Bursting neurons and fading memories: an alternative hypothesis of the pathogenesis of Alzheimer's disease
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
London
Elsevier
[2015]
|
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Beschreibung: | Includes bibliographical references Advances in Alzheimer's disease (AD) research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighboring neurons. However, there are several inconsistencies with this hypothesis, not to mention the inability to show clinical benefit in several failed clinical trials by pharmaceuticals (i.e., from Pfizer, Eli Lilly, etc.), and it is in the field's best interest to explore and test multiple hypotheses for pathology rather than drive the majority of research on this single amyloid theory. Reviewing many scientifically peer-reviewed publications, this book describes the "Inside-Out" hypothesis on how amyloid escapes the circulatory system through a dysfunctional blood-brain barrier to bind to the alpha 7 nicotinic acetylcholine receptor on pyramidal neurons. Over time, excessive amounts of amyloid appear to be internalized, resulting in neuron death and lysis. This simple mechanism readily explains plaque composition, size, shape, and location. Based on the current direction of research in the field, this hypothesis appears years from any research and development |
| Beschreibung: | 1 Online-Ressource (170 pages) |
| ISBN: | 9780128019887 0128019883 9780128019795 0128019794 |
Internformat
MARC
| LEADER | 00000nmm a2200000zc 4500 | ||
|---|---|---|---|
| 001 | BV043216195 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | cr|uuu---uuuuu | ||
| 008 | 151216s2015 |||| o||u| ||||||eng d | ||
| 020 | |a 9780128019887 |9 978-0-12-801988-7 | ||
| 020 | |a 0128019883 |9 0-12-801988-3 | ||
| 020 | |a 9780128019795 |9 978-0-12-801979-5 | ||
| 020 | |a 0128019794 |9 0-12-801979-4 | ||
| 020 | |a 9780128019795 |9 978-0-12-801979-5 | ||
| 035 | |a (OCoLC)896836706 | ||
| 035 | |a (DE-599)BVBBV043216195 | ||
| 040 | |a DE-604 |b ger |e aacr | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-1046 | ||
| 082 | 0 | |a 616.1092379 |2 23 | |
| 100 | 1 | |a D'Andrea, Michael R. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Bursting neurons and fading memories |b an alternative hypothesis of the pathogenesis of Alzheimer's disease |c Michael R. D'Andrea |
| 264 | 1 | |a London |b Elsevier |c [2015] | |
| 300 | |a 1 Online-Ressource (170 pages) | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b c |2 rdamedia | ||
| 338 | |b cr |2 rdacarrier | ||
| 500 | |a Includes bibliographical references | ||
| 500 | |a Advances in Alzheimer's disease (AD) research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighboring neurons. However, there are several inconsistencies with this hypothesis, not to mention the inability to show clinical benefit in several failed clinical trials by pharmaceuticals (i.e., from Pfizer, Eli Lilly, etc.), and it is in the field's best interest to explore and test multiple hypotheses for pathology rather than drive the majority of research on this single amyloid theory. Reviewing many scientifically peer-reviewed publications, this book describes the "Inside-Out" hypothesis on how amyloid escapes the circulatory system through a dysfunctional blood-brain barrier to bind to the alpha 7 nicotinic acetylcholine receptor on pyramidal neurons. Over time, excessive amounts of amyloid appear to be internalized, resulting in neuron death and lysis. This simple mechanism readily explains plaque composition, size, shape, and location. Based on the current direction of research in the field, this hypothesis appears years from any research and development | ||
| 650 | 4 | |a Alzheimer Disease / etiology | |
| 650 | 4 | |a Alzheimer Disease / physiopathology | |
| 650 | 4 | |a Neurons / pathology | |
| 650 | 7 | |a Alzheimer's disease / Pathogenesis |2 fast | |
| 650 | 4 | |a Alzheimer's disease |x Pathogenesis | |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/book/9780128019795 |x Verlag |3 Volltext |
| 912 | |a ZDB-33-ESD |a ZDB-33-EBS | ||
| 940 | 1 | |q FLA_PDA_ESD | |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-028639218 | ||
Datensatz im Suchindex
| _version_ | 1804175720872673280 |
|---|---|
| any_adam_object | |
| author | D'Andrea, Michael R. |
| author_facet | D'Andrea, Michael R. |
| author_role | aut |
| author_sort | D'Andrea, Michael R. |
| author_variant | m r d mr mrd |
| building | Verbundindex |
| bvnumber | BV043216195 |
| collection | ZDB-33-ESD ZDB-33-EBS |
| ctrlnum | (OCoLC)896836706 (DE-599)BVBBV043216195 |
| dewey-full | 616.1092379 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.1092379 |
| dewey-search | 616.1092379 |
| dewey-sort | 3616.1092379 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Electronic eBook |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02755nmm a2200433zc 4500</leader><controlfield tag="001">BV043216195</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">cr|uuu---uuuuu</controlfield><controlfield tag="008">151216s2015 |||| o||u| ||||||eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9780128019887</subfield><subfield code="9">978-0-12-801988-7</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0128019883</subfield><subfield code="9">0-12-801988-3</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9780128019795</subfield><subfield code="9">978-0-12-801979-5</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0128019794</subfield><subfield code="9">0-12-801979-4</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9780128019795</subfield><subfield code="9">978-0-12-801979-5</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)896836706</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV043216195</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">aacr</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-1046</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">616.1092379</subfield><subfield code="2">23</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">D'Andrea, Michael R.</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Bursting neurons and fading memories</subfield><subfield code="b">an alternative hypothesis of the pathogenesis of Alzheimer's disease</subfield><subfield code="c">Michael R. D'Andrea</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">London</subfield><subfield code="b">Elsevier</subfield><subfield code="c">[2015]</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 Online-Ressource (170 pages)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Includes bibliographical references</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Advances in Alzheimer's disease (AD) research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighboring neurons. However, there are several inconsistencies with this hypothesis, not to mention the inability to show clinical benefit in several failed clinical trials by pharmaceuticals (i.e., from Pfizer, Eli Lilly, etc.), and it is in the field's best interest to explore and test multiple hypotheses for pathology rather than drive the majority of research on this single amyloid theory. Reviewing many scientifically peer-reviewed publications, this book describes the "Inside-Out" hypothesis on how amyloid escapes the circulatory system through a dysfunctional blood-brain barrier to bind to the alpha 7 nicotinic acetylcholine receptor on pyramidal neurons. Over time, excessive amounts of amyloid appear to be internalized, resulting in neuron death and lysis. This simple mechanism readily explains plaque composition, size, shape, and location. Based on the current direction of research in the field, this hypothesis appears years from any research and development</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Alzheimer Disease / etiology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Alzheimer Disease / physiopathology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Neurons / pathology</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Alzheimer's disease / Pathogenesis</subfield><subfield code="2">fast</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Alzheimer's disease</subfield><subfield code="x">Pathogenesis</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://www.sciencedirect.com/science/book/9780128019795</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-33-ESD</subfield><subfield code="a">ZDB-33-EBS</subfield></datafield><datafield tag="940" ind1="1" ind2=" "><subfield code="q">FLA_PDA_ESD</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-028639218</subfield></datafield></record></collection> |
| id | DE-604.BV043216195 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T07:20:47Z |
| institution | BVB |
| isbn | 9780128019887 0128019883 9780128019795 0128019794 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-028639218 |
| oclc_num | 896836706 |
| open_access_boolean | |
| owner | DE-1046 |
| owner_facet | DE-1046 |
| physical | 1 Online-Ressource (170 pages) |
| psigel | ZDB-33-ESD ZDB-33-EBS FLA_PDA_ESD |
| publishDate | 2015 |
| publishDateSearch | 2015 |
| publishDateSort | 2015 |
| publisher | Elsevier |
| record_format | marc |
| spelling | D'Andrea, Michael R. Verfasser aut Bursting neurons and fading memories an alternative hypothesis of the pathogenesis of Alzheimer's disease Michael R. D'Andrea London Elsevier [2015] 1 Online-Ressource (170 pages) txt rdacontent c rdamedia cr rdacarrier Includes bibliographical references Advances in Alzheimer's disease (AD) research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighboring neurons. However, there are several inconsistencies with this hypothesis, not to mention the inability to show clinical benefit in several failed clinical trials by pharmaceuticals (i.e., from Pfizer, Eli Lilly, etc.), and it is in the field's best interest to explore and test multiple hypotheses for pathology rather than drive the majority of research on this single amyloid theory. Reviewing many scientifically peer-reviewed publications, this book describes the "Inside-Out" hypothesis on how amyloid escapes the circulatory system through a dysfunctional blood-brain barrier to bind to the alpha 7 nicotinic acetylcholine receptor on pyramidal neurons. Over time, excessive amounts of amyloid appear to be internalized, resulting in neuron death and lysis. This simple mechanism readily explains plaque composition, size, shape, and location. Based on the current direction of research in the field, this hypothesis appears years from any research and development Alzheimer Disease / etiology Alzheimer Disease / physiopathology Neurons / pathology Alzheimer's disease / Pathogenesis fast Alzheimer's disease Pathogenesis http://www.sciencedirect.com/science/book/9780128019795 Verlag Volltext |
| spellingShingle | D'Andrea, Michael R. Bursting neurons and fading memories an alternative hypothesis of the pathogenesis of Alzheimer's disease Alzheimer Disease / etiology Alzheimer Disease / physiopathology Neurons / pathology Alzheimer's disease / Pathogenesis fast Alzheimer's disease Pathogenesis |
| title | Bursting neurons and fading memories an alternative hypothesis of the pathogenesis of Alzheimer's disease |
| title_auth | Bursting neurons and fading memories an alternative hypothesis of the pathogenesis of Alzheimer's disease |
| title_exact_search | Bursting neurons and fading memories an alternative hypothesis of the pathogenesis of Alzheimer's disease |
| title_full | Bursting neurons and fading memories an alternative hypothesis of the pathogenesis of Alzheimer's disease Michael R. D'Andrea |
| title_fullStr | Bursting neurons and fading memories an alternative hypothesis of the pathogenesis of Alzheimer's disease Michael R. D'Andrea |
| title_full_unstemmed | Bursting neurons and fading memories an alternative hypothesis of the pathogenesis of Alzheimer's disease Michael R. D'Andrea |
| title_short | Bursting neurons and fading memories |
| title_sort | bursting neurons and fading memories an alternative hypothesis of the pathogenesis of alzheimer s disease |
| title_sub | an alternative hypothesis of the pathogenesis of Alzheimer's disease |
| topic | Alzheimer Disease / etiology Alzheimer Disease / physiopathology Neurons / pathology Alzheimer's disease / Pathogenesis fast Alzheimer's disease Pathogenesis |
| topic_facet | Alzheimer Disease / etiology Alzheimer Disease / physiopathology Neurons / pathology Alzheimer's disease / Pathogenesis Alzheimer's disease Pathogenesis |
| url | http://www.sciencedirect.com/science/book/9780128019795 |
| work_keys_str_mv | AT dandreamichaelr burstingneuronsandfadingmemoriesanalternativehypothesisofthepathogenesisofalzheimersdisease |