Verfügbarkeit: Arsenic species analysis in foods and biota

Arsenic species analysis in foods and biota:

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Bibliographische Detailangaben
1. Verfasser:	Lischka, Susanne (VerfasserIn)
Format:	Abschlussarbeit Buch
Sprache:	English
Veröffentlicht:	Berlin 2015
Schlagworte:	Chemische Analyse Arsenverbindungen Hochschulschrift
Online-Zugang:	Inhaltsverzeichnis
Beschreibung:	XIV, 135 Seiten Illustrationen, Diagramme (teilweise farbig)

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MARC


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adam_text	CONTENT ZUSAMMENFASSUNG ABSTRACT................................................................................................................................................. II ACKNOWLEDGEMENTS ...................................... ILL LIST O F FIGURES................................................................................................................................... VII LIST O F TABLES......................................................................................................................................IX ABBREVIATIONS................................................................................................................................... XII 1. INTRODUCTION AND SCOPE O F 1 1.1 BACKGROUND AND MOTIVATION....................................................................................................1 1.2 SCOPE OF THE PRESENT ........................................ 6 2. LITERATURE REVIEW............................................................................................................................. 9 2.1 CLASSES * TOXICITY AND METABOLIC PATHWAYS O F ARSENIC SPECIES ............................................ 9 2.1.1 TOXIC * POLAR A R S E N I C A L S 9 2.1.2 NON-TOXIC POLAR ARSENICALS.......................................................................................13 2.13 ARSENOSUGARS........................................... 14 2.1.4 NON-POLAR ARSENICALS - ARSENOLIPIDS AND ARSENOHYDROCARBONS.......................... 15 2.2 SOURCES O F ARSENIC FOT HUMANS............................................................................................. 18 2.3 RELEVANCE O F ARSENIC IN GOVERNMENTAL REGULATION ............................................................. 20 2.4 CERTIFIED MATRIX REFERENCE MATERIALS CONCERNING ORGANOARSENIC SPECIES 22 2.5 STABILITY OF ARSENIC SPECIES...................................................................................................24 2.6 PROPERTIES 01 ISOTOPE LABELLED INTERNAL STANDARDS .............................................................. 28 2.7 ANALYTICAL METHODS FOR THE DETEMI^^ 30 2.7.1 SAMPLE PRE-TREATMENT...............................................................................................33 2.7.2 NEUTRON ACTIVATION ANALYSIS..................................................................................... 34 2.7.3 TOTAL REFLECTION X-RAY FLUORESCENCE SPECTROSCOPY ................................................ 35 2.7.4 ICP-MS ** 2.7.5 HPLC-ICP-MS......................................................................................................... 37 2.7.6 HPLC-ESI-MSMS..................................................................................................38 2.7.7 HPLC-ESI-Q-TOF-MS ........................................................................................... 39 2.7.8 GC-EI-MS ............................................................................................................ 40 2.7.9 SUMMARY................................................................................................................... 41 3 MATERIALS AND METHODS................................................................................................................. 4 * 3.1 MATERIALS ............................................................................................................................... 4 * 3.1.1 CHEMICALS.................................................................................................................. 43 3.1.2 CONSUMABLES AND ANALYTICAL INSTRUMENTS .............................................................. 43 3.2 METHODS 3.2.1 SYNTHESIS O F TWOFOLD ^-LABELLED ARSENOBETAINE ................................................. 45 3.2.2 CHARACTERISATION OF ARSENOBETAINE STANDARD MATERIALS.......................................... 46 3.2.3 PRODUCTION OI -HOUSE FISH MATERIAL......................................................................48 3.2.4 EXTRACTION AND CLEANUP PROTOCOL FOR POLAR ORGANOARSENICALS............................. 49 3.2.5 SPECIES-SPECIFIC ANALYSIS USING HPLCICP-MS...................................................50 3.2.6 DETERMINATION OF TOTAL ARSENIC CONTENT USING ICP-MS ......................................... 51 3.2.7 DETEMIINATIONOFTOTAL ARSENIC CONTENT USING TXRF ............................................ 2 3.2.8 DETERMINATION OF LIPOPHILIC AND HYDROPHILIC ARSENIC BY TXRF........................ 52 3.2.9 EXACT MASS MEASUREMENTS WITH ICP-MS/ESI-Q-TOF-MS *****53 3.2.10 DETERMINATION OF ARSENIC SPECIES USING GC-EI-MS.............................................53 3.2.11 DETERMINATION O F ARSENOBETAINE USING HPLC-ESI-MS/MS ******54 3.2.12 ENZYMATIC ASSAYS......................................................................................................55 4. RESULTS AND DISCUSSION_^^ 4.1 CHARACTERISTICS OF THE MARINE FISH UNDER INVESTIGATION.....................................................58 4.2 COMPILATION OF SAMPLE PRE-TREATMENT CONDITIONS ............................................................. 60 4.2.1 PLE EXTRACTION..........................................................................................................60 4.2.2 UTOASONIC ASSISTED EXTRACTION^ 4.3 ARSENOM O F INVESTIGATED F I S H ....................................... ..................................... 65 4.3.1 POLAR ARSENIC SPECIES................................................................................................ 68 4.3.2 NON-POLAR ARSENIC SPECIES........................................................................................70 4.4 DETERMINATION OFARSENIC SPECIES USING GC-MS .............................................................. 82 4.5 CHARACTERISATION OF ARENOBETAINE STANDARD MATERIAL ........................................................ 89 4.6 VALIDATION OF THE ARSENOBETAI^^ 93 4.6.1 WORKING RANGE AND TESTED MATRICES.........................................................................94 4.6.2 INTERFERENCES............................................................................................................. 94 4.6.3 SAMPLE STABILITY........................................................................................................95 4.6.4 CHROMATOGRAPHIC SEPARATION................................................................................... 95 4.6.5 FIGURES OFMERIT FOR THE VALIDATED 97 4.6.6 ACCURACY AND PRECISION...........................................................................................98 4.6.7 RUGGEDNESS AND ROBUSTOESS.................................................................................... 98 4.6.8 UNCERTAINTY OF MEASUREMENT.................................................................................. 99 4.7 STABILITY O F IN-HOUSE H ED N G M A T E .............................................................................. 100 4.8 EXAMPLES FOR THE CAPABILITY O F THE VALIDATED M ETHOD .................................................... 105 4.8.1 CCQM-P96.1 PILOT STUDY............................................. ..............................105 4.8.2 ENZYMATIC EXPERIMENTS......................................................................................... 106 4.8.3 INVESTIGATION OF POLAR ARSENICAL IN SURSTROEMMING.............................................109 5. CONCLUSION................................................................................................................................... I LL 6. RECOMMENDATIONS FOR FUTURE RESEARCH.................................................................. ******115 BIBLIOGRAPHY..................................................................................................................................... 121 APPENDIX.......................................................................................................................................... 127
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spelling	Lischka, Susanne Verfasser (DE-588)1082051993 aut Arsenic species analysis in foods and biota von Dipl.-Chem. Susanne Lischka Berlin 2015 XIV, 135 Seiten Illustrationen, Diagramme (teilweise farbig) txt rdacontent n rdamedia nc rdacarrier Dissertation Humboldt-Universität zu Berlin 2015 Chemische Analyse (DE-588)4009840-0 gnd rswk-swf Arsenverbindungen (DE-588)4143104-2 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Arsenverbindungen (DE-588)4143104-2 s Chemische Analyse (DE-588)4009840-0 s 1\p DE-604 Reproduziert als Lischka, Susanne Arsenic species analysis in foods and biota Ketsch bei Mannheim : Mikroform Dissertation, 2015 2 Mikrofiches (DE-604)BV043633907 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028760331&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk
spellingShingle	Lischka, Susanne Arsenic species analysis in foods and biota Chemische Analyse (DE-588)4009840-0 gnd Arsenverbindungen (DE-588)4143104-2 gnd
subject_GND	(DE-588)4009840-0 (DE-588)4143104-2 (DE-588)4113937-9
title	Arsenic species analysis in foods and biota
title_auth	Arsenic species analysis in foods and biota
title_exact_search	Arsenic species analysis in foods and biota
title_full	Arsenic species analysis in foods and biota von Dipl.-Chem. Susanne Lischka
title_fullStr	Arsenic species analysis in foods and biota von Dipl.-Chem. Susanne Lischka
title_full_unstemmed	Arsenic species analysis in foods and biota von Dipl.-Chem. Susanne Lischka
title_short	Arsenic species analysis in foods and biota
title_sort	arsenic species analysis in foods and biota
topic	Chemische Analyse (DE-588)4009840-0 gnd Arsenverbindungen (DE-588)4143104-2 gnd
topic_facet	Chemische Analyse Arsenverbindungen Hochschulschrift
url	http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028760331&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
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