The membranes of cells:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Amsterdam
Elsevier
[2016]
|
| Ausgabe: | Third edition |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XII, 439 Seiten Illustrationen |
| ISBN: | 9780128000472 |
Internformat
MARC
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Datensatz im Suchindex
| _version_ | 1804176067921969152 |
|---|---|
| adam_text | Contents
Preface xi
1. Introduction
1.1 Prokaryote Cell Membranes 2
1.2 Eukaryote Cell Membranes 4
1.3 Plasma Membranes 5
1.4 Intracellular Membranes 8
1.4.1 Nuclear Membranes 8
1.4.2 Endoplasmic Reticulum Membranes 9
1.4.3 Golgi Membranes 10
1.4.4 Mitochondrial Membranes 11
1.4.5 Lysosome 13
1.4.6 Peroxisome 14
1.5 Viral Membranes 14
1.6 Membrane Motifs 16
1.7 The Hydrophobic Effect 1 6
1.8 Structure of Water 17
1.9 Nonpolar Molecules and Water 18
1.10 Highlights 24
References 25
2. The Lipids of Biological Membranes
2.1 Phospholipids 27
2.1.1 Chemical Structure 27
2.1.2 Electrical Charge 32
2.1.3 Phospholipid Composition of Biological Membranes 33
2.1.4 Fatty Acid Composition of Phospholipids 33
2.1.5 Structurally Related Phosphorus-Containing Lipids 41
2.1.6 Phospholipases 43
2.2 Sphingolipids 45
2.3 Glycolipids 49
2.4 Sterols 50
2.5 Two-Headed Lipids 52
2.6 Lipopolysaccharide 52
2.7 Lipid Identification 52
2.8 Highlights 54
References 56
v
vi Contents
3. Biogenesis of Membrane Lipids
3.1 Desaturation of Fatty Acids 57
3.2 Biosynthesis of Phospholipids 60
3.2.1 Biosynthesis of Phosphatidate 60
3.2.2 Biosynthesis of Diacylglycérol from Phosphatidate 60
3.2.3 Biosynthesis of Phosphatidylcholine 61
3.2.4 Phosphatidylethanolamine Biosynthesis 63
3.2.5 Phosphatidylserine Biosynthesis 64
3.2.6 Phosphatidylglycerol and Diphosphatidylglycerol Synthesis 64
3.2.7 Phosphatidylinositol Biosynthesis 65
3.3 Biosynthesis of Sphîngolipîds 66
3.4 Cholesterol Biosynthesis 66
3.5 Assembly of Newly Synthesized Lipids into Membranes 67
3.6 Highlights 70
References 71
4. Detergents
4.1 Nonionic Detergents 73
4.2 Ionic Detergents 75
4.2.1 Lysophospholipids 77
4.3 Detergent Properties 77
4.4 Detergents and Membrane Rafts 82
4.5 Highlights 83
References 84
5. Membrane Models
5.1 The Evidence for the Lipid Bilayer 86
5.2 The Singer Nicholson Model for Membranes 89
5.3 Current Model for Biological Membranes 90
5.4 Highlights 93
References 93
6. Laboratory Membrane Systems
6.1 Structure of Laboratory Membrane Systems 95
6.1.1 Liposomes 95
6.1.2 Sonicated Vesicles 97
6.1.3 Large Unilamellar Vesicles 98
6.1.4 Black Lipid Membrane 1 00
6.1.5 Lipid Monolayers 102
6.1.6 Bicelles 104
6.1.7 Nanodisks 105
6.1.8 Lipodisqs® 106
6.2 Properties Derived from Laboratory Membrane Systems 1 07
6.3 Hydration 109
6.4 Ion Binding 110
6.5 Highlights 112
References 113
Contents vîi
7. Structures of Lîpïd Assemblies
7.1 Lamelïar (Bilayer) Structure
7.2 In ter digitated Bi layers ^
7.3 Micellar Phase 120
7.4 Hexagonal I Phase (H|) 121
7.5 Hexagonal II Phase (Hu) 121
7.6 Cubic Phase 127
7.7 Subphase for Phospholipid Bilayers 127
7.8 Solution Phase 127
7.9 Lipid Phase Transitions 128
7.10 Phase Transitions in Cell Membranes 135
7.11 Lamellar to Hu Phase Transition 138
7.12 Lipid Microdomains in Membranes 140
7.13 Lipid Conformation in Membranes 142
7.13.1 Phospholipid Hydrocarbon Chain Conformations 142
7.13.2 Conformation of the Glycerol Region of the Glycerolipids 145
7.13.3 Phospholipid Headgroup Conformation 147
7.14 Water in the Lipid Bilayer 150
7.15 Highlights 150
References 151
8. Lipid Dynamics in Membranes
v ; 8.1 Introduction 155
8.2 ESR 156
8.3 2H NMR 156
8.4 Motional Order 158
8.4.1 Order Parameters in Membranes 160
8.4.2 Analytical Description of Order Parameter 161
8.4.3 Effects of Phase Transitions on Order Parameters in Membranes 1 64
8.4.4 Effects of Double Bonds in the Phospholipid Acyl
Chains on Motional Order Parameters 1 64
8.4.5 Permeability and Membrane Order 165
8.4.6 Effects of Chofesteroi 166
8.5 Motional Rates 167
8.5.1 Motional Rates for the Dominant Hydrocarbon
Chain Motions in the Lipid Bilayer 1 70
8.5.2 Phospholipid Headgroup Motions 171
8.5.3 Sterol Dynamics 172
8.6 Integrated View of Motional Order and Dynamics 1 72
8.7 Membrane Fluidity 173
8.8 Free Volume Within a Membrane Bilayer 1 74
8.9 Lateral Diffusion of Membrane Components 176
8.10 Lateral Phase Separation 178
8.11 Transmembrane Movement of Lipids 180
8.12 Movement of Phospholipids Between Membranes 1 82
8.13 Transmembrane Lipid Asymmetry 182
8.14 Highlights I05
References
vüi Contents
9. Cholesterol and Related Sterols: Roles in Membrane
Structure and Function
9.1 Structure and Properties of the Cholesterol Molecule 191
9.2 Cholesterol Location in Cells 1 92
9.2.1 Distribution of Cholesterol in Cells 192
9.2.2 Cholesterol Movement Between Membranes 1 93
9.2.3 Partitioning of Cholesterol Among Membranes 1 94
9.2.4 Intracellular Movement 198
9.2.5 Sterol Carrier Proteins 198
9.2.6 Transmembrane Movement of Cholesterol 199
9.2.7 Location of Cholesterol in the Lipid Biiayer 1 99
9.3 Cholesterol Modulates Membrane Physical Properties 200
9.3.1 Ordering of Lipid Bilayers by Cholesterol 201
9.3.2 Cholesterol Reduces Passive Permeability 203
9.3.3 The Condensing Effect of Cholesterol 205
9.3.4 Effects of Cholesterol on Phospholipid Headgroups 205
9.3.5 Effects of Cholesterol on Lateral Diffusion 206
9.3.6 Effects of Cholesterol on Lipid Phase Transitions 206
9.3.7 Cholesterol Cannot Form Lipid Bilayers 207
9.4 Role of Sterols in Sterol-Requiring Cells 207
9.4.1 Sterol Requirements in Cell Biology 207
9.5 Essential Role of Cholesterol in Mammalian and Other
Sterol-Requiring Cells 209
9.6 Hypothesis for a Specific Sterol Requirement 211
9.7 Highlights 214
References 215
10. Membrane Proteins
10.1 Classification of Membrane Proteins 220
10.2 Peripheral Membrane Proteins 223
10.2.1 Cytochrome c, an Associated Membrane Protein 223
10.2.2 Spectrin, a Membrane Skeleton Protein 225
10.3 Integral Membrane Proteins 226
10.3.1 Acetylcholinesterase, an Anchored Protein 226
10.3.2 Human Erythrocyte Glycophorins Are Transmembrane
Proteins 227
10.4 Primary Structure of Membrane Proteins 231
10.5 Secondary Structure of Integral Membrane Proteins 237
10.6 Tertiary Structure of Membrane Proteins 240
10.7 Quaternary Structure of Membrane Proteins 242
10.8 Three-Dimensional Structure of Integral Membrane
Proteins—Experimental Approaches 243
10.9 Principles of Membrane Protein Structure 245
10.10 Domain Structure of Membrane Proteins 258
10.11 Membrane Protein Stability 260
10.12 Dynamics of Membrane Proteins in Membranes 261
10.13 Membrane Protein Asymmetry in Membranes 262
10.14 Posttranslational Modification of Membrane Proteins 263
10.15 Highlights 264
References 2 65
Contents ix
11. Membrane Biogenesis
11.1 Assembly of Newly Synthesized Lipids into Membranes 269
11.2 Transport of Lipids to Target Membranes 274
11.3 Membrane Protein Biosynthesis 277
11.4 Biosynthesis and Insertion of Integral Membrane Proteins into
Endoplasmic Reticulum 278
11.5 Posttranslational Modifications of Membrane Proteins 286
11.6 Degradation of Membrane Proteins 287
11.7 Highlights 287
References 288
12. Lipid—Protein Interactions in Membranes
12.1 Influence of Membrane Proteins on Bulk Membrane Lipid
Properties in a Bilayer 294
12.2 Specific Lipid Influence on Membrane Protein Function 299
12.3 Tight Noncovalent Binding of Lipids to Membrane Proteins 302
12.3.1 Diphosphatidylglycerol (cardiolipin) 306
12.3.2 Phosphatidylglycerol 309
12.3.3 Phosphatidylethanoiamine 310
12.3.4 Phosphatidylinositol 312
12.3.5 Phosphatidylcholine 313
12.3.6 Cholesterol 314
12.4 Pleckstrin Homology Domains 318
12.5 Phospholipase Binding to Phospholipid Substrate 319
12.6 Boundary Lipids in Membranes Containing Transmembrane
Proteins 319
12.7 Dynamics of Lipids Interacting with Membrane Proteins 321
12.8 Membrane Proteins and Rafts 324
12.9 Proteins That Bend Bilayers 325
12.10 Lipids Covalently Bonded to Proteins 325
12.11 Reconstitution 326
12.12 Highlights 328
References 329
13. Membrane Transport
13.1 Passive Diffusion 336
13.2 Facilitated Diffusion 340
13.2.1 Carriers 340
13.2.2 Channels Formed by Antibiotics 345
13.2.3 Protein Channels 347
13.3 Active Transport 362
13.3.1 Lactose Permease 364
13.3.2 Na+ K+ ATPase 366
13.3.3 Sarco(endo)plasmic Reticulum Calcium Pump 369
13.3.4 ATP Synthase 371
13.3.5 Phosphotransferase System of Bacteria 373
13.4 Highlights 375
References 375
x Contents
14. Membrane Fusion
14.1 Fundamentals of the Membrane Fusion Process 382
14.2 Measurement of Membrane Fusion 383
14.3 Fusion of Phospholipid Vesicles 384
14.4 Virus Fusion 386
14.5 Sendai Virus 387
14.6 Influenza Virus 390
14.7 Intracellular Membrane Fusion 393
14.8 Highlights 396
References 397
15. Membrane Receptors
15.1 LDL Receptor 401
15.2 Receptor-Mediated Endocytosis 403
15.3 Transferrin Receptor 405
15.4 Receptor Tyrosine Kinases—Insulin Receptor 406
15.5 Receptor Tyrosine Kinases—Epidermal Growth Factor Receptor 408
15.6 Nicotinic Acetylcholine Receptor 409
15.7 Integrins, Adhesion Receptors 411
15.8 Cuanyly! Cyclase Receptors 412
15.9 G-Protein Coupled Receptors 413
15.10 Highlights 421
References 422
Index
427
|
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| spelling | Yeagle, Philip Verfasser (DE-588)172469317 aut The membranes of cells Philip L. Yeagle, University of Connecticut, Storrs, CT, USA Third edition Amsterdam Elsevier [2016] 2016 XII, 439 Seiten Illustrationen txt rdacontent n rdamedia nc rdacarrier Biochemie (DE-588)4006777-4 gnd rswk-swf Biomembran (DE-588)4006884-5 gnd rswk-swf Plasmamembran (DE-588)4067550-6 gnd rswk-swf Biomembran (DE-588)4006884-5 s DE-604 Plasmamembran (DE-588)4067550-6 s Biochemie (DE-588)4006777-4 s 1\p DE-604 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028874254&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Yeagle, Philip The membranes of cells Biochemie (DE-588)4006777-4 gnd Biomembran (DE-588)4006884-5 gnd Plasmamembran (DE-588)4067550-6 gnd |
| subject_GND | (DE-588)4006777-4 (DE-588)4006884-5 (DE-588)4067550-6 |
| title | The membranes of cells |
| title_auth | The membranes of cells |
| title_exact_search | The membranes of cells |
| title_full | The membranes of cells Philip L. Yeagle, University of Connecticut, Storrs, CT, USA |
| title_fullStr | The membranes of cells Philip L. Yeagle, University of Connecticut, Storrs, CT, USA |
| title_full_unstemmed | The membranes of cells Philip L. Yeagle, University of Connecticut, Storrs, CT, USA |
| title_short | The membranes of cells |
| title_sort | the membranes of cells |
| topic | Biochemie (DE-588)4006777-4 gnd Biomembran (DE-588)4006884-5 gnd Plasmamembran (DE-588)4067550-6 gnd |
| topic_facet | Biochemie Biomembran Plasmamembran |
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