Transfer of multidrug-resistant pathogens between humans and animals:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | VII, 172 Seiten Illustrationen, Diagramme |
Internformat
MARC
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| 100 | 1 | |a Schmithausen, Ricarda Maria |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Transfer of multidrug-resistant pathogens between humans and animals |c vorgelegt von Ricarda Maria Schmithausen |
| 264 | 1 | |c 2016 | |
| 300 | |a VII, 172 Seiten |b Illustrationen, Diagramme | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 502 | |b Dissertation |c Rheinische Friedrich-Wilhelms-Universität Bonn |d 2015 | ||
| 546 | |a Zsfassung in dt. Sprache | ||
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-028911436 | ||
Datensatz im Suchindex
| _version_ | 1804176126776442880 |
|---|---|
| adam_text | CONTENT
CONTENT................................................................................................................................................I
UST OF
ABBREVIATIONS......................................................................................................................
*V
1 GENERAL
INTRODUCTION................................................................................................................
1
1.1 INTRODUCTION AND PROBLEM
STATEMENT................................................................................
1
1.2 THESIS
OUTHNE....................................................................................................................
3
2 BACKGROUND
INFORMATION..........................................................................................................7
2.1 EMERGENCE AND SPREAD OF ANTBIOTIC-RESISTANT BACTERIA
..................................................
7
2.1.1 ANTIBIOTIC USE IN LIVESTOCK PRODUCTION
...................................................................
7
2.1.2 RESISTANCE MECHANISMS
*
TRANSFER
*
AND BIOAVAILABILITY.........................................9
2.1.3 CHARACTERISTICS OF MULTIDRUG-RESISTANT
BACTERIA...................................................10
2.2 RESERVOIRS AND TRANSMISSION PATHWAYS OF LA-MRSA AND
ESBL-E........**.... 13
2.2.1 TRANSMISSION
PATHWAYS.......................................................................................
13
2.2.2 LA-MRSA AND ESBL-E IN
HUMANS.....................................................................14
2.2.3 LA-MRSA AND ESBL-E IN PIGS AND COMPANION ANIMALS .***.*******15
2.2.4 RESERVOIR STABLE
ENVIRONMENT.............................................................................
17
2.2.5 LA-MRSA AND ESBL-E IN THE FOOD
CHAIN...........................................................21
2.3 BIOTOPE
APPROACH............................................................................................................23
2.3.1 ANIMAL HEALTH IN THE LIVESTOCK
BIOTOPE................................................................23
2.3.2 PREVENTIVE HEALTH MANAGEMENT - PART OF QUALITY MANAGEMENT 25
2.3.3 ONE HEALTH CROSSING
BIOTOPES..........................................................................27
3 ANALYSIS OF TRANSMISSION OF MRSA AND ESBL-E AMONG PIGS AND FARM
PERSONNEL * 31
3.1
INTRODUCTION......................................................................................................................33
3.2 MATERIAL AND
METHODS......................................................................................................34
3.2.1 STUDY DESIGN AND SAMPLING
APPROACH...............................................................
3*
3.2.2
FARMS...................................................................................................................
34
3.2.3 PARTICIPATION OF FARM
S..........................................................................................35
3.2.4 SAMPLE COLLECTION N
PIGS...............................................................................
36
3.2.5 HUMAN
SPECIMEN................................................................................................
36
3.2.6 AIR
SAMPLES..........................................................................................................37
3.2.7 BACTERIAL
CULTURE..................................................................................................
37
3.2.8 CONFIRMATION OF MRSA AND SPA
TYPING............................................................... 37
3.2.9 IDENTIFICATION, ANTIMICROBIAL SUSCEPTIBILITY TESTING AND MOLECULAR
TYPING OF
ESBL-E...........................................................................................
*****.*38
3.2.10 STATISTICAL
ANALYSIS...............................................................................................
38
3.3
RESULTS.............................................................................................................................38
3.3.1 PREVALENCE OF MRSA AND ESBL-* IN
PIGS.........................................................40
3.3.2 FREQUENCY OF MRSA AND ESBL-E COLONIZED FARM
S..........................................42
3.3.3 MRSA AND ESBL-E COLONIZATION VARIES DEPENDING ON THE PIG
PRODUCTION
42
......................................................................................................................
****
1
3.3.4 MRSA AND ESBL-* DETECTION IN HUMANS WORKING AND LIVING N THE FARM
ENVIRONMENT..........................................................................................................43
3.3.5 MRSA AND ESBL-E TRANSMISSION IN THE SLAUGHTERING P
*
OCESS_._____..__._ ._ .._43
3.3.6 EVALUATION OF AIR AS TRANSMISSION
MEDIUM...........................................................43
3.3.7 ANTIMICROBIAL SUSCEPTIBILITY TESTING OF MRSA ISOLATES
.........................................
44
3.3.8 MOLECULAR TYPING OF
MRSA..................................................................................44
3.3.9 ANALYSIS OF ESBL ENZYMES REVEALS PREDOMINANCE OF CTX-M
._....._...46
3.3.10 REP-PCR-TYPING OF ESBL_E ISOLATES REVEALS HETEROGENEITY OF
ESBL-E..........46
3.3.11 USAGE OF ANTIBIOTICS ON
FARMS.............................................................................
48
3.4
DISCUSSION.......................................................................................................................
50
3.5 SUPPORTING
INFORMATION....................................................................................................54
4 ERADICATION OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS AND OF
ENTEROBACTERIACEAE EXPRESSING EXTENDED-SPECTRUM BETA-LACTAMASES ON A
MODEL
PIG
FARM...................................................................................................................................
65
4.1
INTRODUCTION......................................................................................................................67
4.2 MATERIAL AND
METHODS......................................................................................................68
4.2.1 FORMAL SURVEILLANCE PROCEDURES AND ETHICS
STATEMENT.....................................68
4.2.2 TIME COURSE AND SAMPLING APPROACH
................................................................
68
4.2.3 CLEANING AND DISINFECTION
...................................................................................
70
4.2.4 SAMPLE COLLECTION AND LABORATORY
ANALYSES.......................................................70
4.3
RESULTS.............................................................................................................................74
4.31 SITUATION AT THE OUTSET: PREVALENCE OF MRSA AND ESBL-E *N
P*GS___...__..._._....74
4.3.2 SITUATION AT THE OUTSET: MRSA AND ESBL-E IN ENVIRONMENTAL
SAMPLES .._.._...75
4.3.3 AFTE
*
DECONTAMINATION: PREVALENCE OF MRSA AND ESBL-E N
PIGS..................76
4.3.4 AFTER DECONTAMINATION: PREVALENCE OF MRSA AND ESBL-E IN THE
ENVIRONMENT........................................................................................................
77
4.3.5 SPA TYPING OF MRSA
STRAINS...............................................................................78
4.3.6 TRANSMISSION OF MRSA TO HUMANS *N THE FARM ENVI
*ONMENT.. _.__......_.....__.. _78
4.3.7 PREVALENCE OF MRSA IN COMPANION ANIMALS
....................................................
79
4.3.8 DUST SAMPLES N STABLE
ENVIRONMENT.................................................................80
4.3.9 USAGE OF ANTIBIOTICS ON THE FARM DURING THE REPORT PERIOD.......
4.4
DISCUSSION......................................................................................................................80
5 ESBL-E AND MRSA MONITORING INTEGRATED INTO A CHAIN-ORIENTED HERD
HEALTH
MANAGEMENT
SYSTEM.............................................................................................................85
5.1
INTRODUCTION......................................................................................................................87
CONTENT III
5.2 STATE OF
KNOWLEDGE..........................................................................................................
88
5.2.1 LNT
*
A-FARM AND INTER-FARM TRANSFER OF INFECTIONS
..................................................
88
5.2.2 AUDIT AND MONITORING STRATEGIES
.........................................................................
90
5.3 METHODOLOGICAL
PROCEDURE..............................................................................................
94
5.31 TEST PROCEDURE AND TEST FARM
S...........................................................................94
5.3.2 PARAMETER PROFILE FOR AUDITS AND MONITORING
......................................................
97
5.3.3 RISK SCORJNG AND DEFINITION OF SCATTER PLOT COORDINATES 103
5.4
RESULTS...........................................................................................................................
108
5.4.1 FREQUENCY OF MRSA AND ESBL-E OCCURRENCE IN THE STABLE BIOTOPE 108
5.4.2 CATEGORIZATION OF FARMS ACCORDING TO VA RIO S METHODS OF RISK
ASSESSMENT........................................................................................................
110
5.4.3 RISK ASSESSMENT OF TRANSMISSION BETWEEN THE LIVESTOCK AND HEALTH
CARE
SYSTEM
BIOTOPES.................................................................................................113
5.4.4 PROPOSAL TO INTEGRATE MRSA AND ESBL-E MONITORING INTO INTER-FARM
HEALTH MANAGEMENT
PROGRAMS.........................................................................115
5.5
DSCUSSION......................................................................................................................
119
6 GENERAL
CONCLUSIONS.............................................................................................................123
REFERENCES.....................................................................................................................................
133
LIST OF FIGURES
LIST OF
TABLES.................................................................................................................................169
ACKNOWLEDGMENTS........................................................................................................................
171
|
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| spelling | Schmithausen, Ricarda Maria Verfasser aut Transfer of multidrug-resistant pathogens between humans and animals vorgelegt von Ricarda Maria Schmithausen 2016 VII, 172 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Dissertation Rheinische Friedrich-Wilhelms-Universität Bonn 2015 Zsfassung in dt. Sprache (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028911436&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Schmithausen, Ricarda Maria Transfer of multidrug-resistant pathogens between humans and animals |
| subject_GND | (DE-588)4113937-9 |
| title | Transfer of multidrug-resistant pathogens between humans and animals |
| title_auth | Transfer of multidrug-resistant pathogens between humans and animals |
| title_exact_search | Transfer of multidrug-resistant pathogens between humans and animals |
| title_full | Transfer of multidrug-resistant pathogens between humans and animals vorgelegt von Ricarda Maria Schmithausen |
| title_fullStr | Transfer of multidrug-resistant pathogens between humans and animals vorgelegt von Ricarda Maria Schmithausen |
| title_full_unstemmed | Transfer of multidrug-resistant pathogens between humans and animals vorgelegt von Ricarda Maria Schmithausen |
| title_short | Transfer of multidrug-resistant pathogens between humans and animals |
| title_sort | transfer of multidrug resistant pathogens between humans and animals |
| topic_facet | Hochschulschrift |
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