Review of the Environmental Protection Agency's draft IRIS assessment of formaldehyde:
Gespeichert in:
| Körperschaft: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Washington, D.C.
National Academies Press
c2011
|
| Schlagworte: | |
| Online-Zugang: | FAW01 FAW02 Volltext |
| Beschreibung: | Includes bibliographical references Formaldehyde is ubiquitous in indoor and outdoor air, and everyone is exposed to formaldehyde at some concentration daily. Formaldehyde is used to produce a wide array of products, particularly building materials; it is emitted from many sources, including power plants, cars, gas and wood stoves, and cigarettes; it is a natural product in some foods; and it is naturally present in the human body as a metabolic intermediate. Much research has been conducted on the health effects of exposure to formaldehyde, including effects on the upper airway, where formaldehyde is deposited when inhaled, and effects on tissues distant from the site of initial contact. The U.S. Environmental Protection Agency (EPA) released noncancer and cancer assessments of formaldehyde for its Integrated Risk Information System (IRIS) in 1990 and 1991, respectively. The agency began reassessing formaldehyde in 1998 and released a draft IRIS assessment in June 2010. Given the complexity of the issues and the knowledge that the assessment will be used as the basis of regulatory decisions, EPA asked the National Research Council (NRC) to conduct an independent scientific review of the draft IRIS assessment. In this report, the Committee to Review EPA's Draft IRIS Assessment of Formaldehyde first addresses some general issues associated with the draft IRIS assessment. The committee next focuses on questions concerning specific aspects of the draft assessment, including derivation of the reference concentrations and the cancer unit risk estimates for formaldehyde. The committee closes with recommendations for improving the IRIS assessment of formaldehyde and provides some general comments on the IRIS development process REVIEW OF THE ENVIRONMENTAL PROTECTION AGENCY'S DRAFT IRIS ASSESSMENT OF FORMALDEHYDE -- - Introduction -- - Review of Methods -- - Toxicokinetics and Modes of Action of Formaldehyde -- - Portal-of-Entry Health Effects -- - Systemic Health Effects -- - Reference Concentrations for Noncancer Effects and Unit Risks for Cancers -- - A Roadmap for Revision -- - Appendix A - Biographic Information on the Committee to Review EPA'S Draft IRIS Assessment of Formaldehyde -- - Appendix B - Weight-of-Evidence Descriptions from U.S. Environmental Protection Agency Guidelines |
| Beschreibung: | 1 Online-Ressource (xiii, 190 p.) |
| ISBN: | 030921193X 0309211948 1283135159 9780309211932 9780309211949 9781283135153 |
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| 245 | 1 | 0 | |a Review of the Environmental Protection Agency's draft IRIS assessment of formaldehyde |c Committee to Review EPA's Draft IRIS Assessment of Formaldehyde, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies, National Research Council of the National Academies |
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| 500 | |a Formaldehyde is ubiquitous in indoor and outdoor air, and everyone is exposed to formaldehyde at some concentration daily. Formaldehyde is used to produce a wide array of products, particularly building materials; it is emitted from many sources, including power plants, cars, gas and wood stoves, and cigarettes; it is a natural product in some foods; and it is naturally present in the human body as a metabolic intermediate. Much research has been conducted on the health effects of exposure to formaldehyde, including effects on the upper airway, where formaldehyde is deposited when inhaled, and effects on tissues distant from the site of initial contact. The U.S. Environmental Protection Agency (EPA) released noncancer and cancer assessments of formaldehyde for its Integrated Risk Information System (IRIS) in 1990 and 1991, respectively. The agency began reassessing formaldehyde in 1998 and released a draft IRIS assessment in June 2010. Given the complexity of the issues and the knowledge that the assessment will be used as the basis of regulatory decisions, EPA asked the National Research Council (NRC) to conduct an independent scientific review of the draft IRIS assessment. In this report, the Committee to Review EPA's Draft IRIS Assessment of Formaldehyde first addresses some general issues associated with the draft IRIS assessment. The committee next focuses on questions concerning specific aspects of the draft assessment, including derivation of the reference concentrations and the cancer unit risk estimates for formaldehyde. The committee closes with recommendations for improving the IRIS assessment of formaldehyde and provides some general comments on the IRIS development process | ||
| 500 | |a REVIEW OF THE ENVIRONMENTAL PROTECTION AGENCY'S DRAFT IRIS ASSESSMENT OF FORMALDEHYDE -- - Introduction -- - Review of Methods -- - Toxicokinetics and Modes of Action of Formaldehyde -- - Portal-of-Entry Health Effects -- - Systemic Health Effects -- - Reference Concentrations for Noncancer Effects and Unit Risks for Cancers -- - A Roadmap for Revision -- - Appendix A - Biographic Information on the Committee to Review EPA'S Draft IRIS Assessment of Formaldehyde -- - Appendix B - Weight-of-Evidence Descriptions from U.S. Environmental Protection Agency Guidelines | ||
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| spelling | National Research Council (U.S.) Committee to Review EPA's Draft IRIS Assessment of Formaldehyde Verfasser aut Review of the Environmental Protection Agency's draft IRIS assessment of formaldehyde Committee to Review EPA's Draft IRIS Assessment of Formaldehyde, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies, National Research Council of the National Academies Formaldehyde Washington, D.C. National Academies Press c2011 1 Online-Ressource (xiii, 190 p.) txt rdacontent c rdamedia cr rdacarrier Includes bibliographical references Formaldehyde is ubiquitous in indoor and outdoor air, and everyone is exposed to formaldehyde at some concentration daily. Formaldehyde is used to produce a wide array of products, particularly building materials; it is emitted from many sources, including power plants, cars, gas and wood stoves, and cigarettes; it is a natural product in some foods; and it is naturally present in the human body as a metabolic intermediate. Much research has been conducted on the health effects of exposure to formaldehyde, including effects on the upper airway, where formaldehyde is deposited when inhaled, and effects on tissues distant from the site of initial contact. The U.S. Environmental Protection Agency (EPA) released noncancer and cancer assessments of formaldehyde for its Integrated Risk Information System (IRIS) in 1990 and 1991, respectively. The agency began reassessing formaldehyde in 1998 and released a draft IRIS assessment in June 2010. Given the complexity of the issues and the knowledge that the assessment will be used as the basis of regulatory decisions, EPA asked the National Research Council (NRC) to conduct an independent scientific review of the draft IRIS assessment. In this report, the Committee to Review EPA's Draft IRIS Assessment of Formaldehyde first addresses some general issues associated with the draft IRIS assessment. The committee next focuses on questions concerning specific aspects of the draft assessment, including derivation of the reference concentrations and the cancer unit risk estimates for formaldehyde. The committee closes with recommendations for improving the IRIS assessment of formaldehyde and provides some general comments on the IRIS development process REVIEW OF THE ENVIRONMENTAL PROTECTION AGENCY'S DRAFT IRIS ASSESSMENT OF FORMALDEHYDE -- - Introduction -- - Review of Methods -- - Toxicokinetics and Modes of Action of Formaldehyde -- - Portal-of-Entry Health Effects -- - Systemic Health Effects -- - Reference Concentrations for Noncancer Effects and Unit Risks for Cancers -- - A Roadmap for Revision -- - Appendix A - Biographic Information on the Committee to Review EPA'S Draft IRIS Assessment of Formaldehyde -- - Appendix B - Weight-of-Evidence Descriptions from U.S. Environmental Protection Agency Guidelines United States / Environmental Protection Agency United States Environmental Protection Agency Formaldehyde / toxicity Formaldehyde / adverse effects Risk Assessment TECHNOLOGY & ENGINEERING / Chemical & Biochemical bisacsh Formaldehyde Toxicology Formaldehyde Risk assessment USA United States Environmental Protection Agency Sonstige oth http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=372485 Aggregator Volltext |
| spellingShingle | Review of the Environmental Protection Agency's draft IRIS assessment of formaldehyde United States / Environmental Protection Agency United States Environmental Protection Agency Formaldehyde / toxicity Formaldehyde / adverse effects Risk Assessment TECHNOLOGY & ENGINEERING / Chemical & Biochemical bisacsh Formaldehyde Toxicology Formaldehyde Risk assessment |
| title | Review of the Environmental Protection Agency's draft IRIS assessment of formaldehyde |
| title_alt | Formaldehyde |
| title_auth | Review of the Environmental Protection Agency's draft IRIS assessment of formaldehyde |
| title_exact_search | Review of the Environmental Protection Agency's draft IRIS assessment of formaldehyde |
| title_full | Review of the Environmental Protection Agency's draft IRIS assessment of formaldehyde Committee to Review EPA's Draft IRIS Assessment of Formaldehyde, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies, National Research Council of the National Academies |
| title_fullStr | Review of the Environmental Protection Agency's draft IRIS assessment of formaldehyde Committee to Review EPA's Draft IRIS Assessment of Formaldehyde, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies, National Research Council of the National Academies |
| title_full_unstemmed | Review of the Environmental Protection Agency's draft IRIS assessment of formaldehyde Committee to Review EPA's Draft IRIS Assessment of Formaldehyde, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies, National Research Council of the National Academies |
| title_short | Review of the Environmental Protection Agency's draft IRIS assessment of formaldehyde |
| title_sort | review of the environmental protection agency s draft iris assessment of formaldehyde |
| topic | United States / Environmental Protection Agency United States Environmental Protection Agency Formaldehyde / toxicity Formaldehyde / adverse effects Risk Assessment TECHNOLOGY & ENGINEERING / Chemical & Biochemical bisacsh Formaldehyde Toxicology Formaldehyde Risk assessment |
| topic_facet | United States / Environmental Protection Agency United States Environmental Protection Agency Formaldehyde / toxicity Formaldehyde / adverse effects Risk Assessment TECHNOLOGY & ENGINEERING / Chemical & Biochemical Formaldehyde Toxicology Formaldehyde Risk assessment USA |
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