Structure-based ligand design:
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Weinheim
Wiley-VCH
©1998
|
| Schriftenreihe: | Methods and principles in medicinal chemistry
v. 6 |
| Schlagworte: | |
| Online-Zugang: | FRO01 UBG01 Volltext |
| Beschreibung: | Includes bibliographical references and index Most drugs bind to a clearly defined macromolecular target that is complementary in terms of structure and chemistry. This observation is the basic paradigm of structure-based ligand design. Although this method first emerged in the 1980s, it has already become a powerful tool for pharmaceutical research. Much has been learned, however, since the first attempts to discover drugs on the basis of available biochemical and structural data. Nowadays, structure-based ligand design is an established method for creating drugs with new structural features, for modifying binding activities and pharmaco |
| Beschreibung: | 1 Online-Ressource (xiv, 153 pages) |
| ISBN: | 9783527612161 3527612165 9783527612178 3527612173 9783527293438 3527293434 |
Internformat
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Datensatz im Suchindex
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| any_adam_object | |
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| dewey-full | 615/.7 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615/.7 |
| dewey-search | 615/.7 |
| dewey-sort | 3615 17 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Electronic eBook |
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| id | DE-604.BV043389431 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T07:24:37Z |
| institution | BVB |
| isbn | 9783527612161 3527612165 9783527612178 3527612173 9783527293438 3527293434 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-028808015 |
| oclc_num | 310352420 |
| open_access_boolean | |
| owner | DE-861 |
| owner_facet | DE-861 |
| physical | 1 Online-Ressource (xiv, 153 pages) |
| psigel | ZDB-35-WIC UBG_PDA_WIC ZDB-35-WIC FRO_PDA_WIC ZDB-35-WIC UBG_PDA_WIC |
| publishDate | 1998 |
| publishDateSearch | 1998 |
| publishDateSort | 1998 |
| publisher | Wiley-VCH |
| record_format | marc |
| series2 | Methods and principles in medicinal chemistry |
| spelling | Structure-based ligand design edited by Klaus Gubernator, Hans-Joachim Böhm Weinheim Wiley-VCH ©1998 1 Online-Ressource (xiv, 153 pages) txt rdacontent c rdamedia cr rdacarrier Methods and principles in medicinal chemistry v. 6 Includes bibliographical references and index Most drugs bind to a clearly defined macromolecular target that is complementary in terms of structure and chemistry. This observation is the basic paradigm of structure-based ligand design. Although this method first emerged in the 1980s, it has already become a powerful tool for pharmaceutical research. Much has been learned, however, since the first attempts to discover drugs on the basis of available biochemical and structural data. Nowadays, structure-based ligand design is an established method for creating drugs with new structural features, for modifying binding activities and pharmaco Ligands Receptors, Cell Surface / physiology Drug Design Structure-Activity Relationship MEDICAL / Pharmacology bisacsh Drugs / Design fast Ligand binding (Biochemistry) fast Pharmaceutical chemistry fast QSAR (Biochemistry) fast Récepteurs de surface cellulaire / Physiologie Relation structure-activité Conception de médicaments Liganden gtt Molecular design gtt Bioactivering gtt Enzyminhibitoren gtt Quimica farmaceutica larpcal Bioquimica larpcal Ligands ram Ligands (biochimie) ram Wirkstoff-Rezeptor-Bindung swd Arzneimitteldesign swd Medizin Ligand binding (Biochemistry) Pharmaceutical chemistry QSAR (Biochemistry) Drugs / Design Molekülstruktur (DE-588)4170383-2 gnd rswk-swf Proteine (DE-588)4076388-2 gnd rswk-swf Arzneimitteldesign (DE-588)4278218-1 gnd rswk-swf Enzyminhibitor (DE-588)4152479-2 gnd rswk-swf Ligand (DE-588)4035711-9 gnd rswk-swf Wirkstoff-Rezeptor-Bindung (DE-588)4190019-4 gnd rswk-swf Proteine (DE-588)4076388-2 s Ligand (DE-588)4035711-9 s Molekülstruktur (DE-588)4170383-2 s Arzneimitteldesign (DE-588)4278218-1 s 1\p DE-604 Wirkstoff-Rezeptor-Bindung (DE-588)4190019-4 s 2\p DE-604 Enzyminhibitor (DE-588)4152479-2 s 3\p DE-604 Gubernator, Klaus Sonstige oth Böhm, Hans-Joachim Sonstige oth https://onlinelibrary.wiley.com/doi/book/10.1002/9783527612178 Verlag URL des Erstveröffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 3\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Structure-based ligand design Ligands Receptors, Cell Surface / physiology Drug Design Structure-Activity Relationship MEDICAL / Pharmacology bisacsh Drugs / Design fast Ligand binding (Biochemistry) fast Pharmaceutical chemistry fast QSAR (Biochemistry) fast Récepteurs de surface cellulaire / Physiologie Relation structure-activité Conception de médicaments Liganden gtt Molecular design gtt Bioactivering gtt Enzyminhibitoren gtt Quimica farmaceutica larpcal Bioquimica larpcal Ligands ram Ligands (biochimie) ram Wirkstoff-Rezeptor-Bindung swd Arzneimitteldesign swd Medizin Ligand binding (Biochemistry) Pharmaceutical chemistry QSAR (Biochemistry) Drugs / Design Molekülstruktur (DE-588)4170383-2 gnd Proteine (DE-588)4076388-2 gnd Arzneimitteldesign (DE-588)4278218-1 gnd Enzyminhibitor (DE-588)4152479-2 gnd Ligand (DE-588)4035711-9 gnd Wirkstoff-Rezeptor-Bindung (DE-588)4190019-4 gnd |
| subject_GND | (DE-588)4170383-2 (DE-588)4076388-2 (DE-588)4278218-1 (DE-588)4152479-2 (DE-588)4035711-9 (DE-588)4190019-4 |
| title | Structure-based ligand design |
| title_auth | Structure-based ligand design |
| title_exact_search | Structure-based ligand design |
| title_full | Structure-based ligand design edited by Klaus Gubernator, Hans-Joachim Böhm |
| title_fullStr | Structure-based ligand design edited by Klaus Gubernator, Hans-Joachim Böhm |
| title_full_unstemmed | Structure-based ligand design edited by Klaus Gubernator, Hans-Joachim Böhm |
| title_short | Structure-based ligand design |
| title_sort | structure based ligand design |
| topic | Ligands Receptors, Cell Surface / physiology Drug Design Structure-Activity Relationship MEDICAL / Pharmacology bisacsh Drugs / Design fast Ligand binding (Biochemistry) fast Pharmaceutical chemistry fast QSAR (Biochemistry) fast Récepteurs de surface cellulaire / Physiologie Relation structure-activité Conception de médicaments Liganden gtt Molecular design gtt Bioactivering gtt Enzyminhibitoren gtt Quimica farmaceutica larpcal Bioquimica larpcal Ligands ram Ligands (biochimie) ram Wirkstoff-Rezeptor-Bindung swd Arzneimitteldesign swd Medizin Ligand binding (Biochemistry) Pharmaceutical chemistry QSAR (Biochemistry) Drugs / Design Molekülstruktur (DE-588)4170383-2 gnd Proteine (DE-588)4076388-2 gnd Arzneimitteldesign (DE-588)4278218-1 gnd Enzyminhibitor (DE-588)4152479-2 gnd Ligand (DE-588)4035711-9 gnd Wirkstoff-Rezeptor-Bindung (DE-588)4190019-4 gnd |
| topic_facet | Ligands Receptors, Cell Surface / physiology Drug Design Structure-Activity Relationship MEDICAL / Pharmacology Drugs / Design Ligand binding (Biochemistry) Pharmaceutical chemistry QSAR (Biochemistry) Récepteurs de surface cellulaire / Physiologie Relation structure-activité Conception de médicaments Liganden Molecular design Bioactivering Enzyminhibitoren Quimica farmaceutica Bioquimica Ligands (biochimie) Wirkstoff-Rezeptor-Bindung Arzneimitteldesign Medizin Molekülstruktur Proteine Enzyminhibitor Ligand |
| url | https://onlinelibrary.wiley.com/doi/book/10.1002/9783527612178 |
| work_keys_str_mv | AT gubernatorklaus structurebasedliganddesign AT bohmhansjoachim structurebasedliganddesign |