Integrated bioprocess engineering:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Berlin
De Gruyter
[2018]
|
| Schlagworte: | |
| Online-Zugang: | Inhaltstext Inhaltsverzeichnis |
| Beschreibung: | XI, 344 Seiten Illustrationen, Diagramme |
| ISBN: | 9783110315387 |
Internformat
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Datensatz im Suchindex
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| adam_text |
CONTENTS
PREFACE - A SHORT PITCH FOR THIS BOOK* V
1 INTRODUCTION - A THREAD THROUGH THIS BOOK* 1
1.1 MOTIVATION - WINDOW SHOPPING FOR BIOTECHNOLOGICAL PRODUCTS * 1
1.2 BIOPROCESS ENGINEERING - ATTEMPT AT A DEFINITION * 7
1.3 YEAST PRODUCTION - A CLASSIC BUT INSTRUCTIVE PROCESS * 8
1.4 THE THREE COLUMNS OF BIOPROCESS ENGINEERING - WHAT BIOPROCESSES HAVE
IN COMMON * 11
1.5 INTEGRATION OF SCIENCES - ACQUIRING KNOWLEDGE ON DEMAND * 13
1.6 CHARACTERISTICS OF LIVING CELLS - UNIQUE SELLING POINTS FROM AN
ENGINEERING VIEW * 14
1.7 EXERCISES, QUESTIONS AND SUGGESTIONS * 16
2 BIOSYSTEMS - MICROORGANISMS AND OTHER BIOCATALYSTS * 17
2.1 MOTIVATION - A FIRST BIOENGINEERING VIEW OF MICROBIOLOGY * 18
2.2 DIVERSITY OF BIOSYSTEMS - APPEARANCE IN TECHNICAL ENVIRONMENTS * 19
2.2.1 ENZYMES - THE UNIVERSAL TOOLBOX FOR BIOCATALYSIS * 19
2.2.2 BACTERIA - ORGANISMS FOR ALL SEASONS * 21
2.2.3 ARCHAEA - THE UNDERESTIMATED EXTREMISTS * 23
2.2.4 YEAST - THE WORKHORSE OF BIOPROCESSES * 24
2.2.5 FILAMENTOUS FUNGI - THE BROAD-SPECTRUM CHEMISTS * 26
2.2.6 MICROALGAE - THE SOLAR CELL FACTORY * 27
2.2.7 PLANT CELLS - SLOW BUT RESOURCEFUL* 29
2.2.8 ANIMAL CELLS - MASTERS OF PROTEIN DECORATION * 31
2.2.9 ORGANIZED COMMUNITIES - MAKING RICH BOOTY AS A CONSORTIUM * 32
2.3 CULTIVATION CONDITIONS - ENVIRONMENTAL PARAMETERS TO CARE ABOUT * 33
2.3.1 PRIMARY NUTRITIONAL GROUPS * 33
2.3.2 TEMPERATURE * 34
2.3.3 ACIDITY AND BASICITY * 37
2.3.4 HIGH CONCENTRATIONS * 38
2.4 BRINGING MICROORGANISMS TO WORK - THE CONCEPT OF A *CELL FACTORY* *
39
3 MEDIA - SUPPLYING MICROORGANISMS WITH A COMFORTABLE ENVIRONMENT AND
BUILDING BLOCKS FOR GROWTH * 41
3.1 MEDIA - THE MATERIAL BASIS OF THE PROCESS * 41
3.2 MEDIA DESIGN - STARTING FROM SCRATCH * 42
3.3 PRACTICAL APPLICATION - A DISCUSSION OF RECIPES FROM REFERENCES * 48
3.4 COMPLEX AND TECHNICAL MEDIA * 53
3.5 ADDITIONAL ASPECTS - MUTUAL INTERACTIONS BETWEEN CELLS AND
MEDIUM * 58
3.6
3.7
4
4.1
4.2
4.3
4.4
4.5
4.6
5
5.1
5.2
5.3
5.4
5.5
5.5.1
5.5.2
5.5.3
5.6
6
6.1
6.2
6.3
6.4
6.5
6.6
6.7
6.8
6.9
6.10
THE GOOD, THE BAD AND THE UGLY - MICROORGANISMS AS PRODUCTS * 61
EXERCISES, QUESTIONS AND SUGGESTIONS
-----
64
KINETICS - FINDING QUANTITIES FOR BIOPROCESS REACTIONS * 66
KINETICS - THE SCAFFOLD OF REACTION ENGINEERING* 66
ENZYMES AS BASIC COMPONENTS - DETERMINING KINETICS * 68
THE SPECIFIC GROWTH RATE - DESCRIBING GROWTH BY NUMBERS * 76
THE YIELD COEFFICIENT - COMBINING SUBSTRATE TURNOVER AND GROWTH * 82
THE BATCH PROCESS - THE SIMPLEST FORM OF A BIOPROCESS * 86
EXERCISES, QUESTIONS AND SUGGESTIONS * 88
BIOREACTORS - DESIGNING A HOME FOR THE BIOREACTION * 92
NOT ONLY A VESSEL - FOR WHAT A BIOREACTOR IS NEEDED AND WHAT IT
CAN BE * 92
REVISITING THE STIRRED TANK REACTOR - THE MOST IMPORTANT ISSUES TO LEARN
FROM CHEMICAL ENGINEERING* 94
PNEUMATICALLY DRIVEN BIOREACTORS - A SOFT WAY OF ENERGY TRANSFER * 104
OTHER TYPES OF BIOREACTORS - TRANSLATING DEMANDS INTO DESIGN * 108
GAS TRANSFER - SUPPLYING MICROORGANISMS WITH GASEOUS
COMPOUNDS * 116
TRANSPORT PROCESSES - THE JOURNEY OF GASES THROUGH THE REACTOR * 117
MEASURING GAS TRANSFER
-----
123
ALTERNATIVE MEANS OF GAS SUPPLY* 125
EXERCISES, QUESTIONS AND SUGGESTIONS * 127
NOT ALWAYS SO SIMPLE - THE BATCH PROCESS RECONSIDERED * 129
FORMAL KINETICS - EXTRAPOLATION FROM ENZYMATIC REACTIONS TO CELL
GROWTH
-----
129
LOOKING A STEP DEEPER - ESTIMATING AEROBIC GROWTH YIELDS FROM
METABOLIC FLUXES
-----
132
AEROBIC GROWTH - CASE STUDY OF HETEROTROPHIC PLANT CELLS
-----
134
LOOKING A STEP DEEPER - ESTIMATING ANAEROBIC PRODUCT YIELDS FROM
METABOLIC FLUXES * 137
ANAEROBIC BATCH CULTURE - CASE STUDY OF ETHANOL PRODUCTION * 138
RUNNING EXAMPLE OF YEAST PRODUCTION - GROWTH IN BATCH
PROCESSES * 142
PRIMARY METABOLITES - PRODUCTS DIRECTLY TAKEN FROM CENTRAL
METABOLISM
-----
145
SERVING MANKIND WITH BASIC NEEDS - PRODUCTS NEEDED IN LARGE
AMOUNTS * 148
CONCLUSIONS FOR BATCH PROCESSES - DEALING WITH PROS AND CONS * 153
QUESTIONS AND SUGGESTIONS * 155
7
7.1
7.2
7.2.1
7.2.2
7.3
7.4
7.4.1
7.4.2
7.4.3
7.5
7.6
8
8.1
8.2
8.3
8.4
8.5
8.6
8.7
8.7.1
8.7.2
8.7.3
8.7.4
8.8
8.8.1
8.8.2
LITTLE BY LITTLE ONE GOES FAR - THE FED-BATCH PROCESS * 157
SETTING UP PROCESS EQUATIONS - THE FORMAL DEDUCTION OF A SUITABLE
FEEDING STRATEGY * 158
RUNNING EXAMPLE YEAST PRODUCTION - AN INDUSTRIAL FEEDING
STRATEGY * 161
DEVIATIONS FROM EXPONENTIAL - CONTROLLING PHYSIOLOGY AND OBEYING
TECHNICAL CONSTRAINTS * 161
THE FIRST STEP OF DOWNSTREAM PROCESSING - RELATIONSHIP BETWEEN CELL
SEPARATION AND CELL PHYSIOLOGY* 165
PRODUCTION OF SECONDARY METABOLITES - CASE STUDY OF PENICILLIN
PRODUCTION * 168
PRODUCTION OF RECOMBINANT PROTEINS - THE CELL FACTORY * 173
DIFFERENT WAYS TO GET HOLD OF DESIRED PROTEINS - AN OVERVIEW OF PROTEIN
EXPRESSION SYSTEMS * 174
HIGH DENSITY CULTIVATION - A SPECIFIC FED-BATCH PROCESS FOR RECOMBINANT
PROTEIN PRODUCTION * 176
PRODUCTION OF PHARMACEUTICAL PROTEINS WITH KAMAGATAELLA PFAFFII -
EMPLOYMENT OF A HIGH PERFORMANCE FACTORY * 178
CONCLUSIONS FOR FED-BATCH PROCESSES - DEALING WITH STRENGTHS AND
WEAKNESSES * 180
QUESTIONS AND SUGGESTIONS * 181
MICROALGAE - THE SOLAR CELL FACTORY* 182
BECOMING CURIOUS - CURRENT RESEARCH PROMISES * 182
CHOOSING FROM DIVERSITY - WIDELY USED MICROALGAE FOR COMMERCIAL
BIOPROCESSES * 183
PHYSIOLOGICAL PRINCIPLES - THE UNIQUE FEATURES OF THE MICROALGAL
CELL * 186
LIGHT - THE LITTLE BIT DIFFERENT ENERGY SOURCE * 191
MEDIA FOR MICROALGAE - A CLEAR MATTER OF FACT * 194
KINETICS OF PHOTOBIOPROCESSES - HOW MICROALGAE MAKE USE OF THE
NONMISCIBLE SUBSTRATE * 197
PHOTOBIOREACTORS - THE INTERFACE BETWEEN ALGAE AND SUNLIGHT * 203
STARTING FROM NATURAL CONDITIONS - LAKES AND OPEN PONDS * 203
FLAT PLATE REACTORS - THE BUBBLE COLUMN IN AN *ENLIGHTENED*
GUISE
-----
206
TUBULAR REACTORS * 208
NEW DEVELOPMENTS AND IDEAS * 210
PRODUCTS AND PROCESSES * 211
PRODUCTS FOR FOOD SUPPLEMENTS, FEED AND AQUACULTURE * 211
HIGH VALUE PRODUCTS * 213
8.8.3
8.9
8.10
9
9.1
9.2
9.3
9.4
9.5
9.6
9.7
9.8
10
10.1
10.2
10.3
10.4
10.5
10.6
10.7
11
11.1
11.2
11.3
11.4
11.5
CONVERSION OF PHOTON ENERGY TO CHEMICAL ENERGY - PRODUCING FUELS
BY MICROALGAE * 216
OUTLOOK * 218
QUESTIONS AND SUGGESTIONS * 219
CONTINUOUSLY OPERATING BIOPROCESSES - PRODUCTION UNDER STEADY STATE
CONDITIONS
-----
220
SETTING UP STATIONARY BALANCE EQUATIONS - A GOOD START IN UNDERSTANDING
PROCESS BEHAVIOR * 221
ETHANOL PRODUCTION IN A CONTINUOUS PROCESS -
THE WINDOW OF OPERATION * 226
ENZYMATIC PROCESSES - A SIMPLE BUT EFFECTIVE EXAMPLE FOR CONTINUOUS
BIOPROCESS OPERATION * 229
BIOGAS PRODUCTION VIA ANAEROBIC DIGESTION
-----
231
FROM MINERALS AND PARTICLES - TECHNICAL CONCEPTS FOR USING
CHEMOLITHOTROPHIC MICROORGANISMS * 236
COMPLEX MOLECULAR STRUCTURES - HOW THEY INFLUENCE THE PROCESS * 243
CURRENT DISCUSSION ABOUT CONTINUOUS PROCESSES - MOTIVATION AND
OBSTACLES * 247
QUESTIONS AND SUGGESTIONS * 248
MEASURING PRINCIPLES - HOW TO PUT AN END TO THE BLIND FLIGHT * 250
ONLY A LOOK THROUGH THE KEYHOLE - WHAT MEASUREMENT MEANS FOR PROCESS
UNDERSTANDING AND OPTIMIZATION
-----
250
STATE OF THE ART - OVERVIEW OF MEASUREMENT AT A STANDARD REACTOR* 250
PHYSICAL PARAMETERS - ADAPTATION FROM OTHER FIELDS OF PROCESS
TECHNOLOGY* 253
CHEMICAL PARAMETERS - EMPLOYMENT OF ELECTROCHEMICAL EFFECTS * 254
MEASURING BIOMASS - THE GREAT UNKNOWN *X* * 262
COMPILING A CONSTRUCTION KIT FOR SENSORS - A GENERAL APPROACH FOR
BIOLOGICAL SENSORS * 268
QUESTIONS AND SUGGESTIONS
-----
271
THE PRACTICE OF FERMENTATION - A STEP BY STEP GUIDE THROUGH THE
WORKFLOW * 272
STRUCTURING THE REACTOR AND THE CULTIVATION - ZOOMING IN FROM PRINCIPLE
UNDERSTANDING TO VISIBILITY OF PROCESS DETAILS * 272
THE REACTOR - A COMPLEX ASSEMBLY OF PARTS AND MODULES * 273
STRUCTURING THE CULTIVATION PROCESS - FROM PLANNING TO FINAL DATA
ACQUISITION * 275
MEDIA PREPARATION * 277
PRECULTURE PREPARATION * 278
11.6 REACTOR INSTALLATION AND SETUP * 279
11.6.1 FERMENTATION VESSEL SETUP * 280
11.6.2 PERIPHERAL DEVICES * 281
11.6.3 SENSOR INSTALLATION * 282
11.6.4 AUTOCLAVING THE BIOREACTOR * 283
11.7 MANAGING THE ACTUAL CULTIVATION PROCESS * 287
11.8 INTEGRATION ON THE PROCESS LEVEL - HOW TO INCLUDE THE FERMENTATION
INTO A
WHOLE PROCESS CHAIN * 292
11.9 QUESTIONS AND SUGGESTIONS * 293
12 MODELING - ART AND HANDCRAFT OF MATHEMATICALLY DESCRIBING
BIOPROCESSES * 295
12.1 MODELING - WHAT IT MIGHT BE AND WHAT IT IS GOOD FOR * 295
12.2 PREDATOR-PREY MODEL * 299
12.3 LINEAR NETWORKS - FINDING STATIONARY FLUX EQUATIONS * 302
12.4 AEROBIC GROWTH - SETTING UP A FIRST GENERAL MODEL * 304
12.5 ANAEROBIC GROWTH - TRAPS AND PITFALLS * 307
12.6 BACK TO BAKER*S YEAST - MORE DEGREES OF FREEDOM * 310
12.7 BACK TO MICROALGAE - A MORE SPATIAL AND HIERARCHICAL STRUCTURE FOR
SUBSYSTEM DEFINITION * 315
12.8 INTEGRATION INTO SOCIETY - THE FINAL PROOF OF MEANING * 319
12.9 SUGGESTIONS * 322
FURTHER READING - STILL CURIOUS? * 323
ACKNOWLEDGMENTS - DEDICATED TO ALL THE PEOPLE WHO SUPPORTED THE
COMPILATION OF
THIS BOOK * 327
COPYRIGHTS - PICTURES PROVIDED WITH COURTESY AND ACCEPTED WITH THANKS *
333
INDEX * 335 |
| any_adam_object | 1 |
| author | Posten, Clemens |
| author_facet | Posten, Clemens |
| author_role | aut |
| author_sort | Posten, Clemens |
| author_variant | c p cp |
| building | Verbundindex |
| bvnumber | BV043517763 |
| classification_rvk | WF 9700 WF 9720 VN 7280 |
| ctrlnum | (OCoLC)1041132758 (DE-599)DNB1061098931 |
| discipline | Chemie / Pharmazie Biologie |
| format | Book |
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| id | DE-604.BV043517763 |
| illustrated | Illustrated |
| indexdate | 2024-08-03T02:57:55Z |
| institution | BVB |
| isbn | 9783110315387 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-028933774 |
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| owner_facet | DE-1102 DE-703 DE-29T DE-634 DE-83 |
| physical | XI, 344 Seiten Illustrationen, Diagramme |
| publishDate | 2018 |
| publishDateSearch | 2018 |
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| publisher | De Gruyter |
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| spelling | Posten, Clemens Verfasser aut Integrated bioprocess engineering Clemens Posten Berlin De Gruyter [2018] © 2018 XI, 344 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Biotechnologie (DE-588)4069491-4 gnd rswk-swf Bioverfahrenstechnik (DE-588)4307166-1 gnd rswk-swf Bioverfahrenstechnik (DE-588)4307166-1 s DE-604 Biotechnologie (DE-588)4069491-4 s Erscheint auch als Online-Ausgabe, PDF 978-3-11-031539-4 Erscheint auch als Online-Ausgabe, EPUB 978-3-11-038200-6 X:MVB text/html http://deposit.dnb.de/cgi-bin/dokserv?id=4828465&prov=M&dok_var=1&dok_ext=htm Inhaltstext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028933774&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Posten, Clemens Integrated bioprocess engineering Biotechnologie (DE-588)4069491-4 gnd Bioverfahrenstechnik (DE-588)4307166-1 gnd |
| subject_GND | (DE-588)4069491-4 (DE-588)4307166-1 |
| title | Integrated bioprocess engineering |
| title_auth | Integrated bioprocess engineering |
| title_exact_search | Integrated bioprocess engineering |
| title_full | Integrated bioprocess engineering Clemens Posten |
| title_fullStr | Integrated bioprocess engineering Clemens Posten |
| title_full_unstemmed | Integrated bioprocess engineering Clemens Posten |
| title_short | Integrated bioprocess engineering |
| title_sort | integrated bioprocess engineering |
| topic | Biotechnologie (DE-588)4069491-4 gnd Bioverfahrenstechnik (DE-588)4307166-1 gnd |
| topic_facet | Biotechnologie Bioverfahrenstechnik |
| url | http://deposit.dnb.de/cgi-bin/dokserv?id=4828465&prov=M&dok_var=1&dok_ext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028933774&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT postenclemens integratedbioprocessengineering |