 XVII, 357 Seiten Diagramme, Illustrationen txt rdacontent n rdamedia nc rdacarrier HPLC (DE-588)4072641-1 gnd rswk-swf Chemie Chemische Analyse Chemistry Chromatographie Chromatographie / Trennverfahren Chromatography / Separation Techniques Environmental Analysis Flüssigkeitschromatographie Pharmaceutical & Medicinal Chemistry Pharmazeutische u. Medizinische Chemie Trennverfahren Umweltanalytik HPLC (DE-588)4072641-1 s DE-604 Erscheint auch als Online-Ausgabe, EPUB 978-3-527-67763-4 Erscheint auch als Online-Ausgabe, MOBI 978-3-527-67764-1 Erscheint auch als Online-Ausgabe, PDF 978-3-527-67762-7 In Beziehung stehendes Werk Kromidas, Stavros The HPLC expert II DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029009051&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | The HPLC expert possibilities and limitations of modern high performance liquid chromatography HPLC (DE-588)4072641-1 gnd |
| subject_GND | (DE-588)4072641-1 |
| title | The HPLC expert possibilities and limitations of modern high performance liquid chromatography |
| title_auth | The HPLC expert possibilities and limitations of modern high performance liquid chromatography |
| title_exact_search | The HPLC expert possibilities and limitations of modern high performance liquid chromatography |
| title_full | The HPLC expert possibilities and limitations of modern high performance liquid chromatography edited by Stavros Kromidas |
| title_fullStr | The HPLC expert possibilities and limitations of modern high performance liquid chromatography edited by Stavros Kromidas |
| title_full_unstemmed | The HPLC expert possibilities and limitations of modern high performance liquid chromatography edited by Stavros Kromidas |
| title_short | The HPLC expert |
| title_sort | the hplc expert possibilities and limitations of modern high performance liquid chromatography |
| title_sub | possibilities and limitations of modern high performance liquid chromatography |
| topic | HPLC (DE-588)4072641-1 gnd |
| topic_facet | HPLC |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029009051&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT kromidasstavros thehplcexpertpossibilitiesandlimitationsofmodernhighperformanceliquidchromatography |