Fundamentals of Neurodegeneration and Protein Misfolding Disorders:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Cham
Springer International Publishing
2015
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| Schriftenreihe: | Biological and Medical Physics, Biomedical Engineering
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| Schlagworte: | |
| Online-Zugang: | TUM01 UBT01 Volltext Inhaltsverzeichnis Abstract |
| Beschreibung: | 1 Online Ressource (XXII, 378 p. 122 illus., 103 illus. in color) |
| ISBN: | 9783319221175 |
| ISSN: | 1618-7210 |
| DOI: | 10.1007/978-3-319-22117-5 |
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Datensatz im Suchindex
| _version_ | 1804175709126524928 |
|---|---|
| adam_text | FUNDAMENTALS OF NEURODEGENERATION AND PROTEIN MISFOLDING DISORDERS
/ BECKERMAN, MARTIN
: 2015
TABLE OF CONTENTS / INHALTSVERZEICHNIS
INTRODUCTION
PROTEIN FOLDING, PART I: BASIC PRINCIPLES
PROTEIN FOLDING, PART II: ENERGY LANDSCAPES AND PROTEIN DYNAMICS
PROTEIN MISFOLDING AND AGGREGATION
PROTEIN QUALITY CONTROL, PART I: MOLECULAR CHAPERONES AND THE
UBIQUITIN-PROTEASOME SYSTEM
PROTEIN QUALITY CONTROL, PART II: AUTOPHAGY AND AGING
PRION DISEASES
ALZHEIMER’S DISEASE
PARKINSON’S DISEASE
HUNTINGTON’S DISEASE AND OTHER UNSTABLE REPEAT DISORDERS
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL LOBAR DEGENERATION
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
FUNDAMENTALS OF NEURODEGENERATION AND PROTEIN MISFOLDING DISORDERS
/ BECKERMAN, MARTIN
: 2015
ABSTRACT / INHALTSTEXT
THIS UNIQUE TEXT INTRODUCES STUDENTS AND RESEARCHERS TO THE WORLD OF
MISFOLDED PROTEINS, TOXIC OLIGOMERS, AND AMYLOID ASSEMBLAGES, AND THE
DISEASES OF THE BRAIN THAT RESULT. DURING THE PAST FEW YEARS THE
CONNECTIONS BETWEEN FAILURES IN PROTEIN QUALITY CONTROL AND NEUROLOGICAL
DISORDERS HAVE BEEN REINFORCED AND STRENGTHENED BY DISCOVERIES ON
MULTIPLE FRONTS.THESE FINDINGS PROVIDE NOVEL INSIGHTS ON HOW
AMYLOIDOGENIC OLIGOMERS AND FIBRILS FORM, INTERCONVERT FROM ONE STATE TO
ANOTHER, AND PROPAGATE FROM CELL TO CELL AND REGION TO REGION. STARTING
WITH PROTEIN FOLDING AND PROTEIN QUALITY CONTROL BASICS, THE READER WILL
LEARN HOW MISFOLDED PROTEINS CAN CAUSE DISEASES RANGING FROM PRION
DISEASES TO ALZHEIMER’S DISEASE AND PARKINSON’S DISEASE TO
HUNTINGTON’S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL
LOBAR DEGENERATION. AUTHORITATIVE BUTWRITTEN IN A CLEAR AND ENGAGING
STYLE, FUNDAMENTALS OF NEURODEGENERATION AND PROTEIN MISFOLDING
DISORDERSADDRESSES ONE OF TODAY’S FOREFRONT AREAS OF SCIENCE AND
MEDICINE. THE TEXT EMPHASIZES THE NEW GROUNDBREAKING BIOPHYSICAL AND
BIOCHEMICAL METHODS THAT ENABLE MOLECULAR-LEVEL EXPLORATIONS AND THE
CONCEPTUAL BREAKTHROUGHS THAT RESULT. IT CONTAINS SEPARATE CHAPTERS ON
EACH OF THE MAJOR DISEASE CLASSES. SPECIAL EMPHASIS IS PLACED ON THOSE
FACTORS AND THEMES THAT ARE COMMON TO THE DISEASES, ESPECIALLY FAILURES
IN SYNAPTIC TRANSMISSION, MITOCHONDRIAL CONTROL, AND AXONAL TRANSPORT;
BREAKDOWNS IN RNA PROCESSING; THE POTENTIAL ROLE OF ENVIRONMENTAL
FACTORS; AND THE CONFOUNDING EFFECTS OF NEUROINFLAMMATION. THE BOOK IS
IDEAL FOR USE IN TEACHING AT THE ADVANCED UNDERGRADUATE AND GRADUATE
LEVELS, AND SERVES AS A COMPREHENSIVE REFERENCE FOR A BROAD AUDIENCE OF
STUDENTS AND RESEARCHERS IN NEUROSCIENCE, MOLECULAR BIOLOGY, BIOLOGICAL
PHYSICS AND BIOMEDICAL ENGINEERING
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
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| spelling | Beckerman, Martin Verfasser aut Fundamentals of Neurodegeneration and Protein Misfolding Disorders Martin Beckerman Cham Springer International Publishing 2015 1 Online Ressource (XXII, 378 p. 122 illus., 103 illus. in color) txt rdacontent c rdamedia cr rdacarrier Biological and Medical Physics, Biomedical Engineering 1618-7210 Medicine Neurosciences Medicinal chemistry Neurology Proteins Biophysics Biological physics Biomedical engineering Biomedicine Biophysics and Biological Physics Protein Science Biomedical Engineering Medicinal Chemistry Medizin Erscheint auch als Druckausgabe 978-3-319-22116-8 https://doi.org/10.1007/978-3-319-22117-5 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028632893&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028632893&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract |
| spellingShingle | Beckerman, Martin Fundamentals of Neurodegeneration and Protein Misfolding Disorders Medicine Neurosciences Medicinal chemistry Neurology Proteins Biophysics Biological physics Biomedical engineering Biomedicine Biophysics and Biological Physics Protein Science Biomedical Engineering Medicinal Chemistry Medizin |
| title | Fundamentals of Neurodegeneration and Protein Misfolding Disorders |
| title_auth | Fundamentals of Neurodegeneration and Protein Misfolding Disorders |
| title_exact_search | Fundamentals of Neurodegeneration and Protein Misfolding Disorders |
| title_full | Fundamentals of Neurodegeneration and Protein Misfolding Disorders Martin Beckerman |
| title_fullStr | Fundamentals of Neurodegeneration and Protein Misfolding Disorders Martin Beckerman |
| title_full_unstemmed | Fundamentals of Neurodegeneration and Protein Misfolding Disorders Martin Beckerman |
| title_short | Fundamentals of Neurodegeneration and Protein Misfolding Disorders |
| title_sort | fundamentals of neurodegeneration and protein misfolding disorders |
| topic | Medicine Neurosciences Medicinal chemistry Neurology Proteins Biophysics Biological physics Biomedical engineering Biomedicine Biophysics and Biological Physics Protein Science Biomedical Engineering Medicinal Chemistry Medizin |
| topic_facet | Medicine Neurosciences Medicinal chemistry Neurology Proteins Biophysics Biological physics Biomedical engineering Biomedicine Biophysics and Biological Physics Protein Science Biomedical Engineering Medicinal Chemistry Medizin |
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