Virtual ADMET Assessment in Target Selection and Maturation:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Amsterdam
IOS Press
2006
|
| Schriftenreihe: | Solvay Pharmaceuticals Conferences
v. 6 |
| Schlagworte: | |
| Online-Zugang: | FAW01 FAW02 Volltext |
| Beschreibung: | Preface; List of Contributors; Contents; Conference Preface; The Risky Business of Developing Drugs; Benefits and Limits of in Silico Predictions; Musings on ADME Predictions and Molecular Structure; Lipophilicity: Its Calculation and Application in ADMET Predictions; Interpretation of the Role of the Electrotopological State and Molecular Connectivity Indices in the Prediction of Physical Properties and ADME-Tox Behavior -- Case Study: Human Plasma Protein Binding; Molecular Descriptors for Predicting ADMET Properties; Molecular Fields to Assess Recognition Forces and Property Spaces Extracting Pharmacophores from Bio-Active MoleculesIn Silico Models for Human Bioavailability; In Silico Models to Predict Brain Uptake; Algorithms to Predict Affinity for Transporters; Predicting Affinity for and Metabolism by Cytochromes P450; Expert Systems to Predict Biotransformation; Expert Systems to Predict Toxicity; From in Vivo to in Vitro/in Silico ADME: Progress and Challenges; Author Index Today, biologists and medicinal chemists realize that there is a strong relationship between pharmacodynamic (what the drug does to the organism) and pharmacokinetic (what the organism does to the drug) effects. A significant contributing factor to the evolution in drug discovery was the methodological and technological revolution with the advent of combinatorial chemistry, high-throughput screening and profiling, and in silico prediction of target-based activity and ADMET (absorption, distribution, metabolism, excretion and toxicity) properties. High-throughput screening and in silico methods |
| Beschreibung: | 1 Online-Ressource (268 pages) |
| ISBN: | 142946772X 1433701553 9781429467728 9781433701559 |
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| spelling | Testa, B. Verfasser aut Virtual ADMET Assessment in Target Selection and Maturation Amsterdam IOS Press 2006 1 Online-Ressource (268 pages) txt rdacontent c rdamedia cr rdacarrier Solvay Pharmaceuticals Conferences v. 6 Preface; List of Contributors; Contents; Conference Preface; The Risky Business of Developing Drugs; Benefits and Limits of in Silico Predictions; Musings on ADME Predictions and Molecular Structure; Lipophilicity: Its Calculation and Application in ADMET Predictions; Interpretation of the Role of the Electrotopological State and Molecular Connectivity Indices in the Prediction of Physical Properties and ADME-Tox Behavior -- Case Study: Human Plasma Protein Binding; Molecular Descriptors for Predicting ADMET Properties; Molecular Fields to Assess Recognition Forces and Property Spaces Extracting Pharmacophores from Bio-Active MoleculesIn Silico Models for Human Bioavailability; In Silico Models to Predict Brain Uptake; Algorithms to Predict Affinity for Transporters; Predicting Affinity for and Metabolism by Cytochromes P450; Expert Systems to Predict Biotransformation; Expert Systems to Predict Toxicity; From in Vivo to in Vitro/in Silico ADME: Progress and Challenges; Author Index Today, biologists and medicinal chemists realize that there is a strong relationship between pharmacodynamic (what the drug does to the organism) and pharmacokinetic (what the organism does to the drug) effects. A significant contributing factor to the evolution in drug discovery was the methodological and technological revolution with the advent of combinatorial chemistry, high-throughput screening and profiling, and in silico prediction of target-based activity and ADMET (absorption, distribution, metabolism, excretion and toxicity) properties. High-throughput screening and in silico methods Drug development MEDICAL / Drug Guides bisacsh MEDICAL / Pharmacology bisacsh MEDICAL / Pharmacy bisacsh MEDICAL / Nursing / Pharmacology bisacsh Datenverarbeitung Medizin Drug development Data processing Congresses Drug development Congresses (DE-588)1071861417 Konferenzschrift gnd-content Turski, L. Sonstige oth http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=187952 Aggregator Volltext |
| spellingShingle | Testa, B. Virtual ADMET Assessment in Target Selection and Maturation Drug development MEDICAL / Drug Guides bisacsh MEDICAL / Pharmacology bisacsh MEDICAL / Pharmacy bisacsh MEDICAL / Nursing / Pharmacology bisacsh Datenverarbeitung Medizin Drug development Data processing Congresses Drug development Congresses |
| subject_GND | (DE-588)1071861417 |
| title | Virtual ADMET Assessment in Target Selection and Maturation |
| title_auth | Virtual ADMET Assessment in Target Selection and Maturation |
| title_exact_search | Virtual ADMET Assessment in Target Selection and Maturation |
| title_full | Virtual ADMET Assessment in Target Selection and Maturation |
| title_fullStr | Virtual ADMET Assessment in Target Selection and Maturation |
| title_full_unstemmed | Virtual ADMET Assessment in Target Selection and Maturation |
| title_short | Virtual ADMET Assessment in Target Selection and Maturation |
| title_sort | virtual admet assessment in target selection and maturation |
| topic | Drug development MEDICAL / Drug Guides bisacsh MEDICAL / Pharmacology bisacsh MEDICAL / Pharmacy bisacsh MEDICAL / Nursing / Pharmacology bisacsh Datenverarbeitung Medizin Drug development Data processing Congresses Drug development Congresses |
| topic_facet | Drug development MEDICAL / Drug Guides MEDICAL / Pharmacology MEDICAL / Pharmacy MEDICAL / Nursing / Pharmacology Datenverarbeitung Medizin Drug development Data processing Congresses Drug development Congresses Konferenzschrift |
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