Comprehensive biomarker discovery and validation for clinical application:
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Cambridge
Royal Society of Chemistry
2013
|
| Schriftenreihe: | RSC drug discovery series
v.33 |
| Schlagworte: | |
| Online-Zugang: | FAW01 FAW02 Volltext |
| Beschreibung: | This book focuses on proteomics biomarker discovery and validation procedures from the clinical perspective. It provides an overview of current technology and the challenges encountered throughout the process. This covers all key stages, from biomarker discovery and validation, through to registration with the European and US regulatory authorities (FDA and EMEA). All the important elements (such as patient selection, sample handling, data processing, and statistical analysis) are described in detail and the reader is introduced to each topic with well-described examples or guidelines for best practice. Case studies are also included to demonstrate clinical applications. Individual chapters explain the best performing techniques for profiling complex body fluids and biomarker discovery. This includes the application of mass spectrometry imaging combined with chromatography in profiling platforms and the use of laser micro dissection and MALDI imaging to study tissues in their natural environment. Future developments needed to improve the success rate of translating biomarker discovery into useful clinical tests are also discussed. Common pitfalls and success stories are described as are the limitations of the various technologies involved. Broad and interdisciplinary in approach, this book provides an excellent source of information for industrial and academic researchers, and those managing biobanks |
| Beschreibung: | 1 Online-Ressource |
| ISBN: | 1849734224 1849734364 9781849734226 9781849734363 |
Internformat
MARC
| LEADER | 00000nmm a2200000zcb4500 | ||
|---|---|---|---|
| 001 | BV043118149 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | cr|uuu---uuuuu | ||
| 008 | 151126s2013 |||| o||u| ||||||eng d | ||
| 020 | |a 1849734224 |9 1-84973-422-4 | ||
| 020 | |a 1849734364 |9 1-84973-436-4 | ||
| 020 | |a 9781849734226 |9 978-1-84973-422-6 | ||
| 020 | |a 9781849734363 |9 978-1-84973-436-3 | ||
| 035 | |a (OCoLC)853659751 | ||
| 035 | |a (DE-599)BVBBV043118149 | ||
| 040 | |a DE-604 |b ger |e aacr | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-1046 |a DE-1047 | ||
| 082 | 0 | |a 610.28 |2 23 | |
| 245 | 1 | 0 | |a Comprehensive biomarker discovery and validation for clinical application |c edited by Péter Horvatovich and Rainer Bischoff |
| 264 | 1 | |a Cambridge |b Royal Society of Chemistry |c 2013 | |
| 300 | |a 1 Online-Ressource | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b c |2 rdamedia | ||
| 338 | |b cr |2 rdacarrier | ||
| 490 | 0 | |a RSC drug discovery series |v v.33 | |
| 500 | |a This book focuses on proteomics biomarker discovery and validation procedures from the clinical perspective. It provides an overview of current technology and the challenges encountered throughout the process. This covers all key stages, from biomarker discovery and validation, through to registration with the European and US regulatory authorities (FDA and EMEA). All the important elements (such as patient selection, sample handling, data processing, and statistical analysis) are described in detail and the reader is introduced to each topic with well-described examples or guidelines for best practice. Case studies are also included to demonstrate clinical applications. Individual chapters explain the best performing techniques for profiling complex body fluids and biomarker discovery. This includes the application of mass spectrometry imaging combined with chromatography in profiling platforms and the use of laser micro dissection and MALDI imaging to study tissues in their natural environment. Future developments needed to improve the success rate of translating biomarker discovery into useful clinical tests are also discussed. Common pitfalls and success stories are described as are the limitations of the various technologies involved. Broad and interdisciplinary in approach, this book provides an excellent source of information for industrial and academic researchers, and those managing biobanks | ||
| 650 | 4 | |a Biological Markers | |
| 650 | 7 | |a HEALTH & FITNESS / Holism |2 bisacsh | |
| 650 | 7 | |a HEALTH & FITNESS / Reference |2 bisacsh | |
| 650 | 7 | |a MEDICAL / Alternative Medicine |2 bisacsh | |
| 650 | 7 | |a MEDICAL / Atlases |2 bisacsh | |
| 650 | 7 | |a MEDICAL / Essays |2 bisacsh | |
| 650 | 7 | |a MEDICAL / Family & General Practice |2 bisacsh | |
| 650 | 7 | |a MEDICAL / Holistic Medicine |2 bisacsh | |
| 650 | 7 | |a MEDICAL / Osteopathy |2 bisacsh | |
| 650 | 7 | |a Biochemical markers |2 fast | |
| 650 | 4 | |a Medizin | |
| 650 | 4 | |a Biochemical markers | |
| 700 | 1 | |a Horvatovich, Péter |e Sonstige |4 oth | |
| 700 | 1 | |a Bischoff, Rainer |e Sonstige |4 oth | |
| 856 | 4 | 0 | |u http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=706402 |x Aggregator |3 Volltext |
| 912 | |a ZDB-4-EBA | ||
| 999 | |a oai:aleph.bib-bvb.de:BVB01-028542340 | ||
| 966 | e | |u http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=706402 |l FAW01 |p ZDB-4-EBA |q FAW_PDA_EBA |x Aggregator |3 Volltext | |
| 966 | e | |u http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=706402 |l FAW02 |p ZDB-4-EBA |q FAW_PDA_EBA |x Aggregator |3 Volltext | |
Datensatz im Suchindex
| _version_ | 1804175544792645632 |
|---|---|
| any_adam_object | |
| building | Verbundindex |
| bvnumber | BV043118149 |
| collection | ZDB-4-EBA |
| ctrlnum | (OCoLC)853659751 (DE-599)BVBBV043118149 |
| dewey-full | 610.28 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 610 - Medicine and health |
| dewey-raw | 610.28 |
| dewey-search | 610.28 |
| dewey-sort | 3610.28 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Electronic eBook |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>03527nmm a2200529zcb4500</leader><controlfield tag="001">BV043118149</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">cr|uuu---uuuuu</controlfield><controlfield tag="008">151126s2013 |||| o||u| ||||||eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">1849734224</subfield><subfield code="9">1-84973-422-4</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">1849734364</subfield><subfield code="9">1-84973-436-4</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9781849734226</subfield><subfield code="9">978-1-84973-422-6</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9781849734363</subfield><subfield code="9">978-1-84973-436-3</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)853659751</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV043118149</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">aacr</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-1046</subfield><subfield code="a">DE-1047</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">610.28</subfield><subfield code="2">23</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Comprehensive biomarker discovery and validation for clinical application</subfield><subfield code="c">edited by Péter Horvatovich and Rainer Bischoff</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Cambridge</subfield><subfield code="b">Royal Society of Chemistry</subfield><subfield code="c">2013</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">RSC drug discovery series</subfield><subfield code="v">v.33</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">This book focuses on proteomics biomarker discovery and validation procedures from the clinical perspective. It provides an overview of current technology and the challenges encountered throughout the process. This covers all key stages, from biomarker discovery and validation, through to registration with the European and US regulatory authorities (FDA and EMEA). All the important elements (such as patient selection, sample handling, data processing, and statistical analysis) are described in detail and the reader is introduced to each topic with well-described examples or guidelines for best practice. Case studies are also included to demonstrate clinical applications. Individual chapters explain the best performing techniques for profiling complex body fluids and biomarker discovery. This includes the application of mass spectrometry imaging combined with chromatography in profiling platforms and the use of laser micro dissection and MALDI imaging to study tissues in their natural environment. Future developments needed to improve the success rate of translating biomarker discovery into useful clinical tests are also discussed. Common pitfalls and success stories are described as are the limitations of the various technologies involved. Broad and interdisciplinary in approach, this book provides an excellent source of information for industrial and academic researchers, and those managing biobanks</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Biological Markers</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">HEALTH & FITNESS / Holism</subfield><subfield code="2">bisacsh</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">HEALTH & FITNESS / Reference</subfield><subfield code="2">bisacsh</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">MEDICAL / Alternative Medicine</subfield><subfield code="2">bisacsh</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">MEDICAL / Atlases</subfield><subfield code="2">bisacsh</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">MEDICAL / Essays</subfield><subfield code="2">bisacsh</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">MEDICAL / Family & General Practice</subfield><subfield code="2">bisacsh</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">MEDICAL / Holistic Medicine</subfield><subfield code="2">bisacsh</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">MEDICAL / Osteopathy</subfield><subfield code="2">bisacsh</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Biochemical markers</subfield><subfield code="2">fast</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Medizin</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Biochemical markers</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Horvatovich, Péter</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bischoff, Rainer</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=706402</subfield><subfield code="x">Aggregator</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-4-EBA</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-028542340</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=706402</subfield><subfield code="l">FAW01</subfield><subfield code="p">ZDB-4-EBA</subfield><subfield code="q">FAW_PDA_EBA</subfield><subfield code="x">Aggregator</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=706402</subfield><subfield code="l">FAW02</subfield><subfield code="p">ZDB-4-EBA</subfield><subfield code="q">FAW_PDA_EBA</subfield><subfield code="x">Aggregator</subfield><subfield code="3">Volltext</subfield></datafield></record></collection> |
| id | DE-604.BV043118149 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T07:17:59Z |
| institution | BVB |
| isbn | 1849734224 1849734364 9781849734226 9781849734363 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-028542340 |
| oclc_num | 853659751 |
| open_access_boolean | |
| owner | DE-1046 DE-1047 |
| owner_facet | DE-1046 DE-1047 |
| physical | 1 Online-Ressource |
| psigel | ZDB-4-EBA ZDB-4-EBA FAW_PDA_EBA |
| publishDate | 2013 |
| publishDateSearch | 2013 |
| publishDateSort | 2013 |
| publisher | Royal Society of Chemistry |
| record_format | marc |
| series2 | RSC drug discovery series |
| spelling | Comprehensive biomarker discovery and validation for clinical application edited by Péter Horvatovich and Rainer Bischoff Cambridge Royal Society of Chemistry 2013 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier RSC drug discovery series v.33 This book focuses on proteomics biomarker discovery and validation procedures from the clinical perspective. It provides an overview of current technology and the challenges encountered throughout the process. This covers all key stages, from biomarker discovery and validation, through to registration with the European and US regulatory authorities (FDA and EMEA). All the important elements (such as patient selection, sample handling, data processing, and statistical analysis) are described in detail and the reader is introduced to each topic with well-described examples or guidelines for best practice. Case studies are also included to demonstrate clinical applications. Individual chapters explain the best performing techniques for profiling complex body fluids and biomarker discovery. This includes the application of mass spectrometry imaging combined with chromatography in profiling platforms and the use of laser micro dissection and MALDI imaging to study tissues in their natural environment. Future developments needed to improve the success rate of translating biomarker discovery into useful clinical tests are also discussed. Common pitfalls and success stories are described as are the limitations of the various technologies involved. Broad and interdisciplinary in approach, this book provides an excellent source of information for industrial and academic researchers, and those managing biobanks Biological Markers HEALTH & FITNESS / Holism bisacsh HEALTH & FITNESS / Reference bisacsh MEDICAL / Alternative Medicine bisacsh MEDICAL / Atlases bisacsh MEDICAL / Essays bisacsh MEDICAL / Family & General Practice bisacsh MEDICAL / Holistic Medicine bisacsh MEDICAL / Osteopathy bisacsh Biochemical markers fast Medizin Biochemical markers Horvatovich, Péter Sonstige oth Bischoff, Rainer Sonstige oth http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=706402 Aggregator Volltext |
| spellingShingle | Comprehensive biomarker discovery and validation for clinical application Biological Markers HEALTH & FITNESS / Holism bisacsh HEALTH & FITNESS / Reference bisacsh MEDICAL / Alternative Medicine bisacsh MEDICAL / Atlases bisacsh MEDICAL / Essays bisacsh MEDICAL / Family & General Practice bisacsh MEDICAL / Holistic Medicine bisacsh MEDICAL / Osteopathy bisacsh Biochemical markers fast Medizin Biochemical markers |
| title | Comprehensive biomarker discovery and validation for clinical application |
| title_auth | Comprehensive biomarker discovery and validation for clinical application |
| title_exact_search | Comprehensive biomarker discovery and validation for clinical application |
| title_full | Comprehensive biomarker discovery and validation for clinical application edited by Péter Horvatovich and Rainer Bischoff |
| title_fullStr | Comprehensive biomarker discovery and validation for clinical application edited by Péter Horvatovich and Rainer Bischoff |
| title_full_unstemmed | Comprehensive biomarker discovery and validation for clinical application edited by Péter Horvatovich and Rainer Bischoff |
| title_short | Comprehensive biomarker discovery and validation for clinical application |
| title_sort | comprehensive biomarker discovery and validation for clinical application |
| topic | Biological Markers HEALTH & FITNESS / Holism bisacsh HEALTH & FITNESS / Reference bisacsh MEDICAL / Alternative Medicine bisacsh MEDICAL / Atlases bisacsh MEDICAL / Essays bisacsh MEDICAL / Family & General Practice bisacsh MEDICAL / Holistic Medicine bisacsh MEDICAL / Osteopathy bisacsh Biochemical markers fast Medizin Biochemical markers |
| topic_facet | Biological Markers HEALTH & FITNESS / Holism HEALTH & FITNESS / Reference MEDICAL / Alternative Medicine MEDICAL / Atlases MEDICAL / Essays MEDICAL / Family & General Practice MEDICAL / Holistic Medicine MEDICAL / Osteopathy Biochemical markers Medizin |
| url | http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=706402 |
| work_keys_str_mv | AT horvatovichpeter comprehensivebiomarkerdiscoveryandvalidationforclinicalapplication AT bischoffrainer comprehensivebiomarkerdiscoveryandvalidationforclinicalapplication |