Optogenetics:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Berlin
De Gruyter
2013
|
| Schriftenreihe: | Dahlem workshop reports
|
| Schlagworte: | |
| Online-Zugang: | FAW01 FAW02 Volltext |
| Beschreibung: | 6.5.1 Closed-loop optogenetic control and optical feedback from behavior and individual neurons List of contributing authors; Introduction; 1 The biophysics and engineering of signaling photoreceptors; 1.1 Photoreceptors; 1.1.1 Novel photoreceptors; 1.1.2 Biophysics of photoreceptors and signal transduction; 1.2 Engineering of photoreceptors; 1.2.1 Approaches to designing light-regulated biological processes; 1.3 Case study -- transcriptional control in cells by light; 1.4 Conclusion; Acknowledgements; References; 2 Current challenges in optogenetics; 2.1 Introduction; 2.2 Background: current functionality of tools 2.3 Unsolved problems and open questions: technology from cell biology, optics, and behavior2.4 Unsolved problems and open questions: genomics and biophysics; 2.5 Conclusion; References; 3 Challenges and opportunities for optochemical genetics; 3.1 Introduction; 3.2 Photosensitizing receptors; 3.3 PCL and PTL development and applications; 3.4 Advantages and disadvantages of PCLs and PTLs; 3.5 Conclusion; References; 4 Optogenetic imaging of neural circuit dynamics using voltage-sensitive fluorescent proteins: potential, challenges and perspectives; 4.1 Introduction; 4.2 The biological problem 4.3 The large scale challenge of circuit neurosciences4.4 The current approach to the large-scale integration problem; 4.5 Large-scale recordings of neuronal activities using optogenetic approaches; 4.6 Genetically encoded voltage indicators: state of development and application; 4.7 Unsolved methodological / technical challenges; References; 5 Why optogenetic "control" is not (yet) control; Acknowledgments; References; 6 Optogenetic actuation, inhibition, modulation and readout for neuronal networks generating behavior in the nematode Caenorhabditis elegans 6.1 Introduction -- the nematode as a genetic model in systems neurosciencesystems neuroscience6.2 Imaging of neural activity in the nematode; 6.2.1 Genetically encoded Ca2+ indicators (GECIs); 6.2.2 Imaging populations of neurons in immobilized animals; 6.2.3 Imaging neural activity in freely moving animals; 6.2.4 Other genetically encoded indicators of neuronal function; 6.3 Optogenetic tools established in the nematode; 6.3.1 Channelrhodopsin (ChR2) and ChR variants with different functional properties for photodepolarization 6.3.2 Halorhodopsin and light-triggered proton pumps for photohyperpolarization6.3.3 Photoactivated Adenylyl Cyclase (PAC) for phototriggered cAMPdependent effects that facilitate neuronal transmission; 6.3.4 Other optogenetic approaches; 6.3.5 Stimulation of single neurons by optogenetics in freely behaving C. elegans; 6.4 Examples for optogenetic applications in C. elegans; 6.4.1 Optical control of synaptic transmission at the neuromuscular junction and between neurons; 6.4.2 Optical control of neural network activity in the generation of behavior; 6.5 Future challenges Optogenetics combines genetic engineering with optics to observe and control the function of cells using light, with clinical implications for restoration of vision and treatment of neurological diseases. As a new discipline much of the basic science and methods are currently under investigation and active development, thus there is a strong need for introductory literature in this field. This graduate level textbook provides an overview of the field of optogenetics in 5 concise chapters: Optogenetic tools, Applications in cellular systems, Mapping neuronal networks, Clinical applications and |
| Beschreibung: | 1 Online-Ressource (240 pages) |
| ISBN: | 3110270722 9783110270723 |
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| 500 | |a 2.3 Unsolved problems and open questions: technology from cell biology, optics, and behavior2.4 Unsolved problems and open questions: genomics and biophysics; 2.5 Conclusion; References; 3 Challenges and opportunities for optochemical genetics; 3.1 Introduction; 3.2 Photosensitizing receptors; 3.3 PCL and PTL development and applications; 3.4 Advantages and disadvantages of PCLs and PTLs; 3.5 Conclusion; References; 4 Optogenetic imaging of neural circuit dynamics using voltage-sensitive fluorescent proteins: potential, challenges and perspectives; 4.1 Introduction; 4.2 The biological problem | ||
| 500 | |a 4.3 The large scale challenge of circuit neurosciences4.4 The current approach to the large-scale integration problem; 4.5 Large-scale recordings of neuronal activities using optogenetic approaches; 4.6 Genetically encoded voltage indicators: state of development and application; 4.7 Unsolved methodological / technical challenges; References; 5 Why optogenetic "control" is not (yet) control; Acknowledgments; References; 6 Optogenetic actuation, inhibition, modulation and readout for neuronal networks generating behavior in the nematode Caenorhabditis elegans | ||
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Datensatz im Suchindex
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| any_adam_object | |
| author | Hegemann, Peter |
| author_facet | Hegemann, Peter |
| author_role | aut |
| author_sort | Hegemann, Peter |
| author_variant | p h ph |
| building | Verbundindex |
| bvnumber | BV043133225 |
| collection | ZDB-4-EBA |
| ctrlnum | (OCoLC)858761864 (DE-599)BVBBV043133225 |
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| dewey-ones | 591 - Specific topics in natural history of animals |
| dewey-raw | 591.188 |
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| dewey-sort | 3591.188 |
| dewey-tens | 590 - Animals |
| discipline | Biologie |
| format | Electronic eBook |
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| series2 | Dahlem workshop reports |
| spelling | Hegemann, Peter Verfasser aut Optogenetics Berlin De Gruyter 2013 1 Online-Ressource (240 pages) txt rdacontent c rdamedia cr rdacarrier Dahlem workshop reports 6.5.1 Closed-loop optogenetic control and optical feedback from behavior and individual neurons List of contributing authors; Introduction; 1 The biophysics and engineering of signaling photoreceptors; 1.1 Photoreceptors; 1.1.1 Novel photoreceptors; 1.1.2 Biophysics of photoreceptors and signal transduction; 1.2 Engineering of photoreceptors; 1.2.1 Approaches to designing light-regulated biological processes; 1.3 Case study -- transcriptional control in cells by light; 1.4 Conclusion; Acknowledgements; References; 2 Current challenges in optogenetics; 2.1 Introduction; 2.2 Background: current functionality of tools 2.3 Unsolved problems and open questions: technology from cell biology, optics, and behavior2.4 Unsolved problems and open questions: genomics and biophysics; 2.5 Conclusion; References; 3 Challenges and opportunities for optochemical genetics; 3.1 Introduction; 3.2 Photosensitizing receptors; 3.3 PCL and PTL development and applications; 3.4 Advantages and disadvantages of PCLs and PTLs; 3.5 Conclusion; References; 4 Optogenetic imaging of neural circuit dynamics using voltage-sensitive fluorescent proteins: potential, challenges and perspectives; 4.1 Introduction; 4.2 The biological problem 4.3 The large scale challenge of circuit neurosciences4.4 The current approach to the large-scale integration problem; 4.5 Large-scale recordings of neuronal activities using optogenetic approaches; 4.6 Genetically encoded voltage indicators: state of development and application; 4.7 Unsolved methodological / technical challenges; References; 5 Why optogenetic "control" is not (yet) control; Acknowledgments; References; 6 Optogenetic actuation, inhibition, modulation and readout for neuronal networks generating behavior in the nematode Caenorhabditis elegans 6.1 Introduction -- the nematode as a genetic model in systems neurosciencesystems neuroscience6.2 Imaging of neural activity in the nematode; 6.2.1 Genetically encoded Ca2+ indicators (GECIs); 6.2.2 Imaging populations of neurons in immobilized animals; 6.2.3 Imaging neural activity in freely moving animals; 6.2.4 Other genetically encoded indicators of neuronal function; 6.3 Optogenetic tools established in the nematode; 6.3.1 Channelrhodopsin (ChR2) and ChR variants with different functional properties for photodepolarization 6.3.2 Halorhodopsin and light-triggered proton pumps for photohyperpolarization6.3.3 Photoactivated Adenylyl Cyclase (PAC) for phototriggered cAMPdependent effects that facilitate neuronal transmission; 6.3.4 Other optogenetic approaches; 6.3.5 Stimulation of single neurons by optogenetics in freely behaving C. elegans; 6.4 Examples for optogenetic applications in C. elegans; 6.4.1 Optical control of synaptic transmission at the neuromuscular junction and between neurons; 6.4.2 Optical control of neural network activity in the generation of behavior; 6.5 Future challenges Optogenetics combines genetic engineering with optics to observe and control the function of cells using light, with clinical implications for restoration of vision and treatment of neurological diseases. As a new discipline much of the basic science and methods are currently under investigation and active development, thus there is a strong need for introductory literature in this field. This graduate level textbook provides an overview of the field of optogenetics in 5 concise chapters: Optogenetic tools, Applications in cellular systems, Mapping neuronal networks, Clinical applications and Electrooptical devices Neural networks (Neurobiology) Neural transmission Physiological optics Science SCIENCE / Life Sciences / Zoology / General bisacsh Electrooptical devices fast Neural networks (Neurobiology) fast Neural transmission fast Physiological optics fast Nervennetz gnd Optogenetik gnd Naturwissenschaft Nervennetz (DE-588)4041638-0 gnd rswk-swf Optogenetik (DE-588)1043139133 gnd rswk-swf 1\p (DE-588)4143413-4 Aufsatzsammlung gnd-content Nervennetz (DE-588)4041638-0 s Optogenetik (DE-588)1043139133 s 2\p DE-604 Sigrist, Stephan Sonstige oth http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=641741 Aggregator Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Hegemann, Peter Optogenetics Electrooptical devices Neural networks (Neurobiology) Neural transmission Physiological optics Science SCIENCE / Life Sciences / Zoology / General bisacsh Electrooptical devices fast Neural networks (Neurobiology) fast Neural transmission fast Physiological optics fast Nervennetz gnd Optogenetik gnd Naturwissenschaft Nervennetz (DE-588)4041638-0 gnd Optogenetik (DE-588)1043139133 gnd |
| subject_GND | (DE-588)4041638-0 (DE-588)1043139133 (DE-588)4143413-4 |
| title | Optogenetics |
| title_auth | Optogenetics |
| title_exact_search | Optogenetics |
| title_full | Optogenetics |
| title_fullStr | Optogenetics |
| title_full_unstemmed | Optogenetics |
| title_short | Optogenetics |
| title_sort | optogenetics |
| topic | Electrooptical devices Neural networks (Neurobiology) Neural transmission Physiological optics Science SCIENCE / Life Sciences / Zoology / General bisacsh Electrooptical devices fast Neural networks (Neurobiology) fast Neural transmission fast Physiological optics fast Nervennetz gnd Optogenetik gnd Naturwissenschaft Nervennetz (DE-588)4041638-0 gnd Optogenetik (DE-588)1043139133 gnd |
| topic_facet | Electrooptical devices Neural networks (Neurobiology) Neural transmission Physiological optics Science SCIENCE / Life Sciences / Zoology / General Nervennetz Optogenetik Naturwissenschaft Aufsatzsammlung |
| url | http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=641741 |
| work_keys_str_mv | AT hegemannpeter optogenetics AT sigriststephan optogenetics |