Transglutaminases: Multiple Functional Modifiers and Targets for New Drug Discovery
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Tokyo
Springer
2015
|
| Schlagworte: | |
| Online-Zugang: | TUM01 UBT01 Volltext Abstract Inhaltsverzeichnis |
| Beschreibung: | 1 Online Ressource (VIII, 391 p. 85 illus., 37 illus. in color) |
| ISBN: | 9784431558255 |
| DOI: | 10.1007/978-4-431-55825-5 |
Internformat
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Datensatz im Suchindex
| _version_ | 1804176016683302912 |
|---|---|
| adam_text | TRANSGLUTAMINASES
/
: 2015
ABSTRACT / INHALTSTEXT
THIS BOOK PRESENTS BASIC AND EXTENSIVE INFORMATION ON THE PHYSIOLOGICAL
AND PATHOLOGICAL SIGNIFICANCE OF THE PROTEIN-MODIFYING ENZYMES,
TRANSGLUTAMINASES, WHICH ARE INVOLVED IN MULTIPLE BIOLOGICAL EVENTS BY
CATALYZING A UNIQUE AND IMPORTANT POSTTRANSLATIONAL MODIFICATION
REACTION, CROSS-LINKING OF PROTEINS, AND INTERACTING WITH A LARGE NUMBER
OF PROTEINS INSIDE AND OUTSIDE OF CELLS. ALTHOUGH SEVERAL OF THEIR
ESSENTIAL PHYSIOLOGICAL ROLES HAVE BEEN REVEALED, MANY UNKNOWN AND SO
FAR NOT FULLY UNDERSTOOD FUNCTIONS HAVE REMAINED. IN HUMANS, THERE ARE
EIGHT ACTIVE ISOZYMES HAVING DISTINCT TISSUE AND SUBCELLULAR
DISTRIBUTION PATTERNS WITH DIFFERENT SUBSTRATES AND PHYSIOLOGICAL ROLES.
ACCORDINGLY, ABERRANT REGULATION OF THE ENZYME REACTIONS OR EXPRESSION
MAY LEAD TO OR HAS BEEN IMPLICATED IN VARIOUS PATHOLOGIES INCLUDING
NEURODEGENERATION, FIBROSIS, CANCER, INFLAMMATION, CELIAC DISEASE, AND
HEMOSTASIS DISORDERS.TO PROVIDE THOSE WHO ARE NEW TO THE FIELD WITH
BASIC KNOWLEDGE AND RECENT INFORMATION ON TRANSGLUTAMINASE STRUCTURES
AND REACTIONS, THE MECHANISM BY WHICH TRANSGLUTAMINASES MODIFY SUBSTRATE
PROTEINS AND THEIR CONTRIBUTIONS TO MULTIPLE BIOLOGICAL PHENOMENA AS
WELL AS DISEASE PHENOTYPES, THE PUBLICATION OF THE PRESENT
TRANSGLUTAMINASE BOOK WAS PLANNED, TO CONSIST OF REVIEW ARTICLES BY 17
EXPERT INVESTIGATORS WORKING IN THIS EXCITING AREA OF RESEARCH. THE BOOK
CONTAINS DETAILED INFORMATION RELATED TO SEVERAL TRANSGLUTAMINASES FROM
ASPECTS IN CHEMICAL AND CELLULAR BIOLOGY, MEDICAL SCIENCES, AND
BIOTECHNOLOGY THAT WILL ALSO SUPPLY STARTING POINTS FOR DRUG DISCOVERY.
ALTHOUGH MANY PROMINENT FINDINGS HAVE BEEN PUBLISHED IN RECENT YEARS,
THIS TYPE OF COMPREHENSIVE REVIEW BOOK HAS BEEN MISSING IN THE
SCIENTIFIC LITERATURE. THIS VOLUME WILL BE USEFUL FOR INVESTIGATORS WHO
EITHER CURRENTLY WORK ON OR WILL START ADDRESSING
TRANSGLUTAMINASE-RELATED RESEARCH, AND BEYOND THAT, FOR A BROAD AUDIENCE
IN THE SCIENTIFIC COMMUNITY.
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
TRANSGLUTAMINASES
/
: 2015
TABLE OF CONTENTS / INHALTSVERZEICHNIS
1 STRUCTURE OF TRANSGLUTAMINASES. UNIQUE FEATURES SERVE DIVERSE
FUNCTIONS
2 CONTROL OF TG FUNCTIONS DEPENDING ON THEIR LOCALIZATION
3 PREFERRED SUBSTRATE STRUCTURE OF TRANSGLUTAMINASES
4 INSIGHTS INTO TRANSGLUTAMINASE 2 FUNCTION GAINED FROM
GENETICALLY-MODIFIED ANIMAL MODELS
5 TRANGLUTAMINASE IN INVERTEBRATES
6 FORMATION OF INTEGRIN-BINDING SITE ON POLYMER OF TRANSGLUTAMINATION
7 TRANSGLUTAMINASE 2-MEDIATED GENE REGULATION
8 THE ROLE OF TRANSGLUTAMINASE TYPE 2 IN THE REGULATION OF AUTOPHAGY
9 TRANSGLUTAMINASE 2 AND CELIAC DISEASE
10 TRANSGLUTAMINASE II AND METASTASIS: HOW HOT IS THE LINK?- 11
TRANSGLUTAMINASES: EXPRESSION IN KIDNEY AND RELATION TO KIDNEY FIBROSIS
12 TRANSGLUTAMINASES IN BONE FORMATION AND BONE MATRIX STABILIZATION
13 TRANSGLUTAMINASES AND NEUROLOGICAL DISEASES
14 TRANSGLUTAMINASE; MECHANISM BY OXIDATIVE STRESS
15 BLOOD COAGULATION FACTOR XIII : A MULTIFUNCTIONAL TRANSGLUTAMINASE
16 INHIBITION OF TRANSGLUTAMINASE
17 SUBSTRATE ENGINEERING OF MICROBIAL TRANSGLUTAMINASE FOR SITE-SPECIFIC
PROTEIN MODIFICATION AND BIOCONJUGATION
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
| any_adam_object | 1 |
| building | Verbundindex |
| bvnumber | BV043422437 |
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| dewey-full | 615.19 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.19 |
| dewey-search | 615.19 |
| dewey-sort | 3615.19 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Medizin |
| doi_str_mv | 10.1007/978-4-431-55825-5 |
| format | Electronic eBook |
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| indexdate | 2024-07-10T07:25:29Z |
| institution | BVB |
| isbn | 9784431558255 |
| language | English |
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| spelling | Transglutaminases Multiple Functional Modifiers and Targets for New Drug Discovery Kiyotaka Hitomi, Soichi Kojima, Laszlo Fesus, ed. Tokyo Springer 2015 1 Online Ressource (VIII, 391 p. 85 illus., 37 illus. in color) txt rdacontent c rdamedia cr rdacarrier Medicine Pharmaceutical technology Biochemistry Enzymology Biomedicine Pharmaceutical Sciences/Technology Animal Biochemistry Medizin Hitomi, Kiyotaka Sonstige oth Kojima, Soichi Sonstige oth Fesus, Laszlo Sonstige oth Erscheint auch als Druckausgabe 978-4-431-55823-1 https://doi.org/10.1007/978-4-431-55825-5 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028840330&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Abstract Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028840330&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Transglutaminases Multiple Functional Modifiers and Targets for New Drug Discovery Medicine Pharmaceutical technology Biochemistry Enzymology Biomedicine Pharmaceutical Sciences/Technology Animal Biochemistry Medizin |
| title | Transglutaminases Multiple Functional Modifiers and Targets for New Drug Discovery |
| title_auth | Transglutaminases Multiple Functional Modifiers and Targets for New Drug Discovery |
| title_exact_search | Transglutaminases Multiple Functional Modifiers and Targets for New Drug Discovery |
| title_full | Transglutaminases Multiple Functional Modifiers and Targets for New Drug Discovery Kiyotaka Hitomi, Soichi Kojima, Laszlo Fesus, ed. |
| title_fullStr | Transglutaminases Multiple Functional Modifiers and Targets for New Drug Discovery Kiyotaka Hitomi, Soichi Kojima, Laszlo Fesus, ed. |
| title_full_unstemmed | Transglutaminases Multiple Functional Modifiers and Targets for New Drug Discovery Kiyotaka Hitomi, Soichi Kojima, Laszlo Fesus, ed. |
| title_short | Transglutaminases |
| title_sort | transglutaminases multiple functional modifiers and targets for new drug discovery |
| title_sub | Multiple Functional Modifiers and Targets for New Drug Discovery |
| topic | Medicine Pharmaceutical technology Biochemistry Enzymology Biomedicine Pharmaceutical Sciences/Technology Animal Biochemistry Medizin |
| topic_facet | Medicine Pharmaceutical technology Biochemistry Enzymology Biomedicine Pharmaceutical Sciences/Technology Animal Biochemistry Medizin |
| url | https://doi.org/10.1007/978-4-431-55825-5 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028840330&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028840330&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
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