G protein-coupled receptors: from structure to function
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Cambridge
Royal Society of Chemistry
2011
|
| Schriftenreihe: | RSC drug discovery series
|
| Schlagworte: | |
| Online-Zugang: | FAW01 FAW02 Volltext |
| Beschreibung: | Includes index G protein-coupled receptors (GPCRs) are the largest family of cell-surface receptors, with more than 800 members identified thus far in the human genome. They regulate the function of most cells in the body, and represent approximately 3% of the genes in the human genome. These receptors respond to a wide variety of structurally diverse ligands, ranging from small molecules, such as biogenic amines, nucleotides and ions, to lipids, peptides, proteins, and even light. Ligands (agonists and antagonists) acting on GPCRs are important in the treatment of numerous diseases, including cardiovascular and mental disorders, retinal degeneration, cancer, and AIDS. It is estimated that these receptors represent about one third of the actual identified targets of clinically used drugs.The determination of rhodopsin crystal structure and, more recently, of opsin, 1 and 2 adrenergic and A2A adenosine receptors provides both academia and industry with extremely valuable data for a better understanding of the molecular determinants of receptor function and a more reliable rationale for drug design. GPCR structure and function constitutes a hot topic.The book, which lies between the fields of chemical biology, molecular pharmacology and medicinal chemistry, is divided into three parts. The first part considers what receptor structures tell us about the mechanism of receptor activation. Part II focuses on receptor function. It discusses what the data from biophysical and mutational studies, and the analysis of the interactions of the receptor with ligands and regulator proteins, tell us about the process of signal transduction. The final part, on modelling and simulation, details new insights on the link between structure and mechanism and their implications in drug design Includes bibliographical references and index |
| Beschreibung: | 1 Online-Ressource (xxxv, 512 p.) |
| ISBN: | 1849731837 1849733449 9781849731836 9781849733441 |
Internformat
MARC
| LEADER | 00000nmm a2200000zc 4500 | ||
|---|---|---|---|
| 001 | BV043162408 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | cr|uuu---uuuuu | ||
| 008 | 151126s2011 |||| o||u| ||||||eng d | ||
| 020 | |a 1849731837 |9 1-84973-183-7 | ||
| 020 | |a 1849733449 |c electronic bk. |9 1-84973-344-9 | ||
| 020 | |a 9781849731836 |9 978-1-84973-183-6 | ||
| 020 | |a 9781849733441 |c electronic bk. |9 978-1-84973-344-1 | ||
| 035 | |a (OCoLC)754110226 | ||
| 035 | |a (DE-599)BVBBV043162408 | ||
| 040 | |a DE-604 |b ger |e aacr | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-1046 |a DE-1047 | ||
| 082 | 0 | |a 572.696 |2 22 | |
| 245 | 1 | 0 | |a G protein-coupled receptors |b from structure to function |c edited by Jesus Giraldo and Jean-Philippe Pin |
| 264 | 1 | |a Cambridge |b Royal Society of Chemistry |c 2011 | |
| 300 | |a 1 Online-Ressource (xxxv, 512 p.) | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b c |2 rdamedia | ||
| 338 | |b cr |2 rdacarrier | ||
| 490 | 0 | |a RSC drug discovery series | |
| 500 | |a Includes index | ||
| 500 | |a G protein-coupled receptors (GPCRs) are the largest family of cell-surface receptors, with more than 800 members identified thus far in the human genome. They regulate the function of most cells in the body, and represent approximately 3% of the genes in the human genome. These receptors respond to a wide variety of structurally diverse ligands, ranging from small molecules, such as biogenic amines, nucleotides and ions, to lipids, peptides, proteins, and even light. Ligands (agonists and antagonists) acting on GPCRs are important in the treatment of numerous diseases, including cardiovascular and mental disorders, retinal degeneration, cancer, and AIDS. It is estimated that these receptors represent about one third of the actual identified targets of clinically used drugs.The determination of rhodopsin crystal structure and, more recently, of opsin, 1 and 2 adrenergic and A2A adenosine receptors provides both academia and industry with extremely valuable data for a better understanding of the molecular determinants of receptor function and a more reliable rationale for drug design. GPCR structure and function constitutes a hot topic.The book, which lies between the fields of chemical biology, molecular pharmacology and medicinal chemistry, is divided into three parts. The first part considers what receptor structures tell us about the mechanism of receptor activation. Part II focuses on receptor function. It discusses what the data from biophysical and mutational studies, and the analysis of the interactions of the receptor with ligands and regulator proteins, tell us about the process of signal transduction. The final part, on modelling and simulation, details new insights on the link between structure and mechanism and their implications in drug design | ||
| 500 | |a Includes bibliographical references and index | ||
| 650 | 7 | |a Cell receptors / Structure-activity relationships |2 fast | |
| 650 | 7 | |a G proteins / Receptors |2 fast | |
| 650 | 7 | |a SCIENCE / Life Sciences / Biochemistry |2 bisacsh | |
| 650 | 4 | |a Receptors, G-Protein-Coupled / drug effects | |
| 650 | 4 | |a Receptors, G-Protein-Coupled / genetics | |
| 650 | 4 | |a Drug Discovery | |
| 650 | 4 | |a Receptors, G-Protein-Coupled / physiology | |
| 650 | 4 | |a Structure-Activity Relationship | |
| 650 | 4 | |a G proteins |x Receptors | |
| 650 | 4 | |a Cell receptors |x Structure-activity relationships | |
| 700 | 1 | |a Giraldo, Jesús |e Sonstige |4 oth | |
| 700 | 1 | |a Pin, Jean-Philippe |e Sonstige |4 oth | |
| 710 | 2 | |a Royal Society of Chemistry (Great Britain) |e Sonstige |4 oth | |
| 856 | 4 | 0 | |u http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=519511 |x Aggregator |3 Volltext |
| 912 | |a ZDB-4-EBA | ||
| 999 | |a oai:aleph.bib-bvb.de:BVB01-028586599 | ||
| 966 | e | |u http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=519511 |l FAW01 |p ZDB-4-EBA |q FAW_PDA_EBA |x Aggregator |3 Volltext | |
| 966 | e | |u http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=519511 |l FAW02 |p ZDB-4-EBA |q FAW_PDA_EBA |x Aggregator |3 Volltext | |
Datensatz im Suchindex
| _version_ | 1804175634006540288 |
|---|---|
| any_adam_object | |
| building | Verbundindex |
| bvnumber | BV043162408 |
| collection | ZDB-4-EBA |
| ctrlnum | (OCoLC)754110226 (DE-599)BVBBV043162408 |
| dewey-full | 572.696 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 572 - Biochemistry |
| dewey-raw | 572.696 |
| dewey-search | 572.696 |
| dewey-sort | 3572.696 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| format | Electronic eBook |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>04069nmm a2200541zc 4500</leader><controlfield tag="001">BV043162408</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">cr|uuu---uuuuu</controlfield><controlfield tag="008">151126s2011 |||| o||u| ||||||eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">1849731837</subfield><subfield code="9">1-84973-183-7</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">1849733449</subfield><subfield code="c">electronic bk.</subfield><subfield code="9">1-84973-344-9</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9781849731836</subfield><subfield code="9">978-1-84973-183-6</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9781849733441</subfield><subfield code="c">electronic bk.</subfield><subfield code="9">978-1-84973-344-1</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)754110226</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV043162408</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">aacr</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-1046</subfield><subfield code="a">DE-1047</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">572.696</subfield><subfield code="2">22</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">G protein-coupled receptors</subfield><subfield code="b">from structure to function</subfield><subfield code="c">edited by Jesus Giraldo and Jean-Philippe Pin</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Cambridge</subfield><subfield code="b">Royal Society of Chemistry</subfield><subfield code="c">2011</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 Online-Ressource (xxxv, 512 p.)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">RSC drug discovery series</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Includes index</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">G protein-coupled receptors (GPCRs) are the largest family of cell-surface receptors, with more than 800 members identified thus far in the human genome. They regulate the function of most cells in the body, and represent approximately 3% of the genes in the human genome. These receptors respond to a wide variety of structurally diverse ligands, ranging from small molecules, such as biogenic amines, nucleotides and ions, to lipids, peptides, proteins, and even light. Ligands (agonists and antagonists) acting on GPCRs are important in the treatment of numerous diseases, including cardiovascular and mental disorders, retinal degeneration, cancer, and AIDS. It is estimated that these receptors represent about one third of the actual identified targets of clinically used drugs.The determination of rhodopsin crystal structure and, more recently, of opsin, 1 and 2 adrenergic and A2A adenosine receptors provides both academia and industry with extremely valuable data for a better understanding of the molecular determinants of receptor function and a more reliable rationale for drug design. GPCR structure and function constitutes a hot topic.The book, which lies between the fields of chemical biology, molecular pharmacology and medicinal chemistry, is divided into three parts. The first part considers what receptor structures tell us about the mechanism of receptor activation. Part II focuses on receptor function. It discusses what the data from biophysical and mutational studies, and the analysis of the interactions of the receptor with ligands and regulator proteins, tell us about the process of signal transduction. The final part, on modelling and simulation, details new insights on the link between structure and mechanism and their implications in drug design</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Includes bibliographical references and index</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Cell receptors / Structure-activity relationships</subfield><subfield code="2">fast</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">G proteins / Receptors</subfield><subfield code="2">fast</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">SCIENCE / Life Sciences / Biochemistry</subfield><subfield code="2">bisacsh</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Receptors, G-Protein-Coupled / drug effects</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Receptors, G-Protein-Coupled / genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Drug Discovery</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Receptors, G-Protein-Coupled / physiology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Structure-Activity Relationship</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">G proteins</subfield><subfield code="x">Receptors</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cell receptors</subfield><subfield code="x">Structure-activity relationships</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Giraldo, Jesús</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Pin, Jean-Philippe</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="710" ind1="2" ind2=" "><subfield code="a">Royal Society of Chemistry (Great Britain)</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=519511</subfield><subfield code="x">Aggregator</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-4-EBA</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-028586599</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=519511</subfield><subfield code="l">FAW01</subfield><subfield code="p">ZDB-4-EBA</subfield><subfield code="q">FAW_PDA_EBA</subfield><subfield code="x">Aggregator</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=519511</subfield><subfield code="l">FAW02</subfield><subfield code="p">ZDB-4-EBA</subfield><subfield code="q">FAW_PDA_EBA</subfield><subfield code="x">Aggregator</subfield><subfield code="3">Volltext</subfield></datafield></record></collection> |
| id | DE-604.BV043162408 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T07:19:24Z |
| institution | BVB |
| isbn | 1849731837 1849733449 9781849731836 9781849733441 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-028586599 |
| oclc_num | 754110226 |
| open_access_boolean | |
| owner | DE-1046 DE-1047 |
| owner_facet | DE-1046 DE-1047 |
| physical | 1 Online-Ressource (xxxv, 512 p.) |
| psigel | ZDB-4-EBA ZDB-4-EBA FAW_PDA_EBA |
| publishDate | 2011 |
| publishDateSearch | 2011 |
| publishDateSort | 2011 |
| publisher | Royal Society of Chemistry |
| record_format | marc |
| series2 | RSC drug discovery series |
| spelling | G protein-coupled receptors from structure to function edited by Jesus Giraldo and Jean-Philippe Pin Cambridge Royal Society of Chemistry 2011 1 Online-Ressource (xxxv, 512 p.) txt rdacontent c rdamedia cr rdacarrier RSC drug discovery series Includes index G protein-coupled receptors (GPCRs) are the largest family of cell-surface receptors, with more than 800 members identified thus far in the human genome. They regulate the function of most cells in the body, and represent approximately 3% of the genes in the human genome. These receptors respond to a wide variety of structurally diverse ligands, ranging from small molecules, such as biogenic amines, nucleotides and ions, to lipids, peptides, proteins, and even light. Ligands (agonists and antagonists) acting on GPCRs are important in the treatment of numerous diseases, including cardiovascular and mental disorders, retinal degeneration, cancer, and AIDS. It is estimated that these receptors represent about one third of the actual identified targets of clinically used drugs.The determination of rhodopsin crystal structure and, more recently, of opsin, 1 and 2 adrenergic and A2A adenosine receptors provides both academia and industry with extremely valuable data for a better understanding of the molecular determinants of receptor function and a more reliable rationale for drug design. GPCR structure and function constitutes a hot topic.The book, which lies between the fields of chemical biology, molecular pharmacology and medicinal chemistry, is divided into three parts. The first part considers what receptor structures tell us about the mechanism of receptor activation. Part II focuses on receptor function. It discusses what the data from biophysical and mutational studies, and the analysis of the interactions of the receptor with ligands and regulator proteins, tell us about the process of signal transduction. The final part, on modelling and simulation, details new insights on the link between structure and mechanism and their implications in drug design Includes bibliographical references and index Cell receptors / Structure-activity relationships fast G proteins / Receptors fast SCIENCE / Life Sciences / Biochemistry bisacsh Receptors, G-Protein-Coupled / drug effects Receptors, G-Protein-Coupled / genetics Drug Discovery Receptors, G-Protein-Coupled / physiology Structure-Activity Relationship G proteins Receptors Cell receptors Structure-activity relationships Giraldo, Jesús Sonstige oth Pin, Jean-Philippe Sonstige oth Royal Society of Chemistry (Great Britain) Sonstige oth http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=519511 Aggregator Volltext |
| spellingShingle | G protein-coupled receptors from structure to function Cell receptors / Structure-activity relationships fast G proteins / Receptors fast SCIENCE / Life Sciences / Biochemistry bisacsh Receptors, G-Protein-Coupled / drug effects Receptors, G-Protein-Coupled / genetics Drug Discovery Receptors, G-Protein-Coupled / physiology Structure-Activity Relationship G proteins Receptors Cell receptors Structure-activity relationships |
| title | G protein-coupled receptors from structure to function |
| title_auth | G protein-coupled receptors from structure to function |
| title_exact_search | G protein-coupled receptors from structure to function |
| title_full | G protein-coupled receptors from structure to function edited by Jesus Giraldo and Jean-Philippe Pin |
| title_fullStr | G protein-coupled receptors from structure to function edited by Jesus Giraldo and Jean-Philippe Pin |
| title_full_unstemmed | G protein-coupled receptors from structure to function edited by Jesus Giraldo and Jean-Philippe Pin |
| title_short | G protein-coupled receptors |
| title_sort | g protein coupled receptors from structure to function |
| title_sub | from structure to function |
| topic | Cell receptors / Structure-activity relationships fast G proteins / Receptors fast SCIENCE / Life Sciences / Biochemistry bisacsh Receptors, G-Protein-Coupled / drug effects Receptors, G-Protein-Coupled / genetics Drug Discovery Receptors, G-Protein-Coupled / physiology Structure-Activity Relationship G proteins Receptors Cell receptors Structure-activity relationships |
| topic_facet | Cell receptors / Structure-activity relationships G proteins / Receptors SCIENCE / Life Sciences / Biochemistry Receptors, G-Protein-Coupled / drug effects Receptors, G-Protein-Coupled / genetics Drug Discovery Receptors, G-Protein-Coupled / physiology Structure-Activity Relationship G proteins Receptors Cell receptors Structure-activity relationships |
| url | http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=519511 |
| work_keys_str_mv | AT giraldojesus gproteincoupledreceptorsfromstructuretofunction AT pinjeanphilippe gproteincoupledreceptorsfromstructuretofunction AT royalsocietyofchemistrygreatbritain gproteincoupledreceptorsfromstructuretofunction |