Fluorine in pharmaceutical and medicinal chemistry: from biophysical aspects to clinial applications
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
London
Imperial College Press
2012
|
| Schriftenreihe: | Molecular medicine and medicinal chemistry
6 |
| Schlagworte: | |
| Online-Zugang: | FAW01 FAW02 Volltext |
| Beschreibung: | Includes bibliographical references and index 1. Synthesis and properties of fluorinated nucleobases in DNA and RNA / Holger Gohlke, Jelena Bozilovic and Joachim W. Engels -- 2. Molecular interactions of fluorinated amino acids within the hydrophobic core of a coiled coil peptide / Toni Vagt, Mario Salwiczek and Beate Koksch -- 3. Probing the binding affinity and proteolytic stability of trifluoromethyl peptide mimics as protease inhibitors / Matteo Zanda [and others] -- 4. Trifluoromethyl-substituted [symbol]-amino acids as solid-state [symbol]F NMR labels for structural studies of membrane-bound peptides / Vladimir S. Kubyshkin [and others] -- 5. Fluorine-containing pharmaceuticals / Steve Swallow -- 6. Applications of pentafluorosulfanyl substitution in life sciences research / John T. Welch -- 7. Strategic incorporation of fluorine into taxoid anticancer agents / Antonella Pepe, Liang Sun and Iwao Ojima -- 8. Synthesis and antiviral, antitumour activities of fluorinated sugar nucleosides / Feng Zheng, Xiao-Long Qiu and Feng-Ling Qing -- 9. Synthesis of fluorinated neurotransmitter analogues / Margit Winkler and David O'Hagan -- 10. [symbol]F-radionuclide chemistry / Romain Bejot and Veronique Gouverneur -- 11. [symbol]F-labelled tracers for PET oncology and neurology applications / Sajinder K. Luthra and Edward G. Robins -- 12. [symbol]F NMR: clinical and molecular imaging applications / Vikram D. Kodibagkar [and others] Fluorine chemistry is an expanding area of research that is attracting international interest, due to the impact of fluorine in drug discovery and in clinical and molecular imaging (e.g. PET, MRI). Many researchers and academics are entering this area of research, while scientists in industrial and clinical environments are also indirectly exposed to fluorine chemistry through the use of fluorinated compounds for imaging. This book provides an overview of the impact that fluorine has made in the life sciences. In the first section, the emphasis is on how fluorine substitution of amino acids, peptides, nucleobases and carbohydrates can provide invaluable information at a molecular level. The following chapters provide answers to the key questions posed on the importance of fluorine in drug discovery and clinical applications. For example, the reader will discover how fluorine has found its place as a key element in improving drug efficacy, with reference to some of the best-selling drugs on the market. Finally, a thorough review on the design, synthesis and use of 18F-radiotracers for positron emission tomography is provided, and this is complemented with a discussion on how 19F NMR has advanced molecular and clinical imaging |
| Beschreibung: | 1 Online-Ressource (xxiii, 546 pages) |
| ISBN: | 1280668962 1848166346 1848166362 9781280668968 9781848166349 9781848166363 |
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| illustrated | Not Illustrated |
| indexdate | 2024-07-10T07:19:12Z |
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| isbn | 1280668962 1848166346 1848166362 9781280668968 9781848166349 9781848166363 |
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| spelling | Fluorine in pharmaceutical and medicinal chemistry from biophysical aspects to clinial applications Véronique Gouverneur, Klaus Müller, editors London Imperial College Press 2012 1 Online-Ressource (xxiii, 546 pages) txt rdacontent c rdamedia cr rdacarrier Molecular medicine and medicinal chemistry 6 Includes bibliographical references and index 1. Synthesis and properties of fluorinated nucleobases in DNA and RNA / Holger Gohlke, Jelena Bozilovic and Joachim W. Engels -- 2. Molecular interactions of fluorinated amino acids within the hydrophobic core of a coiled coil peptide / Toni Vagt, Mario Salwiczek and Beate Koksch -- 3. Probing the binding affinity and proteolytic stability of trifluoromethyl peptide mimics as protease inhibitors / Matteo Zanda [and others] -- 4. Trifluoromethyl-substituted [symbol]-amino acids as solid-state [symbol]F NMR labels for structural studies of membrane-bound peptides / Vladimir S. Kubyshkin [and others] -- 5. Fluorine-containing pharmaceuticals / Steve Swallow -- 6. Applications of pentafluorosulfanyl substitution in life sciences research / John T. Welch -- 7. Strategic incorporation of fluorine into taxoid anticancer agents / Antonella Pepe, Liang Sun and Iwao Ojima -- 8. Synthesis and antiviral, antitumour activities of fluorinated sugar nucleosides / Feng Zheng, Xiao-Long Qiu and Feng-Ling Qing -- 9. Synthesis of fluorinated neurotransmitter analogues / Margit Winkler and David O'Hagan -- 10. [symbol]F-radionuclide chemistry / Romain Bejot and Veronique Gouverneur -- 11. [symbol]F-labelled tracers for PET oncology and neurology applications / Sajinder K. Luthra and Edward G. Robins -- 12. [symbol]F NMR: clinical and molecular imaging applications / Vikram D. Kodibagkar [and others] Fluorine chemistry is an expanding area of research that is attracting international interest, due to the impact of fluorine in drug discovery and in clinical and molecular imaging (e.g. PET, MRI). Many researchers and academics are entering this area of research, while scientists in industrial and clinical environments are also indirectly exposed to fluorine chemistry through the use of fluorinated compounds for imaging. This book provides an overview of the impact that fluorine has made in the life sciences. In the first section, the emphasis is on how fluorine substitution of amino acids, peptides, nucleobases and carbohydrates can provide invaluable information at a molecular level. The following chapters provide answers to the key questions posed on the importance of fluorine in drug discovery and clinical applications. For example, the reader will discover how fluorine has found its place as a key element in improving drug efficacy, with reference to some of the best-selling drugs on the market. Finally, a thorough review on the design, synthesis and use of 18F-radiotracers for positron emission tomography is provided, and this is complemented with a discussion on how 19F NMR has advanced molecular and clinical imaging MEDICAL / Drug Guides bisacsh MEDICAL / Nursing / Pharmacology bisacsh MEDICAL / Pharmacology bisacsh MEDICAL / Pharmacy bisacsh Fluorine fast Pharmaceutical chemistry fast Medizin Fluorine Pharmaceutical chemistry Fluor (DE-588)4017696-4 gnd rswk-swf Pharmazeutische Chemie (DE-588)4132158-3 gnd rswk-swf Untersuchung Medizin (DE-588)4187104-2 gnd rswk-swf Fluor (DE-588)4017696-4 s Pharmazeutische Chemie (DE-588)4132158-3 s Untersuchung Medizin (DE-588)4187104-2 s 1\p DE-604 Gouverneur, Véronique Sonstige oth Müller, Klaus Sonstige oth http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=457253 Aggregator Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Fluorine in pharmaceutical and medicinal chemistry from biophysical aspects to clinial applications MEDICAL / Drug Guides bisacsh MEDICAL / Nursing / Pharmacology bisacsh MEDICAL / Pharmacology bisacsh MEDICAL / Pharmacy bisacsh Fluorine fast Pharmaceutical chemistry fast Medizin Fluorine Pharmaceutical chemistry Fluor (DE-588)4017696-4 gnd Pharmazeutische Chemie (DE-588)4132158-3 gnd Untersuchung Medizin (DE-588)4187104-2 gnd |
| subject_GND | (DE-588)4017696-4 (DE-588)4132158-3 (DE-588)4187104-2 |
| title | Fluorine in pharmaceutical and medicinal chemistry from biophysical aspects to clinial applications |
| title_auth | Fluorine in pharmaceutical and medicinal chemistry from biophysical aspects to clinial applications |
| title_exact_search | Fluorine in pharmaceutical and medicinal chemistry from biophysical aspects to clinial applications |
| title_full | Fluorine in pharmaceutical and medicinal chemistry from biophysical aspects to clinial applications Véronique Gouverneur, Klaus Müller, editors |
| title_fullStr | Fluorine in pharmaceutical and medicinal chemistry from biophysical aspects to clinial applications Véronique Gouverneur, Klaus Müller, editors |
| title_full_unstemmed | Fluorine in pharmaceutical and medicinal chemistry from biophysical aspects to clinial applications Véronique Gouverneur, Klaus Müller, editors |
| title_short | Fluorine in pharmaceutical and medicinal chemistry |
| title_sort | fluorine in pharmaceutical and medicinal chemistry from biophysical aspects to clinial applications |
| title_sub | from biophysical aspects to clinial applications |
| topic | MEDICAL / Drug Guides bisacsh MEDICAL / Nursing / Pharmacology bisacsh MEDICAL / Pharmacology bisacsh MEDICAL / Pharmacy bisacsh Fluorine fast Pharmaceutical chemistry fast Medizin Fluorine Pharmaceutical chemistry Fluor (DE-588)4017696-4 gnd Pharmazeutische Chemie (DE-588)4132158-3 gnd Untersuchung Medizin (DE-588)4187104-2 gnd |
| topic_facet | MEDICAL / Drug Guides MEDICAL / Nursing / Pharmacology MEDICAL / Pharmacology MEDICAL / Pharmacy Fluorine Pharmaceutical chemistry Medizin Fluor Pharmazeutische Chemie Untersuchung Medizin |
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