Forensic DNA typing: biology, technology, and genetics of STR markers
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Bibliographische Detailangaben
1. Verfasser: Butler, John M., (John Marshall) (VerfasserIn)
Format: Elektronisch E-Book
Sprache:English
Veröffentlicht: Amsterdam Elsevier Academic Press c2005
Ausgabe:2nd ed
Schlagworte:
Online-Zugang:FAW01
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Beschreibung:Includes bibliographical references and indexes
Overview and history of DNA typing -- - DNA biology review -- - Sample collection, DNA extraction and DNA quantitation -- - The polymerase chain reaction (DNA amplification) -- - Commonly used short tandem repeat markers and commercial kits -- - Biology of STRs : stutter products, non-template addition, microvariants, null alleles, and mutation rates -- - Forensic issues : degraded DNA, PCR inhibition, contamination, mixed samples and low copy number -- - Single nucleotide polymorphisms and other bi-allelic markers -- Y chromosome DNA testing -- Mitochondrial DNA analysis -- Non-human DNA testing and microbial forensics -- - DNA separation methods : slab-gel and capillary electrophoresis -- - DNA detection methods : fluorescent dyes and silver-staining -- - Instrumentation for STR typing : ABI 310, ABI 3100, FMBIO systems -- - STR genotyping issues -- - Laboratory validation -- - New technologies, automation, and expert systems -- - Combined DNA index system (CODIS) and the use of DNA databases -- - Basic genetic principles, statistics, and probability -- STR population database analyses -- Profile frequency estimates, likelihood ratios, and source attribution -- Approaches to statistical analysis of mixtures and degraded DNA -- Kinship and parentage testing -- Mass disaster DNA victim identification
Beschreibung:1 Online-Ressource (xvii, 660 p.)
ISBN:0080470610
9780080470610

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