A means to an end: the biological basis of aging and death
Gespeichert in:
1. Verfasser: | |
---|---|
Format: | Elektronisch E-Book |
Sprache: | English |
Veröffentlicht: |
New York
Oxford University Press
2002
|
Schlagworte: | |
Online-Zugang: | FAW01 FAW02 Volltext |
Beschreibung: | Originally published: 1999 Includes bibliographical references and index Why do we age? Is aging inevitable? Will advances in medical knowledge allow us to extend the human lifespan beyond its present limits? Because growing old has long been the one irreducible reality of human existence, these intriguing questions arise more often in the context of science fiction than science fact. But recent discoveries in the fields of cell biology and molecular genetics are seriously challenging the assumption that human lifespans are beyond our control.; With such discoveries in mind, noted cell biologist William R. Clark clearly and skillfully describes how senescence begins at the level of individual cells and how cellular replication may be bound up with aging of the entire organism. He explores the evolutionary origin and function of aging, the cellular connections between aging and cancer, the parallels between cellular senescence and Alzheimer's disease, and the insights gained through studying human genetic disorders-such as; Werner's syndrome-that mimic the symptoms of aging. Clark also explains how reduction in caloric intake may actually help increase lifespan, and how the destructive effects of oxidative elements in the body may be limited by the consumption of antioxidants found in fruits and vegetables. In a final; chapter, Clark considers the social and economic aspects of living longer, the implications of gene therapy on senescence, and what we might learn about aging from experiments in cloning.; This is a highly readable, provocative account of some of the most far-reaching and controversial questions we are likely to ask in the next century |
Beschreibung: | 1 Online-Ressource (xv, 234 pages) |
ISBN: | 0195125932 0195153758 0195303369 019802911X 1280502045 9780195125931 9780195153750 9780195303360 9780198029113 9781280502040 |
Internformat
MARC
LEADER | 00000nmm a2200000zc 4500 | ||
---|---|---|---|
001 | BV043130558 | ||
003 | DE-604 | ||
005 | 00000000000000.0 | ||
007 | cr|uuu---uuuuu | ||
008 | 151126s2002 |||| o||u| ||||||eng d | ||
020 | |a 0195125932 |9 0-19-512593-2 | ||
020 | |a 0195153758 |9 0-19-515375-8 | ||
020 | |a 0195303369 |9 0-19-530336-9 | ||
020 | |a 019802911X |9 0-19-802911-X | ||
020 | |a 1280502045 |9 1-280-50204-5 | ||
020 | |a 9780195125931 |9 978-0-19-512593-1 | ||
020 | |a 9780195153750 |9 978-0-19-515375-0 | ||
020 | |a 9780195303360 |9 978-0-19-530336-0 | ||
020 | |a 9780198029113 |9 978-0-19-802911-3 | ||
020 | |a 9781280502040 |9 978-1-280-50204-0 | ||
035 | |a (OCoLC)60932736 | ||
035 | |a (DE-599)BVBBV043130558 | ||
040 | |a DE-604 |b ger |e aacr | ||
041 | 0 | |a eng | |
049 | |a DE-1046 |a DE-1047 | ||
082 | 0 | |a 612.6/7 |2 22 | |
100 | 1 | |a Clark, William R. |e Verfasser |4 aut | |
245 | 1 | 0 | |a A means to an end |b the biological basis of aging and death |c William R. Clark |
264 | 1 | |a New York |b Oxford University Press |c 2002 | |
300 | |a 1 Online-Ressource (xv, 234 pages) | ||
336 | |b txt |2 rdacontent | ||
337 | |b c |2 rdamedia | ||
338 | |b cr |2 rdacarrier | ||
500 | |a Originally published: 1999 | ||
500 | |a Includes bibliographical references and index | ||
500 | |a Why do we age? Is aging inevitable? Will advances in medical knowledge allow us to extend the human lifespan beyond its present limits? Because growing old has long been the one irreducible reality of human existence, these intriguing questions arise more often in the context of science fiction than science fact. But recent discoveries in the fields of cell biology and molecular genetics are seriously challenging the assumption that human lifespans are beyond our control.; With such discoveries in mind, noted cell biologist William R. Clark clearly and skillfully describes how senescence begins at the level of individual cells and how cellular replication may be bound up with aging of the entire organism. He explores the evolutionary origin and function of aging, the cellular connections between aging and cancer, the parallels between cellular senescence and Alzheimer's disease, and the insights gained through studying human genetic disorders-such as; Werner's syndrome-that mimic the symptoms of aging. Clark also explains how reduction in caloric intake may actually help increase lifespan, and how the destructive effects of oxidative elements in the body may be limited by the consumption of antioxidants found in fruits and vegetables. In a final; chapter, Clark considers the social and economic aspects of living longer, the implications of gene therapy on senescence, and what we might learn about aging from experiments in cloning.; This is a highly readable, provocative account of some of the most far-reaching and controversial questions we are likely to ask in the next century | ||
650 | 7 | |a MEDICAL / Nursing / Gerontology |2 bisacsh | |
650 | 7 | |a FAMILY & RELATIONSHIPS / Aging |2 bisacsh | |
650 | 7 | |a Aging / Molecular aspects |2 fast | |
650 | 7 | |a Apoptosis |2 fast | |
650 | 7 | |a Cells / Aging |2 fast | |
650 | 4 | |a Medizin | |
650 | 4 | |a Apoptosis | |
650 | 4 | |a Aging |x Molecular aspects | |
650 | 4 | |a Cells |x Aging | |
650 | 0 | 7 | |a Altern |0 (DE-588)4068596-2 |2 gnd |9 rswk-swf |
650 | 0 | 7 | |a Zelle |0 (DE-588)4067537-3 |2 gnd |9 rswk-swf |
689 | 0 | 0 | |a Altern |0 (DE-588)4068596-2 |D s |
689 | 0 | 1 | |a Zelle |0 (DE-588)4067537-3 |D s |
689 | 0 | |8 1\p |5 DE-604 | |
856 | 4 | 0 | |u http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=121455 |x Aggregator |3 Volltext |
912 | |a ZDB-4-EBA | ||
999 | |a oai:aleph.bib-bvb.de:BVB01-028554749 | ||
883 | 1 | |8 1\p |a cgwrk |d 20201028 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | |
966 | e | |u http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=121455 |l FAW01 |p ZDB-4-EBA |q FAW_PDA_EBA |x Aggregator |3 Volltext | |
966 | e | |u http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=121455 |l FAW02 |p ZDB-4-EBA |q FAW_PDA_EBA |x Aggregator |3 Volltext |
Datensatz im Suchindex
_version_ | 1804175569450958848 |
---|---|
any_adam_object | |
author | Clark, William R. |
author_facet | Clark, William R. |
author_role | aut |
author_sort | Clark, William R. |
author_variant | w r c wr wrc |
building | Verbundindex |
bvnumber | BV043130558 |
collection | ZDB-4-EBA |
ctrlnum | (OCoLC)60932736 (DE-599)BVBBV043130558 |
dewey-full | 612.6/7 |
dewey-hundreds | 600 - Technology (Applied sciences) |
dewey-ones | 612 - Human physiology |
dewey-raw | 612.6/7 |
dewey-search | 612.6/7 |
dewey-sort | 3612.6 17 |
dewey-tens | 610 - Medicine and health |
discipline | Medizin |
format | Electronic eBook |
fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>04080nmm a2200637zc 4500</leader><controlfield tag="001">BV043130558</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">cr|uuu---uuuuu</controlfield><controlfield tag="008">151126s2002 |||| o||u| ||||||eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0195125932</subfield><subfield code="9">0-19-512593-2</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0195153758</subfield><subfield code="9">0-19-515375-8</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0195303369</subfield><subfield code="9">0-19-530336-9</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">019802911X</subfield><subfield code="9">0-19-802911-X</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">1280502045</subfield><subfield code="9">1-280-50204-5</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9780195125931</subfield><subfield code="9">978-0-19-512593-1</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9780195153750</subfield><subfield code="9">978-0-19-515375-0</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9780195303360</subfield><subfield code="9">978-0-19-530336-0</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9780198029113</subfield><subfield code="9">978-0-19-802911-3</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9781280502040</subfield><subfield code="9">978-1-280-50204-0</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)60932736</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV043130558</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">aacr</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-1046</subfield><subfield code="a">DE-1047</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">612.6/7</subfield><subfield code="2">22</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Clark, William R.</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">A means to an end</subfield><subfield code="b">the biological basis of aging and death</subfield><subfield code="c">William R. Clark</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">New York</subfield><subfield code="b">Oxford University Press</subfield><subfield code="c">2002</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 Online-Ressource (xv, 234 pages)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Originally published: 1999</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Includes bibliographical references and index</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Why do we age? Is aging inevitable? Will advances in medical knowledge allow us to extend the human lifespan beyond its present limits? Because growing old has long been the one irreducible reality of human existence, these intriguing questions arise more often in the context of science fiction than science fact. But recent discoveries in the fields of cell biology and molecular genetics are seriously challenging the assumption that human lifespans are beyond our control.; With such discoveries in mind, noted cell biologist William R. Clark clearly and skillfully describes how senescence begins at the level of individual cells and how cellular replication may be bound up with aging of the entire organism. He explores the evolutionary origin and function of aging, the cellular connections between aging and cancer, the parallels between cellular senescence and Alzheimer's disease, and the insights gained through studying human genetic disorders-such as; Werner's syndrome-that mimic the symptoms of aging. Clark also explains how reduction in caloric intake may actually help increase lifespan, and how the destructive effects of oxidative elements in the body may be limited by the consumption of antioxidants found in fruits and vegetables. In a final; chapter, Clark considers the social and economic aspects of living longer, the implications of gene therapy on senescence, and what we might learn about aging from experiments in cloning.; This is a highly readable, provocative account of some of the most far-reaching and controversial questions we are likely to ask in the next century</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">MEDICAL / Nursing / Gerontology</subfield><subfield code="2">bisacsh</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">FAMILY & RELATIONSHIPS / Aging</subfield><subfield code="2">bisacsh</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Aging / Molecular aspects</subfield><subfield code="2">fast</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Apoptosis</subfield><subfield code="2">fast</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Cells / Aging</subfield><subfield code="2">fast</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Medizin</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Apoptosis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Aging</subfield><subfield code="x">Molecular aspects</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cells</subfield><subfield code="x">Aging</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Altern</subfield><subfield code="0">(DE-588)4068596-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Zelle</subfield><subfield code="0">(DE-588)4067537-3</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Altern</subfield><subfield code="0">(DE-588)4068596-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Zelle</subfield><subfield code="0">(DE-588)4067537-3</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="8">1\p</subfield><subfield code="5">DE-604</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=121455</subfield><subfield code="x">Aggregator</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-4-EBA</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-028554749</subfield></datafield><datafield tag="883" ind1="1" ind2=" "><subfield code="8">1\p</subfield><subfield code="a">cgwrk</subfield><subfield code="d">20201028</subfield><subfield code="q">DE-101</subfield><subfield code="u">https://d-nb.info/provenance/plan#cgwrk</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=121455</subfield><subfield code="l">FAW01</subfield><subfield code="p">ZDB-4-EBA</subfield><subfield code="q">FAW_PDA_EBA</subfield><subfield code="x">Aggregator</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=121455</subfield><subfield code="l">FAW02</subfield><subfield code="p">ZDB-4-EBA</subfield><subfield code="q">FAW_PDA_EBA</subfield><subfield code="x">Aggregator</subfield><subfield code="3">Volltext</subfield></datafield></record></collection> |
id | DE-604.BV043130558 |
illustrated | Not Illustrated |
indexdate | 2024-07-10T07:18:22Z |
institution | BVB |
isbn | 0195125932 0195153758 0195303369 019802911X 1280502045 9780195125931 9780195153750 9780195303360 9780198029113 9781280502040 |
language | English |
oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-028554749 |
oclc_num | 60932736 |
open_access_boolean | |
owner | DE-1046 DE-1047 |
owner_facet | DE-1046 DE-1047 |
physical | 1 Online-Ressource (xv, 234 pages) |
psigel | ZDB-4-EBA ZDB-4-EBA FAW_PDA_EBA |
publishDate | 2002 |
publishDateSearch | 2002 |
publishDateSort | 2002 |
publisher | Oxford University Press |
record_format | marc |
spelling | Clark, William R. Verfasser aut A means to an end the biological basis of aging and death William R. Clark New York Oxford University Press 2002 1 Online-Ressource (xv, 234 pages) txt rdacontent c rdamedia cr rdacarrier Originally published: 1999 Includes bibliographical references and index Why do we age? Is aging inevitable? Will advances in medical knowledge allow us to extend the human lifespan beyond its present limits? Because growing old has long been the one irreducible reality of human existence, these intriguing questions arise more often in the context of science fiction than science fact. But recent discoveries in the fields of cell biology and molecular genetics are seriously challenging the assumption that human lifespans are beyond our control.; With such discoveries in mind, noted cell biologist William R. Clark clearly and skillfully describes how senescence begins at the level of individual cells and how cellular replication may be bound up with aging of the entire organism. He explores the evolutionary origin and function of aging, the cellular connections between aging and cancer, the parallels between cellular senescence and Alzheimer's disease, and the insights gained through studying human genetic disorders-such as; Werner's syndrome-that mimic the symptoms of aging. Clark also explains how reduction in caloric intake may actually help increase lifespan, and how the destructive effects of oxidative elements in the body may be limited by the consumption of antioxidants found in fruits and vegetables. In a final; chapter, Clark considers the social and economic aspects of living longer, the implications of gene therapy on senescence, and what we might learn about aging from experiments in cloning.; This is a highly readable, provocative account of some of the most far-reaching and controversial questions we are likely to ask in the next century MEDICAL / Nursing / Gerontology bisacsh FAMILY & RELATIONSHIPS / Aging bisacsh Aging / Molecular aspects fast Apoptosis fast Cells / Aging fast Medizin Apoptosis Aging Molecular aspects Cells Aging Altern (DE-588)4068596-2 gnd rswk-swf Zelle (DE-588)4067537-3 gnd rswk-swf Altern (DE-588)4068596-2 s Zelle (DE-588)4067537-3 s 1\p DE-604 http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=121455 Aggregator Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
spellingShingle | Clark, William R. A means to an end the biological basis of aging and death MEDICAL / Nursing / Gerontology bisacsh FAMILY & RELATIONSHIPS / Aging bisacsh Aging / Molecular aspects fast Apoptosis fast Cells / Aging fast Medizin Apoptosis Aging Molecular aspects Cells Aging Altern (DE-588)4068596-2 gnd Zelle (DE-588)4067537-3 gnd |
subject_GND | (DE-588)4068596-2 (DE-588)4067537-3 |
title | A means to an end the biological basis of aging and death |
title_auth | A means to an end the biological basis of aging and death |
title_exact_search | A means to an end the biological basis of aging and death |
title_full | A means to an end the biological basis of aging and death William R. Clark |
title_fullStr | A means to an end the biological basis of aging and death William R. Clark |
title_full_unstemmed | A means to an end the biological basis of aging and death William R. Clark |
title_short | A means to an end |
title_sort | a means to an end the biological basis of aging and death |
title_sub | the biological basis of aging and death |
topic | MEDICAL / Nursing / Gerontology bisacsh FAMILY & RELATIONSHIPS / Aging bisacsh Aging / Molecular aspects fast Apoptosis fast Cells / Aging fast Medizin Apoptosis Aging Molecular aspects Cells Aging Altern (DE-588)4068596-2 gnd Zelle (DE-588)4067537-3 gnd |
topic_facet | MEDICAL / Nursing / Gerontology FAMILY & RELATIONSHIPS / Aging Aging / Molecular aspects Apoptosis Cells / Aging Medizin Aging Molecular aspects Cells Aging Altern Zelle |
url | http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=121455 |
work_keys_str_mv | AT clarkwilliamr ameanstoanendthebiologicalbasisofaginganddeath |