Sequence alignment: methods, models, concepts, and strategies
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berkeley
University of California Press
©2009
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| Schlagworte: | |
| Online-Zugang: | FAW01 FAW02 Volltext |
| Beschreibung: | Includes bibliographical references (pages 297-332) and index Sequence alignment : concepts and history -- Insertion and deletion events, their molecular mechanisms, and their impact on sequence alignments -- Local versus global alignments -- Computing multiple sequence alignment with template-based methods -- Sequence evolution models for simultaneous alignment and phylogeny reconstruction -- Phylogenetic hypotheses and the utility of multiple sequence alignment -- Structural and evolutionary considerations for multiple sequence alignment of RNA, and the challenges for algorithms that ignore them -- Constructing alignment benchmarks -- Simulation approaches to evaluating alignment error and methods for comparing alternate alignments -- Robust inferences from ambiguous alignments -- Strategies for efficient exploitation of the informational content of protein multiple alignments The sequencing of the human genome involved thousands of scientists but used relatively few tools. Today, obtaining sequences is simpler, but aligning the sequences-making sure that sequences from one source are properly compared to those from other sources-remains a complicated but underappreciated aspect of comparative molecular biology. This volume, the first to focus on this crucial step in analyzing sequence data, is about the practice of alignment, the procedures by which alignments are established, and more importantly, how the outcomes of any alignment algorithm should be interpreted |
| Beschreibung: | 1 Online-Ressource (xvi, 337 pages) |
| ISBN: | 0520256972 0520943740 9780520256972 9780520943742 |
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| isbn | 0520256972 0520943740 9780520256972 9780520943742 |
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| spelling | Sequence alignment methods, models, concepts, and strategies edited by Michael S. Rosenberg Berkeley University of California Press ©2009 1 Online-Ressource (xvi, 337 pages) txt rdacontent c rdamedia cr rdacarrier Includes bibliographical references (pages 297-332) and index Sequence alignment : concepts and history -- Insertion and deletion events, their molecular mechanisms, and their impact on sequence alignments -- Local versus global alignments -- Computing multiple sequence alignment with template-based methods -- Sequence evolution models for simultaneous alignment and phylogeny reconstruction -- Phylogenetic hypotheses and the utility of multiple sequence alignment -- Structural and evolutionary considerations for multiple sequence alignment of RNA, and the challenges for algorithms that ignore them -- Constructing alignment benchmarks -- Simulation approaches to evaluating alignment error and methods for comparing alternate alignments -- Robust inferences from ambiguous alignments -- Strategies for efficient exploitation of the informational content of protein multiple alignments The sequencing of the human genome involved thousands of scientists but used relatively few tools. Today, obtaining sequences is simpler, but aligning the sequences-making sure that sequences from one source are properly compared to those from other sources-remains a complicated but underappreciated aspect of comparative molecular biology. This volume, the first to focus on this crucial step in analyzing sequence data, is about the practice of alignment, the procedures by which alignments are established, and more importantly, how the outcomes of any alignment algorithm should be interpreted Sequence Alignment / methods COMPUTERS / Bioinformatics bisacsh SCIENCE / Life Sciences / Evolution bisacsh Bioinformatics fast Computational biology fast Sequence alignment (Bioinformatics) fast Bioinformatics Computational biology Sequence alignment (Bioinformatics) Rosenberg, Michael S. Sonstige oth http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=305982 Aggregator Volltext |
| spellingShingle | Sequence alignment methods, models, concepts, and strategies Sequence Alignment / methods COMPUTERS / Bioinformatics bisacsh SCIENCE / Life Sciences / Evolution bisacsh Bioinformatics fast Computational biology fast Sequence alignment (Bioinformatics) fast Bioinformatics Computational biology Sequence alignment (Bioinformatics) |
| title | Sequence alignment methods, models, concepts, and strategies |
| title_auth | Sequence alignment methods, models, concepts, and strategies |
| title_exact_search | Sequence alignment methods, models, concepts, and strategies |
| title_full | Sequence alignment methods, models, concepts, and strategies edited by Michael S. Rosenberg |
| title_fullStr | Sequence alignment methods, models, concepts, and strategies edited by Michael S. Rosenberg |
| title_full_unstemmed | Sequence alignment methods, models, concepts, and strategies edited by Michael S. Rosenberg |
| title_short | Sequence alignment |
| title_sort | sequence alignment methods models concepts and strategies |
| title_sub | methods, models, concepts, and strategies |
| topic | Sequence Alignment / methods COMPUTERS / Bioinformatics bisacsh SCIENCE / Life Sciences / Evolution bisacsh Bioinformatics fast Computational biology fast Sequence alignment (Bioinformatics) fast Bioinformatics Computational biology Sequence alignment (Bioinformatics) |
| topic_facet | Sequence Alignment / methods COMPUTERS / Bioinformatics SCIENCE / Life Sciences / Evolution Bioinformatics Computational biology Sequence alignment (Bioinformatics) |
| url | http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=305982 |
| work_keys_str_mv | AT rosenbergmichaels sequencealignmentmethodsmodelsconceptsandstrategies |