Improving the quality of cancer clinical trials: workshop summary
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Washington, D.C.
National Academies Press
c2008
|
| Schlagworte: | |
| Online-Zugang: | FAW01 FAW02 Volltext |
| Beschreibung: | Includes bibliographical references Introduction -- New clinical trial designs. Phase 0 trials -- Adaptive trial designs -- Targeting multiple pathways with multiple drugs -- Preclinical model systems -- Molecular imaging. Current and developing methods -- Challenges of molecular imaging -- Screening for predictive markers. The challenges of clinical validation -- Bioimaging predictive markers -- Clinical translation -- Panel discussion -- Costs of clinical trials. Regulatory costs -- Patient accrual -- Global outsourcing -- Time is money -- Public-private collaborations -- Regulatory issues. Regulatory barriers to innovation -- Patient advocacy perspective -- Regulation of in vitro diagnostics -- Regulatory issues in improving cancer clinical trials -- Reports from the case study discussion groups. Adaptive trial design -- Phase 0 trials -- Imaging -- Use of proteomics/genomics to assign therapy in lung cancer -- Use of genetics/genomics to assign therapy Scientists and clinicians seek a new paradigm that could improve the efficiency, cost-effectiveness, and overall success rate of cancer clinical trials, while maintaining the highest standards of quality. To explore innovative paradigms for cancer clinical trials and other ways to improve their quality, the National Cancer Policy Forum held a workshop, Improving the Quality of Cancer Clinical Trials, in Washington, DC. The main goals of the workshop were to examine new approaches to clinical trial design and execution that would: better inform decisions and plans of those responsible for developing new cancer therapies; more rapidly move new diagnostic tests and treatments toward regulatory approval and use in the clinic; and, be less costly than current trials. The resulting workshop summary will serve as input to the deliberations of an Institute of Medicine committee that will develop consensus-based recommendations for moving the field of cancer clinical trials forward |
| Beschreibung: | 1 Online-Ressource (xii, 124 p.) |
| ISBN: | 0309116686 0309116694 128172680X 9780309116688 9780309116695 9781281726803 |
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| 500 | |a Scientists and clinicians seek a new paradigm that could improve the efficiency, cost-effectiveness, and overall success rate of cancer clinical trials, while maintaining the highest standards of quality. To explore innovative paradigms for cancer clinical trials and other ways to improve their quality, the National Cancer Policy Forum held a workshop, Improving the Quality of Cancer Clinical Trials, in Washington, DC. The main goals of the workshop were to examine new approaches to clinical trial design and execution that would: better inform decisions and plans of those responsible for developing new cancer therapies; more rapidly move new diagnostic tests and treatments toward regulatory approval and use in the clinic; and, be less costly than current trials. The resulting workshop summary will serve as input to the deliberations of an Institute of Medicine committee that will develop consensus-based recommendations for moving the field of cancer clinical trials forward | ||
| 650 | 7 | |a HEALTH & FITNESS / Diseases / Cancer |2 bisacsh | |
| 650 | 7 | |a Cancer / Treatment |2 fast | |
| 650 | 7 | |a Clinical trials |2 fast | |
| 650 | 4 | |a Neoplasms / drug therapy / United States | |
| 650 | 4 | |a Clinical Trials as Topic / United States | |
| 650 | 4 | |a Cancer |x Treatment |z United States | |
| 650 | 4 | |a Clinical trials | |
| 651 | 4 | |a USA | |
| 700 | 1 | |a Patlak, Margie |e Sonstige |4 oth | |
| 700 | 1 | |a Nass, Sharyl J. |e Sonstige |4 oth | |
| 710 | 2 | |a National Cancer Policy Forum (U.S.) |e Sonstige |4 oth | |
| 710 | 2 | |a Institute of Medicine (U.S.) |e Sonstige |4 oth | |
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| indexdate | 2024-07-10T07:19:39Z |
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| isbn | 0309116686 0309116694 128172680X 9780309116688 9780309116695 9781281726803 |
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| spelling | Improving the quality of cancer clinical trials workshop summary National Cancer Policy Forum, Margie Patlack and Sharyl Nass, rapporteurs Washington, D.C. National Academies Press c2008 1 Online-Ressource (xii, 124 p.) txt rdacontent c rdamedia cr rdacarrier Includes bibliographical references Introduction -- New clinical trial designs. Phase 0 trials -- Adaptive trial designs -- Targeting multiple pathways with multiple drugs -- Preclinical model systems -- Molecular imaging. Current and developing methods -- Challenges of molecular imaging -- Screening for predictive markers. The challenges of clinical validation -- Bioimaging predictive markers -- Clinical translation -- Panel discussion -- Costs of clinical trials. Regulatory costs -- Patient accrual -- Global outsourcing -- Time is money -- Public-private collaborations -- Regulatory issues. Regulatory barriers to innovation -- Patient advocacy perspective -- Regulation of in vitro diagnostics -- Regulatory issues in improving cancer clinical trials -- Reports from the case study discussion groups. Adaptive trial design -- Phase 0 trials -- Imaging -- Use of proteomics/genomics to assign therapy in lung cancer -- Use of genetics/genomics to assign therapy Scientists and clinicians seek a new paradigm that could improve the efficiency, cost-effectiveness, and overall success rate of cancer clinical trials, while maintaining the highest standards of quality. To explore innovative paradigms for cancer clinical trials and other ways to improve their quality, the National Cancer Policy Forum held a workshop, Improving the Quality of Cancer Clinical Trials, in Washington, DC. The main goals of the workshop were to examine new approaches to clinical trial design and execution that would: better inform decisions and plans of those responsible for developing new cancer therapies; more rapidly move new diagnostic tests and treatments toward regulatory approval and use in the clinic; and, be less costly than current trials. The resulting workshop summary will serve as input to the deliberations of an Institute of Medicine committee that will develop consensus-based recommendations for moving the field of cancer clinical trials forward HEALTH & FITNESS / Diseases / Cancer bisacsh Cancer / Treatment fast Clinical trials fast Neoplasms / drug therapy / United States Clinical Trials as Topic / United States Cancer Treatment United States Clinical trials USA Patlak, Margie Sonstige oth Nass, Sharyl J. Sonstige oth National Cancer Policy Forum (U.S.) Sonstige oth Institute of Medicine (U.S.) Sonstige oth http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=233565 Aggregator Volltext |
| spellingShingle | Improving the quality of cancer clinical trials workshop summary HEALTH & FITNESS / Diseases / Cancer bisacsh Cancer / Treatment fast Clinical trials fast Neoplasms / drug therapy / United States Clinical Trials as Topic / United States Cancer Treatment United States Clinical trials |
| title | Improving the quality of cancer clinical trials workshop summary |
| title_auth | Improving the quality of cancer clinical trials workshop summary |
| title_exact_search | Improving the quality of cancer clinical trials workshop summary |
| title_full | Improving the quality of cancer clinical trials workshop summary National Cancer Policy Forum, Margie Patlack and Sharyl Nass, rapporteurs |
| title_fullStr | Improving the quality of cancer clinical trials workshop summary National Cancer Policy Forum, Margie Patlack and Sharyl Nass, rapporteurs |
| title_full_unstemmed | Improving the quality of cancer clinical trials workshop summary National Cancer Policy Forum, Margie Patlack and Sharyl Nass, rapporteurs |
| title_short | Improving the quality of cancer clinical trials |
| title_sort | improving the quality of cancer clinical trials workshop summary |
| title_sub | workshop summary |
| topic | HEALTH & FITNESS / Diseases / Cancer bisacsh Cancer / Treatment fast Clinical trials fast Neoplasms / drug therapy / United States Clinical Trials as Topic / United States Cancer Treatment United States Clinical trials |
| topic_facet | HEALTH & FITNESS / Diseases / Cancer Cancer / Treatment Clinical trials Neoplasms / drug therapy / United States Clinical Trials as Topic / United States Cancer Treatment United States USA |
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