Pharmacokinetics and metabolism in drug design:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Weinheim
Wiley-VCH
©2001
|
| Schriftenreihe: | Methods and principles in medicinal chemistry
|
| Schlagworte: | |
| Online-Zugang: | FRO01 UBG01 Volltext |
| Beschreibung: | Includes bibliographical references and index The medical benefits of a drug are not only dependent on its biological effect, but also on its "life cycle" within the organism - from its absorption into the blood, distribution to tissue until its eventual breakdown or excretion by the liver and kidneys. Here, the authors, all of them employed at Pfizer in the discovery and development of new active substances, discuss the significant parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. The authors cover everything from the fundamental principles right up to the latest developments using high throughput methods to analyze the pharmacokinetic properties of active substances. Particular emphasis is placed on the impact of pharmacokinetic parameters on the discovery of new drugs - one of the most challenging tasks in global pharmaceutical research. Thus, this book is aimed at all those dealing professionally with the development and application of pharmaceutical substances. Furthermore, the readily comprehensible style of writing makes it equally suitable for students of pharmacy and related subjects, who feel that pharmacokinetics is covered too briefly in the standard textbooks |
| Beschreibung: | 1 Online-Ressource (xi, 149 pages) |
| ISBN: | 3527600213 9783527600212 |
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| 500 | |a The medical benefits of a drug are not only dependent on its biological effect, but also on its "life cycle" within the organism - from its absorption into the blood, distribution to tissue until its eventual breakdown or excretion by the liver and kidneys. Here, the authors, all of them employed at Pfizer in the discovery and development of new active substances, discuss the significant parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. The authors cover everything from the fundamental principles right up to the latest developments using high throughput methods to analyze the pharmacokinetic properties of active substances. Particular emphasis is placed on the impact of pharmacokinetic parameters on the discovery of new drugs - one of the most challenging tasks in global pharmaceutical research. Thus, this book is aimed at all those dealing professionally with the development and application of pharmaceutical substances. Furthermore, the readily comprehensible style of writing makes it equally suitable for students of pharmacy and related subjects, who feel that pharmacokinetics is covered too briefly in the standard textbooks | ||
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Datensatz im Suchindex
| _version_ | 1804175954278350848 |
|---|---|
| any_adam_object | |
| author | Smith, Dennis A. |
| author_facet | Smith, Dennis A. |
| author_role | aut |
| author_sort | Smith, Dennis A. |
| author_variant | d a s da das |
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| bvnumber | BV043385699 |
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| dewey-full | 615.7 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.7 |
| dewey-search | 615.7 |
| dewey-sort | 3615.7 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Medizin |
| format | Electronic eBook |
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| id | DE-604.BV043385699 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T07:24:29Z |
| institution | BVB |
| isbn | 3527600213 9783527600212 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-028804283 |
| oclc_num | 85820570 |
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| physical | 1 Online-Ressource (xi, 149 pages) |
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| publisher | Wiley-VCH |
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| series2 | Methods and principles in medicinal chemistry |
| spelling | Smith, Dennis A. Verfasser aut Pharmacokinetics and metabolism in drug design by Dennis A. Smith, Han van de Waterbeemd and Don K. Walker Weinheim Wiley-VCH ©2001 1 Online-Ressource (xi, 149 pages) txt rdacontent c rdamedia cr rdacarrier Methods and principles in medicinal chemistry Includes bibliographical references and index The medical benefits of a drug are not only dependent on its biological effect, but also on its "life cycle" within the organism - from its absorption into the blood, distribution to tissue until its eventual breakdown or excretion by the liver and kidneys. Here, the authors, all of them employed at Pfizer in the discovery and development of new active substances, discuss the significant parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. The authors cover everything from the fundamental principles right up to the latest developments using high throughput methods to analyze the pharmacokinetic properties of active substances. Particular emphasis is placed on the impact of pharmacokinetic parameters on the discovery of new drugs - one of the most challenging tasks in global pharmaceutical research. Thus, this book is aimed at all those dealing professionally with the development and application of pharmaceutical substances. Furthermore, the readily comprehensible style of writing makes it equally suitable for students of pharmacy and related subjects, who feel that pharmacokinetics is covered too briefly in the standard textbooks Pharmaceutical medicinal chemistry Pharmaceutical Preparations / metabolism Drug Design Pharmacokinetics Drugs / Design fast Drugs / Metabolism fast Pharmacokinetics fast Drugs / Metabolism Drugs / Design Arzneimitteldesign (DE-588)4278218-1 gnd rswk-swf Biotransformation (DE-588)4006908-4 gnd rswk-swf Pharmakokinetik (DE-588)4115557-9 gnd rswk-swf Arzneimitteldesign (DE-588)4278218-1 s Pharmakokinetik (DE-588)4115557-9 s Biotransformation (DE-588)4006908-4 s 1\p DE-604 Van de Waterbeemd, Han Sonstige oth Walker, Don K. Sonstige oth Erscheint auch als Druckausgabe 3-527-30197-6 Erscheint auch als Druckausgabe 978-3-527-30197-3 https://onlinelibrary.wiley.com/doi/book/10.1002/3527600213 Verlag URL des Erstveröffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Smith, Dennis A. Pharmacokinetics and metabolism in drug design Pharmaceutical medicinal chemistry Pharmaceutical Preparations / metabolism Drug Design Pharmacokinetics Drugs / Design fast Drugs / Metabolism fast Pharmacokinetics fast Drugs / Metabolism Drugs / Design Arzneimitteldesign (DE-588)4278218-1 gnd Biotransformation (DE-588)4006908-4 gnd Pharmakokinetik (DE-588)4115557-9 gnd |
| subject_GND | (DE-588)4278218-1 (DE-588)4006908-4 (DE-588)4115557-9 |
| title | Pharmacokinetics and metabolism in drug design |
| title_auth | Pharmacokinetics and metabolism in drug design |
| title_exact_search | Pharmacokinetics and metabolism in drug design |
| title_full | Pharmacokinetics and metabolism in drug design by Dennis A. Smith, Han van de Waterbeemd and Don K. Walker |
| title_fullStr | Pharmacokinetics and metabolism in drug design by Dennis A. Smith, Han van de Waterbeemd and Don K. Walker |
| title_full_unstemmed | Pharmacokinetics and metabolism in drug design by Dennis A. Smith, Han van de Waterbeemd and Don K. Walker |
| title_short | Pharmacokinetics and metabolism in drug design |
| title_sort | pharmacokinetics and metabolism in drug design |
| topic | Pharmaceutical medicinal chemistry Pharmaceutical Preparations / metabolism Drug Design Pharmacokinetics Drugs / Design fast Drugs / Metabolism fast Pharmacokinetics fast Drugs / Metabolism Drugs / Design Arzneimitteldesign (DE-588)4278218-1 gnd Biotransformation (DE-588)4006908-4 gnd Pharmakokinetik (DE-588)4115557-9 gnd |
| topic_facet | Pharmaceutical medicinal chemistry Pharmaceutical Preparations / metabolism Drug Design Pharmacokinetics Drugs / Design Drugs / Metabolism Arzneimitteldesign Biotransformation Pharmakokinetik |
| url | https://onlinelibrary.wiley.com/doi/book/10.1002/3527600213 |
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