Opioid receptors as therapeutic targets for nociceptor specific regional analgesia: = Opioidrezeptoren als therapeutisches Target einer nozizeptionsspezifischen Regionalanalgesie
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| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Würzburg
16th December 2015
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| Schlagworte: | |
| Online-Zugang: | kostenfrei Inhaltsverzeichnis |
| Beschreibung: | 94 Blatt Illustrationen, Diagramme |
Internformat
MARC
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| 245 | 1 | 0 | |a Opioid receptors as therapeutic targets for nociceptor specific regional analgesia |b = Opioidrezeptoren als therapeutisches Target einer nozizeptionsspezifischen Regionalanalgesie |c vorgelegt von Egle Maria Mambretti from Monza, Italy |
| 246 | 1 | 1 | |a Opioidrezeptoren als therapeutisches Target einer nozizeptionsspezifischen Regionalanalgesie |
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Datensatz im Suchindex
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| adam_text | OP*O*D RECEPTORS AS THERAPEUTIC TARGETS
FOR NOCICEPTOR SPECIFIC REGIONAL ANALGESIA
OPIOIDREZEPTOREN ALS THERAPEUTISCHES TARGET
EINER NOZIZEPTIONSSPEZIFISCHEN REGIONALANALGESIE
DOCTORAL THESIS FOR A DOCTORAL DEGREE
AT THE GRADUATE SCHOOL OF LIFE SCIENCES,
JULIUS-MAXIMILIANS-UNIVERSITAT WUERZBURG,
SECTION NEUROSCIENCE
SUBMITTED BY
EGLE MARIA MAMBRETTI
FROM
MONZA, ITALY
WURZBURG, 16TH DECEMBER 2015
TABLE OF CONTENTS
ABBREVIATION 8
SUMMARY 10
ZUSAMMENFASSUNG 11
1. INTRODUCTION 13
1.1 OPIOIDS AND OPIOID RECEPTORS 13
1.1.1 OPIOID RECEPTORS 13
OPIOID RECEPTOR STRUCTURE 14
1.1.1.2 OPIOID RECEPTOR EXPRESSION 15
1.1.1.3 OPIOID RECEPTOR ACTIVATION AND MECHANISM OF ACTION 17
1.1.1.4 OPIOID RECEPTOR VISUALIZATION 19
1.2 OPIOIDS AND PAIN 20
1.2.1 PAIN CLASSIFICATION 20
1.2.2 PAIN PATHWAYS AND TRANSMISSION 20
1.2.3 PAIN TREATMENT 23
1.2.4 OPIOID RECEPTOR AGONISTS AND ANTAGONISTS 24
1.3 SCIATIC NERVE 25
1.3.1 SCIATIC NERVE STRUCTURE AND PERINEURIAL BARRIER 25
1.3.1.1 FIBER TYPE COMPOSITION 25
1.3.1.2 NERVE SHEATHS 26
1.4 HYPERTONIC SOLUTION 27
1.5 AIM OF THE STUDY 28
2. MATERIALS AND METHODS 30
2.1 MATERIALS 30
2.1.1 ANIMALS 30
2.1.2 BUFFERS 31
2.1.3 REAGENTS AND KITS 32
2.1.4 PRIMERS AND PROBES 32
2.1.5 ANTIBODIES 33
2.1.6 ADDITIONAL REAGENTS AND CHEMICALS 33
2.1.7 EXPERIMENTAL INSTRUMENTS AND SOFTWARE 34
2.2 METHODS 36
2.2.1 TREATMENT OF RATS AND MICE 36
2.2.2 MOP-MCHERRY PCR GENOTYPING 36
2.2.3 TISSUE PREPARATION FOR IMMUNOHISTOCHEMISTRY STAINING 37
2.2.4 IMMUNOFLUORESCENCE 38
2.2.5 DAB REACTION 38
2.2.6 PRE-EMBEDDING _ U N O G O LD 39
2.2.7 IMAGE ACQUISITION 40
2.2.8 ANALYSIS ON MAGES AND QUANTIFICATION OF STAINING 40
2.2.9 WESTERN BLOT 42
2.2.10 RNA ISOLATION 43
2.2.11 CDNA SYNTHESIS AND QPCR 43
2.2.12 STATISTICS 45
3. RESULTS 46
3.1 MOP DETECTION USINGPOLYCLONAL MOP ANTIBODIES 46
3.1.1 MOP MMUNOLABELING IN THE BRAIN 46
3.1.2 MOP IMMUNOLABELING IN THE PERIPHERAL NERVOUS SYSTEM 47
3.2 DOUBLE STAINING USING POLYCLONA MOP ANTIBODES WITH CGRP, PGP9.5 AND
SLOO-ANTIBODIES 50
3.2.1 MOP AND CGRP 51
3.2.2 MOP AND PGP9.5 52
3.2.3M O PANDSL
*
0 52
3.3 PRE-EMBEDDING IMMUNOGOLD LABELING USING POLYCLONAL MOP ANTIBODIES
N RAT SCIATIC NERVE 53
3.4 WESTERN BLOT ON NEURONAL TISSUES DETECTS POSSIBLE UNSPECIFIC SIGNAL
OF
MOPANTIBODIES 56
3.5 MOP DETECTION USING A MONOCLONAL MOP ANTIBODY AND FUSION PROTEIN
DETECTION IN MOP-MCHERRY KNOCK-IN MICE 57
3.5.1MOP-RABMAB 57
3.5.1.1 IMMUNOFLUORESCENCE LABELING ON CENTRAL AND PERIPHERAL
NERVOUSSYSTEM 57
3.5.1.2 IMMUNOENZYME LABELING 58
3.5.1.3 IMMUNOELECTRON MICROSCOPIC LABELING 59
3.5.1.4 PROTEIN SIZE VERIFICATION 61
3.5.2 FUSION PROTEIN DETECTION IN MOP-MCHERRY KNOCK-IN MICE 61
3.5.2.1 IMMUNOFLUORESCENCE ON CENTRAL AND PERIPHERAL NERVOUS TISSUE 61
3.5.2.2 IMMUNOENZYME LABELING 63
3.5.2.3 LMMUNOELECTRON MICROSCOPIC LABELING 64
3.5.2.4 PROTEIN SIZE VERIFICATION 67
3.6 NO CHANGE IN MOP MRNA EXPRESSION 60 MIN AFTER PERISCIATIC HTS
APPLICATION 68
3.7 NO CHANGE IN MOP IMMUNOREACTIVITY 60 MIN AFTER PE
*
SCATC INJECTION OF HTS 69
4. DISCUSSION 72
4.1 ADVANTAGES AND DISADVANTAGES OF ALL THE METHODS EMPLOYED 72
4.2 UNSPECIFIC LABELING OF RABBIT AND GUINEA PIG POLYCLONAL
MOP-ANTIBODIES *N
PERIPHERAL NERVOUS SYSTEM 75
4.3 SPECIFIC LABELLING OF MOP USING MOP-RABMAB ANTIBODY AND
MCHERRY-DETECTION
N KNOCK-IN MICE * PERIPHERAL NOCICEPT*VE AXONS 76
4.3.1 SPECIFICITY OF MOP-RABMAB IN THE SCIATIC NERVE 77
4.3.2 SPECIFIC AND INTENSE IMMUNOREACTIVITY OF MOP-MCHERRY IN THE
SCIATIC
NERVE 78
4.4 NO SUSTAINED INFLUENCE OF HTS ON MOP LEVELS 80
4.5 REGULATION OF AXONAL TRANSPORT AND MEMBRANE-CYTOPLASM SHUTTLING 82
4.6 POTENTIAL MECHANISMS OF OPIOID ACTION ON NOCICEPTIVE AXONS 83
CONCLUSION 84
5. REFERENCES 85
CURRICULUM VITAE 91
PUBLICATIONS 94
|
| any_adam_object | 1 |
| author | Mambretti, Egle Maria 1985- |
| author_GND | (DE-588)1096524864 |
| author_facet | Mambretti, Egle Maria 1985- |
| author_role | aut |
| author_sort | Mambretti, Egle Maria 1985- |
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| bvnumber | BV043527769 |
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| ctrlnum | (OCoLC)951536503 (DE-599)BVBBV043527769 |
| dewey-full | 610 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 610 - Medicine and health |
| dewey-raw | 610 |
| dewey-search | 610 |
| dewey-sort | 3610 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Thesis Book |
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| spelling | Mambretti, Egle Maria 1985- Verfasser (DE-588)1096524864 aut Opioid receptors as therapeutic targets for nociceptor specific regional analgesia = Opioidrezeptoren als therapeutisches Target einer nozizeptionsspezifischen Regionalanalgesie vorgelegt von Egle Maria Mambretti from Monza, Italy Opioidrezeptoren als therapeutisches Target einer nozizeptionsspezifischen Regionalanalgesie Würzburg 16th December 2015 94 Blatt Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Dissertation Julius-Maximilians-Universität Würzburg 2016 Zusammenfassung in deutscher und englischer Sprache Rezeptor (DE-588)4049722-7 gnd rswk-swf Lokalanästhesie (DE-588)4036262-0 gnd rswk-swf Opioide (DE-588)4172638-8 gnd rswk-swf Nozizeptor (DE-588)4042724-9 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Opioide (DE-588)4172638-8 s Rezeptor (DE-588)4049722-7 s Nozizeptor (DE-588)4042724-9 s Lokalanästhesie (DE-588)4036262-0 s DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:20-opus-128866 https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-128866 Resolving-System kostenfrei Volltext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028943545&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Mambretti, Egle Maria 1985- Opioid receptors as therapeutic targets for nociceptor specific regional analgesia = Opioidrezeptoren als therapeutisches Target einer nozizeptionsspezifischen Regionalanalgesie Rezeptor (DE-588)4049722-7 gnd Lokalanästhesie (DE-588)4036262-0 gnd Opioide (DE-588)4172638-8 gnd Nozizeptor (DE-588)4042724-9 gnd |
| subject_GND | (DE-588)4049722-7 (DE-588)4036262-0 (DE-588)4172638-8 (DE-588)4042724-9 (DE-588)4113937-9 |
| title | Opioid receptors as therapeutic targets for nociceptor specific regional analgesia = Opioidrezeptoren als therapeutisches Target einer nozizeptionsspezifischen Regionalanalgesie |
| title_alt | Opioidrezeptoren als therapeutisches Target einer nozizeptionsspezifischen Regionalanalgesie |
| title_auth | Opioid receptors as therapeutic targets for nociceptor specific regional analgesia = Opioidrezeptoren als therapeutisches Target einer nozizeptionsspezifischen Regionalanalgesie |
| title_exact_search | Opioid receptors as therapeutic targets for nociceptor specific regional analgesia = Opioidrezeptoren als therapeutisches Target einer nozizeptionsspezifischen Regionalanalgesie |
| title_full | Opioid receptors as therapeutic targets for nociceptor specific regional analgesia = Opioidrezeptoren als therapeutisches Target einer nozizeptionsspezifischen Regionalanalgesie vorgelegt von Egle Maria Mambretti from Monza, Italy |
| title_fullStr | Opioid receptors as therapeutic targets for nociceptor specific regional analgesia = Opioidrezeptoren als therapeutisches Target einer nozizeptionsspezifischen Regionalanalgesie vorgelegt von Egle Maria Mambretti from Monza, Italy |
| title_full_unstemmed | Opioid receptors as therapeutic targets for nociceptor specific regional analgesia = Opioidrezeptoren als therapeutisches Target einer nozizeptionsspezifischen Regionalanalgesie vorgelegt von Egle Maria Mambretti from Monza, Italy |
| title_short | Opioid receptors as therapeutic targets for nociceptor specific regional analgesia |
| title_sort | opioid receptors as therapeutic targets for nociceptor specific regional analgesia opioidrezeptoren als therapeutisches target einer nozizeptionsspezifischen regionalanalgesie |
| title_sub | = Opioidrezeptoren als therapeutisches Target einer nozizeptionsspezifischen Regionalanalgesie |
| topic | Rezeptor (DE-588)4049722-7 gnd Lokalanästhesie (DE-588)4036262-0 gnd Opioide (DE-588)4172638-8 gnd Nozizeptor (DE-588)4042724-9 gnd |
| topic_facet | Rezeptor Lokalanästhesie Opioide Nozizeptor Hochschulschrift |
| url | https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-128866 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028943545&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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