Protein-protein complexes: analysis, modeling and drug design
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Format: Elektronisch E-Book
Sprache:English
Veröffentlicht: London Imperial College Press ©2010
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Beschreibung:Includes bibliographical references and index
X-ray study of protein-protein complexes and analysis of interfaces / Joel Janin -- A structural perspective on protein-protein interactions in macromolecular assemblies / Ranjit P. Bahadur -- Energetics of protein-protein interactions / Ilian Jelesarov -- Kinetics of biomacromolecular complex formation: theory and experiment / Georgi V. Pachov, Razif R. Gabdoulline and Rebecca C. Wade -- Evolutionary trace of protein functional determinants / Olivier Lichtarge -- Protein-protein docking / Adrien Saladin and Chantal Prevost -- Data-driven docking: using external information to spark the biomolecular rendez-vous / Adrien S.J. Melquiond and Alexandre M.J.J. Bonvin -- High-resolution protein-protein docking / Nir London and Ora Schueler-Furman -- Scoring and refinement of predicted protein-protein complexes / Martin Zacharias -- Motif-mediated protein interactions and their role in disease / Holger Dinkel and Heinrich Sticht -- Prediction and calculation of protein-protein binding affinities and mutation effects / Sébastien Fiorucci, Serge Antonczak and Jérôme Golebiowski -- Small-molecule inhibitors of protein-protein interactions / Thorsten Berg -- Protein dynamics and drug design: the role of molecular simulations / Giulia Morra, Alessandro Genoni and Giorgio Colombo
Given the immense progress achieved in elucidating protein-protein complex structures and in the field of protein interaction modeling, there is great demand for a book that gives interested researchers/students a comprehensive overview of the field. This book does just that. It focuses on what can be learned about protein-protein interactions from the analysis of protein-protein complex structures and interfaces. What are the driving forces for protein-protein association? How can we extract the mechanism of specific recognition from studying protein-protein interfaces? How can this knowledge
Beschreibung:1 Online-Ressource (ix, 390 pages)
ISBN:184816338X
1848163398
1848163401
9781848163386
9781848163393
9781848163409

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