The Initiation of DNA Replication in Eukaryotes:
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Cham
Springer International Publishing
2016
|
| Ausgabe: | 1st ed. 2016 |
| Schlagworte: | |
| Online-Zugang: | BTU01 HTW01 UBR01 Volltext Inhaltsverzeichnis Abstract |
| Beschreibung: | 1 Online-Ressource (XII, 563 p. 87 illus., 3 illus. in color) |
| ISBN: | 9783319246963 |
| DOI: | 10.1007/978-3-319-24696-3 |
Internformat
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Datensatz im Suchindex
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| adam_text | THE INITIATION OF DNA REPLICATION IN EUKARYOTES
/
: 2016
TABLE OF CONTENTS / INHALTSVERZEICHNIS
1. INTRODUCTION TO DNA REPLICATION INITIATION IN EUKARYOTES
2. CHOICE OF ORIGINS AND REPLICATION TIMING CONTROL IN YEAST
3. REPLICATION TIMING AND INITIATION IN METAZOANS.-4. REPLICATION
TIMING GRADIENTS AND ORIGIN ACTIVATION
5. GENOME WIDE LOCALIZATION OF REPLICATION INITIATION FACTORS
6. GENOME SCALE ANALYSIS OF METAOZOAN REPLICATION ORIGINS
7. ROLE OF DORMANT ORIGINS IN REPLICATION INITIATION
8. CENTROMERES AND DNA REPLICATION INITIATION
9. RIF1 REGULATION OF REPLICATION TIMING
10. ROLE OF ORC IN REPLICATION INITIATION.-11. LICENSING OF
REPLICATION ORIGINS- LOADING MCM2-7
12. ROLE OF CHROMATIN IN REPLICATION INITIATION
13. ROLE OF MCM2-7 IN REPLICATION INITIATION
14. ROLE OF CDK IN REPLICATION INITIATION
15. ROLE OF DDK IN REPLICATION INITIATION
16. ROLES OF SLD2, SLD3, AND DPB11 IN REPLICATION INITIATION
17. ROLE OF MCM10 IN REPLICATION INITIATION
18. ROLE OF POST-TRANSLATIONAL MODIFICATIONS IN REPLICATION INITIATION
19. ASSEMBLY OF THE CDC45-MCM2-7-GINS COMPLEX, THE REPLICATION
HELICASE.-20.ACTIVITY OF THE CDC45-MCM2-7-GINS COMPLEX, THE
REPLICATION HELICASE
21. STRUCTURE FUNCTION STUDIES OF REPLICATION INITIATION FACTORS
22. POL-ALPHA ACTIVATION AND COUPLING WITH HELICASE UNWINDING
23. REPLICATION INITIATION AND DNA DAMAGE
24. PROTEIN PHOSPHATASES AND REPLICATION INITIATION
25. SPINDLE CHECKPOINTS AND REPLICATION INITIATION.-26.PROTEIN
DEGRADATION AND REPLICATION INITIATION
27. BREAK-INDUCED REPLICATION.-27.MEIER GORLIN SYNDROME
28. REPLICATION STRESS AND CANCER
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
THE INITIATION OF DNA REPLICATION IN EUKARYOTES
/
: 2016
ABSTRACT / INHALTSTEXT
EVERY TIME A CELL DIVIDES, A COPY OF ITS GENOMIC DNA HAS TO BE
FAITHFULLY COPIED TO GENERATE NEW GENOMIC DNA FOR THE DAUGHTER CELLS.
THE PROCESS OF DNA REPLICATION NEEDS TO BE PRECISELY REGULATED TO ENSURE
THAT REPLICATION OF THE GENOME IS COMPLETE AND ACCURATE, BUT THAT
RE-REPLICATION DOES NOT OCCUR. ERRORS IN DNA REPLICATION CAN LEAD TO
GENOME INSTABILITY AND CANCER. THE PROCESS OF REPLICATION INITIATION
IS OF PARAMOUNT IMPORTANCE, BECAUSE ONCE THE CELL IS COMMITTED TO
REPLICATE DNA, IT MUST FINISH THIS PROCESS. A GREAT DEAL OF PROGRESS
HAS BEEN MADE IN UNDERSTANDING HOW DNA REPLICATION IS INITIATED IN
EUKARYOTIC CELLS IN THE PAST TEN YEARS, BUT THIS IS THE FIRST ONE-SOURCE
BOOK ON THESE FINDINGS. THE INITIATION OF DNA REPLICATION IN
EUKARYOTES WILL FOCUS ON HOW DNA REPLICATION IS INITIATED IN EUKARYOTIC
CELLS. WHILE THE CONCEPT OF REPLICATION INITIATION IS SIMPLE, ITS
ELABORATE REGULATION AND INTEGRATION WITH OTHER CELL PROCESSES RESULTS
IN A HIGH LEVEL OF COMPLEXITY. THIS BOOK WILL COVER HOW THE POSITION
OF REPLICATION INITIATION IS CHOSEN, HOW REPLICATION INITIATION IS
INTEGRATED WITH THE PHASES OF THE CELL CYCLE, AND HOW IT IS REGULATED IN
THE CASE OF DAMAGE TO DNA. IT IS THE CELLULAR PROTEIN MACHINERY THAT
ENABLES REPLICATION INITIATION TO BE ACTIVATED AND REGULATED. WE NOW
HAVE AN IN-DEPTH UNDERSTANDING OF HOW CELLULAR PROTEINS WORK TOGETHER TO
START DNA REPLICATION, AND THIS NEW RESOURCE WILL REVEAL A MECHANISTIC
DESCRIPTION OF DNA REPLICATION INITIATION AS WELL
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
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| indexdate | 2024-07-10T07:28:32Z |
| institution | BVB |
| isbn | 9783319246963 |
| language | English |
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| spelling | The Initiation of DNA Replication in Eukaryotes edited by Daniel L. Kaplan 1st ed. 2016 Cham Springer International Publishing 2016 1 Online-Ressource (XII, 563 p. 87 illus., 3 illus. in color) txt rdacontent c rdamedia cr rdacarrier Medicine Human genetics Systems biology Microbial genetics Microbial genomics Biomedicine Human Genetics Systems Biology Microbial Genetics and Genomics Medizin Kaplan, Daniel L. Sonstige oth Erscheint auch als Druckausgabe 978-3-319-24694-9 https://doi.org/10.1007/978-3-319-24696-3 Verlag URL des Erstveröffentlichers Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028962378&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028962378&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract |
| spellingShingle | The Initiation of DNA Replication in Eukaryotes Medicine Human genetics Systems biology Microbial genetics Microbial genomics Biomedicine Human Genetics Systems Biology Microbial Genetics and Genomics Medizin |
| title | The Initiation of DNA Replication in Eukaryotes |
| title_auth | The Initiation of DNA Replication in Eukaryotes |
| title_exact_search | The Initiation of DNA Replication in Eukaryotes |
| title_full | The Initiation of DNA Replication in Eukaryotes edited by Daniel L. Kaplan |
| title_fullStr | The Initiation of DNA Replication in Eukaryotes edited by Daniel L. Kaplan |
| title_full_unstemmed | The Initiation of DNA Replication in Eukaryotes edited by Daniel L. Kaplan |
| title_short | The Initiation of DNA Replication in Eukaryotes |
| title_sort | the initiation of dna replication in eukaryotes |
| topic | Medicine Human genetics Systems biology Microbial genetics Microbial genomics Biomedicine Human Genetics Systems Biology Microbial Genetics and Genomics Medizin |
| topic_facet | Medicine Human genetics Systems biology Microbial genetics Microbial genomics Biomedicine Human Genetics Systems Biology Microbial Genetics and Genomics Medizin |
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