The Role of Microenvironment in the Control of Tumor Angiogenesis:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Cham
Springer International Publishing
2016
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| Ausgabe: | 1st ed. 2016 |
| Schlagworte: | |
| Online-Zugang: | BTU01 HTW01 UBR01 URL des Erstveröffentlichers Inhaltsverzeichnis Abstract |
| Beschreibung: | 1 Online-Ressource (XI, 86 p. 28 illus., 12 illus. in color) |
| ISBN: | 9783319278209 |
| DOI: | 10.1007/978-3-319-27820-9 |
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Datensatz im Suchindex
| _version_ | 1804176208660791296 |
|---|---|
| adam_text | THE ROLE OF MICROENVIRONMENT IN THE CONTROL OF TUMOR ANGIOGENESIS
/ RIBATTI, DOMENICO
: 2016
TABLE OF CONTENTS / INHALTSVERZEICHNIS
PRELIMS
TUMOR MICROENVIRONMENT
TUMOR BLOOD VESSELS AND TUMOR ENDOTHELIAL CELLS
TUMOR ANGIOGENESIS
INFLAMMATORY CELLS IN TUMOR MICROENVIRONMENT
THERAPEUTIC STRATEGIES, THE CONCEPT OF “NORMALIZATION” AND THE ROLE
OF VEGF INHIBITION
INDEX.
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
THE ROLE OF MICROENVIRONMENT IN THE CONTROL OF TUMOR ANGIOGENESIS
/ RIBATTI, DOMENICO
: 2016
ABSTRACT / INHALTSTEXT
THIS WORK DESCRIBES THE IMPORTANCE OF TUMOR MICROENVIRONMENT IN
FAVOURING TUMOR PROGRESSION AND ANGIOGENESIS. UNDER PHYSIOLOGICAL
CONDITIONS, ANGIOGENESIS IS DEPENDENT ON THE BALANCE OF POSITIVE AND
NEGATIVE ANGIOGENIC MODULATORS WITHIN THE VASCULAR MICROENVIRONMENT AND
REQUIRES THE FUNCTIONAL ACTIVITIES OF A NUMBER OF MOLECULES, INCLUDING
ANGIOGENIC FACTORS, EXTRACELLULAR MATRIX PROTEINS, ADHESION MOLECULES
AND PROTEOLYTIC ENZYMES. IN NORMAL TISSUES, VASCULAR QUIESCENCE IS
MAINTAINED BY THE DOMINANT INFLUENCE OF ENDOGENOUS ANGIOGENESIS
INHIBITORS OVER ANGIOGENIC STIMULI. TUMOR ANGIOGENESIS IS LINKED TO A
SWITCH IN THE BALANCE BETWEEN POSITIVE AND NEGATIVE REGULATORS, AND
MAINLY DEPENDS ON THE RELEASE BY INFLAMMATORY OR NEOPLASTIC CELLS OF
SPECIFIC GROWTH FACTORS FOR ENDOTHELIAL CELLS, THAT STIMULATE THE GROWTH
OF THE BLOOD VESSELS OF THE HOST OR THE DOWN-REGULATION OF NATURAL
ANGIOGENESIS INHIBITORS. IN PARTICULAR, THE INFLAMMATORY INFILTRATE MAY
CONTRIBUTE TO TUMOR ANGIOGENESIS, AND THERE ARE MANY REPORTS OF
ASSOCIATIONS BETWEEN TUMOR INFLAMMATORY INFILTRATE, VASCULARITY AND
PROGNOSIS. NEW THERAPEUTIC APPROACHES HAVE BEEN DEVELOPED WITH THE AIM
TO CONTROL TUMOR ANGIOGENESIS THROUGH TARGETING OF DIFFERENT COMPONENTS
OF TUMOR MICROENVIRONMENT
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
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| edition | 1st ed. 2016 |
| format | Electronic eBook |
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| spelling | Ribatti, Domenico Verfasser aut The Role of Microenvironment in the Control of Tumor Angiogenesis by Domenico Ribatti 1st ed. 2016 Cham Springer International Publishing 2016 1 Online-Ressource (XI, 86 p. 28 illus., 12 illus. in color) txt rdacontent c rdamedia cr rdacarrier Medicine Cancer research Oncology Pathology Pharmacotherapy Biomedicine Cancer Research Medizin Erscheint auch als Druckausgabe 978-3-319-27818-6 https://doi.org/10.1007/978-3-319-27820-9 Verlag URL des Erstveröffentlichers Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028962446&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028962446&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract |
| spellingShingle | Ribatti, Domenico The Role of Microenvironment in the Control of Tumor Angiogenesis Medicine Cancer research Oncology Pathology Pharmacotherapy Biomedicine Cancer Research Medizin |
| title | The Role of Microenvironment in the Control of Tumor Angiogenesis |
| title_auth | The Role of Microenvironment in the Control of Tumor Angiogenesis |
| title_exact_search | The Role of Microenvironment in the Control of Tumor Angiogenesis |
| title_full | The Role of Microenvironment in the Control of Tumor Angiogenesis by Domenico Ribatti |
| title_fullStr | The Role of Microenvironment in the Control of Tumor Angiogenesis by Domenico Ribatti |
| title_full_unstemmed | The Role of Microenvironment in the Control of Tumor Angiogenesis by Domenico Ribatti |
| title_short | The Role of Microenvironment in the Control of Tumor Angiogenesis |
| title_sort | the role of microenvironment in the control of tumor angiogenesis |
| topic | Medicine Cancer research Oncology Pathology Pharmacotherapy Biomedicine Cancer Research Medizin |
| topic_facet | Medicine Cancer research Oncology Pathology Pharmacotherapy Biomedicine Cancer Research Medizin |
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