Physicochemical principles of pharmacy: in manufacture, formulation and clinical use
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
London
Pharmaceutical Press
2016
|
| Ausgabe: | Sixth edition |
| Schlagworte: | |
| Online-Zugang: | Klappentext Inhaltsverzeichnis |
| Beschreibung: | xi, 647 Seiten Illustrationen, Diagramme |
| ISBN: | 9780857111746 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV043375035 | ||
| 003 | DE-604 | ||
| 005 | 20160316 | ||
| 007 | t | ||
| 008 | 160218s2016 a||| |||| 00||| eng d | ||
| 020 | |a 9780857111746 |9 978-0-85711-174-6 | ||
| 035 | |a (OCoLC)1005922270 | ||
| 035 | |a (DE-599)BVBBV043375035 | ||
| 040 | |a DE-604 |b ger |e rda | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-355 |a DE-19 | ||
| 082 | 0 | |a 615.19 |2 22 | |
| 084 | |a VX 5200 |0 (DE-625)147798:253 |2 rvk | ||
| 100 | 1 | |a Florence, Alexander T. |d 1940- |e Verfasser |0 (DE-588)128453249 |4 aut | |
| 245 | 1 | 0 | |a Physicochemical principles of pharmacy |b in manufacture, formulation and clinical use |c Alexander T. Florence, David Attwood |
| 250 | |a Sixth edition | ||
| 264 | 1 | |a London |b Pharmaceutical Press |c 2016 | |
| 300 | |a xi, 647 Seiten |b Illustrationen, Diagramme | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Drugs | |
| 650 | 4 | |a Pharmaceutical chemistry | |
| 650 | 0 | 7 | |a Pharmazeutische Technologie |0 (DE-588)4045699-7 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Arzneiform |0 (DE-588)4068874-4 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Physikalische Chemie |0 (DE-588)4045959-7 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Pharmazeutische Technologie |0 (DE-588)4045699-7 |D s |
| 689 | 0 | 1 | |a Physikalische Chemie |0 (DE-588)4045959-7 |D s |
| 689 | 0 | |5 DE-604 | |
| 689 | 1 | 0 | |a Arzneiform |0 (DE-588)4068874-4 |D s |
| 689 | 1 | |5 DE-604 | |
| 700 | 1 | |a Attwood, David |d 1940- |e Verfasser |0 (DE-588)132643278 |4 aut | |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe, EPUB |z 978-0-85711-259-0 |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe, MOBI |z 978-0-85711-260-6 |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe, PDF |z 978-0-85711-258-3 |
| 856 | 4 | 2 | |m Digitalisierung UB Regensburg - ADAM Catalogue Enrichment |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028793872&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Klappentext |
| 856 | 4 | 2 | |m Digitalisierung UB Regensburg - ADAM Catalogue Enrichment |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028793872&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-028793872 | ||
Datensatz im Suchindex
| _version_ | 1804175938893643776 |
|---|---|
| adam_text | This is an established textbook that provides you with full coverage of
the physicochemical principles essential to the modern pharmacist and
pharmaceutical scientist.
The sixth edition continues to boast a broad chemical and physicochemical
base and covers every aspect of drug properties from the design of dosage
forms to their delivery by all routes to sites of action in the body. Now with
more clinical examples, new questions and extra case studies it encourages
you to apply this knowledge and understand how these fundamental
concepts relate to both clinical and industrial practice. It features brand
new chapters/sections on:
• paediatric and geriatric formulations
• adverse events: the role of formulations and delivery systems
• generic medicines and biosimilars
• solid dose form manufacture.
Contents
Preface xiii
About the authors xv
Introduction
1 Solids
1.1 Classification of solids
1.2 Crystalline solids: structure and properties
1 .3 Amorphous solids
1.4 Dissolution of solid drugs
1.5 Biopharmaceutical importance of particle size
1.6 Wetting of powders
1.7 freeze drying
1.8 Solid dosage forms՝ formulation and manufacture
1.9 Solid dispersions
Summary
References
1
7
8
8
75
25
26
29
32
34
63
66
68
2 Physicochemical properties of drugs in solution 69
2.1 Concentration units 69
2.2 Thermodynamics: a brief introduction 71
2.3 Activity and chemical potential 75
2.4 Osmotic properties of drug solutions 80
2.5 Ionisation of drugs in solution 87
2.6 Diffusion of drugs in solution 105
Summary 106
References 107
3 Drug stability 109
3.1 The chemical decomposition of drugs 109
3.2 Kinetics of chemical decomposition in solution 118
3.3 Solid-dosage forms: kinetics of chemical decomposition 127
3.4 Factors influencing drug stability 129
3.5 Stability testing and prediction of shelf-life 141
Summary I49
References 150
viii I Contents
4 The solubility of drugs 153
4.1 Definitions 154
42 Factors influencing solubility 154
4.3 Measurement of solubility 169
4.4 The solubility parameter 170
4.5 Solubility in mixed solvents: use of cosolvents 171
4.6 Cyclodextrins as solubilising agents 174
4.7 Solubility problems in formulation 177
4.8 Partitioning 181
4.9 Biological activity and partition coefficients: thermodynamic activity and Ferguson s principle 183
4.10 Using log P 183
Summary 190
References 191
5 Surfactants 193
5.1 Am phi path ic compounds 194
5.2 Surface and interfacial properties of surfactants 195
5.3 Micellisation 218
5.4 Liquid crystals and surfactant vesicles 22/
5.5 Properties of some commonly used surfactants 231
5.6 Solubilisation 237
Summary 244
References 244
6 Emulsions, suspensions and related colloidal systems 247
6.1 Colloids and their classification 248
6.2 Colloid stability 249
6.3 Disperse system flow 255
6.4 Emulsions 261
6.5 Suspensions 279
6.6 Miscellaneous colloidal systems 288
6.7 Applications of colloid stability theory to other systems 288
6.8 Foams 291
Summary 293
References 294
7 Polymers and macromolecules 295
7.1 Pharmaceutical polymers 296
72 Water-soluble polymers 301
7.3 General properties of polymer solutions 302
7.4 Water-soluble polymers used In pharmacy and medicine 311
7.5 Water-insoluble polymers and polymer membranes 323
7.6 Some applications of polymeric systems in drug delivery 331
Summary 349
References 349
Further reading 350
I ¡x
351
352
360
365
371
3/4
375
375
3 77
378
379
386
397
398
406
407
408
417
419
422
425
426
427
427
428
437
440
440
443
444
450
451
454
454
458
464
466
46/
472
475
476
478
479
Drug absorption basics and the oral route
8.1 Biological membranes and drug transport
8.2 The oral route and oral absorption
8.3 Oral dosage forms
8.4 Buccal and sublingual absorption
Summary
References
Further reading
Parenteral routes of drug administration
9.1 Intravenous and intra-arterial administration
9.2 Intramuscular and subcutaneous injection
9.3 Transdermal delivery
9.4 Topical treatment of the nails: transungual therapy
9.5 Medication of the eye and the eye as a route for systemic delivery
9.6 The ear (the aural route)
9.7 Absorption from the vagina
9.8 Inhalation therapy
9.9 The nasal route
9.10 Rectal absorption of drugs
9.11 Drug administration to brain, spinal cord and tissues
Summary
References
Paediatric and geriatric formulations
10.1 Introduction
10.2 Paediatric medication
10.3 The elderly and their medication
Summary
References
Physicochemical interactions and incompatibilities
11.1 pH effects in vitro and in vivo
11.2 Dilution of mixed-solvent systems
П.З Cation-anion interactions
11.4 Polyions and drug solutions
11.5 Chelation
11.6 Other complexes
11.7 Adsorption of drugs
11.8 Drug interactions with plastics
11.9 Protein binding
11.10 Reflections on interactions
Summary
Appendix: Drug interactions based on physical mechanisms
References
Further reading
x I Contents
12 Adverse events: the role of formulations and delivery systems 481
12.1 Introduction 482
12.2 bxcipient effects 483
12.3 E-numbers 485
12.4 Cross-reactivity of drugs 48/
12.5 Non-ionic surfactants 48/
12.6 Polyoxyethylene glycols 488
12.7 Adjuvants as therapeutic substances 488
12.8 Active excipients in multiple therapies 490
12.9 Influence of dosage form type 491
12.10 Tear films and eye drops 492
12.11 Reactions to impurities 494
12.12 Crystallisation 503
12.13 Abnormal bioavailability and adverse events 504
12.14 Photochemical reactions and photoinduced reactions 506
12.15 Conclusions 509
References 510
Further reading 511
13 Peptides, proteins and monoclonal antibodies 513
13.1 Structure and solution properties of peptides and proteins 514
13.2 The stability of proteins and peptides 522
13.3 Protein formulation and delivery 527
13.4 A therapeutic protein and a peptide 534
13.5 DNA and oligonucleotides 537
13.6 Therapeutic monoclonal antibodies 538
13.7 Vaccine formulation 544
Summary 546
References 546
14 Pharmaceutical nanotechnology 549
14.1 Introduction 549
142 Rationale for nanoparticles for drug delivery and targeting 550
143 Particle structures 552
14.4 The primacy of particle size 552
14.5 Physicochemical characterisation of nanosystems 555
14.6 Preparing nanoparticles 557
14.7 Challenges in targeting 562
14.8 Detoxification: reducing blood levels 567
14.9 Regulatory challenges: characterisation 567
Summary 568
References 568
Further reading 568
15 Physical assessment of dosage forms 569
15.1 Introduction 570
Contents I xi
15.2 Dissolution testing of solid oral dosage forms 570
15.3 Drug release from parenteral preparations 574
15.4 Mechanical strength of tablets 57/
15.5 Rheological characteristics of formulations 5/8
15.6 Adhesivity of dosage forms: desired and undesired 579
15.7 Mechanical strength of buccal films 582
15.8 Gastro-retentive systems: buoyancy tests 582
15.9 Evaluation of aerosols 583
Summary 586
References 586
Further reading 587
16 Generic medicines and biosimilars 589
16.1 Introduction 590
16.2 Regulatory statements on generic products 591
16.3 Reading and deconstructing the literature on bioequivalence 594
16.4 Biosimilars: protein drugs, monoclonal antibodies 598
16.5 Conclusions 600
References 601
Further reading 601
Derivations 603
Index
625
|
| any_adam_object | 1 |
| author | Florence, Alexander T. 1940- Attwood, David 1940- |
| author_GND | (DE-588)128453249 (DE-588)132643278 |
| author_facet | Florence, Alexander T. 1940- Attwood, David 1940- |
| author_role | aut aut |
| author_sort | Florence, Alexander T. 1940- |
| author_variant | a t f at atf d a da |
| building | Verbundindex |
| bvnumber | BV043375035 |
| classification_rvk | VX 5200 |
| ctrlnum | (OCoLC)1005922270 (DE-599)BVBBV043375035 |
| dewey-full | 615.19 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.19 |
| dewey-search | 615.19 |
| dewey-sort | 3615.19 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Medizin |
| edition | Sixth edition |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02303nam a2200481 c 4500</leader><controlfield tag="001">BV043375035</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20160316 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">160218s2016 a||| |||| 00||| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9780857111746</subfield><subfield code="9">978-0-85711-174-6</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)1005922270</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV043375035</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield><subfield code="a">DE-19</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">615.19</subfield><subfield code="2">22</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">VX 5200</subfield><subfield code="0">(DE-625)147798:253</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Florence, Alexander T.</subfield><subfield code="d">1940-</subfield><subfield code="e">Verfasser</subfield><subfield code="0">(DE-588)128453249</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Physicochemical principles of pharmacy</subfield><subfield code="b">in manufacture, formulation and clinical use</subfield><subfield code="c">Alexander T. Florence, David Attwood</subfield></datafield><datafield tag="250" ind1=" " ind2=" "><subfield code="a">Sixth edition</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">London</subfield><subfield code="b">Pharmaceutical Press</subfield><subfield code="c">2016</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">xi, 647 Seiten</subfield><subfield code="b">Illustrationen, Diagramme</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Drugs</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pharmaceutical chemistry</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Pharmazeutische Technologie</subfield><subfield code="0">(DE-588)4045699-7</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Arzneiform</subfield><subfield code="0">(DE-588)4068874-4</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Physikalische Chemie</subfield><subfield code="0">(DE-588)4045959-7</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Pharmazeutische Technologie</subfield><subfield code="0">(DE-588)4045699-7</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Physikalische Chemie</subfield><subfield code="0">(DE-588)4045959-7</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="1" ind2="0"><subfield code="a">Arzneiform</subfield><subfield code="0">(DE-588)4068874-4</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Attwood, David</subfield><subfield code="d">1940-</subfield><subfield code="e">Verfasser</subfield><subfield code="0">(DE-588)132643278</subfield><subfield code="4">aut</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Online-Ausgabe, EPUB</subfield><subfield code="z">978-0-85711-259-0</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Online-Ausgabe, MOBI</subfield><subfield code="z">978-0-85711-260-6</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Online-Ausgabe, PDF</subfield><subfield code="z">978-0-85711-258-3</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">Digitalisierung UB Regensburg - ADAM Catalogue Enrichment</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028793872&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Klappentext</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">Digitalisierung UB Regensburg - ADAM Catalogue Enrichment</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028793872&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-028793872</subfield></datafield></record></collection> |
| id | DE-604.BV043375035 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T07:24:15Z |
| institution | BVB |
| isbn | 9780857111746 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-028793872 |
| oclc_num | 1005922270 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-19 DE-BY-UBM |
| owner_facet | DE-355 DE-BY-UBR DE-19 DE-BY-UBM |
| physical | xi, 647 Seiten Illustrationen, Diagramme |
| publishDate | 2016 |
| publishDateSearch | 2016 |
| publishDateSort | 2016 |
| publisher | Pharmaceutical Press |
| record_format | marc |
| spelling | Florence, Alexander T. 1940- Verfasser (DE-588)128453249 aut Physicochemical principles of pharmacy in manufacture, formulation and clinical use Alexander T. Florence, David Attwood Sixth edition London Pharmaceutical Press 2016 xi, 647 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Drugs Pharmaceutical chemistry Pharmazeutische Technologie (DE-588)4045699-7 gnd rswk-swf Arzneiform (DE-588)4068874-4 gnd rswk-swf Physikalische Chemie (DE-588)4045959-7 gnd rswk-swf Pharmazeutische Technologie (DE-588)4045699-7 s Physikalische Chemie (DE-588)4045959-7 s DE-604 Arzneiform (DE-588)4068874-4 s Attwood, David 1940- Verfasser (DE-588)132643278 aut Erscheint auch als Online-Ausgabe, EPUB 978-0-85711-259-0 Erscheint auch als Online-Ausgabe, MOBI 978-0-85711-260-6 Erscheint auch als Online-Ausgabe, PDF 978-0-85711-258-3 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028793872&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Klappentext Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028793872&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Florence, Alexander T. 1940- Attwood, David 1940- Physicochemical principles of pharmacy in manufacture, formulation and clinical use Drugs Pharmaceutical chemistry Pharmazeutische Technologie (DE-588)4045699-7 gnd Arzneiform (DE-588)4068874-4 gnd Physikalische Chemie (DE-588)4045959-7 gnd |
| subject_GND | (DE-588)4045699-7 (DE-588)4068874-4 (DE-588)4045959-7 |
| title | Physicochemical principles of pharmacy in manufacture, formulation and clinical use |
| title_auth | Physicochemical principles of pharmacy in manufacture, formulation and clinical use |
| title_exact_search | Physicochemical principles of pharmacy in manufacture, formulation and clinical use |
| title_full | Physicochemical principles of pharmacy in manufacture, formulation and clinical use Alexander T. Florence, David Attwood |
| title_fullStr | Physicochemical principles of pharmacy in manufacture, formulation and clinical use Alexander T. Florence, David Attwood |
| title_full_unstemmed | Physicochemical principles of pharmacy in manufacture, formulation and clinical use Alexander T. Florence, David Attwood |
| title_short | Physicochemical principles of pharmacy |
| title_sort | physicochemical principles of pharmacy in manufacture formulation and clinical use |
| title_sub | in manufacture, formulation and clinical use |
| topic | Drugs Pharmaceutical chemistry Pharmazeutische Technologie (DE-588)4045699-7 gnd Arzneiform (DE-588)4068874-4 gnd Physikalische Chemie (DE-588)4045959-7 gnd |
| topic_facet | Drugs Pharmaceutical chemistry Pharmazeutische Technologie Arzneiform Physikalische Chemie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028793872&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028793872&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT florencealexandert physicochemicalprinciplesofpharmacyinmanufactureformulationandclinicaluse AT attwooddavid physicochemicalprinciplesofpharmacyinmanufactureformulationandclinicaluse |