Developments in T cell based cancer immunotherapies:
Gespeichert in:
| Weitere Verfasser: | , , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Cham ; Heidelberg ; New York ; Dordrecht ; London
Humana Press
[2015]
|
| Schriftenreihe: | Cancer drug discovery and development
|
| Schlagworte: | |
| Online-Zugang: | Inhaltstext Klappentext Inhaltsverzeichnis |
| Beschreibung: | xv, 305 Seiten Illustrationen |
| ISBN: | 3319211668 9783319211664 |
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Datensatz im Suchindex
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Cancer Drug Discovery and Development
Beverly A. Teicher, Series editor
Ena Wang · Paolo A. Ascierto · David F. Stroncek Editors
Developments in T Cell Based Cancer Immunotherapies
This volume illustrates the salient aspects of cancer biology relevant to the successful
implementation of immunotherapy. Topics include enhancement of antigen-specific
immune responses by anti-cancer vaccines, modulation of the function of T cells within
the tumor microenvironment, and the effects of genetic, epigenetic, developmental, and
environmental determinants on T cell function. Other topics covered include the ex vivo
expansion of T or other immune cells and their genetic modification or reprogramming
to increase their ability to survive and expand when adoptively transferred back to the
patients. Specific attention is devoted to the genetic manipulation of T cells through
the introduction of re-directed T cell receptors, chimeric antibody receptors, and other
genetic manipulation aimed at improving their effectiveness as anti-cancer agents.
Furthermore, the revolutionary role of checkpoint inhibitors and their potential in
combination with other immunotherapeutic approaches or with standard chemo and
radiation therapv are extensivelvdiscussed.
Contents
1 Insights on Peptide Vaccines in Cancer Immunotherapy. 1
Kwong Y. Tsang, Caroline Jochems, and Jeffrey Schiom
2 Strategies for Improving Vaccines to Elicit T Cells
to Treat Cancer. 29
Jay A. Berzofsky, Lauren V. Wood, and Masaki Terabe
3 T Cell Fate in the Tumor Microenvironment. 53
Joel Crespo. Ilona Kryezek. Theodore Welling, Shuang Wei,
and Weiping Zou
4 Influence of Antigen Receptor Avidity, Affinity,
and Specificity on Genetically Engineered T Cells. 75
Kaoru Nagato. Timothy T. Spear, and Michael I. Nishimura
5 Toward the Identification of Genetic Determinants
of Responsiveness to Cancer Immunotherapy. 99
Davide Bedognetti. Sara Tomei, Wouter Hendrickx.
Francesco M. Marineóla, and Ena Wang
6 Production of Clinical T Cell Therapies. 129
David Stroncek. Jianjian Jin, Virginia David-Ocampo,
Vicki Fellowes. Larry Moses, and Marianna Sabatino
7 Clinical Success of Adoptive Cell Transfer Therapy
Using Tumor Infiltrating Lymphocytes. 151
Jessica Chacon. Krit Ritthipichai. Geok Sim. Michiko Harao,
Jie Qing Chen. Caitlin Creasy. Chántale Bematchez.
Patrick Hwu. and Laszlo Radvanyi
8 Harnessing Stem Cell-Like Memory՝ T Cells for Adoptive
Cell Transfer Therapy of Cancer . Í 83
Enrico Lugli and Luca Gattinoni
IX
x Contents
9 T Cell Blockade Immunotherapy Against Cancer
and Abscopal Effect in Combination Therapy. 211
Giuseppe V. Masucci, Luigi De Petris, Andreas Lundqvist,
Rolf Kiessling, and Rolf Lewensohn
10 T Cell Modulation: Anti-PD-1 Antibodies for the Treatment
of Cancer. 231
Patrick A. Ott and F. Stephen Hodi
11 Enhancing T Cell Performance Against Cancer
in Combination Treatment Strategies. 245
Maria Libera Ascierto, Salvador Martin Algarra, Ignacio Melero,
and Paolo A. Ascierto
12 Chimeric Antigen Receptor (CAR) T Cells. 259
Daniel W. Lee and Alan S. Wayne
13 Rapamycin-Resistant T Cells and Pentostatin-Based
Immuno-Selective Conditioning for the Allogeneic
T Cell Therapy of Cancer. 281
Daniel H. Fowler and David C. Halverson
Index
303 |
| any_adam_object | 1 |
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| dewey-full | 610 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 610 - Medicine and health |
| dewey-raw | 610 |
| dewey-search | 610 |
| dewey-sort | 3610 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Book |
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| spelling | Developments in T cell based cancer immunotherapies Paolo A. Ascierto, David F. Stroncek, Ena Wang, editors Developments in T cell-based cancer immunotherapies Cham ; Heidelberg ; New York ; Dordrecht ; London Humana Press [2015] xv, 305 Seiten Illustrationen txt rdacontent n rdamedia nc rdacarrier Cancer drug discovery and development T-Lymphozyt (DE-588)4127387-4 gnd rswk-swf Immuntherapie (DE-588)4026640-0 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Research cancer immunotherapy t cell biology cancer immunology adoptive t cell therapy Cell Therapy Krebs Medizin (DE-588)4073781-0 s Immuntherapie (DE-588)4026640-0 s T-Lymphozyt (DE-588)4127387-4 s DE-604 Ascierto, Paolo A. edt Stroncek, David F. edt Wang, Ena edt Springer International Publishing (DE-588)1064344704 pbl Erscheint auch als Online-Ausgabe 978-3-319-21167-1 X:MVB text/html http://deposit.dnb.de/cgi-bin/dokserv?id=5283319&prov=M&dok_var=1&dok_ext=htm Inhaltstext Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028627122&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Klappentext Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028627122&sequence=000002&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Developments in T cell based cancer immunotherapies T-Lymphozyt (DE-588)4127387-4 gnd Immuntherapie (DE-588)4026640-0 gnd Krebs Medizin (DE-588)4073781-0 gnd |
| subject_GND | (DE-588)4127387-4 (DE-588)4026640-0 (DE-588)4073781-0 |
| title | Developments in T cell based cancer immunotherapies |
| title_alt | Developments in T cell-based cancer immunotherapies |
| title_auth | Developments in T cell based cancer immunotherapies |
| title_exact_search | Developments in T cell based cancer immunotherapies |
| title_full | Developments in T cell based cancer immunotherapies Paolo A. Ascierto, David F. Stroncek, Ena Wang, editors |
| title_fullStr | Developments in T cell based cancer immunotherapies Paolo A. Ascierto, David F. Stroncek, Ena Wang, editors |
| title_full_unstemmed | Developments in T cell based cancer immunotherapies Paolo A. Ascierto, David F. Stroncek, Ena Wang, editors |
| title_short | Developments in T cell based cancer immunotherapies |
| title_sort | developments in t cell based cancer immunotherapies |
| topic | T-Lymphozyt (DE-588)4127387-4 gnd Immuntherapie (DE-588)4026640-0 gnd Krebs Medizin (DE-588)4073781-0 gnd |
| topic_facet | T-Lymphozyt Immuntherapie Krebs Medizin |
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