Blood-brain barrier in drug discovery: optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Hoboken, New Jersey
Wiley
[2015]
|
| Schlagworte: | |
| Online-Zugang: | FRO01 UBG01 Volltext |
| Beschreibung: | Includes bibliographical references and index "Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant - and most challenging - areas of drug discovery. Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects. Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies. Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes. Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK). Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market"--Provided by publisher |
| Beschreibung: | 1 Online-Ressource |
| ISBN: | 9781118788493 1118788494 9781118788547 1118788540 9781118788523 1118788524 9781322572406 1322572402 |
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Datensatz im Suchindex
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| dewey-ones | 615 - Pharmacology and therapeutics |
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| dewey-search | 615.7/8 |
| dewey-sort | 3615.7 18 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Medizin |
| format | Electronic eBook |
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| id | DE-604.BV043397214 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T07:24:53Z |
| institution | BVB |
| isbn | 9781118788493 1118788494 9781118788547 1118788540 9781118788523 1118788524 9781322572406 1322572402 |
| language | English |
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| spelling | Blood-brain barrier in drug discovery optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs edited by Li Di, Edward H. Kerns Hoboken, New Jersey Wiley [2015] 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Includes bibliographical references and index "Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant - and most challenging - areas of drug discovery. Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects. Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies. Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes. Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK). Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market"--Provided by publisher Blood-Brain Barrier / metabolism Central Nervous System Agents / pharmacokinetics Blood-Brain Barrier / drug effects Central Nervous System Diseases / drug therapy Drug Discovery / methods Drug-Related Side Effects and Adverse Reactions / prevention & control MEDICAL / Pharmacology bisacsh Medizin Blood-brain barrier / Metabolism Drug development Arzneimittelforschung (DE-588)4003120-2 gnd rswk-swf Blut-Hirn-Schranke (DE-588)4007279-4 gnd rswk-swf Neuropharmakologie (DE-588)4041896-0 gnd rswk-swf Wirkstofffreisetzung (DE-588)4190018-2 gnd rswk-swf Blut-Hirn-Schranke (DE-588)4007279-4 s Neuropharmakologie (DE-588)4041896-0 s Arzneimittelforschung (DE-588)4003120-2 s Wirkstofffreisetzung (DE-588)4190018-2 s 1\p DE-604 Di, Li Sonstige oth Kerns, Edward Harvel Sonstige oth Erscheint auch als Druck-Ausgabe, Hardcover 978-1-118-78835-6 Erscheint auch als Druck-Ausgabe, Hardcover 1-118-78835-4 https://onlinelibrary.wiley.com/doi/book/10.1002/9781118788523 Verlag URL des Erstveröffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Blood-brain barrier in drug discovery optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs Blood-Brain Barrier / metabolism Central Nervous System Agents / pharmacokinetics Blood-Brain Barrier / drug effects Central Nervous System Diseases / drug therapy Drug Discovery / methods Drug-Related Side Effects and Adverse Reactions / prevention & control MEDICAL / Pharmacology bisacsh Medizin Blood-brain barrier / Metabolism Drug development Arzneimittelforschung (DE-588)4003120-2 gnd Blut-Hirn-Schranke (DE-588)4007279-4 gnd Neuropharmakologie (DE-588)4041896-0 gnd Wirkstofffreisetzung (DE-588)4190018-2 gnd |
| subject_GND | (DE-588)4003120-2 (DE-588)4007279-4 (DE-588)4041896-0 (DE-588)4190018-2 |
| title | Blood-brain barrier in drug discovery optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs |
| title_auth | Blood-brain barrier in drug discovery optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs |
| title_exact_search | Blood-brain barrier in drug discovery optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs |
| title_full | Blood-brain barrier in drug discovery optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs edited by Li Di, Edward H. Kerns |
| title_fullStr | Blood-brain barrier in drug discovery optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs edited by Li Di, Edward H. Kerns |
| title_full_unstemmed | Blood-brain barrier in drug discovery optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs edited by Li Di, Edward H. Kerns |
| title_short | Blood-brain barrier in drug discovery |
| title_sort | blood brain barrier in drug discovery optimizing brain exposure of cns drugs and minimizing brain side effects for peripheral drugs |
| title_sub | optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs |
| topic | Blood-Brain Barrier / metabolism Central Nervous System Agents / pharmacokinetics Blood-Brain Barrier / drug effects Central Nervous System Diseases / drug therapy Drug Discovery / methods Drug-Related Side Effects and Adverse Reactions / prevention & control MEDICAL / Pharmacology bisacsh Medizin Blood-brain barrier / Metabolism Drug development Arzneimittelforschung (DE-588)4003120-2 gnd Blut-Hirn-Schranke (DE-588)4007279-4 gnd Neuropharmakologie (DE-588)4041896-0 gnd Wirkstofffreisetzung (DE-588)4190018-2 gnd |
| topic_facet | Blood-Brain Barrier / metabolism Central Nervous System Agents / pharmacokinetics Blood-Brain Barrier / drug effects Central Nervous System Diseases / drug therapy Drug Discovery / methods Drug-Related Side Effects and Adverse Reactions / prevention & control MEDICAL / Pharmacology Medizin Blood-brain barrier / Metabolism Drug development Arzneimittelforschung Blut-Hirn-Schranke Neuropharmakologie Wirkstofffreisetzung |
| url | https://onlinelibrary.wiley.com/doi/book/10.1002/9781118788523 |
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