High throughput screening: methods and protocols
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York
Humana Press
[2016]
|
| Ausgabe: | Third edition |
| Schriftenreihe: | Methods in molecular biology
1439 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XI, 308 Seiten Illustrationen, Diagramme |
| ISBN: | 9781493936717 |
Internformat
MARC
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Datensatz im Suchindex
| _version_ | 1804176016126509056 |
|---|---|
| adam_text | Titel: High throughput screening
Autor: Janzen, William P
Jahr: 2016
Contents
Preface.................................................................... v
Contributors............................................................... ix
1 Design and Implementation of High-Throughput Screening Assays.......... 1
David J. Powell, Robert P. Hertsberg, and Ricardo Macarron
2 Characterization of Inhibitor Binding Through Multiple Inhibitor
Analysis: A Novel Local Fitting Method.................................. 33
Thomas V. Riera, Tim J. Wigle, and Robert A. Copeland
3 High-Throughput Screening Using Mass Spectrometry
within Drug Discovery................................................. 47
Mattias Rohman and Jonathan Wingfield
4 Structure-Based Virtual Screening of Commercially Available
Compound Libraries................................................... 65
Dmitri Kireev
5 AlphaScreen-Based Assays: Ultra-High-Throughput Screening
for Small-Molecule Inhibitors of Challenging Enzymes
and Protein-Protein Interactions......................................... 77
Adam Yasgar, Aßt Jadhav, Anton Simeonov, and Nathan P. Coussens
6 Instrument Quality Control............................................. 99
Chatura Jayakody and Emily A. Hull-Ryde
7 Application of Fluorescence Polarization in HTS Assays.................... 115
Xinyi Huang and Ann Aulabaugh
8 Time-Resolved Fluorescence Assays...................................... 131
Chen-Ting Ma and Eduard A. Sergienko
9 Protein Kinase Selectivity Profiling Using Microfluid Mobility
Shift Assays............................................................ 143
Peter Drueckes
10 Screening for Inhibitors of Kinase Autophosphorylation.................... 159
Bianca Heedmann and Martin Klumpp
11 A Fluorescence-Based High-Throughput Screening Assay
to Identify Growth Inhibitors of the Pathogenic Fungus
Aspergillus fumigatus................................................... 171
Thomas M. Smith, Daryl L. Richie, and Jianshi Tao
12 Mycobacterium tuberculosis High-Throughput Screening.................... 181
E. Lucile White, Nichole A. Tower, and Lynn Rasmussen
13 Identification of State-Dependent Blockers for Voltage-
Gated Calcium Channels Using a FLIPR-Based Assay...................... 197
Alberto di Silvio, JeanFrancois Rolland, and Michela Stucchi
vii
viii
Contents
14 A Luciferase Reporter Gene System for High-Throughput Screening
of y-Globin Gene Activators............................................. 207
Wensheng Xie, Robert Silvers, Michael Ouellette, Zining Wu, Quinn Lu,
Hu Li, Kathleen Gallagher, Kathy Johnson, and Monica Montoute
15 A High-Throughput Flow Cytometry Assay for Identification
of Inhibitors of 3 , 5 -Cyclic Adenosine Monophosphate Efflux.............. 227
Dominique Perez, Peter C. Simons, Telena Smagley,
Larry A. Sklar, and Alexandre Chigaev
16 High-Throughput Cell Toxicity Assays................................... 245
David Murray, Lisa McWilliams, and Mark Wigglesworth
17 BRET: NanoLuc-Based Bioluminescence Resonance Energy
Transfer Platform to Monitor Protein-Protein
Interactions in Live Cells............................................... 263
Xiu-Lei Mo and Haian Fu
18 Application of Imaging-Based Assays in Microplate Formats
for High-Content Screening............................................ 273
Adam I. Fogel, Scott E. Martin, and Samuel A. Hasson
Index..................................................................... 305
|
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| spelling | High throughput screening methods and protocols edited by William P. Janzen, Epizyme, Inc. Cambridge, MA, USA Third edition New York Humana Press [2016] XI, 308 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Methods in molecular biology 1439 Springer protocols High throughput screening (DE-588)4596131-1 gnd rswk-swf Arzneimittelentwicklung (DE-588)4143176-5 gnd rswk-swf 1\p (DE-588)4143413-4 Aufsatzsammlung gnd-content High throughput screening (DE-588)4596131-1 s Arzneimittelentwicklung (DE-588)4143176-5 s DE-604 Janzen, William P. (DE-588)139819452 edt Erscheint auch als Online-Ausgabe 978-1-4939-3673-1 Methods in molecular biology 1439 (DE-604)BV035362695 1439 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028840025&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | High throughput screening methods and protocols Methods in molecular biology High throughput screening (DE-588)4596131-1 gnd Arzneimittelentwicklung (DE-588)4143176-5 gnd |
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| title | High throughput screening methods and protocols |
| title_auth | High throughput screening methods and protocols |
| title_exact_search | High throughput screening methods and protocols |
| title_full | High throughput screening methods and protocols edited by William P. Janzen, Epizyme, Inc. Cambridge, MA, USA |
| title_fullStr | High throughput screening methods and protocols edited by William P. Janzen, Epizyme, Inc. Cambridge, MA, USA |
| title_full_unstemmed | High throughput screening methods and protocols edited by William P. Janzen, Epizyme, Inc. Cambridge, MA, USA |
| title_short | High throughput screening |
| title_sort | high throughput screening methods and protocols |
| title_sub | methods and protocols |
| topic | High throughput screening (DE-588)4596131-1 gnd Arzneimittelentwicklung (DE-588)4143176-5 gnd |
| topic_facet | High throughput screening Arzneimittelentwicklung Aufsatzsammlung |
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