Pattern changes of the inflammatory infiltrate in prurigo nodularis during antipruritic therapy: results of a four-week observational immunhistochemical study
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| Format: | Abschlussarbeit Buch |
| Sprache: | English German |
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2015
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| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Zusammenfassung in deutscher Sprache |
| Beschreibung: | Illustrationen, Diagramme |
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MARC
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| 245 | 1 | 0 | |a Pattern changes of the inflammatory infiltrate in prurigo nodularis during antipruritic therapy |b results of a four-week observational immunhistochemical study |c vorgelegt von Julia Dangelmaier |
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| 502 | |b Dissertation |c Westfälische Wilhelms-Universität |d 2015 | ||
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Datensatz im Suchindex
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| adam_text | CONTENT
1. INTRODUCTION 1
1.1 DEFINITION OF PRURIGO NODULARIS 1
1.2 EPIDEMIOLOGY OF PRURIGO NODULARIS 1
1.3 ETIOLOGY OF PRURIGO NODULARIS 1
1.4 PATHOGENESIS OF PRURITUS AND PRURIGO NODULARIS 2
1.5 CLINICAL FEATURES OF PRURIGO NODULARIS 6
1.6 HISTOLOGICAL FEATURES OF PRURIGO NODULARIS 7
1.7 IMMUNHISTOLOGICAL FEATURES OF PRURIGO NODULARIS 8
1.8 THERAPIES 8
1.8.1 DESLORATADINE 9
1.8.2 CYCLOSPORINE A 9
1.8.3 APREPITANT 10
1.9 AIM OF THIS RESEARCH 11
2. PATIENTS AND METHODS 11
2.1 PATIENTS 11
2.2 METHODS 12
2.3 STATISTICAL ANALYSIS 13
3. RESULTS 13
IX
HTTP://D-NB.INFO/1083813528
3.1 CLINICAL RESULTS 14
3.1.1 CHANGE OF ITCH INTENSITY 14
3.1.2 CHANGE OF SKIN APPEARANCE 14
3.2 HISTOLOGICAL PRESENTATION OF PN 14
3.3 HISTOLOGICAL CHANGES UNDER ANTIPRURITIC THERAPY 15
3.4 IMMUNHISTOCHEMICAL PRESENTATION OF PN 16
3.5 IMMUNHISTOCHEMICAL CHANGES UNDER ANTIPRURITIC THERAPY 17
4. DISCUSSION 19
4.1 STUDY DESIGN 19
4.2 LIMITATIONS 20
4.3 CLINICAL RESULTS 21
4.4 HISTOLOGICAL RESULTS 21
4.5 HISTOLOGICAL CHANGES UNDER ANTIPRURITIC MEDICATION 22
4.6 IMMUNHISTOCHEMICAL RESULTS 22
4.7 IMMUNHISTOCHEMICAL RESULTS UNDER ANTIPRURITIC THERAPY 25
5. CONCLUSION 27
6. REFERENCES 28
7. APPENDIX 39
7.1 TABLES 39
X
7.1.1 TABLE 1. ANTIBODIES, THEIR TARGETS AND TECHNICAL DETAILS
39
7.1.2 TABLE 2. PATIENT CHARACTERISTICS OF 36 PATIENTS WITH A SKIN
BIOPSY...
41
7.1.3 TABLE 3. RESULTS OF HISTOLOGICAL INVESTIGATION OF THE EPIDERMIS
(H&E, PAS, GIESMA AND ELASTICA STAINING) 43
7.1.4 TABLE 4. RESULTS OF HISTOLOGICAL INVESTIGATION OF THE DERMIS (H&E,
PAS, GIESMA AND ELASTICA STAINING) 45
7.1.5 TABLE 5. RESULTS OF HISTOLOGICAL INVESTIGATION OF THE EPIDERMIS
(H&E, PAS, GIESMA AND ELASTICA STAINING) 47
7.1.6 TABLE 6. RESULTS OF HISTOLOGICAL INVESTIGATION OF THE DERMIS (H&E,
PAS, GIESMA AND ELASTICA STAINING) 49
7.1.7 TABLE 7. CHANGE OF CELL SURFACE EXPRESSION MARKERS BEFORE AND
AFTER A THERAPY WITH DESLORATADINE, CYCLOSPORINE A AND APREPITANT 51
7.1.8 TABLE 8. CHANGE OF CELL SURFACE EXPRESSION MARKERS BEFORE AND
AFTER A THERAPY WITH DESLORATADINE, CYCLOSPORINE A AND APREPITANT 52
7.1.9 TABLE 9. HISTOLOGICAL DIAGNOSIS IN BIOPSIES OF 36 PATIENTS
OBTAINED
BEFORE THERAPY 53
7.1.10 TABLE 10. HISTORICAL DIAGNOSIS IN BIOPSIES OF 36 PATIENTS
OBTAINED
AFTER THERAPY 54
7.2 FIGURES 55
7.2.1 FIGURE 1. CHANGE OF VAS IN 36 PATIENTS TREATED WITH APREPITANT
(N=12), CYCLOSPORINE A (N=13) AND DESLORATADINE (N=11) 55
7.2.2 FIGURE 2. CHANGE OF SSS IN 36 PATIENTS TREATED WITH APREPITANT
(N=12), CYCLOSPORINE A (N=13) AND DESLORATADINE (N=11) 56
XI
7.2.3.1 FIGURE 3.1. BEFORE MEDICATION WITH DESLORATADINE 57
7.2.3.2 FIGURE 3.2. AFTER MEDICATION WITH DESLORATADINE 58
7.2.4.1 FIGURE 4.1. BEFORE MEDICATION WITH CYCLOSPORINE A 59
7.2.4.2 FIGURE 4.2. AFTER MEDICATION WITH CYCLOSPORINE A 60
7.2.5.1 FIGURE 5.1. BEFORE MEDICATION WITH APREPITANT 61
7.2.5.2 FIGURE 5.2. AFTER MEDICATION WITH APREPITANT 62
7.2.6.1 FIGURE 6.1. IMMUNHISTOCHEMICAL STAINING WITH ANTI-CD4 AND
CONVENTIONAL H&E STAINING A) BEFORE AND B) AFTER THERAPY WITH
DESLORATADINE (X 100/X 200) 63
7.2.6.2 FIGURE 6.2. IMMUNHISTOCHEMICAL STAINING WITH ANTI-CD4 AND
CONVENTIONAL H&E STAINING A) BEFORE AND B) AFTER THERAPY WITH
CYCLOSPORINE
A (X 100/X 200) 65
7.2.6.3 FIGURE 6.3. IMMUNHISTOCHEMICAL STAINING WITH ANTI-CD4 AND
CONVENTIONAL H&E STAINING A) BEFORE AND B) AFTER THERAPY WITH APREPITANT
(X
100/X 200) 67
7.2.7.1 FIGURE 7.1 IMMUNHISTOCHEMICAL STAINING WITH ANTI- CD25 AND
CONVENTIONAL H&E STAINING A) BEFORE AND B) AFTER THERAPY WITH
DESLORATADINE (X 100/X 200) 69
7.2.7.2 FIGURE 7.2. IMMUNHISTOCHEMICAL STAINING WITH ANTI- CD25 AND
CONVENTIONAL H&E STAINING A) BEFORE AND B) AFTER THERAPY WITH
CYCLOSPORINE
A (X 100/X 200) 71
7.2.7.3 FIGURE 7.3. IMMUNHISTOCHEMICAL STAINING WITH ANTI-CD25 AND
CONVENTIONAL H&E STAINING A) BEFORE AND B) AFTER THERAPY WITH APREPITANT
(X
100/X 200) 73
XII
7.2.8.1 FIGURE 8.1. IMMUNHISTOCHEMICAL STAINING WITH ANTI-CD45 AND
CONVENTIONAL H&E STAINING A) BEFORE AND B) AFTER THERAPY WITH
DESLORATADINE (X 100/X 200) 75
7.2.8.2 FIGURE 8.2. IMMUNHISTOCHEMICAL STAINING WITH ANTI-CD45 AND
CONVENTIONAL H&E STAINING A) BEFORE AND B) AFTER THERAPY WITH
CYCLOSPORINE
A (X 100/X 200) 77
7.2.8.3 FIGURE 8.3 IMMUNHISTOCHEMICAL STAINING WITH ANTI-CD45 AND
CONVENTIONAL H&E STAINING A) BEFORE AND B) AFTER THERAPY WITH APREPITANT
(X
100/X 200) 79
7.2.9.1 FIGURE 9.1. IMMUNHISTOCHEMICAL STAINING WITH ANTI-CD68 AND
CONVENTIONAL H&E STAINING A) BEFORE AND B) AFTER THERAPY WITH
DESLORATADINE (X 100/X 200) 81
7.2.9.2 FIGURE 9.2. IMMUNHISTOCHEMICAL STAINING WITH ANTI-CD68 AND
CONVENTIONAL H&E STAINING A) BEFORE AND B) AFTER THERAPY WITH
CYCLOSPORINE
A (X 100/X 200) 83
7.2.9.3 FIGURE 9.3. IMMUNHISTOCHEMICAL STAINING WITH ANTI-CD68 AND
CONVENTIONAL H&E STAINING A) BEFORE AND B) AFTER THERAPY WITH APREPITANT
(X
100/X 200) 85
7.2.10.1 FIGURE 10.1 IMMUNHISTOCHEMICAL STAINING WITH ANTI-CD79A
AND CONVENTIONAL H&E STAINING A) BEFORE AND B) AFTER THERAPY WITH
DESLORATADINE (X 100/X 200) 87
7.2.10.2 FIGURE 10.2. IMMUNHISTOCHEMICAL STAINING WITH ANTI-CD79A
AND CONVENTIONAL H&E STAINING A) BEFORE AND B) AFTER THERAPY WITH
CYCLOSPORINE A (X 100/X 200) 89
7.2.10.3 FIGURE 10.3 IMMUNHISTOCHEMICAL STAINING WITH ANTI-CD79A
AND CONVENTIONAL H&E STAINING A) BEFORE AND B) AFTER THERAPY WITH
APREPITANT (X 100/X 200) 91
XIII
7.2.11.1 FIGURE 11.1. IMMUNHISTOCHEMICAL STAINING WITH ANTI-FOXP3 AND
CONVENTIONAL H&E STAINING A) BEFORE AND B) AFTER THERAPY WITH
DESLORATADINE (X 100/X 200) 93
7.2.11.2 FIGURE 11.2. IMMUNHISTOCHEMICAL STAINING WITH ANTI-FOXP3 AND
CONVENTIONAL H&E STAINING A) BEFORE AND B) AFTER THERAPY WITH
CYCLOSPORINE
A (X 100/X 200) 95
7.2.11.3 FIGURE 11.3. IMMUNHISTOCHEMICAL STAINING WITH ANTI-FOXP3
AND CONVENTIONAL H&E STAINING A) BEFORE AND B) AFTER THERAPY WITH
APREPITANT (X 100/X 200) 97
7.2.12.1 FIGURE 12.1. IMMUNHISTOCHEMICAL STAINING WITH ANTI-INTERLEUKIN
17
AND CONVENTIONAL H&E STAINING A) BEFORE AND B) AFTER THERAPY WITH
DESLORATADINE (X 100/X 200) 99
7.2.12.2 FIGURE 12.2. IMMUNHISTOCHEMICAL STAINING WITH ANTI-INTERLEUKIN
17 AND CONVENTIONAL H&E STAINING A) BEFORE AND B) AFTER THERAPY WITH
CYCLOSPORINE A (X 100/X 200) 101
7.2.12.3 FIGURE 12.3. IMMUNHISTOCHEMICAL STAINING WITH ANTI-INTERLEUKIN
17 AND CONVENTIONAL H&E STAINING A) BEFORE AND B) AFTER THERAPY WITH
APREPITANT (X 100/X 200) 103
XIV
|
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| spelling | Dangelmaier, Julia Verfasser aut Pattern changes of the inflammatory infiltrate in prurigo nodularis during antipruritic therapy results of a four-week observational immunhistochemical study vorgelegt von Julia Dangelmaier 2015 Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Zusammenfassung in deutscher Sprache Dissertation Westfälische Wilhelms-Universität 2015 (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028609130&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Dangelmaier, Julia Pattern changes of the inflammatory infiltrate in prurigo nodularis during antipruritic therapy results of a four-week observational immunhistochemical study |
| subject_GND | (DE-588)4113937-9 |
| title | Pattern changes of the inflammatory infiltrate in prurigo nodularis during antipruritic therapy results of a four-week observational immunhistochemical study |
| title_auth | Pattern changes of the inflammatory infiltrate in prurigo nodularis during antipruritic therapy results of a four-week observational immunhistochemical study |
| title_exact_search | Pattern changes of the inflammatory infiltrate in prurigo nodularis during antipruritic therapy results of a four-week observational immunhistochemical study |
| title_full | Pattern changes of the inflammatory infiltrate in prurigo nodularis during antipruritic therapy results of a four-week observational immunhistochemical study vorgelegt von Julia Dangelmaier |
| title_fullStr | Pattern changes of the inflammatory infiltrate in prurigo nodularis during antipruritic therapy results of a four-week observational immunhistochemical study vorgelegt von Julia Dangelmaier |
| title_full_unstemmed | Pattern changes of the inflammatory infiltrate in prurigo nodularis during antipruritic therapy results of a four-week observational immunhistochemical study vorgelegt von Julia Dangelmaier |
| title_short | Pattern changes of the inflammatory infiltrate in prurigo nodularis during antipruritic therapy |
| title_sort | pattern changes of the inflammatory infiltrate in prurigo nodularis during antipruritic therapy results of a four week observational immunhistochemical study |
| title_sub | results of a four-week observational immunhistochemical study |
| topic_facet | Hochschulschrift |
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